Rationale, design, and governance of Prospective Randomized Evaluation of Celecoxib Integrated Safety versus Ibuprofen Or Naproxen (PRECISION), a cardiovascular end point trial of nonsteroidal antiinflammatory agents in patients with arthritis.

No abstract is available for this paper.

• Publication year

  2009

• Venue

  American Heart Journal

• Publication date

  2009-04-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/j.ahj.2008.12.014PMID 19332185
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2008cited by this paper
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  2006cited by this paper
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  2006cited by this paper
• Celecoxib for the prevention of colorectal adenomatous polyps.

  2006cited by this paper
• Celecoxib for the prevention of sporadic colorectal adenomas.

  2006cited by this paper
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  2006cited by this paper
• Risk of Death or Reinfarction Associated With the Use of Selective Cyclooxygenase-2 Inhibitors and Nonselective Nonsteroidal Antiinflammatory Drugs After Acute Myocardial Infarction

  2006cited by this paper
• Expression of concern reaffirmed.

  2006cited by this paper
• Meta-analysis: cardiovascular events associated with nonsteroidal anti-inflammatory drugs.

  2006cited by this paper
• Cardiovascular risk and inhibition of cyclooxygenase: a systematic review of the observational studies of selective and nonselective inhibitors of cyclooxygenase 2.

  2006cited by this paper
• Cardiovascular events associated with rofecoxib in a colorectal adenoma chemoprevention trial.

  2005cited by this paper
• Increased unrecognized coronary heart disease and sudden deaths in rheumatoid arthritis: a population-based cohort study.

  2005cited by this paper
• Expression of concern: Bombardier et al., "Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis," N Engl J Med 2000;343:1520-8.

  2005cited by this paper
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  2005cited by this paper
• Risk of acute myocardial infarction and sudden cardiac death in patients treated with cyclo-oxygenase 2 selective and non-selective non-steroidal anti-inflammatory drugs: nested case-control study.

  2005cited by this paper
• ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction--executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Writing Committee to Revise the 1999 Guidelines for the Management of Patients Wi

  2004cited by this paper
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  2004cited by this paper
• Use of aspirin and ibuprofen compared with aspirin alone and the risk of myocardial infarction.

  2004cited by this paper
• Relationship Between Selective Cyclooxygenase-2 Inhibitors and Acute Myocardial Infarction in Older Adults

  2004cited by this paper
• Cyclo-oxygenase-2 inhibitors versus non-selective non-steroidal anti-inflammatory drugs and congestive heart failure outcomes in elderly patients: a population-based cohort study.

  2004cited by this paper
• The effects of nonselective non-aspirin non-steroidal anti-inflammatory medications on the risk of nonfatal myocardial infarction and their interaction with aspirin.

  2004cited by this paper
• ACC/AHA Guidelines for the Management of Patients With ST-Elevation Myocardial Infarction

  2004cited by this paper
• ACC/AHA 2002 guideline update for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction--summary article: a report of the American College of Cardiology/American Heart Association task force on practice guidelines (Committee on the Management of Patients

  2002cited by this paper
• Risk of cardiovascular events associated with selective COX-2 inhibitors.

  2001cited by this paper
• Gastrointestinal toxicity with celecoxib vs nonsteroidal anti-inflammatory drugs for osteoarthritis and rheumatoid arthritis: the CLASS study: A randomized controlled trial. Celecoxib Long-term Arthritis Safety Study.

  2000influential reference
• Comparison of upper gastrointestinal toxicity of rofecoxib and naproxen in patients with rheumatoid arthritis. VIGOR Study Group.

  2000cited by this paper
• ACC/AHA guidelines for the management of patients with unstable angina and non-ST segment elevation myocardial infarction: executive summary and recommendations.

  2000cited by this paper
• Anti-inflammatory and upper gastrointestinal effects of celecoxib in rheumatoid arthritis: a randomized controlled trial.

  1999cited by this paper
• Osteoarthritis as a Determinant of an Adverse Coronary Heart Disease Risk Profile

  1996cited by this paper
• Equipoise and the ethics of clinical research.

  1987cited by this paper
• A multiple testing procedure for clinical trials.

  1979cited by this paper
• Graphic representation of pain

  1976cited by this paper

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  2025cites this paper
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  2025influential citation
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  2023cites this paper
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  2022cites this paper
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  2022cites this paper
• Clinical Events Classification (CEC) in Clinical Trials: Report on the Current Landscape and Future Directions - Proceedings from the CEC Summit 2018.

  2021cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
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  2020cites this paper
• Analgesic Drugs and Cardiac Safety

  2019cites this paper
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  2019cites this paper
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  2019cites this paper
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  2019cites this paper
• [The possibilities of using chondroitin sulfate in patients with chronic back pain].

  2019cites this paper
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  2019cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2018cites this paper
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  2017cites this paper
• Imprecision: Limitations to Interpretation of a Large Randomized Clinical Trial.

  2017cites this paper
• [New possibilities of treatment of low back pain].

  2017cites this paper
• Cyclooxygenase Inhibition: Pain, Inflammation, and the Cardiovascular System

  2017influential citation
• The Eicosanoids, Redox-Regulated Lipid Mediators in Immunometabolic Disorders

  2017cites this paper
• The Cardiovascular Pharmacology of Nonsteroidal Anti-Inflammatory Drugs.

  2017influential citation
• Infection Risk With Biologic Therapy in Patients With Inflammatory Bowel Disease

  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017cites this paper
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  2017influential citation
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
• Report of the American Heart Association (AHA) Scientific Sessions 2016, New Orleans.

  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2016cites this paper
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  2015cites this paper
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  2015cites this paper
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  2015cites this paper
• Cardiovascular Safety Outcome Trials: A meeting report from the Cardiac Safety Research Consortium.

  2015cites this paper
• Consensus about managing gastrointestinal and cardiovascular risks of nonsteroidal anti-inflammatory drugs?

  2015cites this paper
• Potential hazards of adding nonsteroidal anti-inflammatory drugs to antithrombotic therapy after myocardial infarction: time for more than a gut check.

  2015cites this paper
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  2015cites this paper
• PotentialHazardsofAddingNonsteroidalAnti-inflammatoryDrugs toAntithromboticTherapyAfterMyocardial Infarction Time for More Than a Gut Check

  2015cites this paper
• Pharmacotherapy for Leishmaniasis in the United States: Focus on Miltefosine

  2015cites this paper
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  2015cites this paper
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  2015cites this paper
• Elevation of cardiovascular risk by non-steroidal anti-inflammatory drugs.

  2015cites this paper
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  2015cites this paper
• Non-Inferiority Study Design and Analysis for Safety Endpoints

  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2014cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2013cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012influential citation
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper
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  2012cites this paper