Thrombin stimulation of vascular adhesion molecule-1 in endothelial cells is mediated by protein kinase C (PKC)-delta-NF-kappa B and PKC-zeta-GATA signaling pathways.

No abstract is available for this paper.

• Publication year

  2003

• Venue

  Journal of Biological Chemistry

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  PMID 12493764
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Galpha(q) and Gbetagamma regulate PAR-1 signaling of thrombin-induced NF-kappaB activation and ICAM-1 transcription in endothelial cells.

  2002cited by this paper
• 3'-phosphoinositide-dependent kinase-1 (PDK-1) in PI 3-kinase signaling.

  2002cited by this paper
• Characterization of protein kinase C β isoform's action on retinoblastoma protein phosphorylation, vascular endothelial growth factor-induced endothelial cell proliferation, and retinal neovascularization

  2002cited by this paper
• Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment.

  2002cited by this paper
• Vascular endothelial growth factor induces manganese‐superoxide dismutase expression in endothelial cells by a Racl‐regulated NADPH oxidase‐dependent mechanism

  2001cited by this paper
• Interleukin 4 induces transcription of the 15-lipoxygenase I gene in human endothelial cells.

  2001cited by this paper
• Thrombin Activates the Hypoxia-Inducible Factor-1 Signaling Pathway in Vascular Smooth Muscle Cells: Role of the p22phox-Containing NADPH Oxidase

  2001cited by this paper
• Protein Kinase C Isoforms Involved in the Transcriptional Activation of Cyclin D1 by Transforming Ha-Ras*

  2001cited by this paper
• Rottlerin is a mitochondrial uncoupler that decreases cellular ATP levels and indirectly blocks protein kinase Cdelta tyrosine phosphorylation.

  2001cited by this paper
• Transforming Growth Factor-β1-mediated Inhibition of the flk-1/KDR Gene Is Mediated by a 5′-Untranslated Region Palindromic GATA Site*

  2001cited by this paper
• Regulation of nuclear factor kappa B transactivation. Implication of phosphatidylinositol 3-kinase and protein kinase C zeta in c-Rel activation by tumor necrosis factor alpha.

  2001cited by this paper
• Protein kinase C-delta regulates thrombin-induced ICAM-1 gene expression in endothelial cells via activation of p38 mitogen-activated protein kinase.

  2001cited by this paper
• Thrombin Stimulation of the Vascular Cell Adhesion Molecule-1 Promoter in Endothelial Cells Is Mediated by Tandem Nuclear Factor-κB and GATA Motifs*

  2001cited by this paper
• Regulation of Raf by Akt Controls Growth and Differentiation in Vascular Smooth Muscle Cells*

  2001cited by this paper
• Thrombin Regulates Insulin-Like Growth Factor-1 Receptor Transcription in Vascular Smooth Muscle: Characterization of the Signaling Pathway

  2001cited by this paper
• Serum Response Factor-GATA Ternary Complex Required for Nuclear Signaling by a G-Protein-Coupled Receptor

  2001cited by this paper
• Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway.

  2001cited by this paper
• Aldosterone induces ras methylation in A6 epithelia.

  2000cited by this paper
• Protein kinases as mediators of phosphoinositide 3-kinase signaling.

  2000cited by this paper
• Vascular Endothelial Growth Factor Induces Expression of Connective Tissue Growth Factor via KDR, Flt1, and Phosphatidylinositol 3-Kinase-Akt-dependent Pathways in Retinal Vascular Cells*

  2000cited by this paper
• Protein kinase C isozymes and the regulation of diverse cell responses.

  2000cited by this paper
• Protein kinase C-zeta mediates TNF-alpha-induced ICAM-1 gene transcription in endothelial cells.

  2000cited by this paper
• Further evidence that 3‐phosphoinositide‐dependent protein kinase‐1 (PDK1) is required for the stability and phosphorylation of protein kinase C (PKC) isoforms

  2000cited by this paper
• Vascular endothelial growth factor-stimulated actin reorganization and migration of endothelial cells is regulated via the serine/threonine kinase Akt.

  2000cited by this paper
• Induction of vascular cell adhesion molecule‐1 expression by IL‐4 in human aortic smooth muscle cells is not associated with increased nuclear NF‐κB levels

  1999cited by this paper
• Activation of IkappaB kinase beta by protein kinase C isoforms.

  1999cited by this paper
• PI 3‐kinase γ and protein kinase C‐ζ mediate RAS‐independent activation of MAP kinase by a Gi protein‐coupled receptor

  1999cited by this paper
• IGF-1 induces skeletal myocyte hypertrophy through calcineurin in association with GATA-2 and NF-ATc1

  1999cited by this paper
• Regulation of NF-kappaB RelA phosphorylation and transcriptional activity by p21(ras) and protein kinase Czeta in primary endothelial cells.

  1999cited by this paper
• The proliferative effect of vascular endothelial growth factor requires protein kinase C-alpha and protein kinase C-zeta.

  1999cited by this paper
• Inactivation of the Inhibitory κB Protein Kinase/Nuclear Factor κB Pathway by Par-4 Expression Potentiates Tumor Necrosis Factor α-induced Apoptosis*

  1999cited by this paper
• Requirement for Akt (Protein Kinase B) in Insulin-induced Activation of Glycogen Synthase and Phosphorylation of 4E-BP1 (PHAS-1)*

  1999cited by this paper
• p38 and Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase Pathways Are Required for Nuclear Factor-κB p65 Transactivation Mediated by Tumor Necrosis Factor*

  1998cited by this paper
• Role of Activating Protein-1 in the Regulation of the Vascular Cell Adhesion Molecule-1 Gene Expression by Tumor Necrosis Factor-α*

  1998cited by this paper
• Thrombin Stimulates Smooth Muscle Cell Procollagen Synthesis and mRNA Levels via a PAR-1 Mediated Mechanism

  1998cited by this paper
• Protein kinase C isotypes controlled by phosphoinositide 3-kinase through the protein kinase PDK1.

  1998cited by this paper
• The sevenfold way of PKC regulation.

  1998cited by this paper
• Gbetagamma stimulates phosphoinositide 3-kinase-gamma by direct interaction with two domains of the catalytic p110 subunit.

  1998cited by this paper
• The G beta gamma sensitivity of a PI3K is dependent upon a tightly associated adaptor, p101.

  1997cited by this paper
• Expression and hormonal regulation of transcription factors GATA-4 and GATA-6 in the mouse ovary.

  1997cited by this paper
• Protein kinase C-zeta mediates angiotensin II activation of ERK1/2 in vascular smooth muscle cells.

  1997cited by this paper
• Endothelial cell tyrosine kinase receptor and G protein-coupled receptor activation involves distinct protein kinase C isoforms.

  1996cited by this paper
• Thrombin potently stimulates cytokine production in human vascular smooth muscle cells but not in mononuclear phagocytes.

  1996cited by this paper
• Regulation of GATA-2 Phosphorylation by Mitogen-activated Protein Kinase and Interleukin-3 (*)

  1995cited by this paper
• Evidence for a role of MEK and MAPK during signal transduction by protein kinase C zeta.

  1995cited by this paper
• Vascular smooth muscle cell migration mediated by thrombin and urokinase receptor.

  1995cited by this paper
• Protein kinase C and lipid signaling for sustained cellular responses

  1995cited by this paper
• Ligand-dependent repression of the erythroid transcription factor GATA-1 by the estrogen receptor

  1995cited by this paper
• Cell Type-specific Transactivation of the VCAM-1 Promoter through an NF-κB Enhancer Motif (*)

  1995cited by this paper
• Endothelial interferon regulatory factor 1 cooperates with NF-kappa B as a transcriptional activator of vascular cell adhesion molecule 1

  1995cited by this paper
• Sp1 Is a Component of the Cytokine-inducible Enhancer in the Promoter of Vascular Cell Adhesion Molecule-1 *

  1995cited by this paper
• Activation of protein kinase C family members by the novel polyphosphoinositides PtdIns-3,4-P2 and PtdIns-3,4,5-P3.

  1994cited by this paper
• Proton conductance of the plasma membrane: properties, regulation, and functional role.

  1993cited by this paper
• Identification of a role of the vitronectin receptor and protein kinase C in the induction of endothelial cell vascular formation

  1993cited by this paper
• Shear stress regulates endothelin-1 release via protein kinase C and cGMP in cultured endothelial cells.

  1993cited by this paper
• Activation of the zeta isozyme of protein kinase C by phosphatidylinositol 3,4,5-trisphosphate.

  1993cited by this paper
• Inducible expression of vascular cell adhesion molecule-1 by vascular smooth muscle cells in vitro and within rabbit atheroma.

  1993cited by this paper
• Thrombin stimulates proliferation of cultured rat aortic smooth muscle cells by a proteolytically activated receptor.

  1993cited by this paper
• Fluid shear stress stimulates platelet-derived growth factor expression in endothelial cells.

  1993cited by this paper
• Differential activation of p44mapk (ERK1) by alpha-thrombin and thrombin-receptor peptide agonist.

  1993cited by this paper
• Differential regulation of vascular cell adhesion molecule 1 gene expression by specific NF-kappa B subunits in endothelial and epithelial cells

  1993cited by this paper
• The role of protein kinase C in the induction of VCAM‐1 expression on human umbilical vein endothelial cells

  1993cited by this paper
• Functional analysis of the human vascular cell adhesion molecule 1 promoter

  1992cited by this paper
• Characterization of the promoter for vascular cell adhesion molecule-1 (VCAM-1).

  1992cited by this paper
• Direct expression cloning of vascular cell adhesion molecule 1, a cytokine-induced endothelial protein that binds to lymphocytes.

  1989cited by this paper
• Eukaryotic gene transcription with purified components.

  1983cited by this paper

• Astrocytic ET‐1 System Determines Microglia Phenotype Following Spinal Cord Injury

  2025cites this paper
• SCAR-6 elncRNA locus epigenetically regulates PROZ and modulates coagulation and vascular function

  2024cites this paper
• PKCδ regulates the vascular biology in diabetic atherosclerosis

  2023cites this paper
• PAR4 Inhibition Reduces Coronary Artery Atherosclerosis and Myocardial Fibrosis in SR-B1/LDLR Double Knockout Mice

  2023cites this paper
• An siRNA library screen identifies CYLD and USP34 as deubiquitinases that regulate GPCR-p38 MAPK signaling and distinct inflammatory responses

  2023cites this paper
• Transcriptomic Profiling of Femoral Veins in Deep Vein Thrombosis in a Porcine Model

  2021cites this paper
• miRNAs as cell fate determinants of lateral and paraxial mesoderm differentiation from embryonic stem cells.

  2021cites this paper
• Anthocyanins reduce inflammation and improve glucose and lipid metabolism associated with inhibiting nuclear factor-kappaB activation and increasing PPAR-γ gene expression in metabolic syndrome subjects.

  2020cites this paper
• Liganded T3 receptor β2 inhibits the positive feedback autoregulation of the gene for GATA2, a transcription factor critical for thyrotropin production

  2020cites this paper
• The novel exchange protein activated by cyclic AMP 1 (EPAC1) agonist, I942, regulates inflammatory gene expression in human umbilical vascular endothelial cells (HUVECs)

  2019cites this paper
• Passing the Vascular Barrier: Endothelial Signaling Processes Controlling Extravasation.

  2019cites this paper
• Selol (Se IV) modulates adhesive molecules in control and TNF-α-stimulated HMEC-1 cells.

  2019cites this paper
• Involvement of growth factors in diabetes mellitus and its complications: A general review.

  2018cites this paper
• Impaired Vascular Redox Signaling in the Vascular Complications of Obesity and Diabetes Mellitus

  2017cites this paper
• Sinigrin attenuates the progression of atherosclerosis in ApoE-/- mice fed a high-cholesterol diet potentially by inhibiting VCAM-1 expression.

  2017cites this paper
• Activation of PKC-δ in HTLV-1-infected T cells.

  2015cites this paper
• Thiram activates NF-kappaB and enhances ICAM-1 expression in human microvascular endothelial HMEC-1 cells.

  2015cites this paper
• Ramalin inhibits VCAM-1 expression and adhesion of monocyte to vascular smooth muscle cells through MAPK and PADI4-dependent NF-kB and AP-1 pathways

  2015cites this paper
• ExpressionNonhematopoietic Vascular PECAM-1 Neutrophil Chemotaxis by Regulating Endothelial LSP1 Modulates Extravascular

  2015influential citation
• Endothelial LSP1 Modulates Extravascular Neutrophil Chemotaxis by Regulating Nonhematopoietic Vascular PECAM-1 Expression

  2015influential citation
• Growth arrest‐specific 6 regulates thrombin‐induced expression of vascular cell adhesion molecule‐1 through forkhead box O1 in endothelial cells

  2015cites this paper
• MicroRNA-146 inhibits thrombin-induced NF-κB activation and subsequent inflammatory responses in human retinal endothelial cells.

  2014cites this paper
• Pulmonary endothelial protein kinase C-delta (PKCδ) regulates neutrophil migration in acute lung inflammation.

  2014cites this paper
• Interference with Akt Signaling Protects Against Myocardial Infarction and Death by Limiting the Consequences of Oxidative Stress

  2013cites this paper
• Identification and characterization of a novel porcine endothelial cell‐specific Tie1 promoter

  2013cites this paper
• The HCMV gH/gL/UL128-131 Complex Triggers the Specific Cellular Activation Required for Efficient Viral Internalization into Target Monocytes

  2013cites this paper
• The Association between Polymorphisms in the MRPL4 and TNF-α Genes and Susceptibility to Allergic Rhinitis

  2013cites this paper
• Protein Kinase C and Acute Respiratory Distress Syndrome

  2013cites this paper
• Adhesion Molecule Regulation of Regulatory T Cell Migration

  2013cites this paper
• Chlorophyll-Related Compounds Inhibit Cell Adhesion and Inflammation in Human Aortic Cells

  2013cites this paper
• Inhibition of Protein Kinase C β2 Prevents Tumor Necrosis Factor-α-Induced Apoptosis and Oxidative Stress in Endothelial Cells: The Role of NADPH Oxidase Subunits

  2012cites this paper
• Dynamical Systems Approach to Endothelial Heterogeneity

  2012cites this paper
• Genetic disruption of protein kinase Cδ reduces endotoxin-induced lung injury.

  2012cites this paper
• Hyperglycemia and Endothelial Dysfunction in Atherosclerosis: Lessons from Type 1 Diabetes

  2012cites this paper
• Stereocalpin A inhibits the expression of adhesion molecules in activated vascular smooth muscle cells.

  2012cites this paper
• Sulforaphane suppresses vascular adhesion molecule-1 expression in TNF-α-stimulated mouse vascular smooth muscle cells: involvement of the MAPK, NF-κB and AP-1 signaling pathways.

  2012cites this paper
• Dabigatran etexilate: Another Double-Edged Drug?

  2012cites this paper
• 1α,25-Dihydroxyvitamin D(3) inhibits vascular cellular adhesion molecule-1 expression and interleukin-8 production in human coronary arterial endothelial cells.

  2012cites this paper
• GATA2 Mediates Thyrotropin-Releasing Hormone-Induced Transcriptional Activation of the Thyrotropin β Gene

  2011cites this paper
• Thrombin induces MCP-1 expression through Rho-kinase and subsequent p38MAPK/NF-κB signaling pathway activation in vascular endothelial cells.

  2011cites this paper
• Genome-Wide Approaches Reveal Functional Interleukin-4-Inducible STAT6 Binding to the Vascular Cell Adhesion Molecule 1 Promoter

  2011cites this paper
• Protection against sepsis‐induced lung injury by selective inhibition of protein kinase C‐δ (δ‐PKC)

  2011cites this paper
• Negative Regulation of the Thyrotropin β Gene by Thyroid Hormone

  2011cites this paper
• Docosahexaenoic acid attenuates VCAM-1 expression and NF-κB activation in TNF-α-treated human aortic endothelial cells.

  2011cites this paper
• Blocking NF-κB: an inflammatory issue.

  2011cites this paper
• HGF-promoted motility in primary human melanocytes depends on CD44v6 regulated via NF-kappa B, Egr-1, and C/EBP-beta.

  2010cites this paper
• Histamine modulation of peripheral CRH receptor type 1alpha expression is dependent on Ca(2+) signalling and NF-kappaB/p65 transcriptional activity.

  2010cites this paper
• Thrombin-dependent NF-κB Activation and Monocyte/Endothelial Adhesion Are Mediated by the CARMA3·Bcl10·MALT1 Signalosome*

  2010cites this paper
• Ca2+ Entry via TRPC Channels Is Necessary for Thrombin-induced NF-κB Activation in Endothelial Cells through AMP-activated Protein Kinase and Protein Kinase Cδ*

  2009cites this paper
• Receptor tyrosine kinase EphA2 mediates thrombin-induced upregulation of ICAM-1 in endothelial cells in vitro.

  2009cites this paper
• Canonical Wnt pathway signaling suppresses VCAM-1 expression by marrow stromal and hematopoietic cells.

  2009cites this paper
• Role of 3&bgr;-Hydroxysteroid-&Dgr;24 Reductase in Mediating Antiinflammatory Effects of High-Density Lipoproteins in Endothelial Cells

  2009cites this paper
• Role of protein kinase C beta2 activation in TNF-alpha-induced human vascular endothelial cell apoptosis.

  2009cites this paper
• Critical Role for GATA3 in Mediating Tie2 Expression and Function in Large Vessel Endothelial Cells*

  2009cites this paper
• A +220 GATA motif mediates basal but not endotoxin‐repressible expression of the von Willebrand factor promoter in Hprt‐targeted transgenic mice

  2009cites this paper
• Is thrombin a key player in the 'coagulation-atherogenesis' maze?

  2009cites this paper
• Priming effect of homocysteine on inducible vascular cell adhesion molecule-1 expression in endothelial cells.

  2008cites this paper
• Lipopolysaccharide induces VCAM-1 expression and neutrophil adhesion to human tracheal smooth muscle cells: involvement of Src/EGFR/PI3-K/Akt pathway.

  2008cites this paper
• The anti-tumor agent, ingenol-3-angelate (PEP005), promotes the recruitment of cytotoxic neutrophils by activation of vascular endothelial cells in a PKC-δ dependent manner

  2008cites this paper
• Clenbuterol increases muscle fiber size and GATA‐2 protein in rat skeletal muscle in utero

  2008cites this paper
• Thrombin and protease-activated receptors (PARs) in atherothrombosis

  2008cites this paper
• Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules.

  2008cites this paper
• Roles of integrin activation in eosinophil function and the eosinophilic inflammation of asthma

  2008cites this paper
• Difference in gene expression of macrophage between normal spleen and portal hypertensive spleen identified by cDNA microarray.

  2007cites this paper
• Homocysteine induces VCAM-1 gene expression through NF-kappaB and NAD(P)H oxidase activation: protective role of Mediterranean diet polyphenolic antioxidants.

  2007cites this paper
• Endothelial-Dependent Mechanisms of Leukocyte Recruitment to the Vascular Wall

  2007cites this paper
• Regulation of endothelial nitric oxide synthase by thrombin.

  2007cites this paper
• Gypenoside XLIX, a naturally occurring PPAR-alpha activator, inhibits cytokine-induced vascular cell adhesion molecule-1 expression and activity in human endothelial cells.

  2007cites this paper
• Intertwining of thrombosis and inflammation in atherosclerosis

  2007cites this paper
• Endothelial cell responses to thrombin and shear stress

  2007cites this paper
• C-reactive protein induces VCAM-1 gene expression through NF-kappaB activation in vascular endothelial cells.

  2006cites this paper
• Mechanisms of apoptosis-induction by rottlerin: therapeutic implications for B-CLL

  2006cites this paper
• Inhibitory effects of polymyxin B on NF-kappaB activation and expression of procollagen I, III in pre-eclamptic umbilical artery smooth muscle cells.

  2006cites this paper
• Ca2+ Influx Induced by Protease-activated Receptor-1 Activates a Feed-forward Mechanism of TRPC1 Expression via Nuclear Factor-κB Activation in Endothelial Cells*

  2006cites this paper
• Biological responses to PDGF-BB versus PDGF-DD in human mesangial cells.

  2006cites this paper
• Linking stress to inflammation.

  2006cites this paper
• Thrombin-induced Autoinhibitory Factor, Down Syndrome Critical Region-1, Attenuates NFAT-dependent Vascular Cell Adhesion Molecule-1 Expression and Inflammation in the Endothelium*

  2006cites this paper
• Histone Deacetylase Inhibitor Reduces Monocyte Adhesion to Endothelium Through the Suppression of Vascular Cell Adhesion Molecule-1 Expression

  2006cites this paper
• Activation of Protein Kinase Cζ by Peroxynitrite Regulates LKB1-dependent AMP-activated Protein Kinase in Cultured Endothelial Cells*

  2006cites this paper
• ERK is an anti-inflammatory signal that suppresses expression of NF-kappaB-dependent inflammatory genes by inhibiting IKK activity in endothelial cells.

  2006cites this paper
• Role of focal adhesion kinase and phosphatidylinositol 3'-kinase in integrin fibronectin receptor-mediated, matrix metalloproteinase-1-dependent invasion by metastatic prostate cancer cells.

  2006cites this paper
• Anthocyanins from soybean seed coat inhibit the expression of TNF‐α‐induced genes associated with ischemia/reperfusion in endothelial cell by NF‐κB‐dependent pathway and reduce rat myocardial damages incurred by ischemia and reperfusion in vivo

  2006cites this paper
• Preconditioning of primary human endothelial cells with inflammatory mediators alters the “set point” of the cell

  2005influential citation
• Diabetic Vascular Disease : Pathophysiological Mechanisms in the Diabetic Milieu and Therapeutic Implications

  2005cites this paper
• Glycogen Synthase Kinase-3 Mediates Endothelial Cell Activation by Tumor Necrosis Factor-α

  2005cites this paper
• Diabetic Vascular Disease : Pathophysiological Mechanisms in the Diabetic Milieu and Therapeutic Implications

  2005cites this paper
• TNF-Related Activation-Induced Cytokine Enhances Leukocyte Adhesiveness: Induction of ICAM-1 and VCAM-1 via TNF Receptor-Associated Factor and Protein Kinase C-Dependent NF-κB Activation in Endothelial Cells1

  2005cites this paper
• Proteinase-activated receptors: transducers of proteinase-mediated signaling in inflammation and immune response.

  2005cites this paper
• Thrombin, TNF-alpha, and LPS exert overlapping but nonidentical effects on gene expression in endothelial cells and vascular smooth muscle cells.

  2005cites this paper
• Proatherosclerotic Mechanisms Involving Protein Kinase C in Diabetes and Insulin Resistance

  2005cites this paper
• Inhibition of Mammalian Target of Rapamycin Potentiates Thrombin-Induced Intercellular Adhesion Molecule-1 Expression by Accelerating and Stabilizing NF-κB Activation in Endothelial Cells 1

  2005cites this paper
• Hepatocyte Growth Factor Suppresses Vascular Endothelial Growth Factor–Induced Expression of Endothelial ICAM-1 and VCAM-1 by Inhibiting the Nuclear Factor-&kgr;B Pathway

  2005cites this paper
• Selective Inhibition of Protein Kinase Cβ2 Prevents Acute Effects of High Glucose on Vascular Cell Adhesion Molecule-1 Expression in Human Endothelial Cells

  2004cites this paper
• Gene Expression Phenotypes of Atherosclerosis

  2004cites this paper
• Vascular endothelial growth factor-mediated induction of manganese superoxide dismutase occurs through redox-dependent regulation of forkhead and IkappaB/NF-kappaB.

  2004cites this paper
• Protein kinase Cdelta mediates lysophosphatidic acid-induced NF-kappaB activation and interleukin-8 secretion in human bronchial epithelial cells.

  2004cites this paper
• 15-deoxy prostaglandin J2 enhances allyl alcohol-induced toxicity in rat hepatocytes.

  2004cites this paper
• Learning the codes of fly immunity.

  2004cites this paper
• Role of CL-100, a Dual Specificity Phosphatase, in Thrombin-induced Endothelial Cell Activation*

  2004cites this paper
• Role of PKC-delta during hypoxia in heart-derived H9c2 cells.

  2004cites this paper