Promyelocytic Leukemia Protein, a Protein at the Crossroad of Oxidative Stress and Metabolism

No abstract is available for this paper.

• Publication year

  2017

• Venue

  Antioxidants and Redox Signaling

• Publication date

  2017-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1089/ars.2016.6898PMID 27758112
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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• Stratification and therapeutic potential of PML in metastatic breast cancer

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• The metabolic co-regulator PGC1α suppresses prostate cancer metastasis

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• PML isoform II plays a critical role in nuclear lipid droplet formation

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• A Promyelocytic Leukemia Protein–Thrombospondin-2 Axis and the Risk of Relapse in Neuroblastoma

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• Translational control of PML contributes to TNFα-induced apoptosis of MCF7 breast cancer cells and decreased angiogenesis in HUVECs

  2015influential reference
• System-wide identification of wild-type SUMO-2 conjugation sites

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• The Promyelocytic Leukemia Protein Is Upregulated in Conditions of Obesity and Liver Steatosis

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• Arsenic, Reactive Oxygen, and Endothelial Dysfunction

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• Autophagy in malignant transformation and cancer progression

  2015cited by this paper
• Cytoplasmic PML promotes TGF-β-associated epithelial–mesenchymal transition and invasion in prostate cancer

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• Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase

  2015cited by this paper
• Reactive oxygen species regulate the differentiation of acute promyelocytic leukemia cells through HMGB1-mediated autophagy.

  2015cited by this paper
• Arsenic trioxide disrupts glioma stem cells via promoting PML degradation to inhibit tumor growth

  2015cited by this paper
• PML induces compaction, TRF2 depletion and DNA damage signaling at telomeres and promotes their alternative lengthening

  2015cited by this paper
• MYC/PGC-1α Balance Determines the Metabolic Phenotype and Plasticity of Pancreatic Cancer Stem Cells.

  2015cited by this paper
• Methylated arsenic metabolites bind to PML protein but do not induce cellular differentiation and PML-RARα protein degradation

  2015cited by this paper
• Analysis of p53 transactivation domain mutants reveals Acad11 as a metabolic target important for p53 pro-survival function.

  2015cited by this paper
• PML IV/ARF interaction enhances p53 SUMO-1 conjugation, activation, and senescence

  2015influential reference
• Activation of a promyelocytic leukemia–tumor protein 53 axis underlies acute promyelocytic leukemia cure

  2014influential reference
• MIR125B1 represses the degradation of the PML-RARA oncoprotein by an autophagy-lysosomal pathway in acute promyelocytic leukemia

  2014cited by this paper
• PML nuclear bodies: Assembly and oxidative stress-sensitive sumoylation

  2014influential reference
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  2014cited by this paper
• Control of antioxidative response by the tumor suppressor protein PML through regulating Nrf2 activity

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• Re-entry into quiescence protects hematopoietic stem cells from the killing effect of chronic exposure to type I interferons

  2014cited by this paper
• Oxidative stress–induced assembly of PML nuclear bodies controls sumoylation of partner proteins

  2014cited by this paper
• USP11 regulates PML stability to control Notch-induced malignancy in brain tumours

  2014cited by this paper
• PML nuclear bodies: regulation, function and therapeutic perspectives

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• Illuminating p53 function in cancer with genetically engineered mouse models.

  2014cited by this paper
• Modulation of oxidative stress as an anticancer strategy

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• Trafficking of the Transcription Factor Nrf2 to Promyelocytic Leukemia-Nuclear Bodies

  2013cited by this paper
• Differential Roles of PML Isoforms

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• Cancer metabolism: fatty acid oxidation in the limelight

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• Emerging Cellular Functions of Cytoplasmic PML

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• Analysis of SUMOylated proteins using SUMO-traps

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• PML, SUMOylation, and Senescence

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• Erosion of the chronic myeloid leukaemia stem cell pool by PPARγ agonists

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• Ablation of Promyelocytic Leukemia Protein (PML) Re-patterns Energy Balance and Protects Mice from Obesity Induced by a Western Diet*

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• PML: Not all about Tumor Suppression

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• Metabolic Regulation by p53 Family Members

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• The PML-Interacting Protein DAXX: Histone Loading Gets into the Picture

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• Identifying gene locus associations with promyelocytic leukemia nuclear bodies using immuno-TRAP

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• PML mediates glioblastoma resistance to mammalian target of rapamycin (mTOR)-targeted therapies

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• A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance

  2012cited by this paper
• PML body meets telomere

  2012cited by this paper
• Dualistic function of Daxx at centromeric and pericentromeric heterochromatin in normal and stress conditions

  2012cited by this paper
• (+)α-Tocopheryl succinate inhibits the mitochondrial respiratory chain complex I and is as effective as arsenic trioxide or ATRA against acute promyelocytic leukemia in vivo

  2012cited by this paper
• Up-regulation of endogenous PML induced by a combination of interferon-beta and temozolomide enhances p73/YAP-mediated apoptosis in glioblastoma.

  2012cited by this paper
• A metabolic prosurvival role for PML in breast cancer.

  2012influential reference
• The cell biology of disease: Acute promyelocytic leukemia, arsenic, and PML bodies.

  2012influential reference
• A redox-regulated SUMO/acetylation switch of HIPK2 controls the survival threshold to oxidative stress.

  2012cited by this paper
• Physical and functional interaction between PML and TBX2 in the establishment of cellular senescence

  2011cited by this paper
• The Lkb1 metabolic sensor maintains haematopoietic stem cell survival

  2011cited by this paper
• Four faces of cellular senescence

  2011cited by this paper
• AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

  2011cited by this paper
• Autophagy in tumorigenesis and energy metabolism: friend by day, foe by night.

  2011cited by this paper
• Promyelocytic leukemia inhibits adipogenesis, and loss of promyelocytic leukemia results in fat accumulation in mice.

  2011cited by this paper
• PML-RARα enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway

  2011cited by this paper
• Regulation of E2Fs and senescence by PML nuclear bodies.

  2011cited by this paper
• PML nuclear bodies.

  2010cited by this paper
• SENP3-mediated De-conjugation of SUMO2/3 from Promyelocytic Leukemia Is Correlated with Accelerated Cell Proliferation under Mild Oxidative Stress*

  2010cited by this paper
• Cadmium stress: an oxidative challenge

  2010cited by this paper
• Subcellular distribution of nuclear import-defective isoforms of the promyelocytic leukemia protein

  2010cited by this paper
• Arsenic Trioxide Controls the Fate of the PML-RARα Oncoprotein by Directly Binding PML

  2010cited by this paper
• The Lkb1 metabolic sensor maintains haematopoietic stem cell survival

  2010cited by this paper
• Faculty Opinions recommendation of Arsenic trioxide controls the fate of the PML-RARalpha oncoprotein by directly binding PML.

  2010cited by this paper
• PML Regulates Apoptosis at Endoplasmic Reticulum by Modulating Calcium Release

  2010influential reference
• PML/RARA oxidation and arsenic binding initiate the antileukemia response of As2O3.

  2010cited by this paper
• Sp100 as a potent tumor suppressor: accelerated senescence and rapid malignant transformation of human fibroblasts through modulation of an embryonic stem cell program.

  2010cited by this paper
• Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells

  2010cited by this paper
• LKB1 regulates quiescence and metabolic homeostasis of hematopoietic stem cells

  2010cited by this paper
• Redox regulation of the stability of the SUMO protease SENP3 via interactions with CHIP and Hsp90

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• Nutrient-dependent regulation of PGC-1alpha's acetylation state and metabolic function through the enzymatic activities of Sirt1/GCN5.

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  2008cited by this paper
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  2008cited by this paper
• RNF4 is a poly-SUMO-specific E3 ubiquitin ligase required for arsenic-induced PML degradation

  2008cited by this paper
• Arsenic degrades PML or PML–RARα through a SUMO-triggered RNF4/ubiquitin-mediated pathway

  2008cited by this paper
• Faculty Opinions recommendation of Arsenic degrades PML or PML-RARalpha through a SUMO-triggered RNF4/ubiquitin-mediated pathway.

  2008cited by this paper
• Eradication of acute promyelocytic leukemia-initiating cells through PML-RARA degradation

  2008cited by this paper
• Dynamics of component exchange at PML nuclear bodies

  2008cited by this paper
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  2008cited by this paper
• Structure, dynamics and functions of promyelocytic leukaemia nuclear bodies

  2007influential reference
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  2006cited by this paper
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• Characterization of a Family of Nucleolar SUMO-specific Proteases with Preference for SUMO-2 or SUMO-3*

  2006cited by this paper
• PML nuclear bodies are highly organised DNA-protein structures with a function in heterochromatin remodelling at the G2 phase

  2006cited by this paper

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• The PML1-WDR5 axis regulates H3K4me3 marks and promotes stemness of estrogen receptor-positive breast cancer

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• Downregulation of LRP/LR with siRNA inhibits several cancer hallmarks in lung cancer cells

  2022cites this paper
• PML-controlled responses in severe congenital neutropenia with ELANE-misfolding mutations.

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• Oxidative stress in leukemia and antioxidant treatment

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• The promyelocytic leukemia protein isoform PML1 is an oncoprotein and a direct target of the antioxidant sulforaphane (SFN).

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• Targeting PML in triple negative breast cancer elicits growth suppression and senescence

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  2018cites this paper
• PML: Regulation and multifaceted function beyond tumor suppression

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• Promyelocytic Leukemia Protein (PML) Controls Listeria monocytogenes Infection

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