In situ analysis of human menin in normal and neoplastic pancreatic tissues: evidence for differential expression in exocrine and endocrine cells.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Journal of Clinical Endocrinology and Metabolism

• Publication date

  2003-08-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1210/JC.2002-021840PMID 12915685
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The 32-Kilodalton Subunit of Replication Protein A Interacts with Menin, the Product of the MEN1 Tumor Suppressor Gene

  2003cited by this paper
• Increased menin expression in sporadic pituitary adenomas

  2002cited by this paper
• The multiple endocrine neoplasia type 1 gene product, menin, inhibits insulin production in rat insulinoma cells.

  2002cited by this paper
• Multiple endocrine neoplasia type 1 and adrenal lesions.

  2001cited by this paper
• The tumor suppressor protein menin interacts with NF-κB proteins and inhibits NF-κB-mediated transactivation

  2001cited by this paper
• Inactivation of menin, a Smad3-interacting protein, blocks transforming growth factor type β signaling

  2001cited by this paper
• Menin, a gene product responsible for multiple endocrine neoplasia type 1, interacts with the putative tumor metastasis suppressor nm23.

  2001cited by this paper
• A mouse model of multiple endocrine neoplasia, type 1, develops multiple endocrine tumors.

  2001cited by this paper
• The tumor suppressor protein menin interacts with NF-kappaB proteins and inhibits NF-kappaB-mediated transactivation.

  2001cited by this paper
• Expression analysis of endogenous menin, the product of the multiple endocrine neoplasia type 1 gene, in cell lines and human tissues

  2000cited by this paper
• Proliferation-Associated Expression of the MEN1 Gene as Revealed by In Situ Hybridization: Possible Role of the Menin as a Negative Regulator of Cell Proliferation Under DNA Damage

  2000cited by this paper
• Expression of menin in parathyroid tumors.

  2000cited by this paper
• The expression of the antiproliferative gene ZAC is lost or highly reduced in nonfunctioning pituitary adenomas.

  2000cited by this paper
• Genotype/phenotype correlation of multiple endocrine neoplasia type 1 gene mutations in sporadic gastrinomas.

  2000cited by this paper
• Menin interacts with the AP1 transcription factor JunD and represses JunD-activated transcription.

  1999cited by this paper
• Characterization of the MEN1 Gene Product, Menin, by Site‐specific Polyclonal Antibodies

  1999cited by this paper
• Multiple endocrine neoplasia type 1.

  1999cited by this paper
• Stable overexpression of MEN1 suppresses tumorigenicity of RAS

  1999cited by this paper
• Multiple endocrine neoplasia type 1: clinical and genetic features of the hereditary endocrine neoplasias.

  1999cited by this paper
• Menin, the product of the MEN1 gene, is a nuclear protein.

  1998cited by this paper
• Mutations in the MEN I gene in sporadic neuroendocrine tumours of gastroenteropancreatic system.

  1997cited by this paper
• Mutations in the MEN I gene in sporadic neuroendocrine tumours of gastroenteropancreatic system

  1997cited by this paper
• Somatic mutations of the MEN1 tumor suppressor gene in sporadic gastrinomas and insulinomas.

  1997cited by this paper
• Identification of the multiple endocrine neoplasia type 1 (MEN1) gene. The European Consortium on MEN1.

  1997cited by this paper
• Positional cloning of the gene for multiple endocrine neoplasia-type 1.

  1997cited by this paper
• Expression and Purification of Glutathione‐S‐Transferase Fusion Proteins

  1994cited by this paper
• Cloning and functional analysis of multiply spliced mRNA species of human immunodeficiency virus type 1

  1990cited by this paper
• Preparation of monoclonal antibodies: strategies and procedures.

  1981cited by this paper
• [1] Preparation of monoclonal antibodies: Strategies and procedures

  1981cited by this paper
• ENDOCRINE ADENOMATOSIS AND PEPTIC ULCER IN A LARGE KINDRED. INHERITED MULTIPLE TUMORS AND MOSAIC PLEIOTROPISM IN MAN.

  1963cited by this paper

• Multiple endocrine neoplasia type 1 with Zollinger–Ellison syndrome: clinicopathological analysis of a Japanese family with focus on menin immunohistochemistry

  2023cites this paper
• Clinically Defined Mutations in MEN1 Alter Its Tumor-suppressive Function Through Increased Menin Turnover

  2022cites this paper
• Pancreatic Neuroendocrine Tumors: Molecular Mechanisms and Therapeutic Targets

  2021cites this paper
• Menin Immunoreactivity in Secretory Granules of Human Pancreatic Islet Cells

  2014cites this paper
• p27 Loss Is Associated with Poor Prognosis in Gastroenteropancreatic Neuroendocrine Tumors

  2014cites this paper
• Ligand-Directed AAVP to Deliver a Therapeutic Transgene to Neuroendocrine Tumors of the Pancreas

  2013cites this paper
• The Current Strategy for Managing Pancreatic Neuroendocrine Tumors in Multiple Endocrine Neoplasia Type 1

  2012cites this paper
• MEN1 in pancreatic endocrine tumors: analysis of gene and protein status in 169 sporadic neoplasms reveals alterations in the vast majority of cases.

  2010cites this paper
• Molecular analysis of MEN1 expression in MCF7, T47D and MDA-MB 468 breast cancer cell lines treated with adriamycin using RT-PCR and immunocytochemistry

  2010cites this paper
• Decreased expression and promoter methylation of the menin tumor suppressor in pancreatic ductal adenocarcinoma

  2009cites this paper
• The Zollinger-Ellison syndrome: a comprehensive review of historical, scientific, and clinical considerations.

  2009cites this paper
• Molecular alterations during insulinoma tumorigenesis.

  2007cites this paper
• Menin and its interacting proteins: elucidation of menin function.

  2006cites this paper
• Expression and functional analysis of menin in a multiple endocrine neoplasia type 1 (MEN1) patient with somatic loss of heterozygosity in chromosome 11q13 and unidentified germline mutation of the MEN1 gene

  2006cites this paper
• Chromosomal instability predicts metastatic disease in patients with insulinomas.

  2005cites this paper
• Chromosome 1q loss of heterozygosity frequently occurs in sporadic insulinomas and is associated with tumor malignancy

  2005cites this paper
• A report of a national mutation testing service for the MEN1 gene: clinical presentations and implications for mutation testing

  2005cites this paper
• implications for mutation testing gene : clinical presentations and MEN 1 for the A report of a national mutation testing service and

  2004cites this paper
• Differential expression of menin in sporadic pituitary adenomas.

  2004influential citation