HIF-1alpha controls extracellular matrix synthesis by epiphyseal chondrocytes.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Journal of Cell Science

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 12665562
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Dissecting hypoxia-dependent and hypoxia-independent steps in the HIF-1alpha activation cascade: implications for HIF-1alpha gene therapy.

  2001cited by this paper
• Establishment and characterization of chondrocyte cell lines from the costal cartilage of SV40 large T antigen transgenic mice

  2001cited by this paper
• Combination of reduced oxygen tension and intermittent hydrostatic pressure: a useful tool in articular cartilage tissue engineering.

  2001cited by this paper
• Vascular endothelial growth factor in articular cartilage of healthy and osteoarthritic human knee joints

  2001cited by this paper
• Hypoxia in cartilage: HIF-1alpha is essential for chondrocyte growth arrest and survival.

  2001cited by this paper
• Transcription Factor HIF-1 Is a Necessary Mediator of the Pasteur Effect in Mammalian Cells

  2001cited by this paper
• Vascular endothelial growth factor (VEGF) in cartilage neovascularization and chondrocyte differentiation: auto-paracrine role during endochondral bone formation.

  2000cited by this paper
• HIF-1 and human disease: one highly involved factor.

  2000cited by this paper
• The Roles of Annexins and Types II and X Collagen in Matrix Vesicle-mediated Mineralization of Growth Plate Cartilage*

  2000cited by this paper
• Mitochondrial oxidative phosphorylation is a downstream regulator of nitric oxide effects on chondrocyte matrix synthesis and mineralization.

  2000cited by this paper
• VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation

  1999cited by this paper
• Immunolocalisation of vascular endothelial growth factor (VEGF) in human neonatal growth plate cartilage

  1999cited by this paper
• HIF-1 alpha is required for solid tumor formation and embryonic vascularization.

  1998cited by this paper
• Hypoxia-inducible factor 1 and the molecular physiology of oxygen homeostasis.

  1998cited by this paper
• Inducible gene targeting in mice using the Cre/lox system.

  1998cited by this paper
• Regulation of hypoxia-inducible factor 1alpha is mediated by an O2-dependent degradation domain via the ubiquitin-proteasome pathway.

  1998cited by this paper
• Hypoxia-inducible factor 1alpha (HIF-1alpha) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes.

  1997cited by this paper
• Evidence for a negative Pasteur effect in articular cartilage.

  1997cited by this paper
• Regulated Production of Mineralization-competent Matrix Vesicles in Hypertrophic Chondrocytes

  1997cited by this paper
• Adaptation of chondrocytes to low oxygen tension: Relationship between hypoxia and cellular metabolism

  1996cited by this paper
• Expression of bone‐specific genes by hypertrophic chondrocytes: Implications of the complex functions of the hypertrophic chondrocyte during endochondral bone development

  1996cited by this paper
• End labeling studies of fragmented DNA in the Avian growth plate: Evidence of apoptosis in terminally differentiated chondrocytes

  1995cited by this paper
• Integrin expression on epiphyseal mouse chondrocytes in monolayer culture.

  1995cited by this paper
• Isolation of human type X collagen and immunolocalization in fetal human cartilage.

  1991cited by this paper
• Differentiation of muscle, fat, cartilage, and bone from progenitor cells present in a bone-derived clonal cell population: effect of dexamethasone

  1988cited by this paper
• Differences in matrix vesicle concentration among growth plate zones

  1987cited by this paper
• Changes in proteoglycan aggregates during cartilage mineralization

  1987cited by this paper
• The timing of the onset of osteogenesis in the tibia of the embryonic chick

  1979cited by this paper
• Measurement of pH and ionic composition of pericellular sites.

  1975cited by this paper
• The effect of low oxygen concentration on growth, glycolysis, and sulfate incorporation by articular chondrocytes in monolayer culture.

  1973cited by this paper

• HIF-1α and BMAL1 in bone regeneration: crosstalk between hypoxia response and circadian rhythm

  2026cites this paper
• A novel variant of NOTCH2 causes skeletal fragility

  2025cites this paper
• MgAl-Layered Double Hydroxide-Modified Bioceramic Scaffolds for the Potential Application in Osteochondral Defect Repair

  2025cites this paper
• Intermittent hypoxic stimulation promotes efficient expression of Hypoxia-inducible factor-1α and exerts a chondroprotective effect in an animal osteoarthritis model

  2025cites this paper
• Functional Assessment of Genetically Modified Infrapatellar Fat Pad Mesenchymal Stem/Stromal Cell-Derived Extracellular Vesicles (EVs): Potential Implications for Inflammation/Pain Reversal in Osteoarthritis

  2025cites this paper
• Maintaining high levels of HIF-1α protects osteoarthritis cartilage by activating autophagy.

  2025cites this paper
• The role of HIF-1α in hypoxic metabolic reprogramming in osteoarthritis.

  2025cites this paper
• Regulation of Oxygen Tension as a Strategy to Control Chondrocytic Phenotype for Cartilage Tissue Engineering and Regeneration

  2024cites this paper
• Transcriptome analyses describe the consequences of persistent HIF-1 over-activation in Caenorhabditis elegans

  2024cites this paper
• T-2 toxin-induced damage to articular cartilage in rats coincided with impaired autophagy linked to the HIF-1α/AMPK signaling axis.

  2024cites this paper
• The HIF-1α/PLOD2 axis integrates extracellular matrix organization and cell metabolism leading to aberrant musculoskeletal repair

  2024cites this paper
• Functional genomics of human skeletal development and the patterning of height heritability.

  2024cites this paper
• Hypoxic Conditions Modulate Chondrogenesis through the Circadian Clock: The Role of Hypoxia-Inducible Factor-1α

  2024cites this paper
• HIF‐1α in cartilage homeostasis, apoptosis, and glycolysis in mice with steroid‐induced osteonecrosis of the femoral head

  2024cites this paper
• NOTCH2 sensitizes the chondrocyte to the inflammatory response of tumor necrosis factor α

  2023cites this paper
• Supersulfides support bone growth by promoting chondrocyte proliferation in the growth plates.

  2023cites this paper
• HIF-1α in Osteoarthritis: From Pathogenesis to Therapeutic Implications

  2022cites this paper
• Dual functions of microRNA-17 in maintaining cartilage homeostasis and protection against osteoarthritis

  2022cites this paper
• A critical bioenergetic switch is regulated by IGF2 during murine cartilage development

  2022cites this paper
• A Simple and Efficient Strategy for Preparing a Cell‐Spheroid‐Based Bioink

  2022cites this paper
• Hypoxia and platelet lysate sustain differentiation of primary horse articular chondrocytes in xeno-free supplementation culture.

  2022cites this paper
• Effect of in vitro growth on mouse oocyte competency, mitochondria and transcriptome

  2021cites this paper
• Expression and significance of related genes in the early stage of post-traumatic heterotopic ossification in a rat model of Achilles tenotomy

  2021cites this paper
• Mechanical stimulation of chondrocytes regulates HIF-1α under hypoxic conditions.

  2021cites this paper
• Pyrroline-5-Carboxylate Reductase 1 Directs the Cartilage Protective and Regenerative Potential of Murphy Roths Large Mouse Mesenchymal Stem Cells

  2021cites this paper
• Taurine is an effective therapy against thiram induced tibial dyschondroplasia via HIF-1α/VEGFA and β-catenin/ GSK-3β pathways in broilers.

  2021cites this paper
• The hypertrophic chondrocyte: To be or not to be.

  2021cites this paper
• The role of metabolism in chondrocyte dysfunction and the progression of osteoarthritis.

  2020cites this paper
• Role of the Hypoxia-Inducible Factor Pathway in Normal and Osteoarthritic Meniscus and in Mice after Destabilization of the Medial Meniscus

  2020cites this paper
• The hypoxic microenvironment: a driving force for heterotopic ossification progression

  2020cites this paper
• Conditional ablation of MAPK7 expression in chondrocytes impairs endochondral bone formation in limbs and adaptation of chondrocytes to hypoxia

  2020cites this paper
• Cartilage Homeostasis Affects Femoral Head Necrosis Induced by Methylprednisolone in Broilers

  2020cites this paper
• Transcriptional, epigenetic and microRNA regulation of growth plate.

  2020cites this paper
• IGF-1-releasing PLGA nanoparticles modified 3D printed PCL scaffolds for cartilage tissue engineering

  2020cites this paper
• 3D-printed PCL composite scaffolds incorporating IGF-1 loaded PLGA nanoparticles for cartilage tissue engineering

  2020cites this paper
• Partial deficiency of HIF-1α in chondrocytes effected bone repair of mandibular condylar neck.

  2020cites this paper
• Suppressing Mitochondrial Respiration Is Critical for Hypoxia Tolerance in the Fetal Growth Plate.

  2019cites this paper
• Respiratory chain inactivation links cartilage-mediated growth retardation to mitochondrial diseases

  2019cites this paper
• Hypoxia Inducible Factor-1α in Osteochondral Tissue Engineering

  2019cites this paper
• The Emerging Role of Glucose Metabolism in Cartilage Development

  2019cites this paper
• HIF-1α metabolically controls collagen synthesis and modification in chondrocytes

  2019cites this paper
• Elevated expression of hypoxia-inducible factor-2alpha regulated catabolic factors during intervertebral disc degeneration.

  2019cites this paper
• Deletion of clock gene Bmal1 impaired the chondrocyte function due to disruption of the HIF1α-VEGF signaling pathway

  2019cites this paper
• Hyperosmolar Potassium (K+) Treatment Suppresses Osteoarthritic Chondrocyte Catabolic and Inflammatory Protein Production in a 3-Dimensional In Vitro Model

  2019cites this paper
• Harnessing HIF-1α for osteochondral tissue engineering

  2019cites this paper
• Aquaporin Expression, Regulation and Function in theIntervertebral Disc

  2019cites this paper
• Hypoxia promotes maintenance of the chondrogenic phenotype in rat growth plate chondrocytes through the HIF-1α/YAP signaling pathway

  2018cites this paper
• A role for hypoxia and hypoxia inducible factor during chondrogenesis of bone marrow mesenchymal stem cells

  2018cites this paper
• Deferoxamine-Soaked Suture Improves Angiogenesis and Repair Potential After Acute Injury of the Chicken Achilles Tendon

  2018cites this paper
• Bioactive Scaffolds for Regeneration of Cartilage and Subchondral Bone Interface

  2018cites this paper
• Mice harboring a Hajdu Cheney Syndrome mutation are sensitized to osteoarthritis.

  2018cites this paper
• Long-term Consequences of Traumatic Brain Injury in Bone Metabolism

  2018cites this paper
• Effects of loading on chondrocyte hypoxia, HIF-1α and VEGF in the mandibular condylar cartilage of young rats.

  2018cites this paper
• Exposure to tobacco smoke increases bone loss in spontaneously hypertensive rats

  2018cites this paper
• 13 Genetic Mouse Models for Osteoarthritis Research

  2018cites this paper
• An essential role for IGF2 in cartilage development and glucose metabolism during postnatal long bone growth

  2017cites this paper
• Characterization of layered chondrocyte sheets created in a co‐culture system with synoviocytes in a hypoxic environment

  2017cites this paper
• Bone Cell Bioenergetics and Skeletal Energy Homeostasis.

  2017cites this paper
• Hypoxia regulates RhoA and Wnt/β-catenin signaling in a context-dependent way to control re-differentiation of chondrocytes

  2017cites this paper
• Signaling pathways effecting crosstalk between cartilage and adjacent tissues: Seminars in cell and developmental biology: The biology and pathology of cartilage.

  2017cites this paper
• Hypoxia and Redox Signaling on Extracellular Matrix Remodeling: From Mechanisms to Pathological Implications

  2017cites this paper
• Technology Open Access book

  2017cites this paper
• Hypoxia-induced microRNA-146a represses Bcl-2 through Traf6/IRAK1 but not Smad4 to promote chondrocyte autophagy

  2017cites this paper
• Tibial dyschondroplasia is highly associated with suppression of tibial angiogenesis through regulating the HIF-1α/VEGF/VEGFR signaling pathway in chickens

  2017cites this paper
• Deferoxamine Suppresses Collagen Cleavage and Protease, Cytokine, and COL10A1 Expression and Upregulates AMPK and Krebs Cycle Genes in Human Osteoarthritic Cartilage

  2016cites this paper
• Conditional Deletion of Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Gene Reveals Its Essential Role in Chondrocyte Function and Endochondral Bone Formation.

  2016cites this paper
• Hypoxia in Tendinopathies: From Epigenomics to Chondroid Metaplasia

  2016cites this paper
• Effects of low oxygen tension on gene profile of soluble growth factors in co‐cultured adipose‐derived stromal cells and chondrocytes

  2016cites this paper
• Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Regulates Chondrocyte Differentiation and Secondary Ossification in Mice

  2016cites this paper
• Physiological oxygen tension modulates soluble growth factor profile after crosstalk between chondrocytes and osteoblasts

  2016cites this paper
• Flavonoid Compound Icariin Activates Hypoxia Inducible Factor-1α in Chondrocytes and Promotes Articular Cartilage Repair

  2016cites this paper
• Hypoxia-Inducible Factor (HIF) as a Target for Novel Therapies in Rheumatoid Arthritis

  2016cites this paper
• Elevated concentrations of hypoxia-inducible factor-1α in patients with fracture and concomitant traumatic brain injury

  2016cites this paper
• [Research progress of mechanism of hypoxia-inducible factor-1α signaling pathway in condylar cartilage growth and remodeling].

  2016cites this paper
• Capillary ultrastructure and mitochondrial volume density in skeletal muscle in relation to reduced exercise capacity of patients with intermittent claudication.

  2016cites this paper
• Hypoxia potentiates the BMP-2 driven COL2A1 stimulation in human articular chondrocytes via p38 MAPK.

  2016cites this paper
• Genome-wide transcriptional analyses of Chinese patients reveal cell migration is attenuated in IDH1-mutant glioblastomas.

  2015cites this paper
• Differentiation of Human Ligamentum Flavum Stem Cells Toward Nucleus Pulposus-Like Cells Induced by Coculture System and Hypoxia

  2015cites this paper
• Hypoxia signalling manipulation for bone regeneration

  2015cites this paper
• HIF-1α and growth plate development: what we really know.

  2015cites this paper
• A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation

  2015cites this paper
• The impact of hypoxia on mesenchymal progenitor cells of human skeletal tissue in the pathogenesis of heterotopic ossification

  2015cites this paper
• PRO-ANGIOGENIC AND ANTI-ANGIOGENIC FACTORS IN THE DEGRADATION OF OSTEOARTHRITIC CARTILAGE

  2015cites this paper
• Inflammation: a culprit for vascular calcification in atherosclerosis and diabetes

  2015cites this paper
• HIF-1a and growth plate development: what we really know

  2015cites this paper
• Role of HIF-1α and HIF-2α in osteoarthritis.

  2015cites this paper
• HIF‐1α‐induced HSP70 regulates anabolic responses in articular chondrocytes under hypoxic conditions

  2014cites this paper
• Effect of progressive decrease of oxygen tensions on rat articular chondrocytes : a Light and scanning electron microscopy study

  2014cites this paper
• Cartilage tissue engineering: molecular control of chondrocyte differentiation for proper cartilage matrix reconstruction.

  2014cites this paper
• Hypoxia-inducible factor-1α is required for transforming growth factor-β1-induced type I collagen, periostin and α-smooth muscle actin expression in human periodontal ligament cells.

  2014cites this paper
• Osteoarthritis Pathogenesis: A Review of Molecular Mechanisms

  2014cites this paper
• Interference with the contractile machinery of the fibroblastic chondrocyte cytoskeleton induces re-expression of the cartilage phenotype through involvement of PI3K, PKC and MAPKs.

  2014cites this paper
• Loss of HIF-1α in the Notochord Results in Cell Death and Complete Disappearance of the Nucleus Pulposus

  2014cites this paper
• mTORC1 drives HIF-1α and VEGF-A signalling via multiple mechanisms involving 4E-BP1, S6K1 and STAT3

  2014cites this paper
• Interleukin 6 mediates selected effects of Notch in chondrocytes.

  2013cites this paper
• An Association Study between Hypoxia Inducible Factor-1alpha (HIF-1α) Polymorphisms and Osteonecrosis

  2013cites this paper
• Notch suppresses nuclear factor of activated T cells (NFAT) transactivation and Nfatc1 expression in chondrocytes.

  2013cites this paper
• Smad7 regulates terminal maturation of chondrocytes in the growth plate.

  2013cites this paper
• A potential biologic role for the meniscus in the development of osteoarthritis

  2013influential citation
• Homeostatic Mechanisms in Articular Cartilage and Role of Inflammation in Osteoarthritis

  2013cites this paper