von Hippel-Lindau tumor suppressor mutants faithfully model pathological hypoxia-driven angiogenesis and vascular retinopathies in zebrafish

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Disease Models & Mechanisms

• Publication date

  2010-05-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1242/dmm.004036PMID 20335444
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  2007influential reference
• High-resolution imaging of the dynamic tumor cell–vascular interface in transparent zebrafish

  2007cited by this paper
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  2006influential reference
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  2005influential reference
• Inactivation of the Arylhydrocarbon Receptor Nuclear Translocator (Arnt) Suppresses von Hippel-Lindau Disease-Associated Vascular Tumors in Mice

  2005influential reference
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  2005influential reference
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  2005influential reference
• Expression of stem cells markers in ocular hemangioblastoma associated with von Hippel-Lindau (VHL) disease.

  2005influential reference
• Genetic and cellular analyses of zebrafish atrioventricular cushion and valve development

  2005cited by this paper
• Ocular manifestations of von Hippel-Lindau disease: clinical and genetic investigations.

  2005influential reference
• VEGF as a Key Mediator of Angiogenesis in Cancer

  2005cited by this paper
• CXCL12 and vascular endothelial growth factor synergistically induce neoangiogenesis in human ovarian cancers.

  2005influential reference
• Cellular and molecular analyses of vascular tube and lumen formation in zebrafish

  2005cited by this paper
• Proline hydroxylation and gene expression.

  2005cited by this paper
• Fibronectin is a hypoxia‐independent target of the tumor suppressor VHL

  2004cited by this paper
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  2004cited by this paper
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  2004cited by this paper
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  2003influential reference
• Diabetic retinopathy and diabetic macular edema: pathophysiology, screening, and novel therapies.

  2003influential reference
• von Hippel-Lindau disease.

  2003cited by this paper
• Hepatic vascular tumors, angiectasis in multiple organs, and impaired spermatogenesis in mice with conditional inactivation of the VHL gene.

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  2003cited by this paper
• Regulation of angiogenesis by hypoxia: role of the HIF system

  2003cited by this paper
• In vivo imaging of embryonic vascular development using transgenic zebrafish.

  2002cited by this paper
• Neuropilin-1 is required for vascular development and is a mediator of VEGF-dependent angiogenesis in zebrafish

  2002cited by this paper
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• The vascular anatomy of the developing zebrafish: an atlas of embryonic and early larval development.

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  2001influential reference
• HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus.

  2001cited by this paper
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  2000cited by this paper
• Mechanisms of angiogenesis and arteriogenesis

  2000influential reference
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  2000cited by this paper
• Vascular-specific growth factors and blood vessel formation

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• Hypoxia and Vascular Endothelial Growth Factor Selectively Up-regulate Angiopoietin-2 in Bovine Microvascular Endothelial Cells*

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  1998cited by this paper
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  1997cited by this paper
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  1997cited by this paper
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  1997influential reference
• Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

  1996influential reference
• Vascular Endothelial Growth Factor, a Potent and Selective Angiogenic Agent (*)

  1996cited by this paper
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  1995cited by this paper
• Regulation of angiogenic growth factor expression by hypoxia, transition metals, and chelating agents.

  1995influential reference
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  1995cited by this paper
• Von Hippel-Lindau disease: a genetic study.

  1991cited by this paper
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  1974cited by this paper

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