14‐3‐3γ binds to MDMX that is phosphorylated by UV‐activated Chk1, resulting in p53 activation

No abstract is available for this paper.

• Publication year

  2006

• Venue

  EMBO Journal

• Publication date

  2006-03-22

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/sj.emboj.7601010PMID 16511572PMCID PMC1422168
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• A Structural Basis for 14-3-3σ Functional Specificity*♦

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• Faculty Opinions recommendation of A structural basis for 14-3-3sigma functional specificity.

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• Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2.

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• ATM and Chk2‐dependent phosphorylation of MDMX contribute to p53 activation after DNA damage

  2005cited by this paper
• Phosphorylation of Hdmx mediates its Hdm2- and ATM-dependent degradation in response to DNA damage.

  2005cited by this paper
• DNA Damage-Induced Phosphorylation of MdmX at Serine 367 Activates p53 by Targeting MdmX for Mdm2-Dependent Degradation

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• Mdmx as an essential regulator of p53 activity.

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  2003cited by this paper
• Identification of a domain within MDMX‐S that is responsible for its high affinity interaction with p53 and high‐level expression in mammalian cells

  2003cited by this paper
• HdmX stimulates Hdm2-mediated ubiquitination and degradation of p53

  2003influential reference
• Overexpression of Mdm2 and MdmX fusion proteins alters p53 mediated transactivation, ubiquitination, and degradation.

  2003cited by this paper
• Scansite 2.0: proteome-wide prediction of cell signaling interactions using short sequence motifs

  2003cited by this paper
• 14-3-3 sigma positively regulates p53 and suppresses tumor growth.

  2003cited by this paper
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• DNA Damage Induces MDMX Nuclear Translocation by p53-Dependent and -Independent Mechanisms

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• Determination of Substrate Motifs for Human Chk1 and hCds1/Chk2 by the Oriented Peptide Library Approach*

  2002cited by this paper
• Hdmx Recruitment into the Nucleus by Hdm2 Is Essential for Its Ability to Regulate p53 Stability and Transactivation*

  2002cited by this paper
• MDM 2 Inhibits PCAF ( p 300 / CREB-binding Protein-associated Factor )-mediated p 53 Acetylation *

  2002cited by this paper
• mdmx is a negative regulator of p53 activity in vivo.

  2002cited by this paper
• Mdm4 (Mdmx) Regulates p53-Induced Growth Arrest and Neuronal Cell Death during Early Embryonic Mouse Development

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• Mutual Dependence of MDM2 and MDMX in Their Functional Inactivation of p53*

  2002cited by this paper
• SSRP1 functions as a co‐activator of the transcriptional activator p63

  2002cited by this paper
• Activation of the p53 tumor suppressor protein.

  2002cited by this paper
• MDM2 Inhibits PCAF (p300/CREB-binding Protein-associated Factor)-mediated p53 Acetylation*

  2002cited by this paper
• Regulation of p53

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• ATR-Mediated Checkpoint Pathways Regulate Phosphorylation and Activation of Human Chk1

  2001cited by this paper
• Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53

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• p300 Does Not Require Its Acetylase Activity to Stimulate p73 Function*

  2001cited by this paper
• Post-translational modifications and activation of p53 by genotoxic stresses.

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  2000cited by this paper
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• The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1.

  2000cited by this paper
• The Chk1 Protein Kinase and the Cdc25C Regulatory Pathways Are Targets of the Anticancer Agent UCN-01*

  2000cited by this paper
• The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites.

  2000cited by this paper
• UV but not gamma irradiation accelerates p53-induced apoptosis of teratocarcinoma cells by repressing MDM2 transcription.

  2000cited by this paper
• Surfing the p53 network

  2000cited by this paper
• Hdmx stabilizes Mdm2 and p53.

  2000cited by this paper
• MdmX Protects p53 from Mdm2-Mediated Degradation

  2000cited by this paper
• A role for ATR in the DNA damage-induced phosphorylation of p53.

  1999cited by this paper
• The p38MAPK inhibitor SB203580 alleviates ultraviolet-induced phosphorylation at serine 389 but not serine 15 and activation of p53.

  1999cited by this paper
• MDM2 Suppresses p73 Function without Promoting p73 Degradation

  1999cited by this paper
• A Novel MDMX Transcript Expressed in a Variety of Transformed Cell Lines Encodes a Truncated Protein with Potent p53 Repressive Activity*

  1999cited by this paper
• Stabilization of the MDM2 Oncoprotein by Interaction with the Structurally Related MDMX Protein*

  1999cited by this paper
• Phosphorylation of human keratin 18 serine 33 regulates binding to 14‐3‐3 proteins

  1998cited by this paper
• The requirement for the p53 proline‐rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression

  1998cited by this paper
• Requirement for p53 and p21 to sustain G2 arrest after DNA damage.

  1998cited by this paper
• 14-3-3sigma is a p53-regulated inhibitor of G2/M progression.

  1997cited by this paper
• The structural basis for 14-3-3:phosphopeptide binding specificity.

  1997cited by this paper
• Oncoprotein MDM2 is a ubiquitin ligase E3 for tumor suppressor p53

  1997cited by this paper
• Raf-1 Kinase and Exoenzyme S Interact with 14-3-3ζ through a Common Site Involving Lysine 49*

  1997cited by this paper
• Mdm2 promotes the rapid degradation of p53

  1997cited by this paper
• Regulation of p53 stability by Mdm2

  1997cited by this paper
• MDMX: a novel p53‐binding protein with some functional properties of MDM2.

  1996cited by this paper
• Interaction of 14-3-3 with signaling proteins is mediated by the recognition of phosphoserine.

  1996cited by this paper
• C2 Region-derived Peptides Inhibit Translocation and Function of β Protein Kinase C in Vivo(*)

  1995cited by this paper
• A novel form of Epstein-Barr virus latency in normal B cells in vivo.

  1995cited by this paper
• Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

  1995cited by this paper
• Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

  1995cited by this paper
• Tumor suppressor p53 is a direct transcriptional activator of the human bax gene.

  1995cited by this paper
• Identification of the 14.3.3 ζ Domains Important for Self-association and Raf Binding (*)

  1995cited by this paper
• p53-dependent inhibition of cyclin-dependent kinase activities in human fibroblasts during radiation-induced G1 arrest.

  1994cited by this paper
• WAF1, a potential mediator of p53 tumor suppression.

  1993cited by this paper
• Structure and organization of amplified DNA on double minutes containing the mdm2 oncogene.

  1993cited by this paper
• The p53-mdm-2 autoregulatory feedback loop.

  1993cited by this paper
• The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.

  1993cited by this paper
• mdm2 expression is induced by wild type p53 activity.

  1993cited by this paper
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