Ursolic acid promotes cancer cell death by inducing Atg5‐dependent autophagy

No abstract is available for this paper.

• Publication year

  2013

• Venue

  International Journal of Cancer

• Publication date

  2013-12-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/ijc.28301PMID 23737395
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Interferon-γ induces autophagy with growth inhibition and cell death in human hepatocellular carcinoma (HCC) cells through interferon-regulatory factor-1 (IRF-1).

  2012cited by this paper
• Conductive thermal ablation of 4T1 murine breast carcinoma reduces severe hypoxia in surviving tumour

  2012cited by this paper
• D‐4F, an apoA‐I mimetic peptide, inhibits proliferation and tumorigenicity of epithelial ovarian cancer cells by upregulating the antioxidant enzyme MnSOD

  2012cited by this paper
• Decreased Beclin-1 expression is correlated with the growth of the primary tumor in patients with squamous cell carcinoma and adenocarcinoma of the lung.

  2012cited by this paper
• Expression of beclin 1, an autophagy-related protein, in human cervical carcinoma and its clinical significance.

  2012cited by this paper
• Inhibition of doxorubicin‐induced autophagy in hepatocellular carcinoma Hep3B cells by sorafenib – the role of extracellular signal‐regulated kinase counteraction

  2011cited by this paper
• Bcl‐2 and Bcl‐xL play important roles in the crosstalk between autophagy and apoptosis

  2011cited by this paper
• Induction of apoptotic cell death by ursolic acid through mitochondrial death pathway and extrinsic death receptor pathway in MDA-MB-231 cells

  2011cited by this paper
• Ursolic acid inhibits multiple cell survival pathways leading to suppression of growth of prostate cancer xenograft in nude mice

  2011cited by this paper
• Regulation of autophagic activity by 14-3-3ζ proteins associated with class III phosphatidylinositol-3-kinase

  2011cited by this paper
• Decreased expression of Beclin-1 and LC3 in human lung cancer

  2011cited by this paper
• Inhibition of cell proliferation, invasion and migration by ursolic acid in human lung cancer cell lines.

  2011cited by this paper
• Beclin 1-independent autophagy contributes to apoptosis in cortical neurons

  2011cited by this paper
• ARSENIC TRIOXIDE INDUCES A BECLIN-1 INDEPENDENT AUTOPHAGIC PATHWAY VIA MODULATION OF SNON/SKIL EXPRESSION IN OVARIAN CARCINOMA CELLS

  2010cited by this paper
• Activation of autophagy during cell death requires the engulfment receptor Draper

  2010cited by this paper
• Ursolic Acid, a Pentacyclin Triterpene, Potentiates TRAIL-induced Apoptosis through p53-independent Up-regulation of Death Receptors

  2010cited by this paper
• Enhancement of chemotherapeutic agent‐induced apoptosis by inhibition of NF‐κB using ursolic acid

  2010cited by this paper
• Oleanolic acid and ursolic acid induce apoptosis in HuH7 human hepatocellular carcinoma cells through a mitochondrial-dependent pathway and downregulation of XIAP.

  2010cited by this paper
• SnoN/SkiL, a TGFβ signaling mediator

  2010cited by this paper
• Ursolic acid induces doxorubicin-resistant HepG2 cell death via the release of apoptosis-inducing factor.

  2010cited by this paper
• Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells.

  2009cited by this paper
• Costimulation as a platform for the development of vaccines: a peptide-based vaccine containing a novel form of 4-1BB ligand eradicates established tumors.

  2009cited by this paper
• Activation of the PI3K-Akt-mTOR signaling pathway promotes necrotic cell death via suppression of autophagy

  2009cited by this paper
• Ursolic Acid Triggers Apoptosis and Bcl-2 Downregulation in MCF-7 Breast Cancer Cells

  2009cited by this paper
• The Rac1/MKK7/JNK pathway signals upregulation of Atg5 and subsequent autophagic cell death in response to oncogenic Ras.

  2009cited by this paper
• Ursolic acid: an anti- and pro-inflammatory triterpenoid.

  2008cited by this paper
• Role of non-canonical Beclin 1-independent autophagy in cell death induced by resveratrol in human breast cancer cells

  2008cited by this paper
• BAC-mediated transgenic expression of fluorescent autophagic protein Beclin 1 reveals a role for Beclin 1 in lymphocyte development

  2008cited by this paper
• Autophagy fights disease through cellular self-digestion

  2008cited by this paper
• How to Interpret LC3 Immunoblotting

  2007cited by this paper
• Autophagy suppresses tumor progression by limiting chromosomal instability.

  2007cited by this paper
• 3-Methyladenine suppresses cell migration and invasion of HT1080 fibrosarcoma cells through inhibiting phosphoinositide 3-kinases independently of autophagy inhibition.

  2007cited by this paper
• Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death.

  2007cited by this paper
• Proteomic analysis of ursolic acid-induced apoptosis in cervical carcinoma cells.

  2006cited by this paper
• Antiproliferative and antiviral mechanisms of ursolic acid and dexamethasone in cervical carcinoma cell lines

  2006cited by this paper
• Targeting the gatekeeper residue in phosphoinositide 3-kinases.

  2005cited by this paper
• Essential Roles of Atg5 and FADD in Autophagic Cell Death

  2005cited by this paper
• Lysosomal Turnover, but Not a Cellular Level, of Endogenous LC3 is a Marker for Autophagy

  2005cited by this paper
• Induction of macroautophagy in human colon cancer cells by soybean B-group triterpenoid saponins.

  2004cited by this paper
• Resveratrol-induced Autophagocytosis in Ovarian Cancer Cells

  2004cited by this paper
• The role of autophagy during the early neonatal starvation period

  2004cited by this paper
• Induction of autophagic cell death in malignant glioma cells by arsenic trioxide.

  2003cited by this paper
• Dissection of Autophagosome Formation Using Apg5-Deficient Mouse Embryonic Stem Cells

  2001cited by this paper
• Oncogenic Ras triggers cell suicide through the activation of a caspase-independent cell death program in human cancer cells

  1999cited by this paper
• Active cell death induced by the anti-estrogens tamoxifen and ICI 164 384 in human mammary carcinoma cells (MCF-7) in culture: the role of autophagy.

  1996cited by this paper
• Anti-angiogenic activity of triterpene acids.

  1995cited by this paper

• Ursolic Acid Suppresses Colorectal Cancer Through Autophagy–Lysosomal Degradation of β-Catenin

  2025cites this paper
• Modulation of Autophagy by Ursolic and Betulinic Acids: Distinct Cytotoxic and Membrane‐Disruption in Malignant and Nonmalignant Cells

  2025cites this paper
• Ursolic acid: A natural pentacyclic triterpenoid with clinical promise in gynecological and breast cancers (Review)

  2025cites this paper
• Mitigating Pro‐Inflammatory SASP and DAMP With Urolithin A: A Novel Senomorphic Strategy

  2025cites this paper
• A combined treatment with Ursolic acid and Solasodine inhibits colorectal cancer progression through the AKT1/ERK1/2-GSK-3β-β-catenin axis.

  2024cites this paper
• Cytotoxic Autophagy: A Novel Treatment Paradigm against Breast Cancer Using Oleanolic Acid and Ursolic Acid

  2024cites this paper
• Nanotherapeutics targeting autophagy regulation for improved cancer therapy

  2024cites this paper
• Modulation of Cell Death Pathways for Cellular Protection and Anti-Tumoral Activity: The Role of Thymus spp. Extracts and Their Bioactive Molecules

  2023cites this paper
• Advances in autophagy modulation of natural products in cervical cancer.

  2023cites this paper
• Ursolic Acid Alleviates Cancer Cachexia and Prevents Muscle Wasting via Activating SIRT1

  2023cites this paper
• Natural Compounds Targeting the Autophagy Pathway in the Treatment of Colorectal Cancer

  2023cites this paper
• Research Progress on the Anticancer Molecular Mechanism of Targets Regulating Cell Autophagy

  2023cites this paper
• Ursolic acid: a pentacyclic triterpenoid that exhibits anticancer therapeutic potential by modulating multiple oncogenic targets

  2023cites this paper
• Ursolic acid enhances autophagic clearance and ameliorates motor and non-motor symptoms in Parkinson’s disease mice model

  2022cites this paper
• Ursolic Acid Impairs Cellular Lipid Homeostasis and Lysosomal Membrane Integrity in Breast Carcinoma Cells

  2022cites this paper
• Ursolic acid and SARS-CoV-2 infection: a new horizon and perspective

  2022cites this paper
• Induction of Autophagy by Ursolic Acid Promotes the Elimination of Trypanosoma cruzi Amastigotes From Macrophages and Cardiac Cells

  2022cites this paper
• Ursolic Acid Enhances the Sensitivity of MCF-7 and MDA-MB-231 Cells to Epirubicin by Modulating the Autophagy Pathway

  2022cites this paper
• Antitumor Effects of Natural Bioactive Ursolic Acid in Embryonic Cancer Stem Cells

  2022cites this paper
• Antitumor Effects of Ursolic Acid through Mediating the Inhibition of STAT3/PD-L1 Signaling in Non-Small Cell Lung Cancer Cells

  2021cites this paper
• Ursolic Acid Inhibits Collective Cell Migration and Promotes JNK-Dependent Lysosomal Associated Cell Death in Glioblastoma Multiforme Cells

  2021cites this paper
• Discovery of First-in-Class Dual PARP and EZH2 Inhibitors for Triple-Negative Breast Cancer with Wild-Type BRCA.

  2021cites this paper
• Ursolic Acid Inhibits Breast Cancer Metastasis by Suppressing Glycolytic Metabolism via Activating SP1/Caveolin-1 Signaling

  2021cites this paper
• Novel Approaches of Dysregulating Lysosome Functions in Cancer Cells by Specific Drugs and Its Nanoformulations: A Smart Approach of Modern Therapeutics

  2021cites this paper
• Terpenoids’ anti-cancer effects: focus on autophagy

  2021cites this paper
• Tumor-suppressing effect of bartogenic acid in ovarian (SKOV-3) xenograft mouse model

  2021cites this paper
• Ursolic acid improves the indoxyl sulfate-induced impairment of mitochondrial biogenesis in C2C12 cells

  2021cites this paper
• Ursolic acid: A systematic review of its pharmacology, toxicity and rethink on its pharmacokinetics based on PK-PD model.

  2020cites this paper
• Drug Targets in Cellular Processes of Cancer: From Nonclinical to Preclinical Models

  2020cites this paper
• Autophagy inhibition enhances the inhibitory effects of ursolic acid on lung cancer cells

  2020cites this paper
• Ursolic acid promotes apoptosis, autophagy, and chemosensitivity in gemcitabine-resistant human pancreatic cancer cells.

  2020cites this paper
• Stable Isotope Tracing Metabolomics to Investigate the Metabolic Activity of Bioactive Compounds for Cancer Prevention and Treatment

  2020cites this paper
• Targeting autophagic pathways by plant natural compounds in cancer treatment.

  2020cites this paper
• Ursolic acid inhibits cell migration and promotes JNK-dependent lysosomal associated cell death in Glioblastoma multiforme cells

  2020cites this paper
• Antioxidant and Antiproliferative Potential of Bioactive Molecules Ursolic Acid and Thujone Isolated from Memecylon edule and Elaeagnus indica and Their Inhibitory Effect on Topoisomerase II by Molecular Docking Approach

  2020cites this paper
• Reactive Oxygen Species-Mediated Autophagy by Ursolic Acid Inhibits Growth and Metastasis of Esophageal Cancer Cells

  2020influential citation
• Molecular Insights into the Multifunctional Role of Natural Compounds: Autophagy Modulation and Cancer Prevention

  2020cites this paper
• Squalene deters drivers of RCC disease progression beyond VHL status

  2020cites this paper
• Regulatory Roles of Autophagy in Cancer

  2020cites this paper
• Nano delivery of natural substances as prospective autophagy modulators in glioblastoma.

  2020cites this paper
• Targeting autophagy by natural product Ursolic acid for prevention and treatment of osteoporosis.

  2020cites this paper
• Ursolic and Oleanolic Acids Induce Mitophagy in A549 Human Lung Cancer Cells

  2019cites this paper
• Fluorescent labeling of ursolic acid with FITC for investigation of its cytotoxic activity using confocal microscopy.

  2019cites this paper
• Targeting autophagy using natural compounds for cancer prevention and therapy

  2019cites this paper
• TRP14 promotes resistance to cisplatin by inducing autophagy in ovarian cancer

  2019cites this paper
• Cold Atmospheric Plasma induces accumulation of lysosomes and caspase-independent cell death in U373MG glioblastoma multiforme cells

  2019cites this paper
• Ursolic Acid Suppresses Cholesterol Biosynthesis and Exerts Anti-Cancer Effects in Hepatocellular Carcinoma Cells

  2019cites this paper
• Naturally occurring anti-cancer compounds: shining from Chinese herbal medicine

  2019cites this paper
• Recent Advances in Characterizing Natural Products that Regulate Autophagy.

  2019cites this paper
• Investigating the effect of radiosensitizer for Ursolic Acid and Kamolonol Acetate ‌ on HCT-116 cell line.

  2019cites this paper
• Ursolic acid in health and disease

  2018cites this paper
• Targeting EGFR‐mediated autophagy as a potential strategy for cancer therapy

  2018cites this paper
• Genetic polymorphisms of autophagy-related gene 5 (ATG5) rs473543 predict different disease-free survivals of triple-negative breast cancer patients receiving anthracycline- and/or taxane-based adjuvant chemotherapy

  2018cites this paper
• Phytochemicals as potent modulators of autophagy for cancer therapy.

  2018cites this paper
• Design, synthesis and antineoplastic activity of novel hybrids of podophyllotoxin and indirubin against human leukaemia cancer cells as multifunctional anti-MDR agents.

  2018cites this paper
• Retracted Article: Long non-coding RNA XIST promotes proliferation, autophagy and inhibits apoptosis by regulating microRNA-30c/ATG5 axis in gastric cancer

  2018cites this paper
• Cytotoxic Compounds from Wrightia pubescens (R.Br.)

  2018cites this paper
• Inactivation of Beclin‐1‐dependent autophagy promotes ursolic acid‐induced apoptosis in hypertrophic scar fibroblasts

  2018cites this paper
• Endoplasmic reticulum-targeting photosensitizer Hypericin confers chemo-sensitization towards oxaliplatin through inducing pro-death autophagy.

  2017cites this paper
• Apoptosis as the basic mechanism of cytotoxic action of ursolic and pomolic acids in glioma cells

  2017cites this paper
• Hypoxia-induced autophagy in hepatocellular carcinoma and anticancer therapy

  2017cites this paper
• NF-κB pathway link with ER stress-induced autophagy and apoptosis in cervical tumor cells

  2017cites this paper
• Modulation of Tumour-Related Signaling Pathways by Natural Pentacyclic Triterpenoids and their Semisynthetic Derivatives.

  2017cites this paper
• Ursolic acid-mediated changes in glycolytic pathway promote cytotoxic autophagy and apoptosis in phenotypically different breast cancer cells

  2017cites this paper
• Natural agents mediated autophagic signal networks in cancer

  2017influential citation
• Anti-Parkinsonian effects of β-amyrin are regulated via LGG-1 involved autophagy pathway in Caenorhabditis elegans.

  2017cites this paper
• Ursolic acid affords antidepressant-like effects in mice through the activation of PKA, PKC, CAMK-II and MEK1/2

  2017cites this paper
• PGRMC1-dependent autophagy by hyperoside induces apoptosis and sensitizes ovarian cancer cells to cisplatin treatment.

  2017cites this paper
• Clinical relevance of autophagic therapy in cancer: Investigating the current trends, challenges, and future prospects

  2016cites this paper
• Natural products as modulator of autophagy with potential clinical prospects

  2016cites this paper
• Periplogenin induces necroptotic cell death through oxidative stress in HaCaT cells and ameliorates skin lesions in the TPA- and IMQ-induced psoriasis-like mouse models.

  2016cites this paper
• Title EM 23 , a natural sesquiterpene lactone , targets thioredoxin reductase to activate JNK and cell death pathways in human cervical cancer cells

  2016cites this paper
• Therapeutic Interventions Using Ursolic Acid for Cancer Treatment

  2016cites this paper
• Autophagy Modulation for Organelle-Targeting Therapy

  2016cites this paper
• Phytochemistry and pharmacological activities of the genus Prunella.

  2016cites this paper
• 3,3'-Diindolylmethane induces anti-human gastric cancer cells by the miR-30e-ATG5 modulating autophagy.

  2016cites this paper
• Ursolic acid enhances macrophage autophagy and attenuates atherogenesis[S]

  2016cites this paper
• Involvement of Endoplasmic Reticulum Stress, Autophagy, and Apoptosis in Advanced Glycation End Products-Induced Glomerular Mesangial Cell Injury

  2016cites this paper
• Ursolic acid sensitizes cisplatin-resistant HepG2/DDP cells to cisplatin via inhibiting Nrf2/ARE pathway

  2016cites this paper
• SIRT1/Atg5/autophagy are involved in the antiatherosclerosis effects of ursolic acid

  2016cites this paper
• EM23, a natural sesquiterpene lactone, targets thioredoxin reductase to activate JNK and cell death pathways in human cervical cancer cells

  2016cites this paper
• Cytotoxic Compounds from Kibatalia gitingensis (Elm.) Woodson

  2016cites this paper
• Small-Molecule Regulators of Autophagy as Potential Anti-cancer Therapy

  2016cites this paper
• Novel Therapeutic Approaches to Induce Autophagy in Brain Cancer

  2016cites this paper
• Preparation and Pre-clinical Evaluation of New Pentacyclic Triterpenoids

  2016cites this paper
• The palladacycle, AJ-5, exhibits anti-tumour and anti-cancer stem cell activity in breast cancer cells.

  2015cites this paper
• Autophagy as a pro‐death pathway

  2015cites this paper
• Ursolic Acid Attenuates Diabetic Mesangial Cell Injury through the Up-Regulation of Autophagy via miRNA-21/PTEN/Akt/mTOR Suppression

  2015cites this paper
• Natural autophagy regulators in cancer therapy: a review

  2015cites this paper
• The combination of ursolic acid and leucine potentiates the differentiation of C2C12 murine myoblasts through the mTOR signaling pathway.

  2015cites this paper
• Bioactive Essential Oils and Cancer

  2015cites this paper
• Roles of Autophagy Induced by Natural Compounds in Prostate Cancer

  2015cites this paper
• Triazole analog 1-(1-benzyl-5-(4-chlorophenyl)-1H-1,2,3-triazol-4-yl)-2-(4-bromophenylamino)-1-(4-chlorophenyl)ethanol induces reactive oxygen species and autophagy-dependent apoptosis in both in vitro and in vivo breast cancer models.

  2015cites this paper
• Triterpenes and sterols from sonneratia alba

  2015cites this paper
• Cytotoxic Triterpenes and Sterols from Pipturus arborescens (Link) C.B. Rob.

  2015cites this paper
• Autophagic responses to hypoxia and anticancer therapy in head and neck cancer.

  2015cites this paper
• Ursolic Acid Inhibits Leucine-Stimulated mTORC1 Signaling by Suppressing mTOR Localization to Lysosome

  2014cites this paper
• Ursolic acid ameliorates autoimmune arthritis via suppression of Th17 and B cell differentiation

  2014cites this paper
• Synergistic effect of xylitol and ursolic acid combination on oral biofilms

  2014cites this paper
• Ursolic acid induces autophagy in U87MG cells via ROS-dependent endoplasmic reticulum stress.

  2014cites this paper