Invasion and Intracellular Development of the Human Granulocytic Ehrlichiosis Agent in Tick Cell Culture

No abstract is available for this paper.

• Publication year

  1999

• Venue

  Journal of Clinical Microbiology

• Publication date

  1999-08-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1128/JCM.37.8.2518-2524.1999PMID 10405394PMCID PMC85271
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Experimental Transmission of Ehrlichia equi to Horses through Naturally Infected Ticks (Ixodes pacificus) from Northern California

  1998cited by this paper
• Ehrlichial DNA amplified from Ixodes ricinus (Acari: Ixodidae) in France.

  1998cited by this paper
• Serologic Evidence of Infection with Ehrlichia spp. in Wild Rodents (Muridae: Sigmodontinae) in the United States

  1998cited by this paper
• Detection of Human Granulocytic Ehrlichiosis Agent and Borrelia Burgdorferi in Ticks by Polymerase Chain Reaction

  1998cited by this paper
• Experimental infection of the human granulocytic ehrlichiosis agent in horses.

  1998cited by this paper
• Phylogenetic Placement of Rickettsiae from the Ticks Amblyomma americanum and Ixodes scapularis

  1998cited by this paper
• Morphology and development of Anaplasma marginale (Rickettsiales: Anaplasmataceae) in cultured Ixodes scapularis (Acari: Ixodidae) cells.

  1998cited by this paper
• Dogs infected with a human granulocytotropic Ehrlichia spp. (Rickettsiales: Ehrlichieae).

  1997cited by this paper
• Transmission of the agent of human granulocytic ehrlichiosis by host-seeking Ixodus scapularis (Acari:Ixodidae) in southern New York state.

  1997cited by this paper
• DEVELOPMENT AND USE OF SPECIFIC POLYMERASE REACTION FOR THE DETECTION OF AN ORGANISM RESEMBLING EHRLICHIA SP. IN WHITE-TAILED DEER

  1997cited by this paper
• Coexistence of Ehrlichia phagocytophila and Borrelia burgdorferi sensu lato in Ixodes ricinus ticks from Italy as determined by 16S rRNA gene sequencing

  1997cited by this paper
• Human granulocytic ehrlichiosis in southern Germany: increased seroprevalence in high-risk groups

  1997cited by this paper
• Prevalence of granulocytic Ehrlichia infection among white-tailed deer in Wisconsin

  1997cited by this paper
• Isolation of the equine granulocytic ehrlichiosis agent, Ehrlichia equi, in tick cell culture

  1996cited by this paper
• Direct cultivation of the causative agent of human granulocytic ehrlichiosis.

  1996cited by this paper
• A 16S rRNA-based PCR assay for detection and identification of granulocytic Ehrlichia species in dogs, horses, and cattle

  1996cited by this paper
• Perpetuation of the agent of human granulocytic ehrlichiosis in a deer tick-rodent cycle.

  1996cited by this paper
• Establishment of the tick (Acari:Ixodidae)-borne cattle pathogen Anaplasma marginale (Rickettsiales:Anaplasmataceae) in tick cell culture.

  1996cited by this paper
• Geographic, clinical, serologic, and molecular evidence of granulocytic ehrlichiosis, a likely zoonotic disease, in Minnesota and Wisconsin dogs

  1996cited by this paper
• Ixodes pacificus (Acari: Ixodidae) as a vector of Ehrlichia equi (Rickettsiales: Ehrlichieae).

  1996cited by this paper
• Protection against Ehrlichia equi is conferred by prior infection with the human granulocytotropic Ehrlichia (HGE agent)

  1995cited by this paper
• Ixodes dammini as a potential vector of human granulocytic ehrlichiosis.

  1995cited by this paper
• Ultrastructural variation of cultured Ehrlichia chaffeensis.

  1995cited by this paper
• Identification of the causative agent of granulocytic ehrlichiosis in Swedish dogs and horses by direct solid phase sequencing of PCR products from the 16S rRNA gene.

  1995cited by this paper
• Establishment, maintenance and description of cell lines from the tick Ixodes scapularis.

  1994cited by this paper
• Human granulocytic ehrlichiosis in the upper Midwest United States. A new species emerging?

  1994influential reference
• Abrogation of gamma interferon-induced inhibition of Ehrlichia chaffeensis infection in human monocytes with iron-transferrin

  1994cited by this paper
• Identification of a granulocytotropic Ehrlichia species as the etiologic agent of human disease

  1994cited by this paper
• Ultrastructural analysis of the invasion of tick cells by Lyme disease spirochetes (Borrelia burgdorferi) in vitro

  1994cited by this paper
• DISCONTINUOUS VENTILATION IN A NON-INSECT, THE TICK AMBLYOMMA MARMOREUM (ACARI, IXODIDAE): CHARACTERIZATION AND METABOLIC MODULATION

  1993cited by this paper
• Proposals to unify the genera Bartonella and Rochalimaea, with descriptions of Bartonella quintana comb. nov., Bartonella vinsonii comb. nov., Bartonella henselae comb. nov., and Bartonella elizabethae comb. nov., and to remove the family Bartonellaceae from the order Rickettsiales.

  1993cited by this paper
• Isolation and characterization of an Ehrlichia sp. from a patient diagnosed with human ehrlichiosis

  1991cited by this paper
• A Serological Survey of Ehrlichia Canis, Ehrlichia Equi, Rickettsia Rickettsii, and Borrelia Burgdorferi in Dogs in Oklahoma

  1989cited by this paper
• Equine ehrlichiosis in northern California: 49 cases (1968-1981).

  1987cited by this paper
• unpublished results

  1985cited by this paper
• Morphology of colonies of Anaplasma marginale in nymphal Dermacentor andersoni.

  1984cited by this paper
• Development of Ehrlichia canis, causative agent of canine ehrlichiosis, in the tick Rhipicephalus sanguineus and its differentiation from a symbiotic Rickettsia.

  1976cited by this paper
• MURINE TYPHUS RICKETTSIAE IN THE ORIENTAL RAT FLEA *

  1975influential reference
• A modified method for lead staining of thin sections.

  1968cited by this paper
• THE USE OF LEAD CITRATE AT HIGH pH AS AN ELECTRON-OPAQUE STAIN IN ELECTRON MICROSCOPY

  1963cited by this paper

• Anaplasma phagocytophilum invasin AipB interacts with the β2 integrin β-subunit CD18 to orchestrate infection

  2026cites this paper
• Evaluation of host immune responses following immunization with MSP4 antigen adsorbed onto poly(lactic-co-glycolic acid) microparticles in a BALB/c murine model.

  2026cites this paper
• An arthropod transporter IsOATP4056 exerts inhibitory effect on its interacting membrane protein to facilitate rickettsial pathogen survival in ticks

  2025cites this paper
• Propagation dynamics of Anaplasma marginale in a Brazilian tick cell line (RBME-6) derived from Rhipicephalus microplus

  2025cites this paper
• Investigation of the Blood Microbiome in Horses With Fever of Unknown Origin

  2025cites this paper
• Use of Tick Cell Lines in Co-Infection Studies with a Preliminary Study of Co-Culture of Borrelia burgdorferi and Anaplasma phagocytophilum

  2025cites this paper
• Arthropod autophagy molecules facilitate Anaplasma phagocytophilum infection of Ixodes scapularis tick cells

  2025cites this paper
• Adaptation of Anaplasma phagocytophilum to the tick vector is controlled by the transcriptional regulator Tr1

  2025cites this paper
• McFarland Standards-Based Spectrophotometry Method for Calculating Approximate Multiplicity of Infection for an Obligate Intracellular Bacterium Anaplasma phagocytophilum

  2025cites this paper
• Isolation, Molecular Characterization and In Vitro Propagation of an Anaplasma platys-Like Bacterium in Tick Cells

  2025cites this paper
• Rickettsial pathogen augments tick vesicular-associated membrane proteins for infection and survival in the vector host

  2025influential citation
• Tick Cell Culture Methods.

  2025cites this paper
• Borrelia miyamotoi in vivo antigenic variation demonstrated by serotype reisolations from infected mice

  2025cites this paper
• Uukuniemi virus infection causes a pervasive remodelling of the RNA-binding proteome in tick cells

  2025influential citation
• Molecular Detection of Candidatus Anaplasma camelii in Naturally Infected Dromedary Camels (Camelus dromedarius) in Abu Dhabi Emirate, United Arab Emirates, 2019–2023

  2024cites this paper
• Long-Term Protective Immunity against Ehrlichia chaffeensis Infection Induced by a Genetically Modified Live Vaccine

  2024cites this paper
• Ehrlichia effector TRP120 manipulates bacteremia to facilitate tick acquisition

  2024cites this paper
• Transovarial transmission of pathogenic protozoa and rickettsial organisms in ticks

  2023cites this paper
• Genetic modification, characterization, and co-infection of Franken Sphingomonas and Anaplasma phagocytophilum in tick cells

  2023cites this paper
• Frankenbacteriosis targeting interactions between pathogen and symbiont to control infection in the tick vector

  2023cites this paper
• Evaluation of Immunocompetent Mouse Models for Borrelia miyamotoi Infection

  2023cites this paper
• An Anaplasma phagocytophilum T4SS effector, AteA, is essential for tick infection

  2023cites this paper
• Anti-tick vaccine candidate subolesin is important for blood feeding and innate immune gene expression in soft ticks

  2023cites this paper
• Tick Saliva and Salivary Glands: What Do We Know So Far on Their Role in Arthropod Blood Feeding and Pathogen Transmission

  2022cites this paper
• Comparative Whole Genome Analysis of an Anaplasma phagocytophilum Strain Isolated from Norwegian Sheep

  2022influential citation
• Cryptic Genes for Interbacterial Antagonism Distinguish Rickettsia Species Infecting Blacklegged Ticks From Other Rickettsia Pathogens

  2022cites this paper
• Genomic characterization of Francisella tularensis and other diverse Francisella species from complex samples

  2022cites this paper
• The Ixodes scapularis Symbiont Rickettsia buchneri Inhibits Growth of Pathogenic Rickettsiaceae in Tick Cells: Implications for Vector Competence

  2022influential citation
• Ecological and evolutionary perspectives on tick-borne pathogen co-infections

  2021cites this paper
• Anaplasmataceae: Dichotomous Autophagic Interplay for Infection

  2021cites this paper
• Comparative Analysis of Genome of Ehrlichia sp. HF, a Model Bacterium to Study Fatal Human Ehrlichiosis

  2021cites this paper
• Isolation in Natural Host Cell Lines of Wolbachia Strains wPip from the Mosquito Culex pipiens and wPap from the Sand Fly Phlebotomus papatasi

  2021cites this paper
• Functional Characterization of Multiple Ehrlichia chaffeensis Sodium (Cation)/Proton Antiporter Genes Involved in the Bacterial pH Homeostasis

  2021cites this paper
• How relevant are in vitro culture models for study of tick-pathogen interactions?

  2021cites this paper
• Transmission of ‘Candidatus Anaplasma camelii’ to laboratory animals by camel-specific keds, Hippobosca camelina

  2021cites this paper
• Spiroplasma Isolated From Third-Generation Laboratory Colony Ixodes persulcatus Ticks

  2021cites this paper
• Transmission of ‘Candidatus Anaplasma camelii’ to mice and rabbits by camel-specific keds, Hippobosca camelina

  2021cites this paper
• Isolation of Borrelia miyamotoi and other Borreliae using a modified BSK medium

  2021cites this paper
• An Entry-Triggering Protein of Ehrlichia Is a New Vaccine Candidate against Tick-Borne Human Monocytic Ehrlichiosis

  2020cites this paper
• Disruption of VirB6 Paralogs in Anaplasma phagocytophilum Attenuates Its Growth

  2020cites this paper
• An efficient microinjection method to generate human anaplasmosis agent Anaplasma phagocytophilum-infected ticks

  2020cites this paper
• Isolation and Propagation of Laboratory Strains and a Novel Flea-Derived Field Strain of Wolbachia in Tick Cell Lines

  2020cites this paper
• Experimental Ixodes ricinus-Sheep Cycle of Anaplasma phagocytophilum NV2Os Propagated in Tick Cell Cultures

  2020cites this paper
• Discovery of in vivo Virulence Genes of Obligatory Intracellular Bacteria by Random Mutagenesis

  2020cites this paper
• Clinical and immunological responses in sheep after inoculation with Himar1-transformed Anaplasma phagocytophilum and subsequent challenge with a virulent strain of the bacterium.

  2020cites this paper
• The identification of tick autophagy-related genes in Ixodes scapularis responding to amino acid starvation.

  2020cites this paper
• Global Transcription Profiles of Anaplasma phagocytophilum at Key Stages of Infection in Tick and Human Cell Lines and Granulocytes

  2020cites this paper
• A tick cell line as a powerful tool to screen the antimicrobial susceptibility of the tick-borne pathogen Anaplasma marginale.

  2019cites this paper
• The redox metabolic pathways function to limit Anaplasma phagocytophilum infection and multiplication while preserving fitness in tick vector cells

  2019cites this paper
• Ehrlichia Isolate from a Minnesota Tick: Characterization and Genetic Transformation

  2019cites this paper
• Anaplasma phagocytophilum modifies tick cell microRNA expression and upregulates isc-mir-79 to facilitate infection by targeting the Roundabout protein 2 pathway

  2019cites this paper
• Mutational analysis of gene function in the Anaplasmataceae: Challenges and perspectives.

  2019cites this paper
• Isolation of known and potentially pathogenic tick-borne microorganisms from European ixodid ticks using tick cell lines

  2019cites this paper
• A draft genome sequence for the Ixodes scapularis cell line, ISE6

  2018cites this paper
• “Interactions between pathogenic and non-pathogenic Rickettsiales and the tick host”

  2018cites this paper
• Francisella tularensis novicida infection competence differs in cell lines derived from United States populations of Dermacentor andersoni and Ixodes scapularis

  2018cites this paper
• Successful Infection of Tick Cell Cultures of Rhipicephalus sanguineus (Tropical Lineage) with Ehrlichia canis

  2018cites this paper
• Monovalent cation/sodium: proton antiporter proteins of Ehrlichia chaffeensis

  2018cites this paper
• Guidelines for the Direct Detection of Anaplasma spp. in Diagnosis and Epidemiological Studies

  2017cites this paper
• Ixodes scapularis Tick Cells Control Anaplasma phagocytophilum Infection by Increasing the Synthesis of Phosphoenolpyruvate from Tyrosine

  2017cites this paper
• Peptidoglycan in obligate intracellular bacteria

  2017cites this paper
• A genetic system for targeted mutations to disrupt and restore genes in the obligate bacterium, Ehrlichia chaffeensis

  2017cites this paper
• Co-infection of Trypanosoma pestanai and Anaplasma phagocytophilum in a dog from Germany.

  2017cites this paper
• Guidelines for the Detection of Rickettsia spp.

  2017cites this paper
• Vaccinomics Approach to the Identification of Candidate Protective Antigens for the Control of Tick Vector Infestations and Anaplasma phagocytophilum Infection

  2017cites this paper
• Explorer Isolation of canine Anaplasma phagocytophilum strains from clinical blood samples using the Ixodes ricinus cell line

  2017influential citation
• Vaccination against Louping Ill Virus Protects Goats from Experimental Challenge with Spanish Goat Encephalitis Virus.

  2017cites this paper
• Anaplasma phagocytophilum Infection Subverts Carbohydrate Metabolic Pathways in the Tick Vector, Ixodes scapularis

  2017cites this paper
• Remodeling of tick cytoskeleton in response to infection with Anaplasma phagocytophilum.

  2017cites this paper
• Relative transcription of autophagy-related genes in Amblyomma sculptum and Rhipicephalus microplus ticks

  2017cites this paper
• Growth of Ehrlichia canis, the causative agent of canine monocytic ehrlichiosis, in vector and non-vector ixodid tick cell lines

  2016cites this paper
• Anaplasma phagocytophilum Uses Common Strategies for Infection of Ticks and Vertebrate Hosts.

  2016cites this paper
• Anaplasma phagocytophilum increases the levels of histone modifying enzymes to inhibit cell apoptosis and facilitate pathogen infection in the tick vector Ixodes scapularis

  2016cites this paper
• An O-Methyltransferase Is Required for Infection of Tick Cells by Anaplasma phagocytophilum

  2015influential citation
• Nuclease Tudor-SN Is Involved in Tick dsRNA-Mediated RNA Interference and Feeding but Not in Defense against Flaviviral or Anaplasma phagocytophilum Rickettsial Infection

  2015cites this paper
• Anaplasma marginale and Anaplasma phagocytophilum: Rickettsiales pathogens of veterinary and public health significance

  2015cites this paper
• Propagation of the Israeli vaccine strain of Anaplasma centrale in tick cell lines

  2015cites this paper
• Rickettsia buchneri sp. nov., a rickettsial endosymbiont of the blacklegged tick Ixodes scapularis.

  2015cites this paper
• Transcriptional Analysis of the Conjugal Transfer Genes of Rickettsia bellii RML 369-C

  2015cites this paper
• Integrated Metabolomics, Transcriptomics and Proteomics Identifies Metabolic Pathways Affected by Anaplasma phagocytophilum Infection in Tick Cells*

  2015cites this paper
• Selected Zoonotic Pathogens

  2015cites this paper
• Infection of Ixodes spp. tick cells with different Anaplasma phagocytophilum isolates induces the inhibition of apoptotic cell death.

  2015cites this paper
• Infection of Immature Ixodes scapularis (Acari: Ixodidae) by Membrane Feeding

  2015cites this paper
• Transmission of Anaplasma phagocytophilum from endothelial cells to peripheral granulocytes in vitro under shear flow conditions

  2015influential citation
• Opening the black box of Anaplasma phagocytophilum diversity: current situation and future perspectives

  2015cites this paper
• Ehrlichia chaffeensis Infection in the Reservoir Host (White-Tailed Deer) and in an Incidental Host (Dog) Is Impacted by Its Prior Growth in Macrophage and Tick Cell Environments

  2014cites this paper
• Coinfection of tick cell lines has variable effects on replication of intracellular bacterial and viral pathogens

  2014influential citation
• Functional characterization of two Anaplasma phagocytophilum genes required for infection of mammalian host and tick vectors, respectively

  2014cites this paper
• Characterization of the tick-pathogen interface by functional genomics and proteomics

  2014influential citation
• The Effects of Nosema ceranae on Honey Bee Health

  2014cites this paper
• Motility Characteristics Are Altered for Rickettsia bellii Transformed To Overexpress a Heterologous rickA Gene

  2013cites this paper
• Anaplasma phagocytophilum strains from voles and shrews exhibit specific ankA gene sequences

  2013influential citation
• Targeted and Random Mutagenesis of Ehrlichia chaffeensis for the Identification of Genes Required for In vivo Infection

  2013cites this paper
• TRANSPOSON BASED MUTAGENESIS AND MAPPING OF TRANSPOSON INSERTION SITES WITHIN THE EHRLICHIA CHAFFEENSIS GENOME USING SEMI RANDOM TWO-STEP PCR by VIJAYA VARMA INDUKURI

  2013cites this paper
• TRANSPOSON BASED MUTAGENESIS AND MAPPING OF TRANSPOSON INSERTION SITES WITHIN THE EHRLICHIA CHAFFEENSIS GENOME USING SEMI RANDOM TWO-STEP PCR

  2013cites this paper
• Diagnosis of rickettsial diseases in dogs and cats.

  2013cites this paper
• Anaplasma phagocytophilum Inhibits Apoptosis and Promotes Cytoskeleton Rearrangement for Infection of Tick Cells

  2013cites this paper
• Anaplasma phagocytophilum—a widespread multi-host pathogen with highly adaptive strategies

  2013cites this paper
• Isolation of “Candidatus Rickettsia andeanae” (Rickettsiales: Rickettsiaceae) in Embryonic Cells of Naturally Infected Amblyomma maculatum (Ixodida: Ixodidae)

  2013influential citation
• Reciprocal Regulation of NF-kB (Relish) and Subolesin in the Tick Vector, Ixodes scapularis

  2013cites this paper