Extracellular Vesicles Involvement in the Modulation of the Glioblastoma Environment

Glioblastoma (GBM) is the most deadly primary brain tumour and is a paradigmatic example of heterogeneous cancer. Although expanding data propose the phenotypic plasticity exhibited by glioblastoma cells, as a critical feature involved in the tumour development and posttherapy recurrence, the central machinery responsible for their aggressiveness remains elusive. Despite decades of research, the complex biology of the glioblastoma is still unknown. Progress in genetic and epigenetic discoveries has improved diagnostic classification, prognostic information, and therapeutic planning. In the complex model of intercellular signalling, several studies have shown that extracellular vesicles have a key role in the intercellular communication among GBM cells and the tumour microenvironment modulation. The purpose of this review is to summarize the role of the EV-mediated intercellular crosstalk in the glioblastoma physiopathology.

• Publication year

  2020

• Venue

  Journal of Oncology

• Publication date

  2020-01-28

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1155/2020/3961735PMID 32411235PMCID 7204270
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Link Among Neurological Diseases: Extracellular Vesicles as a Possible Brain Injury Footprint.

  2019cited by this paper
• Proteomics characterization of extracellular vesicles sorted by flow cytometry reveals a disease-specific molecular cross-talk from cerebrospinal fluid and tears in multiple sclerosis.

  2019cited by this paper
• Large oncosomes overexpressing integrin alpha-V promote prostate cancer adhesion and invasion via AKT activation

  2019cited by this paper
• Platelet-Derived Microparticles From Obese Individuals: Characterization of Number, Size, Proteomics, and Crosstalk With Cancer and Endothelial Cells

  2019cited by this paper
• Extracellular Vesicles and Their Potential Use in Monitoring Cancer Progression and Therapy: The Contribution of Proteomics

  2019cited by this paper
• Extracellular vesicles: important collaborators in cancer progression.

  2018cited by this paper
• Enhanced release of acid sphingomyelinase-enriched exosomes generates a lipidomics signature in CSF of Multiple Sclerosis patients

  2018cited by this paper
• Imaging Genetic Heterogeneity in Glioblastoma and Other Glial Tumors: Review of Current Methods and Future Directions.

  2018influential reference
• MiR-134, epigenetically silenced in gliomas, could mitigate the malignant phenotype by targeting KRAS

  2018cited by this paper
• Extracellular Vesicles: Multimodal Envoys in Neural Maintenance and Repair

  2018cited by this paper
• DOCK4 promotes loss of proliferation in glioblastoma progenitor cells through nuclear beta-catenin accumulation and subsequent miR-302-367 cluster expression

  2018cited by this paper
• Eph/ephrin family anchored on exosome facilitate communications between cells

  2018cited by this paper
• Changes in chromatin state reveal ARNT2 at a node of a tumorigenic transcription factor signature driving glioblastoma cell aggressiveness

  2017cited by this paper
• Advances in Experimental Targeted Therapy and Immunotherapy for Patients with Glioblastoma Multiforme.

  2017cited by this paper
• Circulating endothelial cell-derived extracellular vesicles mediate the acute phase response and sickness behaviour associated with CNS inflammation

  2017cited by this paper
• Epigenetic silencing of miR-338 facilitates glioblastoma progression by de-repressing the pyruvate kinase M2-β-catenin axis

  2017cited by this paper
• Astrocyte-shed extracellular vesicles regulate the peripheral leukocyte response to inflammatory brain lesions

  2017cited by this paper
• Diagnostic and Therapeutic Biomarkers in Glioblastoma: Current Status and Future Perspectives

  2017cited by this paper
• Glioblastoma targeted therapy: updated approaches from recent biological insights

  2017influential reference
• Correlation of immune phenotype with IDH mutation in diffuse glioma

  2017cited by this paper
• Glioma stem cells-derived exosomes promote the angiogenic ability of endothelial cells through miR-21/VEGF signal

  2017cited by this paper
• Extracellular Vesicles in Brain Tumors and Neurodegenerative Diseases

  2017influential reference
• Sorting Tubules Regulate Blood-Brain Barrier Transcytosis.

  2017cited by this paper
• Spitting out the demons: Extracellular vesicles in glioblastoma

  2017cited by this paper
• Lipoxin A4 stimulates endothelial miR‐126–5p expression and its transfer via microvesicles

  2017cited by this paper
• Microparticles as new markers of cardiovascular risk in diabetes and beyond

  2016cited by this paper
• Exosomes as new diagnostic tools in CNS diseases.

  2016cited by this paper
• Diffuse Midline Gliomas with Histone H3‐K27M Mutation: A Series of 47 Cases Assessing the Spectrum of Morphologic Variation and Associated Genetic Alterations

  2016cited by this paper
• Evolving Molecular Genetics of Glioblastoma

  2016cited by this paper
• The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

  2016cited by this paper
• IDH mutation and MGMT promoter methylation are associated with the pseudoprogression and improved prognosis of glioblastoma multiforme patients who have undergone concurrent and adjuvant temozolomide-based chemoradiotherapy.

  2016cited by this paper
• Glioblastoma: exosome and microRNA as novel diagnosis biomarkers

  2016cited by this paper
• Hallmarks of glioblastoma: a systematic review

  2016cited by this paper
• MicroRNA and extracellular vesicles in glioblastoma: small but powerful

  2016cited by this paper
• Exosomes isolated from plasma of glioma patients enrolled in a vaccination trial reflect antitumor immune activity and might predict survival

  2015cited by this paper
• miRNA contents of cerebrospinal fluid extracellular vesicles in glioblastoma patients

  2015cited by this paper
• Biomarker-driven diagnosis of diffuse gliomas.

  2015cited by this paper
• Diagnostic, prognostic and predictive relevance of molecular markers in gliomas

  2015cited by this paper
• Molecular and Genomic Alterations in Glioblastoma Multiforme.

  2015cited by this paper
• Chip-based analysis of exosomal mRNA mediating drug resistance in glioblastoma

  2015cited by this paper
• Ephs and Ephrins in malignant gliomas

  2014cited by this paper
• Farewell to oligoastrocytoma: in situ molecular genetics favor classification as either oligodendroglioma or astrocytoma

  2014cited by this paper
• ATRX mRNA expression combined with IDH1/2 mutational status and Ki-67 expression refines the molecular classification of astrocytic tumors: evidence from the whole transcriptome sequencing of 169 samples

  2014cited by this paper
• Extracellular vesicles modulate the glioblastoma microenvironment via a tumor suppression signaling network directed by miR-1.

  2014cited by this paper
• Eph receptors as therapeutic targets in glioblastoma

  2014cited by this paper
• The role of extracellular vesicles in the progression of neurodegenerative disease and cancer.

  2014cited by this paper
• Transcytosis of macromolecules at the blood-brain barrier.

  2014cited by this paper
• Conversion of differentiated cancer cells into cancer stem-like cells in a glioblastoma model after primary chemotherapy

  2014cited by this paper
• Combined analysis of TERT, EGFR, and IDH status defines distinct prognostic glioblastoma classes

  2014influential reference
• Emerging Roles of Extracellular Vesicles in the Nervous System

  2014cited by this paper
• A small noncoding RNA signature found in exosomes of GBM patient serum as a diagnostic tool.

  2014cited by this paper
• Biogenesis, secretion, and intercellular interactions of exosomes and other extracellular vesicles.

  2014cited by this paper
• RNA-seq of 272 gliomas revealed a novel, recurrent PTPRZ1-MET fusion transcript in secondary glioblastomas

  2014cited by this paper
• Interactions of miR-323/miR-326/miR-329 and miR-130a/miR-155/miR-210 as prognostic indicators for clinical outcome of glioblastoma patients

  2013cited by this paper
• As we wait: coping with an imperfect nomenclature for extracellular vesicles

  2013cited by this paper
• Exosomes reflect the hypoxic status of glioma cells and mediate hypoxia-dependent activation of vascular cells during tumor development

  2013cited by this paper
• ATRX loss refines the classification of anaplastic gliomas and identifies a subgroup of IDH mutant astrocytic tumors with better prognosis

  2013cited by this paper
• Glioma microvesicles carry selectively packaged coding and non-coding RNAs which alter gene expression in recipient cells

  2013cited by this paper
• Corrigendum: Comprehensive genomic characterization defines human glioblastoma genes and core pathways

  2013cited by this paper
• Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma

  2013cited by this paper
• Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in glioblastoma.

  2013cited by this paper
• BM mesenchymal stromal cell-derived exosomes facilitate multiple myeloma progression.

  2013cited by this paper
• Exosomes: Vehicles for the Transfer of Toxic Proteins Associated with Neurodegenerative Diseases?

  2012cited by this paper
• Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

  2012cited by this paper
• A novel flow cytometric approach to distinguish circulating endothelial cells from endothelial microparticles: relevance for the evaluation of endothelial dysfunction.

  2012cited by this paper
• MiR-328 Expression Is Decreased in High-Grade Gliomas and Is Associated with Worse Survival in Primary Glioblastoma

  2012cited by this paper
• Classification, Functions, and Clinical Relevance of Extracellular Vesicles

  2012cited by this paper
• Transforming Fusions of FGFR and TACC Genes in Human Glioblastoma

  2012cited by this paper
• Gesicles: Microvesicle "cookies" for transient information transfer between cells.

  2011cited by this paper
• Role of Eph/ephrin tyrosine kinase in malignant glioma.

  2011cited by this paper
• Gene silencing by microRNAs: contributions of translational repression and mRNA decay

  2011cited by this paper
• Genetic profile of astrocytic and oligodendroglial gliomas

  2011cited by this paper
• Hallmarks of cancer: the next generation.

  2011cited by this paper
• Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells.

  2011cited by this paper
• Signals and combinatorial functions of histone modifications.

  2011cited by this paper
• The role of microparticles in the pathogenesis of rheumatic diseases

  2010cited by this paper
• The majority of circulating platelet-derived microparticles fail to bind annexin V, lack phospholipid-dependent procoagulant activity and demonstrate greater expression of glycoprotein Ib

  2010cited by this paper
• Non-coding RNAs: Identification of Cancer-Associated microRNAs by Gene Profiling

  2010cited by this paper
• New mechanism for Notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes.

  2010cited by this paper
• Exosomes--vesicular carriers for intercellular communication.

  2009cited by this paper
• Membrane vesicles as conveyors of immune responses

  2009cited by this paper
• IDH1 and IDH2 mutations in gliomas.

  2009cited by this paper
• Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR

  2009cited by this paper
• Glioblastoma microvesicles transport RNA and protein that promote tumor growth and provide diagnostic biomarkers

  2008cited by this paper
• Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells

  2008influential reference
• Whole-genome analysis of histone H3 lysine 4 and lysine 27 methylation in human embryonic stem cells.

  2007cited by this paper
• Whole-genome mapping of histone H3 Lys4 and 27 trimethylations reveals distinct genomic compartments in human embryonic stem cells.

  2007cited by this paper
• Molecular targets of glioma invasion

  2007cited by this paper
• Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma.

  2005cited by this paper
• Apoptotic bodies from endothelial cells enhance the number and initiate the differentiation of human endothelial progenitor cells in vitro.

  2004cited by this paper
• Disruption of Eph/ephrin signaling affects migration and proliferation in the adult subventricular zone

  2000cited by this paper
• B lymphocytes secrete antigen-presenting vesicles

  1996cited by this paper
• Cellular and Molecular Life Sciences REVIEW Membrane vesicles, current state-of-the-art: emerging role of extracellular vesicles

  year unknowninfluential reference

• Xenoline-polarized macrophages as an alternative in vitro model of tumor-associated macrophages in glioblastoma

  2025cites this paper
• Xenoline-polarized macrophages as a physiologically relevant in vitro model of tumor-associated macrophages in glioblastoma

  2025cites this paper
• Exosomal miR-21-5p from glioma associated mesenchymal stem cells promotes the progression and glycolysis of glioblastoma via PDHA1

  2025cites this paper
• Glioblastoma Cells Express and Secrete Alternatively Spliced Transcripts of Coagulation Factor X

  2025cites this paper
• Emerging Frontiers in Neuro-Oncology: Insights into Extracellular Vesicle-Driven Tumor Mechanisms and Nanotherapeutic Strategies

  2025cites this paper
• Roles of extracellular vesicles in glioblastoma: foes, friends and informers

  2023cites this paper
• A Novel Insight into Paraptosis-Related Classification and Signature in Lower-Grade Gliomas

  2022cites this paper
• Targeted Extracellular Vesicles Delivered Verrucarin A to Treat Glioblastoma

  2022influential citation
• Tumor Microenvironment in Glioma Invasion

  2022cites this paper
• The role of liquid biopsy in the diagnosis of glioblastoma progression

  2022cites this paper
• Artificial intelligence-based locoregional markers of brain peritumoral microenvironment

  2022cites this paper
• Extracellular Vesicle-Mediated Bilateral Communication between Glioblastoma and Astrocytes.

  2020cites this paper
• The role of extracellular vesicles in the diagnosis of glioblastoma progression

  2020cites this paper
• Circulating extracellular vesicles as new inflammation marker in hiv infection.

  2020cites this paper