Basic pharmacology of local anaesthetics.

Alasdair Taylor,Graeme McLeod

Published 2020 in BJA Education

ABSTRACT

Acc © 20 For Describe the basic structure of local anaesthetic agents. Illustrate the relationships between the structure, function and toxicity of local anaesthetic agents. Identify the pharmacological profiles of commonly used local anaesthetics. Speed of onset, potency, and duration depend on the pKa, lipid solubility and protein binding, respectively. All local anaesthetic agents carry a risk of toxicity. Introduction

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