CoFe2O4@HNTs/AuNPs Substrate for Rapid Magnetic Solid-Phase Extraction and Efficient SERS Detection of Complex Samples All-in-One.

Fast and accurate practical sample detection is a great chanllenge in on-site detection. Herein, we developed a CoFe2O4@HNTs/AuNPs substrate for rapid and efficient magnetic solid-phase extraction (MSPE) surface-enhanced Raman scattering (SERS) detection of aromatic amines and nitrofuran in real samples all-in-one. Magnetic CoFe2O4 beads filled inside halloysite nanotubes (HNTs) can avoid aggregation of particles, endow the substrate with rapid magnetic separation ability to simplify pretreatment procedure and reduce complex matrix interference. Meanwhile, outer surface AuNPs can generate electromagnetic enhancement and hot spots to amplify Raman signals of target molecules enriched/concentrated by HNTs. The CoFe2O4@HNTs/AuNPs substrate exhibited excellent SERS activity (high sensitivity, good reproducibility and repeatability), pH-stability (3.0-11.0), and good MSPE ability (fast magnetic enrichment/separation ability within 5 min). The CoFe2O4@HNTs/AuNPs MSPE SERS substrate can be applied for the determination of 4,4'-thioaniline and nitrofurantoin with liner range of 0.054-21.7 mg/L and 0.05-1.0 mg/L, and the limits of detection were down to 0.026 mg/L and 0.014 mg/L, respectively. Furthermore, the enhancement factor (EF) of the substrate to 4,4'-thioaniline is up to 2.7 × 107. Besides, the substrate can realize practical SERS determination of trace 4,4-thioaniline in cosmetics, nitrofurantoin in fish feed and aquatic samples. The recoveries were varied from 71.6% to 103.6% for 4,4-thioaniline in hair dyes, and 81.9% to 116.3% for nitrofunantoin in fish feed and aquatic samples, respectively. Such a robust and efficient MSPE SERS substrate possesses great potential in rapid detection (within 15 min) for practical sample, it also provides a methodology for the preparation of other HNTs-based composites.

• Publication year

  2020

• Venue

  Analytical Chemistry

• Publication date

  2020-02-18

• Fields of study

  Medicine, Materials Science, Chemistry

• Identifiers
  DOI 10.1021/acs.analchem.0c00144PMID 32069032
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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