PML induces compaction, TRF2 depletion and DNA damage signaling at telomeres and promotes their alternative lengthening

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Journal of Cell Science

• Publication date

  2015-05-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/jcs.148296PMID 25908860
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Alternative lengthening of telomeres renders cancer cells hypersensitive to ATR inhibitors

  2015cited by this paper
• Alternative Lengthening of Telomeres is characterized by reduced compaction of telomeric chromatin

  2014cited by this paper
• DNA double-strand breaks promote methylation of histone H3 on lysine 9 and transient formation of repressive chromatin

  2014cited by this paper
• Interchromosomal homology searches drive directional ALT telomere movement and synapsis.

  2014cited by this paper
• Activation of DNA damage response signaling by condensed chromatin.

  2014cited by this paper
• Telomere dynamics in mice and humans.

  2013cited by this paper
• Telomere dysfunction and activation of alternative lengthening of telomeres in B-lymphocytes infected by Epstein–Barr virus

  2013cited by this paper
• ATM Release at Resected Double-Strand Breaks Provides Heterochromatin Reconstitution to Facilitate Homologous Recombination

  2013cited by this paper
• Nucleostemin prevents telomere damage by promoting PML-IV recruitment to SUMOylated TRF1

  2012cited by this paper
• The alternative lengthening of telomeres pathway may operate in non‐neoplastic human cells

  2012cited by this paper
• PML body meets telomere

  2012cited by this paper
• Loss of ATRX, Genome Instability, and an Altered DNA Damage Response Are Hallmarks of the Alternative Lengthening of Telomeres Pathway

  2012cited by this paper
• A three‐dimensional colocalization RNA interference screening platform to elucidate the alternative lengthening of telomeres pathway

  2012cited by this paper
• Prime, repair, restore: the active role of chromatin in the DNA damage response.

  2012cited by this paper
• HP1-Mediated Formation of Alternative Lengthening of Telomeres-Associated PML Bodies Requires HIRA but Not ASF1a

  2011cited by this paper
• Heterochromatin and the DNA damage response: the need to relax.

  2011cited by this paper
• De novo assembly of a PML nuclear subcompartment occurs through multiple pathways and induces telomere elongation

  2011influential reference
• The SUMO protease SENP6 is a direct regulator of PML nuclear bodies

  2011cited by this paper
• Alternative lengthening of telomeres pathway: recombination-mediated telomere maintenance mechanism in human cells.

  2011cited by this paper
• Altered Telomeres in Tumors with ATRX and DAXX Mutations

  2011influential reference
• The Epstein–Barr virus nuclear antigen-1 promotes telomere dysfunction via induction of oxidative stress

  2011cited by this paper
• Multiple roles of ATM in monitoring and maintaining DNA integrity

  2010cited by this paper
• Alternative lengthening of telomeres: models, mechanisms and implications

  2010cited by this paper
• PML3 interacts with TRF1 and is essential for ALT-associated PML bodies assembly in U2OS cells.

  2010cited by this paper
• Chemical Phylogenetics of Histone Deacetylases

  2010cited by this paper
• Three-dimensional organization of promyelocytic leukemia nuclear bodies

  2010cited by this paper
• 3D Geometry-Based Quantification of Colocalizations in Multichannel 3D Microscopy Images of Human Soft Tissue Tumors

  2010cited by this paper
• Telomere recombination requires the MUS81 endonuclease

  2009cited by this paper
• The interaction of NSBP1/HMGN5 with nucleosomes in euchromatin counteracts linker histone-mediated chromatin compaction and modulates transcription.

  2009influential reference
• Telomeric DNA mediates de novo PML body formation.

  2009cited by this paper
• Lysine Acetylation Targets Protein Complexes and Co-Regulates Major Cellular Functions

  2009influential reference
• Probing PML body function in ALT cells reveals spatiotemporal requirements for telomere recombination

  2009cited by this paper
• DNA C-circles are specific and quantifiable markers of alternative-lengthening-of-telomeres activity

  2009cited by this paper
• Dynamics of telomeres and promyelocytic leukemia nuclear bodies in a telomerase-negative human cell line.

  2009cited by this paper
• Spontaneous occurrence of telomeric DNA damage response in the absence of chromosome fusions

  2009influential reference
• The Emerging Role of HP1 in the DNA Damage Response

  2009cited by this paper
• Induction of alternative lengthening of telomeres-associated PML bodies by p53/p21 requires HP1 proteins

  2009influential reference
• Telomere uncapping and alternative lengthening of telomeres.

  2008cited by this paper
• A quantitative real-time PCR method for absolute telomere length.

  2008cited by this paper
• Reverse transfection on cell arrays for high content screening microscopy

  2007cited by this paper
• Protection of telomeres through independent control of ATM and ATR by TRF2 and POT1

  2007cited by this paper
• Suv4-20h deficiency results in telomere elongation and derepression of telomere recombination

  2007cited by this paper
• The SMC5/6 complex maintains telomere length in ALT cancer cells through SUMOylation of telomere-binding proteins

  2007influential reference
• Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies

  2007cited by this paper
• Lack of TRF2 in ALT cells causes PML-dependent p53 activation and loss of telomeric DNA

  2007cited by this paper
• Identification of candidate alternative lengthening of telomeres genes by methionine restriction and RNA interference

  2007cited by this paper
• The number of PML nuclear bodies increases in early S phase by a fission mechanism

  2006cited by this paper
• Evidence for a Role of the Cellular ND10 Protein PML in Mediating Intrinsic Immunity against Human Cytomegalovirus Infections

  2006cited by this paper
• DNA methyltransferases control telomere length and telomere recombination in mammalian cells

  2006cited by this paper
• In Vivo HP1 Targeting Causes Large-Scale Chromatin Condensation and Enhanced Histone Lysine Methylation

  2005cited by this paper
• Suppression of Alternative Lengthening of Telomeres by Sp100-Mediated Sequestration of the MRE11/RAD50/NBS1 Complex

  2005cited by this paper
• Homologous recombination generates T-loop-sized deletions at human telomeres.

  2004cited by this paper
• A silencing pathway to induce H3-K9 and H4-K20 trimethylation at constitutive heterochromatin.

  2004cited by this paper
• Identification and Characterization of a Novel and Specific Inhibitor of the Ataxia-Telangiectasia Mutated Kinase ATM

  2004influential reference
• The Telomeric Protein TRF2 Binds the ATM Kinase and Can Inhibit the ATM-Dependent DNA Damage Response

  2004cited by this paper
• Epigenetic regulation of telomere length in mammalian cells by the Suv39h1 and Suv39h2 histone methyltransferases

  2004cited by this paper
• Histone demethylation mediated by the nuclear amine oxidase homolog LSD1.

  2004influential reference
• Alternative Lengthening of Telomeres Is Characterized by High Rates of Telomeric Exchange

  2004cited by this paper
• Localization of hRad9, hHus1, hRad1, and hRad17 and Caffeine-sensitive DNA Replication at the Alternative Lengthening of Telomeres-associated Promyelocytic Leukemia Body*

  2004cited by this paper
• Functional Interaction between Poly(ADP-Ribose) Polymerase 2 (PARP-2) and TRF2: PARP Activity Negatively Regulates TRF2

  2004influential reference
• Trichostatin A-induced histone acetylation causes decondensation of interphase chromatin

  2003influential reference
• DNA damage foci at dysfunctional telomeres.

  2003cited by this paper
• A DNA damage checkpoint response in telomere-initiated senescence

  2003cited by this paper
• DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

  2003cited by this paper
• Telomere measurement by quantitative PCR.

  2002cited by this paper
• Quantitative Fluorescence In Situ Hybridization (Q‐FISH)

  2001cited by this paper
• Extra-chromosomal telomeric DNA in cells from Atm(-/-) mice and patients with ataxia-telangiectasia.

  2001cited by this paper
• Role of SUMO-1-modified PML in nuclear body formation.

  2000cited by this paper
• ALT-associated PML bodies are present in viable cells and are enriched in cells in the G(2)/M phase of the cell cycle.

  2000cited by this paper
• Telomerase-negative immortalized human cells contain a novel type of promyelocytic leukemia (PML) body.

  1999cited by this paper
• Pml Is Critical for Nd10 Formation and Recruits the Pml-Interacting Protein Daxx to This Nuclear Structure When Modified by Sumo-1

  1999cited by this paper
• Extra-chromosomal telomere repeat DNA in telomerase-negative immortalized cell lines.

  1998cited by this paper
• Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment.

  1998influential reference
• A survey of telomerase activity in human cancer.

  1997cited by this paper
• Evidence for an alternative mechanism for maintaining telomere length in human tumors and tumor-derived cell lines

  1997cited by this paper
• Telomere elongation in immortal human cells without detectable telomerase activity.

  1995cited by this paper
• Telomeres shorten during ageing of human fibroblasts

  1990cited by this paper

• ZEB1 Promotes Alternate Lengthening of Telomeres at Multiple Levels

  2026cites this paper
• WRAP53 is Downregulated in Acute Myeloid Leukemia Patients and Positively Correlates With HTERT Expression

  2026cites this paper
• Specificity and sensitivity of ALT‐associated markers in cancer cells

  2025cites this paper
• Telomeric SUMO level influences the choices of APB formation pathways and ALT efficiency.

  2025cites this paper
• Telomeric SUMO level influences the choices of APB formation pathways and ALT efficiency

  2025cites this paper
• Liquid–Liquid Phase Separation in Major Hallmarks of Cancer

  2025cites this paper
• PML Nuclear bodies: the cancer connection and beyond

  2024cites this paper
• A data-driven active learning approach to reusing ML solutions in scientific applications

  2024cites this paper
• Effects of p53 and ATRX inhibition on telomeric recombination in aging fibroblasts

  2024cites this paper
• Topological stress triggers persistent DNA lesions in ribosomal DNA with ensuing formation of PML-nucleolar compartment

  2024cites this paper
• SUMO promotes DNA repair protein collaboration to support alternative telomere lengthening in the absence of PML

  2024cites this paper
• The landscape of lncRNAs in cell granules: Insights into their significance in cancer

  2024cites this paper
• Disruption of G-quadruplex dynamicity by BRCA2 abrogation instigates phase separation and break-induced replication at telomeres

  2024cites this paper
• Cell Immortalization: In Vivo Molecular Bases and In Vitro Techniques for Obtention

  2023cites this paper
• ALTercations at telomeres: stress, recombination and extrachromosomal affairs.

  2023cites this paper
• The Altered Functions of Shelterin Components in ALT Cells

  2023influential citation
• On the Prevalence and Roles of Proteins Undergoing Liquid–Liquid Phase Separation in the Biogenesis of PML-Bodies

  2023cites this paper
• An alternative extension of telomeres related prognostic model to predict survival in lower grade glioma

  2023influential citation
• Cellular senescence in glioma

  2023cites this paper
• USP7 - a crucial regulator of cancer hallmarks.

  2023cites this paper
• Hyperosmotic-stress-induced liquid-liquid phase separation of ALS-related proteins in the nucleus.

  2022cites this paper
• Easing the Reuse of ML Solutions by Interactive Clustering-based Autotuning in Scientific Applications

  2022cites this paper
• Novel therapeutic approaches in gep-nets based on genetic and epigenetic alterations.

  2022cites this paper
• Emerging Implications of Phase Separation in Cancer

  2022cites this paper
• Orphan nuclear receptors promote alternative lengthening of telomeres (ALT) through ALT-associated PML bodies

  2022cites this paper
• Phospho-SIM and exon8b of PML protein regulate formation of doxorubicin-induced rDNA-PML compartment.

  2022cites this paper
• ALT-FISH quantifies alternative lengthening of telomeres activity by imaging of single-stranded repeats

  2022cites this paper
• Identification of Key Proteins from the Alternative Lengthening of Telomeres-Associated Promyelocytic Leukemia Nuclear Bodies Pathway

  2022cites this paper
• Mutations inhibiting KDM4B drive ALT activation in ATRX-mutated glioblastomas

  2021cites this paper
• Telomeres associated Promyelocytic Leukemia Nuclear Bodies

  2021cites this paper
• RPA shields inherited DNA lesions for post-mitotic DNA synthesis

  2021cites this paper
• Mechanism of Human Telomerase Reverse Transcriptase (hTERT) Regulation and Clinical Impacts in Leukemia

  2021influential citation
• A subset of PARP inhibitors induces lethal telomere fusion in ALT-dependent tumor cells

  2021cites this paper
• Functional characterization of miR-708 microRNA in telomerase positive and negative human cancer cells

  2021cites this paper
• Abnormal function of telomere protein TRF2 induces cell mutation and the effects of environmental tumor-promoting factors

  2021cites this paper
• The Role of Non-Specific Interactions in Canonical and ALT-Associated PML-Bodies Formation and Dynamics

  2021cites this paper
• USP7 Is a Master Regulator of Genome Stability

  2020cites this paper
• Current understanding of human herpesvirus 6 (HHV-6) chromosomal integration.

  2020cites this paper
• Alternative Lengthening of Telomeres: Building Bridges To Connect Chromosome Ends.

  2020cites this paper
• Alternative lengthening of telomeres: from molecular mechanisms to therapeutic outlooks

  2020cites this paper
• Telomere length heterogeneity in ALT cells is maintained by PML-dependent localization of the BTR complex to telomeres

  2020cites this paper
• Subcompartment Formation by Phase Separation.

  2020cites this paper
• TCGA Pan-Cancer Genomic Analysis of Alternative Lengthening of Telomeres (ALT) Related Genes

  2020cites this paper
• Telomere DNA Damage Signaling Regulates Prostate Cancer Tumorigenesis

  2020cites this paper
• PML Nuclear Body Biogenesis, Carcinogenesis, and Targeted Therapy.

  2020cites this paper
• Nuclear body phase separation drives telomere clustering in ALT cancer cells

  2020cites this paper
• The Promyelocytic Leukemia Protein facilitates human herpesvirus 6B chromosomal integration, immediate-early 1 protein multiSUMOylation and its localization at telomeres

  2020cites this paper
• POT1-TPP1 telomere length regulation and disease

  2020cites this paper
• PML nuclear bodies and chromatin dynamics: catch me if you can!

  2020cites this paper
• Protein phase separation and its role in tumorigenesis

  2020cites this paper
• Alternative paths to telomere elongation.

  2020cites this paper
• Double-edged Role of PML Nuclear Bodies during Human Adenovirus Infection.

  2020cites this paper
• Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways

  2019cites this paper
• Telomere analysis using 3D fluorescence microscopy suggests mammalian telomere clustering in hTERT-immortalized Hs68 fibroblasts

  2019cites this paper
• Liquid condensation drives telomere clustering during ALT

  2019cites this paper
• TSPYL5 Depletion Induces Specific Death of ALT Cells through USP7-Dependent Proteasomal Degradation of POT1.

  2019cites this paper
• Telomere Maintenance-Associated PML Is a Potential Specific Therapeutic Target of Human Colorectal Cancer

  2019cites this paper
• Clustered telomeres in phase-separated nuclear condensates engage mitotic DNA synthesis through BLM and RAD52

  2019influential citation
• Alternative Lengthening of Telomeres (ALT) in Tumors and Pluripotent Stem Cells

  2019cites this paper
• Functional Loss of ATRX and TERC Activates Alternative Lengthening of Telomeres (ALT) in LAPC4 Prostate Cancer Cells

  2019cites this paper
• Multimodal Light Microscopy Approaches to Reveal Structural and Functional Properties of Promyelocytic Leukemia Nuclear Bodies

  2018cites this paper
• Telomere Maintenance Mechanisms in Cancer

  2018influential citation
• PML nuclear bodies: from architecture to function.

  2018cites this paper
• Role of PML-Nuclear Bodies in Human Herpesvirus 6A and 6B Genome Integration

  2018cites this paper
• Multi-channel Deep Transfer Learning for Nuclei Segmentation in Glioblastoma Cell Tissue Images

  2018cites this paper
• Nuclear bodies: news insights into structure and function.

  2017cites this paper
• Loss of MECP2 leads to activation of p53 and neuronal senescence

  2017cites this paper
• Modeling Rett Syndrome with Human Induced Pluripotent Stem Cells

  2017cites this paper
• Real-time observation of light-controlled transcription in living cells

  2017cites this paper
• Dissecting telomere maintenance mechanisms in pediatric glioblastoma

  2017cites this paper
• Regulation of Telomere Homeostasis during Epstein-Barr virus Infection and Immortalization

  2017cites this paper
• TelNet - a database for human and yeast genes involved in telomere maintenance

  2017influential citation
• The functional roles of PML nuclear bodies in genome maintenance.

  2017cites this paper
• Epigenetic Regulation of Telomere Maintenance for Therapeutic Interventions in Gliomas

  2017cites this paper
• The Telomeric Response to Viral Infection

  2017cites this paper
• Promyelocytic Leukemia Protein, a Protein at the Crossroad of Oxidative Stress and Metabolism

  2017cites this paper
• Withaferin-A kills cancer cells with and without telomerase: chemical, computational and experimental evidences

  2017cites this paper
• Cancer Cells with Alternative Lengthening of Telomeres Do Not Display a General Hypersensitivity to ATR Inhibition

  2016influential citation
• Quantification of telomere features in tumor tissue sections by an automated 3D imaging-based workflow

  2016cites this paper
• Switch telomerase to ALT mechanism by inducing telomeric DNA damages and dysfunction of ATRX and DAXX

  2016cites this paper
• Markers of cellular senescence. Telomere shortening as a marker of cellular senescence

  2016cites this paper
• A spherical harmonics intensity model for 3D segmentation and 3D shape analysis of heterochromatin foci

  2016cites this paper
• Telomeres and Chromosome Stability

  2016cites this paper
• TERRA and the state of the telomere

  2015cites this paper
• Functional analysis of candidate phosphorylation sites of telomere repeat binding factor 2 (TRF2)

  2015influential citation
• The Journal of Systems & Software

  year unknowncites this paper