The multiple endocrine neoplasia type 1 gene product, menin, inhibits insulin production in rat insulinoma cells.

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Endocrinology

• Publication date

  2002-06-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/ENDO.143.6.8950PMID 12021209
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type β signaling

  2001cited by this paper
• A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors.

  2001cited by this paper
• Expression of menin in parathyroid tumors.

  2000cited by this paper
• Transforming growth factor beta induction of insulin gene expression is mediated by pancreatic and duodenal homeobox gene-1 in rat insulinoma cells.

  2000cited by this paper
• Convergence of transforming growth factor-beta and vitamin D signaling pathways on SMAD transcriptional coactivators.

  1999cited by this paper
• Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription.

  1999cited by this paper
• Menin, the product of the MEN1 gene, is a nuclear protein.

  1998cited by this paper
• Effects of Glucose and Insulin on Rat Apolipoprotein A-I Gene Expression*

  1998cited by this paper
• Positional cloning of the gene for multiple endocrine neoplasia-type 1.

  1997cited by this paper
• Characterization of CLA-1, a Human Homologue of Rodent Scavenger Receptor BI, as a Receptor for High Density Lipoprotein and Apoptotic Thymocytes*

  1997cited by this paper
• Clinical studies of multiple endocrine neoplasia type 1 (MEN1)

  1996cited by this paper
• XIHbox 8, an endoderm-specific Xenopus homeodomain protein, is closely related to a mammalian insulin gene transcription factor.

  1994cited by this paper
• Regulation of insulin gene transcription.

  1993cited by this paper
• The natural history of multiple endocrine neoplasia type 1. Highly uncommon or highly unrecognized?

  1991cited by this paper
• Mutagenesis of the rat insulin II 5'-flanking region defines sequences important for expression in HIT cells

  1989cited by this paper

• Mixed-Lineage Leukaemia Gene Regulates Glucose-Sensitive Gene Expression and Insulin Secretion in Pancreatic Beta Cells

  2024cites this paper
• Menin signaling and therapeutic targeting in breast cancer.

  2024cites this paper
• Combined inhibition of menin-MLL interaction and TGF-β signaling induces replication of human pancreatic beta cells.

  2020cites this paper
• Preclinical drug studies in MEN1-related neuroendocrine neoplasms (MEN1-NENs).

  2020cites this paper
• GLP-1 signaling suppresses menin’s transcriptional block by phosphorylation in β cells

  2019influential citation
• Current and emerging therapies for PNETs in patients with or without MEN1

  2018cites this paper
• MEN1/Menin regulates milk protein synthesis through mTOR signaling in mammary epithelial cells

  2017cites this paper
• Menin and PRMT5 suppress GLP1 receptor transcript and PKA-mediated phosphorylation of FOXO1 and CREB.

  2017cites this paper
• Menin Modulates Mammary Epithelial Cell Numbers in Bovine Mammary Glands Through Cyclin D1

  2017cites this paper
• novel protein partner of tumour suppressor menin , is deregulated in mouse and human MEN 1 glucagonomas Deregulation of Foxa 2 in menin-deficient pancreatic α-cells

  2017cites this paper
• Role of DHS in translation control of islet β-cell replication during high fat induced obesity and glucose intolerance

  2017cites this paper
• Genetics of multiple endocrine neoplasia type 1 syndrome: what's new and what's old

  2017cites this paper
• Foxa2, a novel protein partner of the tumour suppressor menin, is deregulated in mouse and human MEN1 glucagonomas

  2017cites this paper
• MEN1, MEN4, and Carney Complex: Pathology and Molecular Genetics

  2015cites this paper
• Glucagon‐like peptide 1‐potentiated insulin secretion and proliferation of pancreatic β‐cells GLP‐1促进胰岛素分泌和胰岛β细胞增殖的机制

  2014cites this paper
• MEN1-tumorigenesis in the pituitary and pancreatic islet requires Cdk4 but not Cdk2

  2014cites this paper
• Characterization of Drosophila Menin Protein Interactions and a Potential Role for Menin in the Insulin Signalling Pathway

  2013influential citation
• Elucidating the Role of Menin During Islet Cell Development in the Human Fetal Pancreas

  2013cites this paper
• The role of Rhox homeobox factors in tumorigenesis.

  2013cites this paper
• MEN1 gene replacement therapy reduces proliferation rates in a mouse model of pituitary adenomas.

  2012cites this paper
• A Simple Matter of Life and Death—The Trials of Postnatal Beta-Cell Mass Regulation

  2012cites this paper
• Menin and bone metabolism

  2012cites this paper
• Genetic Causes of Familial Pituitary Adenomas

  2011cites this paper
• Scavenger receptor class BI mediates the anti-apoptotic effect of erythropoietin

  2010cites this paper
• The genetics of pituitary adenomas.

  2010cites this paper
• Transcriptional factor prolactin regulatory element-binding protein-mediated gene transcription of ABCA1 via 3',5'-cyclic adenosine-5'-monophosphate.

  2010cites this paper
• Menin dynamics and functional insight: take your partners.

  2010cites this paper
• Menin, a product of the MENI gene, binds to estrogen receptor to enhance its activity in breast cancer cells: possibility of a novel predictive factor for tamoxifen resistance

  2010influential citation
• PREB regulates transcription of pancreatic glucokinase in response to glucose and cAMP

  2009cites this paper
• Exendin‐4 regulates glucokinase expression by CaMKK/CaMKIV pathway in pancreatic β‐cell line

  2009cites this paper
• [Familial pituitary adenomas].

  2009cites this paper
• Differentially regulated genes in MEN1-transfected BON cells using RT-differential display and oligonucleotide microarrays.

  2009cites this paper
• Familial pituitary adenomas

  2009cites this paper
• Regulation of beta cell replication.

  2009cites this paper
• The epidemiology and genetics of pituitary adenomas.

  2009cites this paper
• Familial pituitary adenomas.

  2009cites this paper
• Cell lineage-specific interactions between Men1 and Rb in neuroendocrine neoplasia.

  2008cites this paper
• Tumour suppressor menin is essential for development of the pancreatic endocrine cells.

  2008cites this paper
• MEN1 missense mutations impair sensitization to apoptosis induced by wild-type menin in endocrine pancreatic tumor cells.

  2008cites this paper
• Multiple endocrine neoplasms.

  2008cites this paper
• Multiple endocrine neoplasia.

  2008cites this paper
• In search of tumor suppressing functions of menin.

  2007influential citation
• Reconstituted expression of menin in Men1-deficient mouse Leydig tumour cells induces cell cycle arrest and apoptosis.

  2007cites this paper
• Menin-mediated Caspase 8 Expression in Suppressing Multiple Endocrine Neoplasia Type 1*

  2007cites this paper
• Menin and its interacting proteins: elucidation of menin function.

  2006cites this paper
• Tumor suppressor menin: the essential role of nuclear localization signal domains in coordinating gene expression

  2006cites this paper
• The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression.

  2006cites this paper
• Menin Molecular Interactions: Insights into Normal Functions and Tumorigenesis

  2005cites this paper
• [Genetics of endocrine tumours].

  2005cites this paper
• Clinical and Genetic Features of Familial Pituitary Adenomas

  2005cites this paper
• Génétique des tumeurs endocrines

  2005cites this paper
• Menin Suppresses Osteoblast Differentiation by Antagonizing the AP-1 Factor, JunD*

  2005cites this paper
• Menin molecular interactions: insights into normal functions and tumorigenesis.

  2005cites this paper
• Analysis of p27Kip1 Expression in Insulinomas Developed in Pancreatic β-cell Specific Men1 Mutant Mice

  2005cites this paper
• Direct Binding of DNA by Tumor Suppressor Menin*

  2004cites this paper
• Functional Interaction between Tumor Suppressor Menin and Activator of S-Phase Kinase

  2004cites this paper
• Menin Induces Apoptosis in Murine Embryonic Fibroblasts*

  2004cites this paper
• A Mutant High-Density Lipoprotein Receptor Inhibits Proliferation of Human Breast Cancer Cells

  2004cites this paper
• The role of calcium/calmodulin-dependent protein kinase cascade in glucose upregulation of insulin gene expression.

  2004cites this paper
• Menin Inactivation Leads to Loss of Transforming Growth Factor β Inhibition of Parathyroid Cell Proliferation and Parathyroid Hormone Secretion

  2004cites this paper
• Transcription regulation of the multiple endocrine neoplasia type 1 gene in human and mouse.

  2003cites this paper
• In situ analysis of human menin in normal and neoplastic pancreatic tissues: evidence for differential expression in exocrine and endocrine cells.

  2003cites this paper
• Functional characterization of a promoter region in the human MEN1 tumor suppressor gene.

  2003cites this paper