Advanced nonlinear gas phase control for autotrophic cultivations of different mutants of Ralstonia eutropha

Abstract This paper presents a control architecture suitable for autotrophic cultivations in a stirred tank reactor feeding a gas mixture of H2/CO2/O2. No metabolic information about the cultivated strain is required for the gas phase controller, which can also be used as part of the overall control for the entire process. A gain-scheduled MIMO-PI controller connected to an adaptive feedforward disturbance rejection is proposed. The latter exploits the estimated gas transfer rates of a Kalman filter solely based on a description of the non-biotic processes occurring. Thus, without further knowledge of the autotrophic strain, experiments can be run to generate data and to develop a process model including strain-specific biological details. The wild-type strain H16 of Ralstonia eutropha and two mutants, HF805 and H798, are used to demonstrate how this can be done.

• Publication year

  2020

• Venue

  Journal of Process Control

• Publication date

  2020-04-01

• Fields of study

  Materials Science, Engineering, Environmental Science

• Identifiers
  DOI 10.1016/j.jprocont.2020.02.002
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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