Distinct Mechanisms of Dissemination of NDM-1 Metallo-β-Lactamase in Acinetobacter Species in Argentina

A 4-year surveillance of carbapenem-resistant Acinetobacter spp. isolates in Argentina identified 40 strains carrying blaNDM-1. Genome sequencing revealed that most were Acinetobacter baumannii, whereas seven represented other Acinetobacter spp. The A. baumannii genomes were closely related, suggesting recent spread. blaNDM-1 was located in the chromosome of A. baumannii strains and on a plasmid in non-A. baumannii strains. ABSTRACT A 4-year surveillance of carbapenem-resistant Acinetobacter spp. isolates in Argentina identified 40 strains carrying blaNDM-1. Genome sequencing revealed that most were Acinetobacter baumannii, whereas seven represented other Acinetobacter spp. The A. baumannii genomes were closely related, suggesting recent spread. blaNDM-1 was located in the chromosome of A. baumannii strains and on a plasmid in non-A. baumannii strains. A resistance gene island carrying blaPER-7 and other resistance determinants was found on a plasmid in some A. baumannii strains.

• Publication year

  2020

• Venue

  Antimicrobial Agents and Chemotherapy

• Publication date

  2020-03-02

• Fields of study

  Biology, Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1128/AAC.00324-20PMID 32122888PMCID PMC7179578
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Whole-genome analysis of New Delhi Metallo-Beta-Lactamase-1-producing Acinetobacter haemolyticus from China.

  2020cited by this paper
• Interactive Tree Of Life (iTOL) v4: recent updates and new developments

  2019cited by this paper
• Diversity of metallo-β-lactamase-encoding genes found in distinct species of Acinetobacter isolated from the Brazilian Amazon Region

  2019cited by this paper
• Multiple clones of metallo-β-lactamase-producing Acinetobacter ursingii in a children hospital from Argentina.

  2019cited by this paper
• Carbapenemases in Acinetobacter baumannii. Review of their dissemination in Latin America.

  2018cited by this paper
• Scaling accurate genetic variant discovery to tens of thousands of samples

  2017influential reference
• Detection of blaOXA-23-like and blaNDM-1 in Acinetobacter baumannii from the Eastern Region, Saudi Arabia

  2017cited by this paper
• The blaOXA-23-associated transposons in the genome of Acinetobacter spp. represent an epidemiological situation of the species encountering carbapenems

  2017influential reference
• Quantitative assessment of insertion sequence impact on bacterial genome architecture

  2016cited by this paper
• Transposition of Tn125 Encoding the NDM-1 Carbapenemase in Acinetobacter baumannii

  2016cited by this paper
• Intraspecies Transfer of the Chromosomal Acinetobacter baumannii blaNDM-1 Carbapenemase Gene

  2016cited by this paper
• Emergence of genetically unrelated NDM-1-producing Acinetobacter pittii strains in Paraguay.

  2014cited by this paper
• First Report of NDM-1-Producing Acinetobacter baumannii Sequence Type 25 in Brazil

  2014cited by this paper
• Bacterial Peritonitis Due to Acinetobacter baumannii Sequence Type 25 with Plasmid-Borne New Delhi Metallo-β-Lactamase in Honduras

  2013cited by this paper
• blaNDM-1 Is a Chimera Likely Constructed in Acinetobacter baumannii

  2012cited by this paper
• Prevalence and Risk Factors of Metallo β-lactamase Producing Pseudomonas aeruginosa and Acinetobacter species in Burns and Surgical Wards in a Tertiary Care Hospital

  2012cited by this paper
• Characterization of a multidrug-resistant Acinetobacter baumannii strain carrying the blaNDM-1 and blaOXA-23 carbapenemase genes from the Czech Republic.

  2012cited by this paper
• Coexistence of blaNDM-1 with the prevalent blaOXA23 and blaIMP in pan-drug resistant Acinetobacter baumannii isolates in China.

  2011cited by this paper
• Tn125-Related Acquisition of blaNDM-Like Genes in Acinetobacter baumannii

  2011cited by this paper
• Coexistence of blaOXA-23 with blaNDM-1 and armA in clinical isolates of Acinetobacter baumannii from India.

  2010cited by this paper
• The Population Structure of Acinetobacter baumannii: Expanding Multiresistant Clones from an Ancestral Susceptible Genetic Pool

  2010influential reference
• Emergence of metallo-beta-lactamases in Acinetobacter spp clinical isolates from Argentina.

  2010cited by this paper
• Attributable mortality of imipenem-resistant nosocomial Acinetobacter baumannii bloodstream infection.

  2009cited by this paper
• Velvet: algorithms for de novo short read assembly using de Bruijn graphs.

  2008cited by this paper

• Post-pandemic molecular epidemiology of β-lactam resistance and biofilm formation in multidrug-resistant Acinetobacter baumannii from a Brazilian tertiary hospital.

  2026cites this paper
• Vitamin B12 promotes cefiderocol resistance and small-colony variants in carbapenem-resistant Acinetobacter baumannii

  2026cites this paper
• Emergence of NDM-1 on IncR-IncFIA (HI1) plasmid in carbapenem-resistant Kluyvera ascorbata from China

  2025cites this paper
• Lacticaseibacillus rhamnosus CRL 2244 secreted metabolites display killing and antibiotic synergistic activity against multi-drug resistant pathogens

  2024cites this paper
• Next-Gen Nano Biosensor Technologies to Monitor Carbapenem Resistance for Personalized Medicine

  2024cites this paper
• Genetic profile and characterization of antimicrobial resistance in Acinetobacter baumannii post-COVID-19 pandemic: a study in a tertiary hospital in Recife, Brazil.

  2024cites this paper
• Hetero-antagonism of avibactam and sulbactam with cefiderocol in carbapenem-resistant Acinetobacter spp.

  2024cites this paper
• Carbapenem-resistant Acinetobacter baumannii (CRAB): metabolic adaptation and transcriptional response to human urine (HU)

  2024cites this paper
• Hetero-antagonism of avibactam and sulbactam with cefiderocol in carbapenem-resistant Acinetobacter spp

  2024cites this paper
• Carbapenem-resistant Acinetobacter baumannii (CRAB): metabolic adaptation and transcriptional response to human urine (HU)

  2024cites this paper
• Diversity of genetic platforms harboring the blaPER-2 gene in Enterobacterales and insights into the role of ISPa12 in its mobilization and dissemination.

  2023cites this paper
• Acinetobacter baumannii from Samples of Commercially Reared Turkeys: Genomic Relationships, Antimicrobial and Biocide Susceptibility

  2023cites this paper
• Induced Heteroresistance in Carbapenem-Resistant Acinetobacter baumannii (CRAB) via Exposure to Human Pleural Fluid (HPF) and Its Impact on Cefiderocol Susceptibility

  2023cites this paper
• Phenotypic and transcriptional analysis of the antimicrobial effect of lactic acid bacteria on carbapenem-resistant Acinetobacter baumannii: Lacticaseibacillus rhamnosus CRL 2244 an alternative strategy to overcome resistance?”

  2023cites this paper
• Genomic characterization of an NDM-9-producing Acinetobacter baumannii clinical isolate and role of Glu152Lys substitution in the enhanced cefiderocol hydrolysis of NDM-9

  2023cites this paper
• Antimicrobial activity of the Lacticaseibacillus rhamnosus CRL 2244 and its impact on the phenotypic and transcriptional responses in carbapenem resistant Acinetobacter baumannii

  2023cites this paper
• Multiple host colonization and differential expansion of multidrug-resistant ST25-Acinetobacter baumannii clades

  2023cites this paper
• TREN PENELITIAN BAKTERI RESISTEN PENGHASIL METALLO-BETA LACTAMASE (MBL) TERHADAP ANTIBIOTIK GOLONGAN KARBAPENEM: ANALISIS BIBLIOMETRIK

  2023cites this paper
• Human Serum Proteins and Susceptibility of Acinetobacter baumannii to Cefiderocol: Role of Iron Transport

  2022cites this paper
• A case–control study of infections caused by Klebsiella pneumoniae producing New Delhi metallo-beta-lactamase-1: Predictors and outcomes

  2022cites this paper
• Co-production of blaNDM-1 and blaOXA-23 in multiresistant clinical isolates of Acinetobacter baumannii from Brazil

  2022cites this paper
• Genetic Configuration of Genomic Resistance Islands in Acinetobacter baumannii Clinical Isolates From Egypt

  2022cites this paper
• The Iron Content of Human Serum Albumin Modulates the Susceptibility of Acinetobacter baumannii to Cefiderocol

  2022cites this paper
• Acinetobacter baumannii response to cefiderocol challenge in human urine

  2022cites this paper
• Interplay between Meropenem and Human Serum Albumin on Expression of Carbapenem Resistance Genes and Natural Competence in Acinetobacter baumannii

  2021cites this paper
• Карбапенемазы как фактор устойчивости к антибактериальным препаратам

  2021cites this paper
• Carbapenemases as factors of Resistance to Antibacterial Drugs

  2021cites this paper
• Interaction of Acinetobacter baumannii with Human Serum Albumin: Does the Host Determine the Outcome?

  2021cites this paper
• A New Twist: The Combination of Sulbactam/Avibactam Enhances Sulbactam Activity against Carbapenem-Resistant Acinetobacter baumannii (CRAB) Isolates

  2021cites this paper
• First Report of New Delhi Metallo-β-Lactamase-6 (NDM-6) in a Clinical Acinetobacter baumannii Isolate From Northern Spain

  2020cites this paper
• Characterization of ST25 blaNDM-1 producing Acinetobacter spp. strains leading the increase in NDM-1 emergence in Argentina.

  2020cites this paper
• Carbapenemases: Transforming Acinetobacter baumannii into a Yet More Dangerous Menace

  2020cites this paper
• Genomic analysis of two Acinetobacter baumannii strains belonging to two different STs (ST172 and ST25).

  2020cites this paper