H-ras oncogene point mutations in arthritic synovium.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Arthritis & Rheumatism

• Publication date

  1997-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/ART.1780400913PMID 9324018
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Cellular basis and oncogene expression of rheumatoid joint destruction

  2004cited by this paper
• Spontaneous expression of immediately-early response genes c-fos and egr-1 in collagenase-producing rheumatoid synovial fibroblasts

  2004cited by this paper
• Activated N-ras oncogene and N-ras proto-oncogene act through the same pathway for in vivo tumorigenesis.

  1996cited by this paper
• Oncoprotein expression in human synovial tissue: an immunohistochemical study of different types of arthritis.

  1996cited by this paper
• Synovial fibroblast-like cells strongly express jun-B and C-fos proto-oncogenes in rheumatoid- and osteoarthritis.

  1995cited by this paper
• Biological and structural characterization of a Ras transforming mutation at the phenylalanine-156 residue, which is conserved in all members of the Ras superfamily.

  1995cited by this paper
• Oncogene expression in synovial fluid cells in reactive and early rheumatoid arthritis: a brief report.

  1995cited by this paper
• Sustained and Distinctive Patterns of Gene Activation in Synovial Fibroblasts and Whole Synovial Tissue Obtained from Inflammatory Synovitis

  1994cited by this paper
• Ras activation of genes: Mob-1 as a model.

  1994cited by this paper
• Oncogene activation of human keratin 18 transcription via the Ras signal transduction pathway.

  1994cited by this paper
• Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase.

  1993cited by this paper
• Screening for point mutations by semi-automated DNA sequencing using sequenase and magnetic beads.

  1993cited by this paper
• Activation of the MAP kinase pathway by the protein kinase raf.

  1992cited by this paper
• A dominant activating mutation in the effector region of RAS abolishes IRA2 sensitivity

  1992cited by this paper
• The GTPase superfamily: conserved structure and molecular mechanism

  1991cited by this paper
• Proto-oncogene expression in cultured synovial fibroblasts of patients with rheumatoid arthritis.

  1991cited by this paper
• Classification of disease: osteoarthritis.

  1991cited by this paper
• ras oncogenes: their role in neoplasia

  1990cited by this paper
• Expression of the collagenolytic and Ras-induced cysteine proteinase cathepsin L and proliferation-associated oncogenes in synovial cells of MRL/I mice and patients with rheumatoid arthritis.

  1990cited by this paper
• Revised criteria for the classification of rheumatoid arthritis.

  1990cited by this paper
• Neutron radiation can activate K-ras via a point mutation in codon 146 and induces a different spectrum of ras mutations than does gamma radiation

  1990cited by this paper
• Transin/stromelysin expression in rheumatoid synovium. A transformation-associated metalloproteinase secreted by phenotypically invasive synoviocytes.

  1989cited by this paper
• Structural and functional properties of ras proteins

  1989cited by this paper
• Expression of raf oncogenes activates the PEA1 transcription factor motif

  1989cited by this paper
• Anchorage-independent growth of synoviocytes from arthritic and normal joints. Stimulation by exogenous platelet-derived growth factor and inhibition by transforming growth factor-beta and retinoids.

  1989cited by this paper
• RAS mutations in myelodysplasia detected by amplification, oligonucleotide hybridization, and transformation.

  1988cited by this paper
• Primer-directed enzymatic amplification of DNA with a thermostable DNA polymerase.

  1988cited by this paper
• The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis.

  1988cited by this paper
• The ras gene family and human carcinogenesis.

  1988cited by this paper
• ras genes.

  1987cited by this paper
• Activated oncogenes in B6C3F1 mouse liver tumors: implications for risk assessment.

  1987cited by this paper
• Histopathology of the rheumatoid lesion. Identification of cell types at sites of cartilage erosion.

  1984cited by this paper
• An activated rasN gene: detected in late but not early passage human PA1 teratocarcinoma cells.

  1984cited by this paper
• Histopathology of the rheumatoid lesion

  1984cited by this paper
• Three different mutations in codon 61 of the human N-ras gene detected by synthetic oligonucleotide hybridization.

  1984cited by this paper
• Hypothesis: in vitro evidence for the invasive and tumor-like properties of the rheumatoid pannus.

  1983cited by this paper
• Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations

  1983cited by this paper
• A point mutation is responsible for the acquisition of transforming properties by the T24 human bladder carcinoma oncogene

  1982cited by this paper
• Survival of rheumatoid synovium implanted into nude mice.

  1981cited by this paper
• Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

  1979cited by this paper

• The HRAS-binding C2 domain of PLCη2 suppresses tumor‐like synoviocytes and experimental arthritis in rheumatoid arthritis

  2025cites this paper
• Syringocystadenoma Papilliferum of the Anogenital Area and Buttocks: A Report of 16 Cases, Including Human Papillomavirus Analysis and HRAS and BRAF V600 Mutation Studies

  2019cites this paper
• Treatment effect of CDKN1A on rheumatoid arthritis by mediating proliferation and invasion of fibroblast‐like synoviocytes cells

  2018cites this paper
• Glycogen Metabolism and Rheumatoid Arthritis: The Role of Glycogen Synthase 1 in Regulation of Synovial Inflammation via Blocking AMP-Activated Protein Kinase Activation

  2018cites this paper
• Long noncoding RNA LERFS negatively regulates rheumatoid synovial aggression and proliferation

  2018cites this paper
• Leonurine attenuates fibroblast-like synoviocyte-mediated synovial inflammation and joint destruction in rheumatoid arthritis

  2017cites this paper
• Chapter 69 – Etiology and Pathogenesis of Rheumatoid Arthritis

  2017cites this paper
• Halofuginone inhibits TNF‐&agr;‐induced the migration and proliferation of fibroblast‐like synoviocytes from rheumatoid arthritis patients

  2017cites this paper
• Indirubin inhibits the migration, invasion, and activation of fibroblast-like synoviocytes from rheumatoid arthritis patients

  2017cites this paper
• Regulation of the Cell Cycle and Inflammatory Arthritis by the Transcription Cofactor LBH Gene

  2017cites this paper
• Exploiting the helminth-derived immunomodulator, ES-62 and its small molecule analogues to dissect the mechanisms underpinning the development of the pathogenic phenotype of synovial fibroblasts in autoimmune arthritis.

  2017cites this paper
• Neuropilin-1 in Immune-Mediated Diseases

  2017cites this paper
• MIF allele-dependent regulation of the MIF coreceptor CD44 and role in rheumatoid arthritis

  2016cites this paper
• Protein Inhibitor of Activated STAT3 Regulates Migration, Invasion, and Activation of Fibroblast-like Synoviocytes in Rheumatoid Arthritis

  2016cites this paper
• GREM1 Is a Key Regulator of Synoviocyte Hyperplasia and Invasiveness

  2016cites this paper
• Role of protein arginine methyltransferase 5 in inflammation and migration of fibroblast‐like synoviocytes in rheumatoid arthritis

  2016cites this paper
• Rheumatoid Synoviocytes Hyperplasia and Invasiveness of Primary Placental Growth Factor-1 and -2 Induce

  2015cites this paper
• Inhibitory effects of niclosamide on inflammation and migration of fibroblast-like synoviocytes from patients with rheumatoid arthritis

  2015cites this paper
• Rheumatoid Arthritis Activation of Fibroblast-like Synoviocytes in Regulates Migration, Invasion, and Protein Inhibitor of Activated STAT3

  2015cites this paper
• Placental Growth Factor-1 and -2 Induce Hyperplasia and Invasiveness of Primary Rheumatoid Synoviocytes

  2015cites this paper
• Hyperplasia and Angiogenesis Receptor-Like 1 Induces Synovial Serum Amyloid A Binding to Formyl Peptide

  2015cites this paper
• Knockdown of sphingosine kinase 1 inhibits the migration and invasion of human rheumatoid arthritis fibroblast-like synoviocytes by down-regulating the PI3K/AKT activation and MMP-2/9 production in vitro

  2014cites this paper
• Increased phosphorylation of ezrin is associated with the migration and invasion of fibroblast-like synoviocytes from patients with rheumatoid arthritis.

  2014cites this paper
• Original Article Deoxycytidine kinase promotes the migration and invasion of fibroblast-like synoviocytes from rheumatoid arthritis patients

  2013cites this paper
• Deoxycytidine kinase promotes the migration and invasion of fibroblast-like synoviocytes from rheumatoid arthritis patients.

  2013cites this paper
• BRAF splice variants in rheumatoid arthritis synovial fibroblasts activate MAPK through CRAF.

  2013cites this paper
• IL-17-mediated Bcl-2 expression regulates survival of fibroblast-like synoviocytes in rheumatoid arthritis through STAT3 activation

  2013cites this paper
• Inhibitory effects of simvastatin on migration and invasion of rheumatoid fibroblast-like synoviocytes by preventing geranylgeranylation of RhoA

  2013cites this paper
• Identification of key regulators for the migration and invasion of rheumatoid synoviocytes through a systems approach

  2013cites this paper
• Tissue-Specific Expression of Human Calcineurin-Binding Protein 1 in Mouse Synovial Tissue Can Suppress Inflammatory Arthritis

  2012cites this paper
• Role of p21-activated kinase 1 in regulating the migration and invasion of fibroblast-like synoviocytes from rheumatoid arthritis patients.

  2012cites this paper
• Regulation of inflammatory responses and fibroblast-like synoviocyte apoptosis by calcineurin-binding protein 1 in mice with collagen-induced arthritis.

  2012cites this paper
• Signal Transduction Pathways in Chronic Inflammatory Autoimmune Disease: Small GTPases

  2012cites this paper
• Inhibition of synovial hyperplasia, rheumatoid T cell activation, and experimental arthritis in mice by sulforaphane, a naturally occurring isothiocyanate.

  2010cites this paper
• Fibroblast‐like synoviocytes: key effector cells in rheumatoid arthritis

  2010cites this paper
• Anti-neuropilin-1 peptide inhibition of synoviocyte survival, angiogenesis, and experimental arthritis.

  2010cites this paper
• UvA-DARE ( Digital Academic Repository ) Small GTPases : emerging targets in rheumatoid arthritis

  2009cites this paper
• Serum amyloid A: An acute-phase protein involved in tumour pathogenesis

  2008cites this paper
• Serum Amyloid A Binding to Formyl Peptide Receptor-Like 1 Induces Synovial Hyperplasia and Angiogenesis1

  2006cites this paper
• Bax Translocation Death by Regulating Bcl-2 Expression and Rheumatoid Synoviocytes from Apoptotic Factor 165 with Neuropilin-1 Protects Interaction of Vascular Endothelial Growth

  2006cites this paper
• Genetic basis of secondary osteoarthritis in dogs with joint dysplasia.

  2006cites this paper
• Calcineurin Is Expressed and Plays a Critical Role in Inflammatory Arthritis1

  2006cites this paper
• Hydroxychloroquine potentiates Fas‐mediated apoptosis of rheumatoid synoviocytes

  2006cites this paper
• Interaction of Vascular Endothelial Growth Factor 165 with Neuropilin-1 Protects Rheumatoid Synoviocytes from Apoptotic Death by Regulating Bcl-2 Expression and Bax Translocation1

  2006cites this paper
• Serum Amyloid A Binding to Formyl Peptide

  2006cites this paper
• Expression and Function of Calcineurin in Inflammatory Arthritis

  2006cites this paper
• Role in Inflammatory Arthritis Calcineurin Is Expressed and Plays a Critical

  2006cites this paper
• Arginine-Rich Anti-Vascular Endothelial Growth Factor (Anti-VEGF) Hexapeptide Inhibits Collagen-Induced Arthritis and VEGF-Stimulated Productions of TNF-α and IL-6 by Human Monocytes 1

  2005cites this paper
• Inhibition of Farnesyltransferase Prevents Collagen-Induced Arthritis by Down-Regulation of Inflammatory Gene Expression through Suppression of p21ras-Dependent NF-κB Activation1

  2004cites this paper
• Wnt1 inducible signaling pathway protein-3 regulation and microsatellite structure in arthritis.

  2004cites this paper
• 68Ga-labeled oligonucleotides for in vivo imaging with PET.

  2004cites this paper
• B Activation k -Dependent NF-ras Expression through Suppression of p21 Down-Regulation of Inflammatory Gene Collagen-Induced Arthritis by Inhibition of Farnesyltransferase Prevents

  2004cites this paper
• DNA mismatch repair enzyme expression in synovial tissue

  2004cites this paper
• Microsatallite Instability and Suppressed DNA Repair Enzyme Expression in Rheumatoid Arthritis

  2003cites this paper
• Suppression of arthritic bone destruction by adenovirus-mediated dominant-negative Ras gene transfer to synoviocytes and osteoclasts.

  2003cites this paper
• Rheumatoid Arthritis DNA Repair Enzyme Expression in Microsatellite Instability and Suppressed

  2003cites this paper
• Microsatellite Instability and Suppressed DNA Repair Enzyme Expression in Rheumatoid Arthritis 1

  2003cites this paper
• How important are T cells in chronic rheumatoid synovitis?: II. T cell-independent mechanisms from beginning to end.

  2002cites this paper
• p53, proto-oncogene and rheumatoid arthritis.

  2002cites this paper
• The genetics of the target tissue in rheumatoid arthritis.

  2002cites this paper
• Advances in Understanding the Genetic Basis of Rheumatoid Arthritis and Osteoarthritis

  2002cites this paper
• Suppressed DNA Repair Mechanisms in Rheumatoid Arthritis

  2002cites this paper
• Pathogenesis of rheumatoid arthritis: the role of synoviocytes.

  2001cites this paper
• Sequence Analysis of Human Endogenous Retrovirus Clone 4-1 in Systemic Lupus Erythematosus

  2001cites this paper
• Quantitative analyses of messenger RNA of human endogenous retrovirus in patients with systemic lupus erythematosus.

  2001cites this paper
• Cytochrome P2 polymorphisms and susceptibility to scleroderma: comment on the article by Povey et al.

  2001cites this paper
• Gene therapy for rheumatoid arthritis

  2001cites this paper
• Wild Type and Mutant p53 Differentially Regulate the Gene Expression of Human Collagenase-3 (hMMP-13)*

  2000cites this paper
• Apoptosis in rheumatic diseases.

  2000cites this paper
• Rheumatoid arthritis and p53: how oxidative stress might alter the course of inflammatory diseases.

  2000cites this paper
• Expression of the myc-family proto-oncogenes and related genes max and mad in synovial tissue.

  1999cites this paper
• Apoptosis in Rheumatoid Arthritis

  1999cites this paper
• Expression of p53 Protein in Rheumatoid Arthritis Synovium. An Immunohistochemical Analysis.

  1999cites this paper
• Signal transduction and transcription factors in rheumatic disease.

  1999cites this paper
• Starving the synovium: angiogenesis and inflammation in rheumatoid arthritis.

  1999cites this paper
• [Rheumatoid arthritis: new molecular and cellular aspects].

  1999cites this paper
• Rheumatoide Arthritis: Neue molekulare und zelluläre Aspekte

  1999cites this paper
• T cells as secondary players in rheumatoid arthritis

  1998cites this paper
• Gene Therapy for Rheumatoid Arthritis

  1998cites this paper