The Gap1 general amino acid permease acts as an amino acid sensor for activation of protein kinase A targets in the yeast Saccharomyces cerevisiae

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Molecular Microbiology

• Publication date

  2003-11-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1046/j.1365-2958.2003.03732.xPMID 14617151
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The role of hexose transport and phosphorylation in cAMP signalling in the yeast Saccharomyces cerevisiae.

  2001cited by this paper
• Glucose-sensing mechanisms in eukaryotic cells.

  2001cited by this paper
• Glucose‐induced cAMP signalling in yeast requires both a G‐protein coupled receptor system for extracellular glucose detection and a separable hexose kinase‐dependent sensing process

  2000cited by this paper
• Glucose Activates Mitogen-activated Protein Kinase (Extracellular Signal-regulated Kinase) through Proline-rich Tyrosine Kinase-2 and the Glut1 Glucose Transporter*

  2000cited by this paper
• Stimulation of the yeast high osmolarity glycerol (HOG) pathway: evidence for a signal generated by a change in turgor rather than by water stress

  2000cited by this paper
• Amino Acid Signaling in Saccharomyces cerevisiae: a Permease-Like Sensor of External Amino Acids and F-Box Protein Grr1p Are Required for Transcriptional Induction of the AGP1 Gene, Which Encodes a Broad-Specificity Amino Acid Permease

  1999cited by this paper
• A Saccharomyces cerevisiae G‐protein coupled receptor, Gpr1, is specifically required for glucose activation of the cAMP pathway during the transition to growth on glucose

  1999cited by this paper
• Novel alleles of yeast hexokinase PII with distinct effects on catalytic activity and catabolite repression of SUC2.

  1999cited by this paper
• Sugars as signaling molecules.

  1999cited by this paper
• The Dual Function of Sugar Carriers: Transport and Sugar Sensing

  1999cited by this paper
• Ssy1p and Ptr3p Are Plasma Membrane Components of a Yeast System That Senses Extracellular Amino Acids

  1999cited by this paper
• Novel sensing mechanisms and targets for the cAMP–protein kinase A pathway in the yeast Saccharomyces cerevisiae

  1999cited by this paper
• Designer deletion strains derived from Saccharomyces cerevisiae S288C: A useful set of strains and plasmids for PCR‐mediated gene disruption and other applications

  1998cited by this paper
• The MEP2 ammonium permease regulates pseudohyphal differentiation in Saccharomyces cerevisiae

  1998influential reference
• The hexokinase 2 protein participates in regulatory DNA‐protein complexes necessary for glucose repression of the SUC2 gene in Saccharomyces cerevisiae

  1998cited by this paper
• Functional sensitivity of polar surfaces on transmembrane helix 8 and cytoplasmic loop 8-9 of the Escherichia coli GABA (4-aminobutyrate) transporter encoded by gabP: mutagenic analysis of a consensus amphipathic region found in transporters from bacteria to mammals.

  1998cited by this paper
• Glucose sensing and signaling by two glucose receptors in the yeast Saccharomyces cerevisiae

  1998cited by this paper
• Involvement of distinct G‐proteins, Gpa2 and Ras, in glucose‐ and intracellular acidification‐induced cAMP signalling in the yeast Saccharomyces cerevisiae

  1998cited by this paper
• Dip5p mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate in Saccharomyces cerevisiae

  1998cited by this paper
• The permease homologue Ssy1p controls the expression of amino acid and peptide transporter genes in Saccharomyces cerevisiae

  1998cited by this paper
• A C‐terminal di‐leucine motif and nearby sequences are required for NH4+‐induced inactivation and degradation of the general amino acid permease, Gap1p, of Saccharomyces cerevisiae

  1997cited by this paper
• Copyright © 1997, American Society for Microbiology A Family of Ammonium Transporters in

  1997cited by this paper
• The Sch9 protein kinase in the yeast Saccharomyces cerevisiae controls cAPK activity and is required for nitrogen activation of the fermentable-growth-medium-induced (FGM) pathway.

  1997cited by this paper
• Novel alleles of

  1996cited by this paper
• Glucose-triggered signalling in Saccharomyces cerevisiae: different requirements for sugar phosphorylation between cells grown on glucose and those grown on non-fermentable carbon sources.

  1996cited by this paper
• Ribosomal protein gene transcription in Saccharomyces cerevisiae shows a biphasic response to nutritional changes.

  1996cited by this paper
• Two glucose transporters in Saccharomyces cerevisiae are glucose sensors that generate a signal for induction of gene expression.

  1996cited by this paper
• An overview of membrane transport proteins in Saccharomyces cerevisiae

  1995cited by this paper
• Stress signaling in yeast

  1995cited by this paper
• Transcriptional and posttranslational regulation of the general amino acid permease of Saccharomyces cerevisiae

  1995cited by this paper
• Activation of trehalase during growth induction by nitrogen sources in the yeast Saccharomyces cerevisiae depends on the free catalytic subunits of camp‐dependent protein kinase, but not on functional ras proteins

  1994cited by this paper
• Signal transduction in yeast

  1994cited by this paper
• Cloning and expression of the MEP1 gene encoding an ammonium transporter in Saccharomyces cerevisiae.

  1994cited by this paper
• Nutritional upshift response of ribosomal protein gene transcription in Saccharomyces cerevisiae.

  1994cited by this paper
• Chapter 7 – RAS Genes in the Budding Yeast Saccharomyces cerevisiae

  1993cited by this paper
• Low activity of the yeast cAMP-dependent protein kinase catalytic subunit Tpk3 is due to the poor expression of the TPK3 gene.

  1993cited by this paper
• Chapter 7 Amino acid transporters in yeast: structure, function and regulation

  1992cited by this paper
• Nutrient-induced activation of trehalase in nutrient-starved cells of the yeast Saccharomyces cerevisiae: cAMP is not involved as second messenger.

  1992cited by this paper
• The RAS-adenylate cyclase pathway and cell cycle control in

  1992cited by this paper
• The RAS-adenylate cyclase pathway and cell cycle control inSaccharomyces cerevisiae

  1992cited by this paper
• A family of low and high copy replicative, integrative and single‐stranded S. cerevisiae/E. coli shuttle vectors

  1991cited by this paper
• Applications of high efficiency lithium acetate transformation of intact yeast cells using single‐stranded nucleic acids as carrier

  1991cited by this paper
• Fermentable sugars and intracellular acidification as specific activators of the RAS‐adenylate cyclase signalling pathway in yeast: the relationship to nutrient‐induced cell cycle control

  1991cited by this paper
• The function of ras genes in Saccharomyces cerevisiae.

  1990cited by this paper
• Glucose-induced hyperaccumulation of cyclic AMP and defective glucose repression in yeast strains with reduced activity of cyclic AMP-dependent protein kinase

  1990cited by this paper
• GAP1, the general amino acid permease gene of Saccharomyces cerevisiae. Nucleotide sequence, protein similarity with the other bakers yeast amino acid permeases, and nitrogen catabolite repression.

  1990influential reference
• Studies on the mechanism of the glucose-induced cAMP signal in glycolysis and glucose repression mutants of the yeast Saccharomyces cerevisiae.

  1988cited by this paper
• Three different genes in S. cerevisiae encode the catalytic subunits of the cAMP-dependent protein kinase.

  1987cited by this paper
• Cloning and characterization of BCY1, a locus encoding a regulatory subunit of the cyclic AMP-dependent protein kinase in Saccharomyces cerevisiae

  1987cited by this paper
• Molecular characterization of the CAN1 locus in Saccharomyces cerevisiae. A transmembrane protein without N-terminal hydrophobic signal sequence.

  1985cited by this paper
• Inactivation-reactivation process and repression of permease formation regulate several ammonia-sensitive permeases in the yeast Saccharomyces cerevisiae.

  1983cited by this paper
• Yeast argininosuccinate synthetase. Purification; structural and kinetic properties.

  1979cited by this paper
• Mutations affecting the repressibility of arginine biosynthetic enzymes in Saccharomyces cerevisiae.

  1970cited by this paper
• Multiplicity of the Amino Acid Permeases in Saccharomyces cerevisiae IV. Evidence for a General Amino Acid Permease

  1970cited by this paper
• The utilization of exogenous pyrimidines and the recycling of uridine-5'-phosphate derivatives in Saccharomyces cerevisiae, as studied by means of mutants affected in pyrimidine uptake and metabolism.

  1969cited by this paper
• Multiplicity of the amino acid permeases in Saccharomyces cerevisiae. I. Evidence for a specific arginine-transporting system.

  1966cited by this paper
• Multiplicity of the amino acid permeases in Saccharomyces cerevisiae. IV. Evidence for a general amino acid permease.

  1966influential reference

• Mining Genetically Encoded Biosensors from Filamentous Fungi.

  2026cites this paper
• Characterization and whole genome sequencing of Saccharomyces cerevisiae strains lacking several amino acid transporters: Tools for studying amino acid transport

  2025cites this paper
• A Cystine Transporter Mediates Nutrient Acquisition and Redox Balance During Wheat Stripe Rust Infection

  2025cites this paper
• Juvenile hormone controls trehalose metabolism by regulating trehalase 2 activity in ovarian development of Helicoverpa armigera

  2024cites this paper
• Neglected Issues in T Lymphocyte Metabolism: Purine Metabolism and Control of Nuclear Envelope Regulatory Processes. New Insights into Triggering Potential Metabolic Fragilities

  2024cites this paper
• Yeast Bioflavoring in Beer: Complexity Decoded and Built up Again

  2024cites this paper
• Models for Wine Fermentation and Their Suitability for Commercial Applications

  2024cites this paper
• Research progress on the function and regulatory pathways of amino acid permeases in fungi

  2024cites this paper
• Spray-induced gene silencing (SIGS) as a tool for the management of Pine Pitch Canker forest disease

  2024cites this paper
• Characteristics and functions of Limosilactobacillus reuteri (Lactobacillus reuteri) from the intestine of mice supplemented with three dietary components based on genome resequencing and metabolite analysis

  2023cites this paper
• The Yeast Permease Agp2 Senses Cycloheximide and Undergoes Degradation That Requires the Small Protein Brp1-Cellular Fate of Agp2 in Response to Cycloheximide

  2023cites this paper
• An Overview of the Putative Structural and Functional Properties of the GHBh1 Receptor through a Bioinformatics Approach

  2023cites this paper
• The S-component fold: a link between bacterial transporters and receptors

  2023cites this paper
• The Amino Acid Permease MoGap1 Regulates TOR Activity and Autophagy in Magnaporthe oryzae

  2022cites this paper
• Substrate-induced differential degradation and partitioning of the two tryptophan permeases Tat1 and Tat2 into eisosomes in Saccharomyces cerevisiae.

  2022cites this paper
• Trehalase is required for sex pheromone biosynthesis in Helicoverpa armigera

  2022cites this paper
• Yeast-Mycelial Dimorphism in Pichia pastoris SMD1168 Is Triggered by Nutritional and Environmental Factors

  2022cites this paper
• Using in vivo transcriptomics and RNA enrichment to identify genes involved in virulence of Candida glabrata

  2022cites this paper
• The arginine transporter Can1 acts as a transceptor for regulation of proline utilization in the yeast Saccharomyces cerevisiae

  2022cites this paper
• Heterozygous Mutations in Aromatic Amino Acid Synthesis Genes Trigger TOR Pathway Activation in Saccharomyces cerevisiae.

  2022cites this paper
• Glutamine transport as a possible regulator of nitrogen catabolite repression in Saccharomyces cerevisiae

  2022cites this paper
• Nutrient transceptors physically interact with the yeast S6/protein kinase B homolog, Sch9, a TOR kinase target

  2021cites this paper
• Effectiveness and Fate Nitrogen in Plants Physiology, Molecular Approaches for Maximization and Improving Nitrogen Use Efficiency. A Review

  2021cites this paper
• Diversity of bet‐hedging strategies in microbial communities—Recent cases and insights

  2021cites this paper
• Mitochondrial-derived compartments facilitate cellular adaptation to amino acid stress.

  2021cites this paper
• Nitrate transport and assimilation in plants: a potential review

  2020cites this paper
• A selectively suppressing amino acid transporter: Sodium-coupled neutral amino acid transporter 2 inhibits cell growth and mammalian target of rapamycin complex 1 pathway in skeletal muscle cells

  2020cites this paper
• Mitochondrial-Derived Compartments Facilitate Cellular Adaptation to Amino Acid Stress

  2020cites this paper
• Nutrient sensing and cAMP signaling in yeast: G-protein coupled receptor versus transceptor activation of PKA

  2020influential citation
• Receptor-like role for PQLC2 amino acid transporter in the lysosomal sensing of cationic amino acids

  2020cites this paper
• Nutrient transceptors physically interact with the yeast S 6 / Protein 1 kinase B homolog , Sch 9 , a TOR kinase target 2 3

  2020cites this paper
• Isolation and characterization of Phanerochaete chrysosporium mutants resistant to antifungal compounds

  2020cites this paper
• fermentation

  2020cites this paper
• Amino acid permeases in Cryptococcus neoformans are required for high temperature growth and virulence; and are regulated by Ras signaling

  2019cites this paper
• A Novel Resistance Pathway for Calcineurin Inhibitors in the Human-Pathogenic Mucorales Mucor circinelloides

  2019cites this paper
• PQLC2 recruits the C9orf72 complex to lysosomes in response to cationic amino acid starvation

  2019cites this paper
• Regulation of Amino Acid Transport in Saccharomyces cerevisiae

  2019cites this paper
• Role of Amino Acid Metabolism in the Virulence of Human Pathogenic Fungi

  2019cites this paper
• PQLC2 signals lysosomal cationic amino acid abundance to the C9orf72 complex

  2019cites this paper
• Regulation and metabolic engineering strategies for permeases of Saccharomyces cerevisiae

  2019cites this paper
• Identification by comparative transcriptomics of core regulatory genes for higher alcohol production in a top-fermenting yeast at different temperatures in beer fermentation

  2019cites this paper
• The bifunctional transporter-receptor IRT1 at the heart of metal sensing and signalling.

  2019cites this paper
• Nutrient and Stress Sensing in Pathogenic Yeasts

  2019cites this paper
• Source and sink mechanisms of nitrogen transport and use.

  2018cites this paper
• Overview of carbon and nitrogen catabolite metabolism in the virulence of human pathogenic fungi

  2018cites this paper
• The yeast H+-ATPase Pma1 promotes Rag/Gtr-dependent TORC1 activation in response to H+-coupled nutrient uptake

  2018cites this paper
• Multiple Transceptors for Macro- and Micro-Nutrients Control Diverse Cellular Properties Through the PKA Pathway in Yeast: A Paradigm for the Rapidly Expanding World of Eukaryotic Nutrient Transceptors Up to Those in Human Cells

  2018influential citation
• Emerging Roles of Nucleoside Transporters

  2018cites this paper
• Editorial: Hidden Secrets and Lessons From the Crystal Structures of Integral Membrane Proteins: Channels, Pumps and Receptors

  2018cites this paper
• Whi2 signals low leucine availability to halt yeast growth and cell death.

  2018cites this paper
• Nuevas implicaciones de los transportadores concentrativos de nucleósidos asociadas a la biología tumolar

  2018cites this paper
• Glucose regulation in the methylotrophic yeast Hansenula (Ogataea) polymorpha is mediated by a putative transceptor Gcr1.

  2018cites this paper
• Manipulation of cytokinin level in the ergot fungus Claviceps purpurea emphasizes its contribution to virulence

  2018cites this paper
• The nutrient transceptor/PKA pathway functions independently of TOR and responds to leucine and Gcn2 in a TOR-independent manner

  2017cites this paper
• Effectors involved in fungal–fungal interaction lead to a rare phenomenon of hyperbiotrophy in the tritrophic system biocontrol agent–powdery mildew–plant

  2017cites this paper
• Nutrient Sensing at the Plasma Membrane of Fungal Cells

  2017cites this paper
• Identification of Ftr1 and Zrt1 as iron and zinc micronutrient transceptors for activation of the PKA pathway in Saccharomyces cerevisiae

  2017influential citation
• Achieving global perfect homeostasis through transporter regulation

  2017cites this paper
• Influence of environmental and nutritional conditions on yeast–mycelial dimorphic transition in Trichosporon cutaneum

  2017cites this paper
• Transceptors as a functional link of transporters and receptors

  2017cites this paper
• Nitrate Assimilation in Fusarium fujikuroi Is Controlled by Multiple Levels of Regulation

  2017cites this paper
• Update on amino acid transporter functions and on possible amino acid sensing mechanisms in plants.

  2017cites this paper
• The role of PKA in the translational response to heat stress in Saccharomyces cerevisiae

  2017cites this paper
• Detection of cAMP and of PKA activity in Saccharomyces cerevisiae single cells using Fluorescence Resonance Energy Transfer (FRET) probes.

  2017cites this paper
• Genetic basis of priority effects: insights from nectar yeast

  2016cites this paper
• Characterization of the Candida albicans Amino Acid Permease Family: Gap2 Is the Only General Amino Acid Permease and Gap4 Is an S-Adenosylmethionine (SAM) Transporter Required for SAM-Induced Morphogenesis

  2016cites this paper
• Kinetics, dynamics and localization of basic amino acid transporters in Saccharomyces

  2016cites this paper
• Gibepyrone Biosynthesis in the Rice Pathogen Fusarium fujikuroi Is Facilitated by a Small Polyketide Synthase Gene Cluster*

  2016cites this paper
• A Plasma Membrane Association Module in Yeast Amino Acid Transporters*

  2016cites this paper
• L’exploitation d’un modèle de levure présentant une déficience de l’absorption des anthracyclines révèle qu’une protéine de Caenorhabditis elegans, OCT-1, est un transporteur fonctionnel d’anthracyclines

  2016influential citation
• Function and Regulation of Fungal Amino Acid Transporters: Insights from Predicted Structure.

  2016cites this paper
• Hxt1, a monosaccharide transporter and sensor required for virulence of the maize pathogen Ustilago maydis.

  2015cites this paper
• Branched-Chain Aminotransferases Control TORC1 Signaling in Saccharomyces cerevisiae

  2015cites this paper
• Predicting virulence factors in filamentous fungi: Regulation and evolution of secondary metabolism gene clusters

  2015cites this paper
• Sul1 and Sul2 Sulfate Transceptors Signal to Protein Kinase A upon Exit of Sulfur Starvation

  2015cites this paper
• Amino acids and autophagy: cross-talk and co-operation to control cellular homeostasis

  2015cites this paper
• The General Amino Acid Permease FfGap1 of Fusarium fujikuroi Is Sorted to the Vacuole in a Nitrogen-Dependent, but Npr1 Kinase-Independent Manner

  2015influential citation
• Molecular Mechanism Underlying the Plant NRT1.1 Dual-Affinity Nitrate Transporter

  2015cites this paper
• A genetic approach of wine yeast fermentation capacity in nitrogen-starvation reveals the key role of nitrogen signaling

  2014cites this paper
• Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae

  2014cites this paper
• Serine- and Threonine/Valine-Dependent Activation of PDK and Tor Orthologs Converge on Sch9 to Promote Aging

  2014cites this paper
• Control of morphogenesis, protease secretion and gene expression in Candida albicans by the preferred nitrogen source ammonium.

  2014cites this paper
• Substrate-Induced Ubiquitylation and Endocytosis of Yeast Amino Acid Permeases

  2014cites this paper
• Specific analogues uncouple transport, signalling, oligo-ubiquitination and endocytosis in the yeast Gap1 amino acid transceptor

  2014cites this paper
• Agp2, a Member of the Yeast Amino Acid Permease Family, Positively Regulates Polyamine Transport at the Transcriptional Level

  2013cites this paper
• Yeast nutrient transceptors provide novel insight in the functionality of membrane transporters

  2013cites this paper
• A model for generating several adaptive phenotypes from a single genetic event

  2013cites this paper
• The Antifungal Eugenol Perturbs Dual Aromatic and Branched-Chain Amino Acid Permeases in the Cytoplasmic Membrane of Yeast

  2013cites this paper
• The balance of protein expression and degradation: an ESCRTs point of view.

  2013cites this paper
• cAMP-PKA pathway to induce morphogenesis in Candida albicans

  2013cites this paper
• Quantitative Proton Nuclear Magnetic Resonance Spectroscopy (q1HNMR) and Solid Phase Microextraction Coupled with Gas Chromatography and Mass Spectrometry (SPME-GCMS) for the Determination of the Metabolic Contributions of Two Signaling Pathways in Sacca

  2013cites this paper
• Saccharomyces cerevisiae–Based Platform for Rapid Production and Evaluation of Eukaryotic Nutrient Transporters and Transceptors for Biochemical Studies and Crystallography

  2013cites this paper
• Peptides induce persistent signaling from endosomes by a nutrient transceptor.

  2012cites this paper
• Amino Acid Transporter Genes Are Essential for FLO11-Dependent and FLO11-Independent Biofilm Formation and Invasive Growth in Saccharomyces cerevisiae

  2012cites this paper
• Glucose, Nitrogen, and Phosphate Repletion in Saccharomyces cerevisiae: Common Transcriptional Responses to Different Nutrient Signals

  2012influential citation
• Nerveless and gutsy: intestinal nutrient sensing from invertebrates to humans

  2012cites this paper
• Cell growth and cell cycle in Saccharomyces cerevisiae: basic regulatory design and protein-protein interaction network.

  2012cites this paper
• Transporters for amino acids in plant cells: some functions and many unknowns.

  2012cites this paper
• Yeast 3-Phosphoinositide-dependent Protein Kinase-1 (PDK1) Orthologs Pkh1–3 Differentially Regulate Phosphorylation of Protein Kinase A (PKA) and the Protein Kinase B (PKB)/S6K Ortholog Sch9*

  2011cites this paper
• Especificidad de la proteína quinasa A en Saccharomyces cerevisiae vía fosforilación y localización de las isoformas catalíticas

  2011cites this paper