A comparison of placebo effects in clinical analgesic trials versus studies of placebo analgesia

No abstract is available for this paper.

• Publication year

  2002

• Venue

  Pain

• Publication date

  2002-10-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1016/S0304-3959(02)00205-1PMID 12406519
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Response expectancies in placebo analgesia and their clinical relevance

  2001cited by this paper
• Is the placebo powerless? An analysis of clinical trials comparing placebo with no treatment.

  2001influential reference
• Response variability to analgesics: a role for non‐specific activation of endogenous opioids

  2001influential reference
• Assessing placebo effects without placebo groups: an untapped possibility?

  2001cited by this paper
• Expectations of analgesia do not affect spinal nociceptive R‐III reflex activity: an experimental study into the mechanism of placebo‐induced analgesia

  2000influential reference
• Somatotopic Activation of Opioid Systems by Target-Directed Expectations of Analgesia

  1999influential reference
• Lars Ole Andersen, Mogens H Claësson, Asbjørn Hróbjartsson and Anja Norbæk Sørensen, Placebo. Historie, biologi og effekt , Akademisk Forlag, 1997, pp. 178, illus. (87-500-3413-8).

  1999cited by this paper
• An analysis of factors that contribute to the magnitude of placebo analgesia in an experimental paradigm.

  1999influential reference
• Neuropharmacological Dissection of Placebo Analgesia: Expectation-Activated Opioid Systems versus Conditioning-Activated Specific Subsystems

  1999influential reference
• Control of postoperative pain by transcutaneous electrical nerve stimulation after thoracic operations.

  1997cited by this paper
• An investigation of the placebo effect and age‐related factors in the report of needle pain from venipuncture in children

  1997influential reference
• Classical conditioning and the placebo effect

  1997influential reference
• Mechanisms of Placebo Pain Reduction: An Empirical Investigation

  1996influential reference
• Cognitive-educational treatment of fibromyalgia: a randomized clinical trial. I. Clinical effects.

  1996cited by this paper
• Lidocaine patch: double‐blind controlled study of a new treatment method for post‐herpetic neuralgia

  1996cited by this paper
• The opposite effects of the opiate antagonist naloxone and the cholecystokinin antagonist proglumide on placebo analgesia

  1996influential reference
• A placebo controlled double blind trial to evaluate the effectiveness of pulsed short wave therapy for osteoarthritic hip and knee pain

  1996cited by this paper
• Randomised trial of oral morphine for chronic non-cancer pain.

  1996cited by this paper
• Potentiation of placebo analgesia by proglumide.

  1995influential reference
• Transcutaneous electrical nerve stimulator for procedural pain associated with intravenous needlesticks.

  1995cited by this paper
• Effects of stress management on clinical outcomes in rheumatoid arthritis.

  1995cited by this paper
• A randomized, placebo-controlled trial of exercise therapy in patients with acute low back pain.

  1994cited by this paper
• Effect of TENS on pain, medications, and pulmonary function following coronary artery bypass graft surgery.

  1994cited by this paper
• Is there logic in the placebo?

  1994cited by this paper
• Pain evaluation during carbon dioxide laser vaporization for cervical intraepithelial neoplasia: a randomized trial.

  1994cited by this paper
• Prophylactic penicillin: effect on posttreatment symptoms following root canal treatment of asymptomatic periapical pathosis.

  1993cited by this paper
• TENS for children's procedural pain

  1993cited by this paper
• A randomized, placebo-controlled trial of exercise therapy in patients with acute low back pain.

  1993cited by this paper
• Wirksamkeit der Akupunktur bei Patienten mit generalisierter Tendomyopathie (Fibromyalgie)

  1993cited by this paper
• Immediate Effects of Various Physical Medicine Modalities on Pain Threshold of an Active Myofascial Trigger Point

  1993cited by this paper
• The role of conditioning and verbal expectancy in the placebo response.

  1990influential reference
• Prevention of Breast Pain and Milk Secretion with Bromocriptine After Second‐Trimester Abortion

  1990cited by this paper
• Chiropractic adjustive manipulation on subjects with acute low back pain: visual analog pain scores and plasma beta-endorphin levels.

  1990cited by this paper
• Use of Transcutaneous Electrical Nerve Stimulation For Postoperative Pain

  1989cited by this paper
• Textbook of pain

  1989cited by this paper
• Conditioned response models of placebo phenomena: further support

  1989cited by this paper
• Reduction of postoperative pain and swelling by ultrasound treatment: a placebo effect

  1988influential reference
• Acupuncture for the management of primary dysmenorrhea

  1987cited by this paper
• General practice consultations: is there any point in being positive?

  1987influential reference
• Transcutaneous electrical nerve stimulation following appendicectomy: the placebo effect.

  1986cited by this paper
• Anti-inflammatory effects of ultrasound therapy: evidence for a major placebo effect.

  1986cited by this paper
• Transcutaneous electrical nerve stimulation following appendicectomy: the placebo effect.

  1986cited by this paper
• Conditioned placebo responses.

  1985cited by this paper
• CLINICIANS' EXPECTATIONS INFLUENCE PLACEBO ANALGESIA

  1985cited by this paper
• Clinicians' expectations influence placebo analgesia.

  1985cited by this paper
• Placebo Theory, Research , and Mechanisms

  1985cited by this paper
• Influence of the method of drug administration on analgesic response

  1984influential reference
• Explication and Implications of the Placebo Concept

  1984cited by this paper
• Partial antagonism of placebo analgesia by naloxone

  1983influential reference
• Placebo and naloxone can alter post-surgical pain by separate mechanisms

  1983influential reference
• Influence of sensory suggestibility on treatment outcome in headache patients.

  1983cited by this paper
• Acute pain in a clinical setting: effects of cognitive-behavioural skills training.

  1982cited by this paper
• The effects of psychological preparation on pain and recovery after minor gynaecological surgery: a preliminary report.

  1982cited by this paper
• Biology of placebo analgesia.

  1981cited by this paper
• Situational factors contributing to the placebo effect

  1978influential reference
• MECHANISM OF PLACEBO ANALGESIA

  1978cited by this paper
• The mechanism of placebo analgesia.

  1978cited by this paper
• TREATMENT OF EXCESSIVE AXILLARY SWEATING

  1974cited by this paper
• ANTICIPATION OF ANALGESIA, A PLACEBO EFFECT

  1973cited by this paper
• Increased Stress and Effectiveness of Placebos and "Active" Drugs

  1960cited by this paper
• The powerful placebo.

  1955cited by this paper
• A study of the placebo response.

  1954cited by this paper

• Ethical considerations with using placebo treatments and effects in clinical practice.

  2025cites this paper
• Placebo Effects in Osteopathy and Other Manual Therapies – What They Are and Why They Matter to Clinical Practice, Education, and Research.

  2025cites this paper
• Medicinal cannabis: is current use clinically justified?

  2025cites this paper
• Interventions that inform patients about nocebo effects: A systematic review of the current evidence.

  2025cites this paper
• Placebo Responses in Clinical Trials of Analgesics.

  2025cites this paper
• Meta-analytic evidence for distinct neural correlates of conditioned vs. verbally induced placebo analgesia

  2025cites this paper
• The prediction of the analgesic placebo effect is moderated by direction of attention: results from fibromyalgia and healthy controls.

  2025cites this paper
• The Relationship between Dissociated Measures of Inhibition and Hypnotic and Placebo Analgesia Effects.

  2025cites this paper
• A scoping review of placebo and nocebo responses and effects: insights for clinical trials and practice

  2025cites this paper
• The Effect of Positive, Neutral, and Negative Expectations about Spinal Manipulative Therapy on Pain Intensity in Chronic Low Back Pain: A Randomized Controlled Trial.

  2025cites this paper
• Enhanced Transdermal Delivery of Piroxicam via Nanocarriers, Formulation, Optimization, Characterization, Animal Studies and Randomized Double-Blind Clinical Trial

  2025cites this paper
• The transfer of conditioned and extinguished placebo hypoalgesia across contexts.

  2025cites this paper
• Nocebo effects are stronger and more persistent than placebo effects in healthy individuals

  2025cites this paper
• Differential neural activity predicts the long-term stability of the effects of positive and negative expectations on pain

  2024cites this paper
• Not “that kind” of doctor: an exploratory study on Doctor of Physical Therapy-patient introductions in the United States

  2024cites this paper
• Celecoxib Decreases the Need for Rescue Analgesics after Total Knee Arthroplasty: A Meta-Analysis

  2024cites this paper
• Dopamine has no direct causal role in the formation of treatment expectations and placebo analgesia in humans

  2024cites this paper
• Neuroplasticity Intervention, Amygdala and Insula Retraining (AIR), Significantly Improves Overall Health and Functioning Across Various Chronic Conditions.

  2024cites this paper
• Placebo effects in neuropathic pain conditions.

  2024cites this paper
• Placebo Effects Are Small on Average in the 7.5% CO2 Inhalational Model of Generalized Anxiety

  2024influential citation
• Mit Bewegung gegen den Schmerz – Hypoalgesie durch Training

  2024cites this paper
• Placebo effects in randomized trials of pharmacological and neurostimulation interventions for mental disorders: An umbrella review

  2024cites this paper
• Can observational learning reinforce open-label placebo hypoalgesia?

  2024cites this paper
• Learning by observing: a systematic exploration of modulatory factors and the impact of observationally induced placebo and nocebo effects on treatment outcomes

  2024cites this paper
• Placebo effects beyond dopamine

  2024cites this paper
• Can open label placebos improve pain and gluten tolerance via open label placebos in fibromyalgia patients? A study protocol for a randomised clinical trial in an outpatient centre

  2023cites this paper
• Placebo and nocebo effects and mechanisms associated with pharmacological interventions: an umbrella review

  2023cites this paper
• Placebo analgesia in physical and psychological interventions: Systematic review and meta‐analysis of three‐armed trials

  2023cites this paper
• The importance of context (placebo effects) in conservative interventions for musculoskeletal pain: A systematic review and meta‐analysis of randomized controlled trials

  2023cites this paper
• Klinische Relevanz von Kontextfaktoren als Auslöser von Placebo- und Nocebo-Effekten bei muskuloskelettalen Schmerzen

  2023cites this paper
• Yoga and massage are associated with small experimental placebo effects in chronic orofacial pain

  2023cites this paper
• Placebo or Nocebo Interventions as Affected by Hypnotic Susceptibility

  2023cites this paper
• Can placebo administered in the guise of caffeine reduce the misinformation effect?

  2023cites this paper
• Learned Nocebo Effects on Cutaneous Sensations of Pain and Itch: A Systematic Review and Meta-analysis of Experimental Behavioral Studies on Healthy Humans

  2023cites this paper
• Does active inference provide a comprehensive theory of placebo analgesia?

  2023cites this paper
• Learning pain from others: a systematic review and meta-analysis of studies on placebo hypoalgesia and nocebo hyperalgesia induced by observational learning

  2023cites this paper
• Placebo effects in mental health disorders: protocol for an umbrella review

  2023cites this paper
• Predicting placebo analgesia in patients with chronic pain using natural language processing: a preliminary validation study.

  2022cites this paper
• Maximizing treatment efficacy through patient stratification in neuropathic pain trials

  2022cites this paper
• Deceptive and open-label placebo effects in experimentally induced guilt: a randomized controlled trial in healthy subjects

  2022cites this paper
• The Hand-Withdrawal-Method - An adapted and simplified method of limits for behavioural heat pain assessment.

  2022cites this paper
• Informed Consent for Placebo-Controlled Trials: Do Ethics and Science Conflict?

  2022cites this paper
• Do expectations influence pain? Recognizing Irving Kirsch’s contribution to our understanding of pain

  2022cites this paper
• Are acupuncture and dry needling effective in the management of masticatory muscle pain: a network meta-analysis of randomized clinical trials.

  2022cites this paper
• Placebo effects on cutaneous pain and itch: a systematic review and meta-analysis of experimental results and methodology

  2022cites this paper
• Placebo response varies between different types of sham acupuncture: A randomized double‐blind trial in neck pain patients

  2022influential citation
• Conditioning to Enhance the Effects of Repetitive Transcranial Magnetic Stimulation on Experimental Pain in Healthy Volunteers

  2022cites this paper
• Consideration in Randomized Placebo-Controlled Trial on Neck Pain to Avoid the Placebo Effect in Analgesic Action

  2022cites this paper
• Repurposed and investigational disease-modifying drugs in osteoarthritis (DMOADs)

  2022cites this paper
• Effects of Patients’ Expectation in Dermatology: Evidence from Experimental and Clinical Placebo Studies and Implications for Dermatologic Practice and Research

  2021cites this paper
• The hierarchy of different treatments for myogenous temporomandibular disorders: a systematic review and network meta-analysis of randomized clinical trials

  2021cites this paper
• Cutoff criteria for the placebo response: a cluster and machine learning analysis of placebo analgesia

  2021cites this paper
• The impact of common factors on coaching outcomes

  2021cites this paper
• No evidence that attentional bias towards pain-related words is associated with verbally induced nocebo hyperalgesia: a dot-probe study

  2021cites this paper
• Assessment of pain associated with chronic pancreatitis: An international consensus guideline.

  2021cites this paper
• Effectiveness of placebo interventions for patients with non-specific low back pain: a systematic review.

  2021cites this paper
• When experience is not enough: learning-based cognitive pain modulation with or without instructions.

  2021cites this paper
• Order does matter: the combined effects of classical conditioning and verbal suggestions on placebo hypoalgesia and nocebo hyperalgesia

  2021cites this paper
• Effects of an active break and postural shift intervention on preventing neck and low-back pain among high-risk office workers: a 3-arm cluster-randomized controlled trial

  2021cites this paper
• Neurophysiological mechanisms of chiropractic spinal manipulation for spine pain

  2021cites this paper
• Managing pain in HIV/AIDS: a therapeutic relationship is as effective as an exercise and education intervention for rural amaXhosa women in South Africa

  2021cites this paper
• Targeted Use of Placebo Effects Decreases Experimental Itch in Atopic Dermatitis Patients: A Randomized Controlled Trial

  2021cites this paper
• Does the placebo effect on hot flashes depend on the placebo dose?

  2021cites this paper
• ‘External timing’ of placebo analgesia in an experimental model of sustained pain

  2021cites this paper
• A virtual experimenter does not increase placebo hypoalgesia when delivering an interactive expectancy manipulation

  2020cites this paper
• LISTENING TO THE PLACEBO, OR HOW TO FIND OUT WHY TREATMENTS WORK

  2020cites this paper
• ESCUCHANDO AL PLACEBO, O CÓMO AVERIGUAR POR QUÉ FUNCIONAN LOS TRATAMIENTOS

  2020cites this paper
• Der Placeboeffekt in der Schmerztherapie – für den klinischen Alltag nutzbar? Ja, unbedingt!

  2020cites this paper
• Effects of Procedural Discomfort and Expectation of Benefit on Therapy Continuation in Chronic Migraine Patients Treated With OnabotulinumtoxinA

  2020cites this paper
• The effect of temporal information on placebo analgesia and nocebo hyperalgesia.

  2020cites this paper
• Mindfulness-Based Analgesia or Placebo Effect? The Development and Evaluation of a Sham Mindfulness Intervention for Acute Experimental Pain

  2020cites this paper
• The placebo phenomenon and the underlying mechanisms

  2020cites this paper
• Prior pain exposure and mere possession of a placebo analgesic predict placebo analgesia: Findings from a randomised, double-blinded, controlled trial.

  2020cites this paper
• Is the therapeutic effect of occlusal stabilization appliances more than just placebo effect in the management of painful temporomandibular disorders? A network meta-analysis of randomized clinical trials.

  2020cites this paper
• Placebo effects in pain.

  2020cites this paper
• Influence of placebo analgesia in pharmacological treatment of pain

  2020cites this paper
• Kommentar zum Beitrag von Norbert Schmacke: Homöopathie: Heilslehre „ohne Substanz“

  2020cites this paper
• Can insights from placebo and nocebo mechanisms studies improve the randomized controlled trial?

  2020cites this paper
• Placeboeffekte und ihre Implikationen in der Medizin

  2020cites this paper
• Placebo effects in musculoskeletal radiology procedures

  2020cites this paper
• Context matters: Placebos im Praxisalltag

  2020cites this paper
• Choice, Expectations, and the Placebo Effect for Sleep Difficulty.

  2019cites this paper
• The role of patient beliefs in open-label placebo effects.

  2019cites this paper
• Are Individual Learning Experiences More Important Than Heritable Tendencies? A Pilot Twin Study on Placebo Analgesia

  2019cites this paper
• Placebo and Nocebo Effects in Patients With Takotsubo Cardiomyopathy and Heart-Healthy Controls

  2019cites this paper
• The Powerful Placebo Effect in Cough: Relevance to Treatment and Clinical Trials

  2019cites this paper
• Positive Treatment Expectancies Reduce Clinical Pain and Perceived Limitations in Movement Ability Despite Increased Experimental Pain: A Randomized Controlled Trial on Sham Opioid Infusion in Patients with Chronic Back Pain

  2019cites this paper
• Meta-analysis of pain and function placebo responses in pharmacological osteoarthritis trials

  2019cites this paper
• The Placebo and Nocebo effect on sports performance: A systematic review

  2019cites this paper
• Pain, placebo, and test of treatment efficacy: a narrative review.

  2019cites this paper
• Placebo and Nocebo Effects Across Symptoms: From Pain to Fatigue, Dyspnea, Nausea, and Itch

  2019cites this paper
• Effects of Open- and Closed-Label Nocebo and Placebo Suggestions on Itch and Itch Expectations

  2019cites this paper
• Magnitude, response, and psychological determinants of placebo effects in chronic low-back pain: a randomised, double-blinded, controlled trial

  2019cites this paper
• What is new in the psychology of chronic itch?

  2019cites this paper
• The effectiveness of Mulligan's mobilisation with movement (MWM) on peripheral joints in musculoskeletal (MSK) conditions: A systematic review.

  2019cites this paper
• How May Placebo Mechanisms Influence Orofacial Neuropathic Pain?

  2019cites this paper
• A discursive exploration of public perspectives on placebos and their effects

  2019cites this paper
• Placebo analgesia effects across central nervous system diseases: what do we know and where do we need to go?

  2019cites this paper
• Music-induced analgesia: how does music relieve pain?

  2018cites this paper
• The Influence of Caffeine Expectancies on Sport, Exercise, and Cognitive Performance

  2018cites this paper