The lactate receptor GPR81 promotes breast cancer growth via a paracrine mechanism involving antigen-presenting cells in the tumor microenvironment

No abstract is available for this paper.

• Publication year

  2020

• Venue

  Oncogene

• Publication date

  2020-02-19

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/s41388-020-1216-5PMID 32071396
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Lactate Induces Pro-tumor Reprogramming in Intratumoral Plasmacytoid Dendritic Cells

  2019cited by this paper
• Clinical and Functional Relevance of the Monocarboxylate Transporter Family in Disease Pathophysiology and Drug Therapy

  2018cited by this paper
• GPR81, a Cell-Surface Receptor for Lactate, Regulates Intestinal Homeostasis and Protects Mice from Experimental Colitis

  2018influential reference
• Hydroxy-Carboxylic Acid Receptor Actions in Metabolism.

  2017cited by this paper
• The lactate receptor (HCAR1/GPR81) contributes to doxorubicin chemoresistance via ABCB1 transporter up-regulation in human cervical cancer HeLa cells.

  2017cited by this paper
• Tumor cell-derived lactate induces TAZ-dependent upregulation of PD-L1 through GPR81 in human lung cancer cells

  2017cited by this paper
• Stimulation of lactate receptor (HCAR1) affects cellular DNA repair capacity.

  2017cited by this paper
• Lactate Contribution to the Tumor Microenvironment: Mechanisms, Effects on Immune Cells and Therapeutic Relevance

  2016cited by this paper
• G-protein-coupled receptor 81 promotes a malignant phenotype in breast cancer through angiogenic factor secretion

  2016cited by this paper
• L- and D-lactate enhance DNA repair and modulate the resistance of cervical carcinoma cells to anticancer drugs via histone deacetylase inhibition and hydroxycarboxylic acid receptor 1 activation

  2015cited by this paper
• The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival.

  2014cited by this paper
• Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

  2014cited by this paper
• Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis.

  2014cited by this paper
• Cell surface lactate receptor GPR81 is crucial for cancer cell survival.

  2014cited by this paper
• Original ResearchFull Report: Basic & Translational—Liver & PancreasLactate Reduces Liver and Pancreatic Injury in Toll-Like Receptor– and Inflammasome-Mediated Inflammation via GPR81-Mediated Suppression of Innate Immunity

  2014cited by this paper
• Tumor-Derived Lactate Modifies Antitumor Immune Response: Effect on Myeloid-Derived Suppressor Cells and NK Cells

  2013cited by this paper
• Targeting lactate metabolism for cancer therapeutics.

  2013cited by this paper
• The SLC16 gene family - structure, role and regulation in health and disease.

  2013cited by this paper
• Identification of Hydroxybenzoic Acids as Selective Lactate Receptor (GPR81) Agonists with Antilipolytic Effects.

  2012cited by this paper
• Lactate influx through the endothelial cell monocarboxylate transporter MCT1 supports an NF-κB/IL-8 pathway that drives tumor angiogenesis.

  2011cited by this paper
• Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation.

  2010cited by this paper
• An autocrine lactate loop mediates insulin-dependent inhibition of lipolysis through GPR81.

  2010cited by this paper
• Lactate Inhibits Lipolysis in Fat Cells through Activation of an Orphan G-protein-coupled Receptor, GPR81*

  2009cited by this paper
• GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon.

  2009cited by this paper
• Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond.

  2009cited by this paper
• Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

  2009cited by this paper
• Modulating the Expression of IFN Regulatory Factor 8 Alters the Protumorigenic Behavior of CD11b+Gr-1+ Myeloid Cells1

  2009cited by this paper
• Elucidation of signaling and functional activities of an orphan GPCR, GPR81 Published, JLR Papers in Press, January 3, 2008.

  2008cited by this paper
• Beyond aerobic glycolysis: Transformed cells can engage in glutamine metabolism that exceeds the requirement for protein and nucleotide synthesis

  2007cited by this paper
• Inhibitory effect of tumor cell-derived lactic acid on human T cells.

  2007cited by this paper
• Differential Development of Murine Dendritic Cells by GM-CSF versus Flt3 Ligand Has Implications for Inflammation and Trafficking1

  2007cited by this paper
• Tumor-derived lactic acid modulates dendritic cell activation and antigen expression.

  2006cited by this paper
• From the Cover: Gene set enrichment analysis: A knowledge-based approach for interpreting genome-wide expression profiles

  2005cited by this paper
• Cutting Edge: Generation of Splenic CD8+ and CD8− Dendritic Cell Equivalents in Fms-Like Tyrosine Kinase 3 Ligand Bone Marrow Cultures1

  2005cited by this paper
• Regulation of T Lymphocyte Metabolism

  2004cited by this paper
• The Orphan G Protein-coupled Receptors GPR41 and GPR43 Are Activated by Propionate and Other Short Chain Carboxylic Acids*

  2003cited by this paper
• Generation of murine dendritic cells from flt3-ligand-supplemented bone marrow cultures.

  2000cited by this paper
• High lactate levels predict likelihood of metastases, tumor recurrence, and restricted patient survival in human cervical cancers.

  2000cited by this paper
• c-Myc transactivation of LDH-A: implications for tumor metabolism and growth.

  1997cited by this paper
• Efficient presentation of soluble antigen by cultured human dendritic cells is maintained by granulocyte/macrophage colony-stimulating factor plus interleukin 4 and downregulated by tumor necrosis factor alpha

  1994cited by this paper
• Functional and morphological characterization of four cell lines derived from GH3 cells stably transfected with gonadotropin-releasing hormone receptor complementary deoxyribonucleic acid.

  1994cited by this paper
• Induction of mammary tumors by expression of polyomavirus middle T oncogene: a transgenic mouse model for metastatic disease

  1992cited by this paper
• Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor

  1992cited by this paper
• The relevance of tumour pH to the treatment of malignant disease.

  1984cited by this paper
• LACTIC DEHYDROGENASE IN HUMAN NEOPLASTIC TISSUES.

  1964cited by this paper
• [Origin of cancer cells].

  1956cited by this paper
• On the origin of cancer cells.

  1956cited by this paper
• Origin of Cancer

  1938cited by this paper
• THE METABOLISM OF TUMORS IN THE BODY

  1927cited by this paper

• Lactate: elucidating its indispensable role in human health

  2026cites this paper
• Lactate targeting: Regulatory networks and therapeutic potential in bone diseases.

  2026cites this paper
• The human and murine immune systems: regulated by dichotomous molecules.

  2026cites this paper
• Metabolites as signalling molecules in the tumour immune microenvironment.

  2026cites this paper
• Lactic Acid in Tumour Biology

  2026cites this paper
• The dual faces of lactylation: From post-translational modification to disease regulation

  2026cites this paper
• The crosstalk between nerves and immunity: chronic stress as a driver of tumor progression.

  2026cites this paper
• Molecular Targets for Cancer Immunotherapy: Focusing on (Immune and Tumor) Cell-Derived Metabolites

  2026cites this paper
• An Engineered Probiotic Consortium Based on Quorum‐Sensing for Colorectal Cancer Immunotherapy

  2025cites this paper
• Lactylation in Tumor Immune Escape and Immunotherapy: Multifaceted Functions and Therapeutic Strategies

  2025influential citation
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  2025cites this paper
• Lactate and Lactylation in Respiratory Diseases: from Molecular Mechanisms to Targeted Strategies

  2025cites this paper
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  2025cites this paper
• Tumor Microenvironment Lactate: Is It a Cancer Progression Marker, Immunosuppressant, and Therapeutic Target?

  2025cites this paper
• Immunometabolism: crosstalk with tumor metabolism and implications for cancer immunotherapy

  2025cites this paper
• The Role of Lactate in Immune Regulation: A Metabolic Rheostat via Transporters, Receptors, and Epigenetic Modifiers

  2025cites this paper
• Revisiting the biological role of the Warburg effect: Evolving perspectives on cancer metabolism.

  2025cites this paper
• Lactylation in cancer biology: Unlocking new avenues for research and therapy

  2025cites this paper
• Multifunctional hydrogel promotes rotator cuff healing through anti-inflammation and vascularization

  2025cites this paper
• Lactate and lactylation in tumor immunity

  2025cites this paper
• Lactate and lactylation in breast cancer: current understanding and therapeutic opportunities

  2025influential citation
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  2025cites this paper
• Chronic stress in cancer development and progression.

  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
• Mitochondrial metabolism in laryngeal cancer: Therapeutic mechanisms and prospects.

  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
• The Therapeutic Effect of GPR81 in Autoimmune Hepatitis and Hepatocellular Carcinoma via Regulating the Immune Response

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• Decoding the metabolic dialogue in the tumor microenvironment: from immune suppression to precision cancer therapies

  2025cites this paper
• Deletion of AC8 in glioma cells elevates oxidative phosphorylation by system-wide remodeling of the mitochondrial proteome.

  2025cites this paper
• Lactate-mediated histone lactylation promotes melanoma angiogenesis via IL-33/ST2 axis

  2025cites this paper
• Lactylation in cancer: Advances and opportunities for treatment resistance

  2025cites this paper
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  2025cites this paper
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  2025cites this paper
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  2025cites this paper
• Metabolite to Modifier: Lactate and Lactylation in the Evolution of Tumors

  2025cites this paper
• Metabolic regulation of immunity in the tumor microenvironment.

  2025cites this paper
• Lactate-induced protein lactylation in cancer: functions, biomarkers and immunotherapy strategies

  2025cites this paper
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  2025cites this paper
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  2025cites this paper
• Unconventional receptor functions and location-biased signaling of the lactate GPCR in the nucleus

  2025cites this paper
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  2025cites this paper
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  2025cites this paper
• In situ antigen-capture strategies for enhancing dendritic cell-mediated anti-tumor immunity.

  2025cites this paper
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  2025cites this paper
• Lactate: A key regulator of the immune response.

  2025cites this paper
• Lactate released by lung adenocarcinoma (LUAD) cells promotes M2 macrophage polarization via the GPR132/cAMP/PKA pathway

  2025cites this paper
• Targeting lactylation and the STAT3/CCL2 axis to overcome immunotherapy resistance in pancreatic ductal adenocarcinoma

  2025cites this paper
• Reprogramming of Glucose Metabolism by Nanocarriers to Improve Cancer Immunotherapy: Recent Advances and Applications

  2025cites this paper
• Emerging roles of lysine lactyltransferases and lactylation

  2025cites this paper
• Histone lactylation: from tumor lactate metabolism to epigenetic regulation

  2024cites this paper
• Activation of GPR81 by lactate drives tumour-induced cachexia

  2024cites this paper
• Histone lactylation bridges metabolic reprogramming and epigenetic rewiring in driving carcinogenesis: Oncometabolite fuels oncogenic transcription

  2024cites this paper
• Targeting MHC-I inhibitory pathways for cancer immunotherapy.

  2024cites this paper
• Immunometabolic Maladaptations to the Tumor Microenvironment.

  2024cites this paper
• The emerging role of lactate in tumor microenvironment and its clinical relevance.

  2024cites this paper
• Lactate: a rising star in tumors and inflammation

  2024cites this paper
• A Lactic Acid Metabolism-Related Gene Signature for Predicting Clinical Outcome and Tumor Microenvironmental Status in Patients with Hepatocellular Carcinoma

  2024influential citation
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper
• Tumor Microenvironment: Nurturing Cancer Cells for Immunoevasion and Druggable Vulnerabilities for Cancer Immunotherapy.

  2024cites this paper
• Pan-Cancer Insights: A Study of Microbial Metabolite Receptors in Malignancy Dynamics

  2024cites this paper
• Intratumoral lactic acid neutralization strategy for boosting chemoimmunotherapy using liposomal sodium bicarbonate.

  2024cites this paper
• Lactate and lactylation in gastrointestinal cancer: Current progress and perspectives (Review)

  2024cites this paper
• Lactate/GPR81 recruits regulatory T cells by modulating CX3CL1 to promote immune resistance in a highly glycolytic gastric cancer

  2024cites this paper
• Crosstalk between lactate and tumor-associated immune cells: clinical relevance and insight

  2024cites this paper
• Metabolic Signaling in Cancer Metastasis.

  2024cites this paper
• Targeting the tumor immune microenvironment: GPCRs as key regulators in triple-negative breast cancer.

  2024cites this paper
• Glycolysis: A multifaceted metabolic pathway and signaling hub

  2024cites this paper
• Supramolecular Assemblies via Host-Guest Interactions for Tumor Immunotherapy.

  2024cites this paper
• Cancer specific up-regulated lactate genes associated with immunotherapy resistance in a pan-cancer analysis

  2024cites this paper
• Dynamic glycolytic reprogramming effects on dendritic cells in pancreatic ductal adenocarcinoma

  2024cites this paper
• Metabolic Function and Therapeutic Potential of CD147 for Hematological Malignancies: An Overview

  2024cites this paper
• Reprogramming the immunosuppressive tumor microenvironment through nanomedicine: an immunometabolism perspective

  2024cites this paper
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  2024cites this paper
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  2024cites this paper
• Acid affairs in anti-tumour immunity

  2024cites this paper
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  2024cites this paper
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  2024cites this paper
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  2024cites this paper