Structures of the noncovalent complexes of human and bovine prothrombin fragment 2 with human PPACK-thrombin.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Biochemistry

• Publication date

  1994-01-31

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1021/BI00069A006PMID 8387813
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Thrombin

  2019cited by this paper
• The Ca2+ ion and membrane binding structure of the Gla domain of Ca-prothrombin fragment 1.

  1994cited by this paper
• Structure of the hirulog 3-thrombin complex and nature of the S' subsites of substrates and inhibitors.

  1994cited by this paper
• Heparin binding to the urokinase kringle domain.

  1992cited by this paper
• Crystal structure of the kringle 2 domain of tissue plasminogen activator at 2.4-A resolution.

  1992cited by this paper
• The refined 1.9‐Å X‐ray crystal structure of d‐Phe‐Pro‐Arg chloromethylketone‐inhibited human α‐thrombin: Structure analysis, overall structure, electrostatic properties, detailed active‐site geometry, and structure‐function relationships

  1992cited by this paper
• Sequential 1H NMR assignments and secondary structure of the kringle domain from urokinase.

  1992cited by this paper
• Electrostatic interactions in the association of proteins: An analysis of the thrombin–hirudin complex

  1992cited by this paper
• Active-site-selective labeling of blood coagulation proteinases with fluorescence probes by the use of thioester peptide chloromethyl ketones. II. Properties of thrombin derivatives as reporters of prothrombin fragment 2 binding and specificity of the labeling approach for other proteinases.

  1992cited by this paper
• The calcium ion and membrane binding structure of the Gla domain of calcium-prothrombin fragment 1

  1992cited by this paper
• Structure of the hirugen and hirulog 1 complexes of alpha-thrombin.

  1991cited by this paper
• Proteolytic formation of either of the two prothrombin activation intermediates results in formation of a hirugen-binding site.

  1991cited by this paper
• Crystal and molecular structure of human plasminogen kringle 4 refined at 1.9-A resolution.

  1991cited by this paper
• The Structures of Domains of Blood Proteins

  1991cited by this paper
• Structure of bovine prothrombin fragment 1 refined at 2.25 A resolution.

  1991cited by this paper
• Solution structure of the tissue-type plasminogen activator kringle 2 domain complexed to 6-aminohexanoic acid an antifibrinolytic drug.

  1991cited by this paper
• The refined structure of the epsilon-aminocaproic acid complex of human plasminogen kringle 4.

  1991cited by this paper
• Refined structure of the hirudin-thrombin complex.

  1991cited by this paper
• Extension of molecular replacement: a new search strategy based on Patterson correlation refinement

  1990cited by this paper
• The structure of a complex of recombinant hirudin and human alpha-thrombin.

  1990cited by this paper
• Structural and functional properties of human alpha-thrombin, phosphopyridoxylated alpha-thrombin, and gamma T-thrombin. Identification of lysyl residues in alpha-thrombin that are critical for heparin and fibrin(ogen) interactions.

  1989cited by this paper
• The refined 1.9 A crystal structure of human alpha‐thrombin: interaction with D‐Phe‐Pro‐Arg chloromethylketone and significance of the Tyr‐Pro‐Pro‐Trp insertion segment.

  1989cited by this paper
• Lysine/fibrin binding sites of kringles modeled after the structure of kringle 1 of prothrombin

  1988cited by this paper
• MERLOT, an integrated package of computer programs for the determination of crystal structures by molecular replacement

  1988cited by this paper
• Structure of prothrombin fragment 1 refined at 2.8 A resolution.

  1988cited by this paper
• cDNA sequence of human apolipoprotein(a) is homologous to plasminogen

  1987cited by this paper
• The use of an imaging proportional counter in macromolecular crystallography

  1987cited by this paper
• Crystallographic R Factor Refinement by Molecular Dynamics

  1987cited by this paper
• Incorporation of fast Fourier transforms to speed restrained least‐squares refinement of protein structures

  1987cited by this paper
• The assembly of blood clotting complexes on membranes

  1987cited by this paper
• Three-dimensional structure of the kringle sequence: structure of prothrombin fragment 1.

  1986cited by this paper
• The effect of bovine thrombomodulin on the specificity of bovine thrombin.

  1986cited by this paper
• Evolution of the proteases of blood coagulation and fibrinolysis by assembly from modules.

  1985cited by this paper
• The fibrin-binding site of human plasminogen. Arginines 32 and 34 are essential for fibrin affinity of the kringle 1 domain.

  1984cited by this paper
• Structure of the omega-aminocarboxylic acid-binding sites of human plasminogen. Arginine 70 and aspartic acid 56 are essential for binding of ligand by kringle 4.

  1982cited by this paper
• Localization of individual lysine-binding regions in human plasminogen and investigations on their complex-forming properties.

  1980cited by this paper
• The association of bovine prothrombin fragment 1 with phospholipid. Quantitative characterization of the Ca2+ ion-mediated binding of prothrombin fragment 1 to phospholipid vesicles and a molecular model for its association with phospholipids.

  1979cited by this paper
• The effect of prothrombin fragment 2 on the inhibition of thrombin by antithrombin III.

  1979cited by this paper
• Protein crystallization using incomplete factorial experiments.

  1979cited by this paper
• Metal ion induced conformational transitions of prothrombin and prothrombin fragment 1.

  1978cited by this paper
• Differentiation of metal ion-induced transitions of prothrombin fragment 1.

  1977cited by this paper
• Role of gamma-carboxyglutamic acid. An unusual protein transition required for the calcium-dependent binding of prothrombin to phospholipid.

  1976cited by this paper
• Characteristics of the association between prothrombin fragment 2 and alpha-thrombin.

  1976cited by this paper
• Prothrombin fragments. Ca2+ binding and activation kinetics.

  1975cited by this paper
• The conversion of prothrombin to thrombin. IV. The function of the fragment 2 region during activation in the presence of factor V.

  1974cited by this paper
• A partial gene duplication in the evolution of prothrombin?

  1974cited by this paper
• Vitamin K dependent modifications of glutamic acid residues in prothrombin.

  1974cited by this paper
• The interpretation of protein structures: estimation of static accessibility.

  1971cited by this paper

• Sulfotyrosine, an interaction specificity determinant for extracellular protein-protein interactions

  2021cites this paper
• Exosite Binding in Thrombin: A Global Structural/Dynamic Overview of Complexes with Aptamers and Other Ligands

  2021cites this paper
• Identification and characterization of a factor Va-binding site on human prothrombin fragment 2

  2019cites this paper
• Occlusion of anion-binding exosite 2 in meizothrombin explains its impaired ability to activate factor V

  2018cites this paper
• Structural transitions during prothrombin activation: On the importance of fragment 2

  2016cites this paper
• The Fragment 1 Region of Prothrombin Facilitates the Favored Binding of Fragment 12 to Zymogen and Enforces Zymogen-like Character in the Proteinase*

  2016cites this paper
• Thrombin Inhibitors fromDifferent Animals

  2014cites this paper
• Meizothrombin Is an Unexpectedly Zymogen-like Variant of Thrombin*

  2012cites this paper
• An ensemble view of thrombin allostery

  2012cites this paper
• Allosteric activation of human α-thrombin through exosite 2 by suramin analogs.

  2012cites this paper
• Thrombin Inhibitors from Different Animals

  2010cites this paper
• Polyphosphate binds with high affinity to exosite II of thrombin

  2010cites this paper
• Thrombin Inhibition by Serpins Disrupts Exosite II*

  2010cites this paper
• Ligand Binding Shuttles Thrombin along a Continuum of Zymogen- and Proteinase-like States*

  2010cites this paper
• Crystal structure of prethrombin-1

  2010cites this paper
• Long Range Communication between Exosites 1 and 2 Modulates Thrombin Function*

  2009cites this paper
• Mutagenesis studies toward understanding allostery in thrombin.

  2009cites this paper
• Research Article Na + binding to meizothrombin desF1

  2008cites this paper
• Fibrinogen-elongated γ Chain Inhibits Thrombin-induced Platelet Response, Hindering the Interaction with Different Receptors*

  2008cites this paper
• Na+ binding to meizothrombin desF1

  2008cites this paper
• CoagMDB: a database analysis of missense mutations within four conserved domains in five vitamin K–dependent coagulation serine proteases using a text‐mining tool

  2008cites this paper
• Fate of Membrane-bound Reactants and Products during the Activation of Human Prothrombin by Prothrombinase*

  2008cites this paper
• The interaction of fragment 1 of prothrombin with the membrane surface is a prerequisite for optimum expression of factor Va cofactor activity within prothrombinase

  2008cites this paper
• NMR solution structure of the neurotrypsin Kringle domain.

  2008cites this paper
• Locus specific databases: integrating sequence, structural and clinical analysis in relation to disorders of the coagulation and complement systems.

  2008cites this paper
• 2.15 – Peptidomimetic and Nonpeptide Drug Discovery: Receptor, Protease, and Signal Transduction Therapeutic Targets

  2007cites this paper
• Exosites in the substrate specificity of blood coagulation reactions

  2007cites this paper
• The structure of thrombin: a janus-headed proteinase.

  2006cites this paper
• The Structural Integrity of Anion Binding Exosite I of Thrombin Is Required and Sufficient for Timely Cleavage and Activation of Factor V and Factor VIII*

  2006cites this paper
• The Structure of Thrombin: A Janus-Headed Proteinase

  2006cites this paper
• Amide H/2H exchange reveals a mechanism of thrombin activation.

  2006influential citation
• Conformational analysis of gamma' peptide (410-427) interactions with thrombin anion binding exosite II.

  2006cites this paper
• Structure and interaction modes of thrombin.

  2006cites this paper
• The Preferred Pathway of Glycosaminoglycan-accelerated Inactivation of Thrombin by Heparin Cofactor II*

  2004cites this paper
• Prothrombin Residues 473–487 Contribute to Factor Va Binding in the Prothrombinase Complex*

  2004cites this paper
• The Elusive Role of the Potential Factor X Cation-binding Exosite-1 in Substrate and Inhibitor Interactions*

  2004cites this paper
• Modes and consequences of thrombin's interaction with fibrin.

  2004cites this paper
• Identification of the substrate‐binding exosites of two snake venom serine proteinases: molecular basis for the partition of two essential functions of thrombin

  2004cites this paper
• Thrombin Domains: Structure, Function and Interaction with Platelet Receptors

  2004influential citation
• Lupus-derived antiprothrombin autoantibodies from a V gene phage display library are specific for the kringle 2 domain of prothrombin.

  2004cites this paper
• Effects of Activation Peptide Bond Cleavage and Fragment 2 Interactions on the Pathway of Exosite I Expression during Activation of Human Prethrombin 1 to Thrombin*

  2003cites this paper
• Quantitative structure -- activity relationships (QSARs) of thrombin inhibitors: review, evaluation and comparative analysis.

  2003cites this paper
• Interaction of the 268-282 region of glycoprotein Ibalpha with the heparin-binding site of thrombin inhibits the enzyme activation of factor VIII.

  2003cites this paper
• A new blood coagulation inhibitor from the snake Bothrops jararaca plasma: isolation and characterization.

  2003cites this paper
• Thrombin domains: structure, function and interaction with platelet receptors.

  2003cites this paper
• Evidence That Both Exosites on Thrombin Participate in Its High Affinity Interaction with Fibrin*

  2003cites this paper
• Interaction of the 268-282 region of glycoprotein Ibalpha with the heparin-binding site of thrombin inhibits the enzyme activation of factor VIII.

  2003cites this paper
• Procoagulant Proteins and Diagnostic Agents

  2002cites this paper
• Binding of Exosite Ligands to Human Thrombin

  2002cites this paper
• Structural requirements for the activation of human factor VIII by thrombin.

  2002cites this paper
• Characterization of bothrojaracin interaction with human prothrombin

  2001cites this paper
• Structural Investigations of Coagulation Factors

  2001cites this paper
• An Extensive Interaction Interface between Thrombin and Factor V Is Required for Factor V Activation*

  2001cites this paper
• Molecular Basis for the Partition of the Essential Functions of Thrombin among Snake Venom Serine Proteinases

  2001cites this paper
• Conformational Changes in Thrombin When Complexed by Serpins*

  2001cites this paper
• Structural and functional mapping of the thrombin domain involved in the binding to the platelet glycoprotein Ib.

  2001cites this paper
• Gene targeting in hemostasis. Prothrombin.

  2001cites this paper
• Peptide modified gold-coated polyurethanes as thrombin scavenging surfaces.

  2000cites this paper
• Atomic Structures of Two Nitroxide Spin Labels Complexed with Human Thrombin: Comparison with Solution Studies

  2000cites this paper
• The Asp272–Glu282 Region of Platelet Glycoprotein Ibα Interacts with the Heparin-binding Site of α-Thrombin and Protects the Enzyme from the Heparin-catalyzed Inhibition by Antithrombin III*

  2000cites this paper
• Identification and Three-dimensional Structural Analysis of Nine Novel Mutations in Patients with Prothrombin Deficiency

  2000cites this paper
• Oxidation of Human α-Thrombin by the Myeloperoxidase-H2O2-chloride System: Structural and Functional Effects

  2000cites this paper
• The Role of Glu192 in the Allosteric Control of the S2′ and S3′ Subsites of Thrombin*

  2000cites this paper
• Three Dimensional Structure of Kringle Domain

  2000cites this paper
• The Asp(272)-Glu(282) region of platelet glycoprotein Ibalpha interacts with the heparin-binding site of alpha-thrombin and protects the enzyme from the heparin-catalyzed inhibition by antithrombin III.

  2000cites this paper
• Solution structure and dynamics of the plasminogen kringle 2-AMCHA complex: 3(1)-helix in homologous domains.

  1999cites this paper
• Involvement of Lys 62[217] and Lys 63[218] of Human Anticoagulant Protein C in Heparin Stimulation of Inhibition by the Protein C Inhibitor

  1999cites this paper
• Allosteric changes of thrombin catalytic site induced by interaction of bothrojaracin with anion-binding exosites I and II.

  1999cites this paper
• Thrombin interaction with platelet GpIb: structural mapping and effects on platelet activation (review).

  1999cites this paper
• Expression, isolation and characterization of a mutated human plasminogen kringle 3 with a functional lysine binding site

  1999cites this paper
• Struktur und Funktion des Thrombins

  1999cites this paper
• Binding of human alpha-thrombin to platelet GpIb: energetics and functional effects.

  1998cites this paper
• Inhibition of Thrombin-catalyzed Factor V Activation by Bothrojaracin

  1998cites this paper
• Ligand binding to thrombin exosite II induces dissociation of the thrombin-heparin cofactor II(L444R) complex.

  1998cites this paper
• Localization of the Thrombin-binding Domain on Prothrombin Fragment 2*

  1998cites this paper
• The biology of prothrombin.

  1998cites this paper
• Allosteric effects of a monoclonal antibody against thrombin exosite II.

  1998cites this paper
• Prothrombin Kringle-2 Domain Has a Growth Inhibitory Activity against Basic Fibroblast Growth Factor-stimulated Capillary Endothelial Cells*

  1998cites this paper
• Evidence for multiple enzyme site involvement in the modulation of thrombin activity by products of prothrombin proteolysis.

  1998cites this paper
• Autocatalytic peptide bond cleavages in prothrombin and meizothrombin.

  1998cites this paper
• Structure and ligand binding determinants of the recombinant kringle 5 domain of human plasminogen.

  1998cites this paper
• Thrombin Interaction with Platelet GPIB: Role of the Heparin Binding Domain

  1997cites this paper
• Molecular basis for the resistance of fibrin-bound thrombin to inactivation by heparin/serpin complexes.

  1997cites this paper
• Oxidation of apolipoprotein(a) inhibits kringle‐associated lysine binding: The loss of intrinsic protein fluorescence suggests a role for tryptophan residues in the lysine binding site

  1997cites this paper
• Comparative Analysis of Haemostatic Proteinases: Structural Aspects of Thrombin, Factor Xa, Factor IXa and Protein C

  1997cites this paper
• Molecular modeling and 3D-QSAR studies on the interaction mechanism of tripeptidyl thrombin inhibitors with human alpha-thrombin.

  1997cites this paper
• New insights into the regulation of the blood clotting cascade derived from the X-ray crystal structure of bovine meizothrombin des F1 in complex with PPACK.

  1997cites this paper
• Evidence for Allosteric Linkage between Exosites 1 and 2 of Thrombin*

  1997cites this paper
• Ligand preferences of kringle 2 and homologous domains of human plasminogen: canvassing weak, intermediate, and high-affinity binding sites by 1H-NMR.

  1997cites this paper
• Influence of Arginines 93, 97, and 101 of thrombin to its functional specificity.

  1997cites this paper
• Inhibition of Meizothrombin and Meizothrombin(desF1) by Heparin Cofactor II*

  1997cites this paper
• Strategies for development of novel antithrombotics: modulating thrombin's procoagulant and anticoagulant properties

  1997cites this paper
• The molecular environment of the Na+ binding site of thrombin.

  1997cites this paper
• Molecular reconstruction and homology modelling of the catalytic domain of the common ancestor of the haemostatic vitamin-K-dependent serine proteinases

  1996cites this paper
• Involvement of Thrombin Anion-binding Exosites 1 and 2 in the Activation of Factor V and Factor VIII*

  1996cites this paper
• Comparison of the active-site conformations of bovine α-thrombin and meizothrombin(desF1) by electron spin resonance

  1996cites this paper
• Crystallographic Evidence That the F2 Kringle Catalytic Domain Linker of Prothrombin Does Not Cover the Fibrinogen Recognition Exosite (*)

  1996cites this paper
• Bothrojaracin: a potent two-site-directed thrombin inhibitor.

  1996cites this paper
• Recombinant gene expression and 1H NMR characteristics of the kringle (2 + 3) supermodule: spectroscopic/functional individuality of plasminogen kringle domains.

  1996cites this paper
• Molecular Interactions of Thrombin

  1996cites this paper