Biomimicry as a design tool for nanocontainers: The “shape of things to come” in drug delivery

Abstract Nanocontainers embody a “compartmentalized” structural archetype with the potential to operate on a dimensional scale that can either assimilate or be integrated within bio-driven processes. With expected improvements in sensitive diagnostic assays for early disease detection (e.g., CTCs or circulating tumor cells), this has important implications for developing drug delivery technologies to areas of small confinement in the body. Functionalized nanocontainers with tunable surface properties can help stabilize and release therapeutic chemical and biological drugs within nano- and sub-nano spaced cavities. Here, we discuss recent developments in the field of “nanocontainers” that show promise for addressing some of the more challenging aspects of drug therapeutics.

• Publication year

  2020

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Materials Science, Chemistry, Computer Science, Engineering, Medicine

• Identifiers
  DOI 10.1016/b978-0-12-816770-0.00020-4
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Influence of particle size and shape on their margination and wall-adhesion: implications in drug delivery vehicle design across nano-to-micro scale.

  2018cited by this paper
• DNA Nanocages

  2018cited by this paper
• Selective Encapsulation of Disaccharide Xylobiose by an Aromatic Foldamer Helical Capsule.

  2018cited by this paper
• Cyclodextrin complexes: Perspective from drug delivery and formulation

  2018cited by this paper
• Efficient Graphene/Cyclodextrin-Based Nanocontainer: Synthesis and Host-Guest Inclusion for Self-Healing Anticorrosion Application.

  2018cited by this paper
• Bacterial microcompartments

  2018cited by this paper
• Supramolecular Switching of Ion-Transport in Nanochannels.

  2018cited by this paper
• Mapping heterogeneous polarity in multicompartment nanoparticles

  2018cited by this paper
• Amino acid-derived stimuli-responsive polymers and their applications

  2018cited by this paper
• A biomimetic and pH-sensitive polymeric micelle as carrier for paclitaxel delivery

  2017cited by this paper
• Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes.

  2017cited by this paper
• Light-induced unfolding and refolding of supramolecular polymer nanofibres

  2017cited by this paper
• High drug-loading nanomedicines: progress, current status, and prospects

  2017cited by this paper
• Diverse Applications of Nanomedicine

  2017cited by this paper
• Engineering Compartmentalized Biomimetic Micro- and Nanocontainers.

  2017cited by this paper
• Tunable Dual-Thermoresponsive Core-Shell Nanogels Exhibiting UCST and LCST Behavior.

  2017cited by this paper
• Engineering protein nanocages as carriers for biomedical applications

  2017cited by this paper
• Artificial Cells: Synthetic Compartments with Life-like Functionality and Adaptivity

  2017cited by this paper
• "On the Dot"-The Timing of Self-Assembled Growth to the Quantum Scale.

  2017cited by this paper
• Protein Nanocontainers from Nonviral Origin: Testing the Mechanics of Artificial and Natural Protein Cages by AFM.

  2016cited by this paper
• Converting a Natural Protein Compartment into a Nanofactory for the Size-Constrained Synthesis of Antimicrobial Silver Nanoparticles.

  2016cited by this paper
• Protein self-assembly via supramolecular strategies.

  2016cited by this paper
• Role of nanoparticle size, shape and surface chemistry in oral drug delivery.

  2016cited by this paper
• The Role of Carrier Geometry in Overcoming Biological Barriers to Drug Delivery.

  2016cited by this paper
• Nanoparticles in the clinic

  2016cited by this paper
• NIR-responsive polypeptide copolymer upconversion composite nanoparticles for triggered drug release and enhanced cytotoxicity

  2015cited by this paper
• Advances and Challenges of Liposome Assisted Drug Delivery

  2015cited by this paper
• Cell membrane-camouflaged nanoparticles for drug delivery.

  2015cited by this paper
• Biodegradable protein nanocontainers.

  2015cited by this paper
• Nature's lessons in design: nanomachines to scaffold, remodel and shape membrane compartments.

  2015cited by this paper
• Insoluble drug delivery strategies: review of recent advances and business prospects

  2015cited by this paper
• Diverse Bacterial Microcompartment Organelles

  2014cited by this paper
• Functionalization of protein-based nanocages for drug delivery applications.

  2014cited by this paper
• Effect of tumor shape, size, and tissue transport properties on drug delivery to solid tumors

  2014cited by this paper
• Controlled release from a mechanically-stimulated thermosensitive self-heating composite hydrogel.

  2014cited by this paper
• Bacteria-instructed synthesis of polymers for self-selective microbial binding and labelling

  2014cited by this paper
• Biomechanical properties of red blood cells in health and disease towards microfluidics.

  2014cited by this paper
• Drug discovery: Combichem all over again.

  2014cited by this paper
• Targeting C-type lectin receptors with multivalent carbohydrate ligands.

  2013cited by this paper
• Materials for drug delivery.

  2013cited by this paper
• Bioinspiration and Biomimicry in Chemistry. Reverse‐Engineering Nature. Edited by Gerhard F. Swiegers.

  2013cited by this paper
• Engineering antiphagocytic biomimetic drug carriers.

  2013cited by this paper
• Shape effect in the design of nanowire-coated microparticles as transepithelial drug delivery devices.

  2012cited by this paper
• Virus-based nanocarriers for drug delivery.

  2012cited by this paper
• Mechanical Control of Nanomaterials and Nanosystems

  2012cited by this paper
• Nanochannels: hosts for the supramolecular organization of molecules and complexes.

  2012cited by this paper
• Bio-inspired, bioengineered and biomimetic drug delivery carriers

  2011cited by this paper
• Dynamic molecular processes mediate cellular mechanotransduction

  2011cited by this paper
• Shape change of nanocontainers via a reversible ionic buckling.

  2011cited by this paper
• Messy biology and the origins of evolutionary innovations.

  2010cited by this paper
• “Smart” liposomal nanocontainers in biology and medicine

  2010cited by this paper
• Physical approaches to biomaterial design.

  2009cited by this paper
• Viruses and protein cages as nanocontainers and nanoreactors

  2009cited by this paper
• Synthetic approaches for the preparation of cyclic polymers.

  2009cited by this paper
• Crosslinked actin networks show liquid crystal elastomer behaviour, including soft-mode elasticity

  2007cited by this paper
• Faceting ionic shells into icosahedra via electrostatics

  2007cited by this paper
• Stable drug encapsulation in micelles and microemulsions.

  2007cited by this paper
• Polymeric micelles for drug delivery.

  2006cited by this paper
• Transferrin-Oligomers as Potential Carriers in Anticancer Drug Delivery

  2004cited by this paper
• Mechanosensitive ion channels: molecules of mechanotransduction

  2004cited by this paper
• An operational supramolecular nanovalve.

  2004cited by this paper
• Local rule mechanism for selecting icosahedral shell geometry

  2000cited by this paper
• Micelle formation and solubilization of fluorescent probes in poly(oxyethylene-b-oxypropylene-b-oxyethylene) solutions

  1995cited by this paper

• No citing papers are available for this paper.