The potential role of metformin in the treatment of Parkinson's disease

No abstract is available for this paper.

• Publication year

  2020

• Venue

  Journal of Bio-X Research

• Publication date

  2020-02-25

• Fields of study

  Medicine

• Identifiers
  DOI 10.1097/jbr.0000000000000055
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Dopamine and Cognitive Control in Prefrontal Cortex.

  2019cited by this paper
• Crosstalk between mitochondrial dysfunction, oxidative stress, and age related neurodegenerative disease: Etiologies and therapeutic strategies

  2019cited by this paper
• Emerging pathways to neurodegeneration: Dissecting the critical molecular mechanisms in Alzheimer's disease, Parkinson's disease.

  2019cited by this paper
• The IRS/PI3K/Akt signaling pathway mediates olanzapine‐induced hepatic insulin resistance in male rats

  2019cited by this paper
• An attempt to elucidate the role of iron and zinc ions in development of Alzheimer's and Parkinson's diseases.

  2019cited by this paper
• The role of dopamine in the brain - lessons learned from Parkinson's disease

  2019cited by this paper
• Evidence of metabolic memory-induced neurodegeneration and the therapeutic effects of glucagon-like peptide-1 receptor agonists via Forkhead box class O.

  2019cited by this paper
• The risk of Parkinson's disease in inflammatory bowel disease: A systematic review and meta-analysis.

  2019cited by this paper
• The beneficial roles of metformin on the brain with cerebral ischaemia/reperfusion injury.

  2019cited by this paper
• Protective role of metformin against methamphetamine induced anxiety, depression, cognition impairment and neurodegeneration in rat: The role of CREB/BDNF and Akt/GSK3 signaling pathways.

  2019cited by this paper
• Detrimental effect of type 2 diabetes mellitus in a large case series of Parkinson's disease.

  2019cited by this paper
• Parkinson Disease.

  2019cited by this paper
• Neurotrophic Factors and Their Receptors Are Altered by the Mere Partial IGF-1 Deficiency.

  2019cited by this paper
• Parkinson's disease: Mechanisms, translational models and management strategies

  2019cited by this paper
• Alpha lipoic acid and metformin alleviates experimentally induced insulin resistance and cognitive deficit by modulation of TLR2 signalling

  2019cited by this paper
• Parkinson's disease: A review

  2018cited by this paper
• Metformin Administration During Early Postnatal Life Rescues Autistic-Like Behaviors in the BTBR T+ Itpr3tf/J Mouse Model of Autism

  2018cited by this paper
• Impact of in vitro heavy metal exposure on pancreatic β-cell function.

  2018cited by this paper
• Insulin Confers Differing Effects on Neurite Outgrowth in Separate Populations of Cultured Dorsal Root Ganglion Neurons: The Role of the Insulin Receptor

  2018cited by this paper
• Molecular mechanisms of α-synuclein and GBA1 in Parkinson’s disease

  2018cited by this paper
• Targeting AMPK Signaling as a Neuroprotective Strategy in Parkinson’s Disease

  2018cited by this paper
• Global, regional, and national burden of Parkinson's disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

  2018cited by this paper
• Progress in defining the genetic contribution to type 2 diabetes susceptibility.

  2018cited by this paper
• Reduced Cortical Excitability, Neuroplasticity, and Salivary Cortisol in 11–13-Year-Old Children Born to Women with Gestational Diabetes Mellitus

  2018cited by this paper
• Use of Metformin for Weight Management in Children and Adolescents With Obesity in the Clinical Setting

  2018cited by this paper
• A Parkinson's disease gene, DJ-1, regulates astrogliosis through STAT3.

  2018cited by this paper
• Review of Metformin Use for Type 2 Diabetes Prevention.

  2018cited by this paper
• A preclinical overview of metformin for the treatment of type 2 diabetes.

  2018cited by this paper
• The effects of safranal, a constitute of saffron, and metformin on spatial learning and memory impairments in type-1 diabetic rats: behavioral and hippocampal histopathological and biochemical evaluations.

  2018cited by this paper
• LRRK2 Kinase Activity Induces Mitochondrial Fission in Microglia via Drp1 and Modulates Neuroinflammation

  2018cited by this paper
• Insulin signalling promotes dendrite and synapse regeneration and restores circuit function after axonal injury

  2018cited by this paper
• The beneficial effects of Zn on Akt-mediated insulin and cell survival signaling pathways in diabetes.

  2018cited by this paper
• Single Heterozygous ATP13A2 Mutations Cause Cellular Dysfunction Associated with Parkinson's Disease

  2018cited by this paper
• Metformin in cancer.

  2018cited by this paper
• GLP‐1 receptor agonists show neuroprotective effects in animal models of diabetes

  2018cited by this paper
• Disease Mechanisms-Parkinson's Disease

  2018cited by this paper
• In the Clinic-Parkinsonʼs Disease: Bilateral Deep Brain Stimulation Improves Non-Motor Symptoms of Parkinsonʼs Disease Two Years After Surgery

  2018cited by this paper
• Economic Burden Analysis of Parkinson's Disease Patients in China

  2017cited by this paper
• Metformin lowers α-synuclein phosphorylation and upregulates neurotrophic factor in the MPTP mouse model of Parkinson's disease.

  2017cited by this paper
• Amnestic dementia impairment in Parkinson's disease: The role of body composition, ageing and insulin resistance.

  2017cited by this paper
• Metformin and blood pressure lowering: a questioned association.

  2017cited by this paper
• Age, age at diagnosis and diabetes duration are all associated with vascular complications in type 2 diabetes.

  2017cited by this paper
• Influence of diabetes mellitus on longitudinal atrophy and cognition in Parkinson's disease.

  2017cited by this paper
• Exposure to an enriched environment facilitates motor recovery and prevents short‐term memory impairment and reduction of striatal BDNF in a progressive pharmacological model of parkinsonism in mice

  2017cited by this paper
• Metformin Protects against Experimental Acrylamide Neuropathy in Rats

  2017cited by this paper
• Effects of metformin exposure on neurodegenerative diseases in elderly patients with type 2 diabetes mellitus.

  2017cited by this paper
• Cytoprotective mechanisms of DJ-1 against oxidative stress through modulating ERK1/2 and ASK1 signal transduction

  2017cited by this paper
• Metformin in adults with type 1 diabetes: Design and methods of REducing with MetfOrmin Vascular Adverse Lesions (REMOVAL): An international multicentre trial

  2017cited by this paper
• Clinical Outcomes of Metformin Use in Populations With Chronic Kidney Disease, Congestive Heart Failure, or Chronic Liver Disease

  2017cited by this paper
• Sleep Dysfunction in Parkinson's Disease.

  2017cited by this paper
• Mitochondrial dysfunction and oxidative stress in metabolic disorders - A step towards mitochondria based therapeutic strategies.

  2017cited by this paper
• Oxidative stress and NO generation in the rat pancreatitis induced by pancreatic duct ligation.

  2017cited by this paper
• Metformin, the aspirin of the 21st century: its role in gestational diabetes mellitus, prevention of preeclampsia and cancer, and the promotion of longevity

  2017cited by this paper
• Activation of AMPK is neuroprotective in the oxidative stress by advanced glycosylation end products in human neural stem cells

  2017cited by this paper
• Epidemiology, environmental risk factors and genetics of Parkinson's disease.

  2017cited by this paper
• Neuroactive steroids and diabetic complications in the nervous system.

  2017cited by this paper
• Diabetes, Gray Matter Loss, and Cognition in the Setting of Parkinson Disease.

  2016cited by this paper
• Metformin preconditioning provide neuroprotection through enhancement of autophagy and suppression of inflammation and apoptosis after spinal cord injury.

  2016cited by this paper
• Genetic susceptibility variants in parkinsonism.

  2016cited by this paper
• Antidiabetic drugs restore abnormal transport of amyloid-β across the blood-brain barrier and memory impairment in db/db mice.

  2016cited by this paper
• Prolonged metformin treatment leads to reduced transcription of Nrf2 and neurotrophic factors without cognitive impairment in older C57BL/6J mice.

  2016cited by this paper
• ROS-mediated glucose metabolic reprogram induces insulin resistance in type 2 diabetes.

  2016cited by this paper
• Potential effects of current drug therapies on cognitive impairment in patients with type 2 diabetes.

  2016cited by this paper
• Diabetes mellitus: The linkage between oxidative stress, inflammation, hypercoagulability and vascular complications.

  2016cited by this paper
• Autonomic dysfunction in Parkinson's disease associated with common glucocerebrosidase gene mutations

  2016cited by this paper
• Metformin alleviated EMT and fibrosis after renal ischemia–reperfusion injury in rats

  2016cited by this paper
• Converging roles of ion channels, calcium, metabolic stress, and activity pattern of Substantia nigra dopaminergic neurons in health and Parkinson's disease

  2016cited by this paper
• The epidemiology of Parkinson's disease: risk factors and prevention.

  2016cited by this paper
• The glucagon-like peptide 1 (GLP) receptor as a therapeutic target in Parkinson's disease: mechanisms of action.

  2016cited by this paper
• Association of Polymorphism of Neuronal Nitric Oxide Synthase Gene with Risk to Parkinson’s Disease

  2016cited by this paper
• Metformin, besides exhibiting strong in vivo anti-inflammatory properties, increases mptp-induced damage to the nigrostriatal dopaminergic system.

  2016cited by this paper
• Insulin resistance and Parkinson's disease: A new target for disease modification?

  2016cited by this paper
• Parkinson's disease: Autoimmunity and neuroinflammation.

  2016cited by this paper
• Beneficial Effect of Metformin on Nerve Regeneration and Functional Recovery After Sciatic Nerve Crush Injury in Diabetic Rats

  2016cited by this paper
• Immunologic Effects of Metformin and Pioglitazone Treatment on Metabolic Syndrome and Multiple Sclerosis.

  2016cited by this paper
• Activation of the insulin-signaling pathway in sciatic nerve and hippocampus of type 1 diabetic rats.

  2015cited by this paper
• MRI and oxidative stress markers in neurological worsening of Wilson disease following penicillamine.

  2015cited by this paper
• Synchrotron radiation X-ray fluorescence analysis of Fe, Zn and Cu in mice brain associated with Parkinson’s disease

  2015cited by this paper
• Inflammation is genetically implicated in Parkinson's disease.

  2015cited by this paper
• The neuroprotective role of metformin in advanced glycation end product treated human neural stem cells is AMPK-dependent.

  2015cited by this paper
• Metformin attenuates hyperalgesia and allodynia in rats with painful diabetic neuropathy induced by streptozotocin.

  2015cited by this paper
• Cobalamin status and its relation with depression, cognition and neuropathy in patients with type 2 diabetes mellitus using metformin

  2015cited by this paper
• Insulin resistance in brain alters dopamine turnover and causes behavioral disorders

  2015cited by this paper
• Parkinson’s disease-associated mutant VPS35 causes mitochondrial dysfunction by recycling DLP1 complexes

  2015cited by this paper
• Diabetes is associated with postural and cognitive domains in Parkinson's disease. Results from a single-center study.

  2014cited by this paper
• El estrés oxidativo en las enfermedades neurológicas: ¿causa o consecuencia?

  2014cited by this paper
• Novel action of metformin in the prevention of haloperidol-induced catalepsy in mice: Potential in the treatment of Parkinson's disease?

  2014cited by this paper
• Diabetes mellitus is independently associated with more severe cognitive impairment in Parkinson disease.

  2014cited by this paper
• Metformin protects against seizures, learning and memory impairments and oxidative damage induced by pentylenetetrazole-induced kindling in mice.

  2014cited by this paper
• Effect of Metformin on Ballooning Degeneration in Nonalcoholic Steatohepatitis (NASH): When to Use Metformin in Nonalcoholic Fatty Liver Disease (NAFLD)

  2014cited by this paper
• Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite–like aggregates

  2014cited by this paper
• Neuroprotective effect of metformin in MPTP-induced Parkinson's disease in mice.

  2014cited by this paper
• Metformin Eased Cognitive Impairment Induced by Chronic L-methionine Administration: Potential Role of Oxidative Stress

  2014cited by this paper
• Insulin/IGF1 signaling inhibits age-dependent axon regeneration.

  2014cited by this paper
• Effects of Metformin on the Cerebral Metabolic Changes in Type 2 Diabetic Patients

  2014cited by this paper
• Weight gain and increased central obesity in the early phase of Parkinson's disease.

  2014cited by this paper
• Insulin, IGF-1 and GLP-1 signaling in neurodegenerative disorders: targets for disease modification?

  2014cited by this paper
• Metformin in Gestational Diabetes Mellitus

  2014cited by this paper
• Pharmacodynamic and Therapeutic Investigation of Focused Ultrasound-Induced Blood-Brain Barrier Opening for Enhanced Temozolomide Delivery in Glioma Treatment

  2014cited by this paper
• Diabetes drugs and neurological disorders: new views and therapeutic possibilities.

  2014cited by this paper

• SGLT2 inhibitors vs. metformin for Parkinson's disease risk reduction in type 2 diabetes

  2025cites this paper
• Metformin as a potential neuroprotective agent that influence Parkinson’s disease

  2025cites this paper
• Associations of oral hypoglycemic use, fruit intake, and diabetes duration with gastrointestinal autonomic dysfunction in type 2 diabetes patients in Zanzibar

  2025cites this paper
• Influence of type 2 diabetes on Parkinson’s disease: emerging insights into pathogenesis and progression

  2025cites this paper
• Drug Repurposing of Metformin for the Treatment of Haloperidol-Related Behavior Disorders and Oxidative Stress: A Preliminary Study

  2024cites this paper
• Brain-specific targeted delivery of therapeutic agents using metal–organic framework-based nanomedicine

  2024cites this paper
• Caloric restriction mimetics improve gut microbiota: a promising neurotherapeutics approach for managing age-related neurodegenerative disorders

  2024cites this paper
• Benign outcomes of metformin for various diseases: A review

  2023cites this paper
• Metformin role in Parkinson’s disease: a double-sword effect

  2023influential citation
• The Molecular Mechanisms of the Relationship between Insulin Resistance and Parkinson’s Disease Pathogenesis

  2023cites this paper
• Importance of glucose and its metabolism in neurodegenerative disorder, as well as the combination of multiple therapeutic strategies targeting α-synuclein and neuroprotection in the treatment of Parkinson's disease.

  2023cites this paper
• The role of metformin as a treatment for neuropsychiatric illness.

  2022cites this paper
• Type 2 diabetes mellitus augments Parkinson's disease risk or the other way around: facts, challenges and future possibilities.

  2022cites this paper
• Inhibition of Microtubule Affinity Regulating Kinase 4 by Metformin: Exploring the Neuroprotective Potential of Antidiabetic Drug through Spectroscopic and Computational Approaches

  2022cites this paper
• The role of AMPK-dependent pathways in cellular and molecular mechanisms of metformin: a new perspective for treatment and prevention of diseases

  2022cites this paper
• Is carbonyl/AGE/RAGE stress a hallmark of the brain aging?

  2021cites this paper
• Beneficial effects of metformin on haloperidol-induced motor deficits in rats. A behavioral assessment

  2021cites this paper