Ex situ gas generation for lab scale organic synthesis

Synthetic organic reactions involving gaseous reagents are frequently avoided in the research lab for practical and safety reasons. Nevertheless, reactive gases often represent convenient building blocks with high potential for atom economy. This review article aims at highlighting ex situ gas generation methods as safe and easily executable procedures for organic synthesis. Especially the advent of two-chamber type reactors has been responsible for the renewed interest in gas–liquid biphasic transformations. With the exemption of carbon monoxide, a discussion is provided on the scientific work from the last decade which employs ex situ generated gaseous reagents, produced on-demand and in a place other than the reaction mixture itself. Features of these protocols which are especially appealing to a laboratory bench-scale context will be underscored, with an emphasis on safety and synthetic diversity allowed by the gas-mediated reactions.

• Publication year

  2020

• Venue

  Reaction Chemistry and Engineering

• Publication date

  2020-03-31

• Fields of study

  Chemistry, Engineering, Environmental Science

• Identifiers
  DOI 10.1039/c9re00497a
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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