Autocrine adenosine signaling promotes regulatory T cell-mediated renal protection.

No abstract is available for this paper.

• Publication year

  2012

• Venue

  Journal of the American Society of Nephrology

• Publication date

  2012-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1681/ASN.2012010070PMID 22835488PMCID PMC3431416
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Pharmacologic recruitment of regulatory T cells as a therapy for ischemic acute kidney injury.

  2012cited by this paper
• CD73-deficient mice have increased antitumor immunity and are resistant to experimental metastasis.

  2011cited by this paper
• Extracellular purine metabolism and signaling of CD73-derived adenosine in murine Treg and Teff cells.

  2011cited by this paper
• Infusion of ex vivo expanded T regulatory cells in adults transplanted with umbilical cord blood: safety profile and detection kinetics.

  2011cited by this paper
• Regulatory T cells from IL-10-deficient mice fail to suppress contact hypersensitivity reactions due to lack of adenosine production.

  2011cited by this paper
• Program death-1 signaling and regulatory T cells collaborate to resist the function of adoptively transferred cytotoxic T lymphocytes in advanced acute myeloid leukemia.

  2010cited by this paper
• Endothelial Cells Augment the Suppressive Function of CD4+CD25+Foxp3+ Regulatory T Cells: Involvement of Programmed Death-1 and IL-10

  2010cited by this paper
• Regulatory T cells contribute to the protective effect of ischemic preconditioning in the kidney.

  2010cited by this paper
• Programmed death-1–induced interleukin-10 production by monocytes impairs CD4+ T cell activation during HIV infection

  2010cited by this paper
• Acute kidney injury increases risk of ESRD among elderly.

  2009cited by this paper
• T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune response.

  2009cited by this paper
• CD73 is expressed by human regulatory T helper cells and suppresses proinflammatory cytokine production and Helicobacter felis-induced gastritis in mice.

  2009cited by this paper
• Foxp3+ regulatory T cells participate in repair of ischemic acute kidney injury.

  2009cited by this paper
• PD1 blockade reverses the suppression of melanoma antigen-specific CTL by CD4+ CD25(Hi) regulatory T cells.

  2009cited by this paper
• PD-L1 negatively regulates CD4+CD25+Foxp3+ Tregs by limiting STAT-5 phosphorylation in patients chronically infected with HCV.

  2009cited by this paper
• Dialysis-requiring acute renal failure increases the risk of progressive chronic kidney disease.

  2009cited by this paper
• Regulatory T cells suppress innate immunity in kidney ischemia-reperfusion injury.

  2009cited by this paper
• A2A receptor signaling promotes peripheral tolerance by inducing T-cell anergy and the generation of adaptive regulatory T cells.

  2008cited by this paper
• Pharmacologic characterization of novel adenosine A2A receptor agonists in equine neutrophils.

  2007cited by this paper
• PD-1 and PD-1 ligands: from discovery to clinical application.

  2007cited by this paper
• Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression

  2007cited by this paper
• Evidence Based Selection of Housekeeping Genes

  2007cited by this paper
• Treg suppressive activity involves estrogen-dependent expression of programmed death-1 (PD-1).

  2007cited by this paper
• Incidence and outcomes in acute kidney injury: a comprehensive population-based study.

  2007cited by this paper
• Activation of Adenosine 2A Receptors Attenuates Allograft Rejection and Alloantigen Recognition1

  2007cited by this paper
• Contribution of the PD‐1 ligands/PD‐1 signaling pathway to dendritic cell‐mediated CD4+ T cell activation

  2006cited by this paper
• Adenosine A2A receptor activation reduces hepatic ischemia reperfusion injury by inhibiting CD1d-dependent NKT cell activation

  2006cited by this paper
• Cutting Edge: Critical Role for A2A Adenosine Receptors in the T Cell-Mediated Regulation of Colitis1

  2006cited by this paper
• Crucial Role for Ecto-5′-Nucleotidase (CD73) in Vascular Leakage during Hypoxia

  2004cited by this paper
• Renal protection from ischemia mediated by A2A adenosine receptors on bone marrow-derived cells.

  2003cited by this paper
• Rapid recruitment of inflammatory monocytes is independent of neutrophil migration.

  2003cited by this paper
• Pattern recognition receptors and differentiation antigens define murine myeloid cell heterogeneity ex vivo

  2003cited by this paper
• Pharmacological Stress Myocardial Perfusion Imaging With the Potent and Selective A2A Adenosine Receptor Agonists ATL193 and ATL146e Administered by Either Intravenous Infusion or Bolus Injection

  2001cited by this paper
• Selective A2A adenosine receptor activation reduces ischemia-reperfusion injury in rat kidney.

  1999cited by this paper
• Turnover of adenosine in plasma of human and dog blood.

  1989cited by this paper

• Immunological mechanisms and novel therapeutic strategies for sepsis-associated acute kidney injury (Review)

  2026cites this paper
• Characterising and Evaluating the Immune Microenvironment Landscapes of Colorectal Cancer Shaped by Different Therapies

  2025cites this paper
• The emerging role of tissue regulatory T cells in tissue repair and regeneration

  2025cites this paper
• Mediation of Osseointegration, Osteoimmunology, and Osteoimmunologic Integration by Tregs and Macrophages: A Narrative Review

  2025cites this paper
• CD73/adenosine dynamics in treatment-induced pneumonitis: balancing efficacy with risks of adverse events in combined radio-immunotherapies

  2025cites this paper
• Lymphocytes and innate immune cells in acute kidney injury and repair

  2024cites this paper
• Adenosine A2AR in viral immune evasion and therapy: unveiling new avenues for treating COVID-19 and AIDS

  2024cites this paper
• Neglected Issues in T Lymphocyte Metabolism: Purine Metabolism and Control of Nuclear Envelope Regulatory Processes. New Insights into Triggering Potential Metabolic Fragilities

  2024cites this paper
• Hypoxia-adenosine axis as therapeutic targets for acute respiratory distress syndrome

  2024cites this paper
• Adenosine-mediated immune responses in inflammatory bowel disease

  2024influential citation
• CD39 expression by regulatory T cells participates in CD8+ T cell suppression during experimental Trypanosoma cruzi infection

  2024cites this paper
• VX-702 Ameliorates the Severity of Sepsis-Associated Acute Kidney Injury by Downregulating Inflammatory Factors in Macrophages

  2024cites this paper
• The interplay between the DNA damage response and ectonucleotidases modulates tumor response to therapy

  2023cites this paper
• Tumor intrinsic and extrinsic functions of CD73 and the adenosine pathway in lung cancer

  2023cites this paper
• Improving combination therapies: targeting A2B-adenosine receptor to modulate metabolic tumor microenvironment and immunosuppression

  2023cites this paper
• eATP and autoimmune diabetes.

  2023cites this paper
• Integrative analyses identify CD73 as a prognostic biomarker and immunotherapeutic target in intrahepatic cholangiocarcinoma

  2023cites this paper
• Tumor-infiltrating regulatory T cells as targets of cancer immunotherapy.

  2023cites this paper
• Gal-9/Tim-3 signaling pathway activation suppresses the generation of Th17 cells and promotes the induction of Foxp3+ regulatory T cells in renal ischemia-reperfusion injury.

  2023cites this paper
• ADENOSINE INFLUENCES FOXP3 EXPRESSION OF TREGS VIA THE A2AR/CREB PATHWAY IN A MOUSE MODEL OF SEPSIS

  2023cites this paper
• Molecular Mechanisms Underpinning Immunometabolic Reprogramming: How the Wind Changes during Cancer Progression

  2023cites this paper
• CD73 mediates the therapeutic effects of endometrial regenerative cells in concanavalin A-induced hepatitis by regulating CD4+ T cells

  2023cites this paper
• CD39 expression by regulatory T cells drives CD8+ T cell suppression during experimental Trypanosoma cruzi infection

  2023cites this paper
• The immune checkpoint adenosine 2A receptor is associated with aggressive clinical outcomes and reflects an immunosuppressive tumor microenvironment in human breast cancer

  2023cites this paper
• Adenosinergic metabolism pathway: an emerging target for improving outcomes of solid organ transplantation.

  2023cites this paper
• The role of regulatory T cells in the pathogenesis of acute kidney injury

  2023cites this paper
• Divergent roles of PD-L1 in immune regulation during ischemia–reperfusion injury

  2022influential citation
• Immunomodulatory effect of ADO on liver tumor microenvironment

  2022cites this paper
• Tolerance to DNFB-induced contact hypersensitivity is mediated by CD73 expressing tissue-homing regulatory T cells.

  2022cites this paper
• M2c Macrophages Protect Mice from Adriamycin-Induced Nephropathy by Upregulating CD62L in Tregs

  2022cites this paper
• CD73-Adenosinergic Axis Mediates the Protective Effect of Extracellular Vesicles Derived from Mesenchymal Stromal Cells on Ischemic Renal Damage in a Rat Model of Donation after Circulatory Death

  2022cites this paper
• The Multifaceted Actions of CD73 During Development and Suppressive Actions of Regulatory T Cells

  2022cites this paper
• Role of T cells in ischemic acute kidney injury and repair

  2022influential citation
• Targeting nucleotide metabolism: a promising approach to enhance cancer immunotherapy

  2022cites this paper
• Burnstock oration — purinergic signalling in kidney transplantation

  2022cites this paper
• Soluble Programmed Cell Death Protein 1 and Its Ligand: Potential Biomarkers to Predict Acute Kidney Injury After Surgery in Critically Ill Patients

  2022cites this paper
• A DNA Nanoraft-Based Cytokine Delivery Platform for Alleviation of Acute Kidney Injury.

  2021cites this paper
• Lymphocytes: Versatile Participants in Acute Kidney Injury and Progression to Chronic Kidney Disease

  2021cites this paper
• Role of Purinergic Signalling in Endothelial Dysfunction and Thrombo-Inflammation in Ischaemic Stroke and Cerebral Small Vessel Disease

  2021cites this paper
• Regulation of immune responses through CD39 and CD73 in cancer: Novel checkpoints.

  2021cites this paper
• The role of PD-L1 in the immune dysfunction that mediates hypoxia-induced multiple organ injury

  2021cites this paper
• The role of regulatory T cells in the pathogenesis and treatment of prostate cancer.

  2021cites this paper
• PD-L1/PD-1 Axis in Multiple Myeloma Microenvironment and a Possible Link with CD38-Mediated Immune-Suppression

  2021cites this paper
• Immune regulation in renal inflammation

  2021cites this paper
• CD73 contributes to anti‐inflammatory properties of afferent lymphatic endothelial cells in humans and mice

  2020cites this paper
• Treg expansion with trichostatin A ameliorates kidney ischemia/reperfusion injury in mice by suppressing the expression of costimulatory molecules.

  2020cites this paper
• Regulatory T cells in ischemic cardiovascular injury and repair.

  2020cites this paper
• Rethinking the adenosine-A2AR checkpoint: implications for enhancing anti-tumor immunotherapy.

  2020cites this paper
• Pathophysiology of A1 Adenosine Receptor Inhibition in Acute Kidney Injury Induced by Ischemia-Reperfusion: a Review Study

  2020cites this paper
• Targeting the Tumor Microenvironment for a More Effective and Efficient Cancer Immunotherapy

  2020influential citation
• Regulatory T Cells as a Novel Candidate for Cell-Based Therapy in Kidney Disease

  2020cites this paper
• Purinergic Signaling in the Hallmarks of Cancer

  2020cites this paper
• The Use of Immune Checkpoint Inhibitors in Oncology and the Occurrence of AKI: Where Do We Stand?

  2020influential citation
• The Yin and Yang of Alarmins in Regulation of Acute Kidney Injury

  2020cites this paper
• Ectonucleotidase CD73 and CD39 expression in non-small cell lung cancer relates to hypoxia and immunosuppressive pathways.

  2020cites this paper
• Conversion of extracellular ATP into adenosine: a master switch in renal health and disease

  2020cites this paper
• Harnessing Endogenous T-Regulatory Cells in Acute Kidney Injury

  2020cites this paper
• Hyper-Progressive Disease: The Potential Role and Consequences of T-Regulatory Cells Foiling Anti-PD-1 Cancer Immunotherapy

  2020cites this paper
• FoxP3+ T regulatory cells in cancer: Prognostic biomarkers and therapeutic targets.

  2020cites this paper
• CD73 expression is critical to therapeutic effects of human endometrial regenerative cells in inhibition of cardiac allograft rejection in mice

  2020cites this paper
• Implications of CD39 in immune-related diseases.

  2020cites this paper
• Innate immunity orchestrates the mobilization and homing of hematopoietic stem/progenitor cells by engaging purinergic signaling—an update

  2020cites this paper
• The adenosine pathway in immuno-oncology

  2020cites this paper
• Pannexins in Acute Kidney Injury

  2019cites this paper
• Effect of Interferon- on Expression of CD39 and CD73 Genes in the Human Wharton’s Jelly Mesenchymal Stem Cells

  2019cites this paper
• Dysregulation of Adenosinergic Signaling in Systemic and Organ-Specific Autoimmunity

  2019cites this paper
• Reparative T lymphocytes in organ injury.

  2019cites this paper
• Regulatory innate lymphoid cells suppress innate immunity and reduce renal ischemia/reperfusion injury.

  2019cites this paper
• Targeting Adenosine Receptor Signaling in Cancer Immunotherapy

  2018cites this paper
• Carbon monoxide protects the kidney through the central circadian clock and CD39

  2018cites this paper
• Regulatory T cells in renal disease

  2018influential citation
• Increased degradation of ATP is driven by memory regulatory T cells in kidney transplantation tolerance.

  2018cites this paper
• Regulatory T cells in acute and chronic kidney diseases.

  2018influential citation
• CD39-adenosinergic axis in renal pathophysiology and therapeutics

  2018cites this paper
• Oxygen-dependent regulation of immune checkpoint mechanisms

  2018cites this paper
• Pharmacology of Adenosine Receptors: The State of the Art.

  2018cites this paper
• Ag-specific CD4 T cells promote innate immune responses in liver ischemia reperfusion injury

  2018cites this paper
• Comparison of the expression of cluster of differentiation (CD)39 and CD73 between propofol- and sevoflurane-based anaesthesia during open heart surgery

  2018cites this paper
• The Immune System in Nephrotoxicity

  2018cites this paper
• Effect of Interferon- on Expression of CD39 and CD73 Genes in the Human Wharton’s Jelly Mesenchymal Stem Cells

  2018cites this paper
• Strategies to Reduce Intratumoral Regulatory T Cells

  2018cites this paper
• Adenosine Signalling in the Injured Heart

  2018cites this paper
• Changes in CD73, CD39 and CD26 expression on T-lymphocytes of ANCA-associated vasculitis patients suggest impairment in adenosine generation and turn-over

  2017cites this paper
• The IL-2/Anti-IL-2 Complex Attenuates Cardiac Ischaemia-Reperfusion Injury Through Expansion of Regulatory T Cells

  2017cites this paper
• Proximal Tubule CD73 Is Critical in Renal Ischemia-Reperfusion Injury Protection.

  2017cites this paper
• Early, but not late, treatment with human umbilical cord blood-derived mesenchymal stem cells attenuates cisplatin nephrotoxicity through immunomodulation.

  2017cites this paper
• ATP and T-cell-mediated rejection

  2017cites this paper
• Superagonistic CD28 Protects against Renal Ischemic Injury by Expansion of Regulatory T-Cell

  2017cites this paper
• The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets

  2017cites this paper
• Multifaceted Effects of Extracellular Adenosine Triphosphate and Adenosine in the Tumor–Host Interaction and Therapeutic Perspectives

  2017cites this paper
• Immunopathology of the Urinary System

  2017cites this paper
• The Possible Roles of CD73 and Adenosine in the Osteoimmunological Bone Resorption of Periradicular Periodontitis

  2016cites this paper
• Adenosine production: a common path for mesenchymal stem-cell and regulatory T-cell-mediated immunosuppression

  2016cites this paper
• A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment

  2016cites this paper
• Regulatory T cells in kidney disease and transplantation.

  2016cites this paper
• Human endometrial regenerative cells attenuate renal ischemia reperfusion injury in mice

  2016cites this paper
• Cyclic AMP Represents a Crucial Component of Treg Cell-Mediated Immune Regulation

  2016cites this paper
• Exploration of helminth-derived immunoregulatory molecules as options for therapeutic intervention in allograft rejection and autoimmune disease

  2016cites this paper
• Hypercholesterolemia and Ecto‐enzymes of Purinergic System: Effects of Paullinia cupana

  2016cites this paper
• Immunosuppressive activities of adenosine in cancer.

  2016cites this paper