Induction of 70-kDa Heat Shock Protein and hsp70 mRNA following Transient Focal Cerebral Ischemia in the Rat

No abstract is available for this paper.

• Publication year

  1993

• Venue

  Journal of Cerebral Blood Flow and Metabolism

• Publication date

  1993-01-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/jcbfm.1993.13PMID 8416999
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Localization of 70-kDa stress protein induction in gerbil brain after ischemia

  2004cited by this paper
• Neuronal injury and expression of 72-kDa heat-shock protein after forebrain ischemia in the rat

  2004cited by this paper
• Persistent inhibition of protein synthesis precedes delayed neuronal death in postischemic gerbil hippocampus

  2004cited by this paper
• Time course of induction of a heat shock gene (hsp70) in the rabbit cerebellum after LSD in vivo: Involvement of drug-induced hyperthermia

  2004cited by this paper
• Regional Expression of Heat Shock Protein-70 mRNA and c-Fos mRNA following Focal Ischemia in Rat Brain

  1992cited by this paper
• Zinc toxicity and induction of the 72 kD heat shock protein in primary astrocyte culture

  1992cited by this paper
• Expression of Heat Shock Protein 70 and Heat Shock Cognate 70 Messenger RNAs in Rat Cortex and Cerebellum After Heat Shock or Amphetamine Treatment

  1991cited by this paper
• Heat Shock Protein hsp72 Induction in Cortical and Striatal Astrocytes and Neurons following Infarction

  1991cited by this paper
• The stress protein response in cultured neurons: characterization and evidence for a protective role in excitotoxicity.

  1991cited by this paper
• MK‐801 and ketamine induce heat shock protein HSP72 in injured neurons in posterior cingulate and retrosplenial cortex

  1991cited by this paper
• Heat shock-induced interactions of heat shock transcription factor and the human hsp70 promoter examined by in vivo footprinting

  1991cited by this paper
• Induced Tolerance to Ischemia in Gerbil Hippocampal Neurons

  1991cited by this paper
• The temporal profile of 72-kDa heat-shock protein expression following global ischemia

  1991cited by this paper
• Comparison of the heat shock response in cultured cortical neurons and astrocytes.

  1991cited by this paper
• Induction of heat shock protein 72-like immunoreactivity in the hippocampal formation following transient global ischemia.

  1991cited by this paper
• 70‐Kilodalton Heat Shock Protein Induction in Cerebellar Astrocytes and Cerebellar Granule Cells In Vitro: Comparison with Immunocytochemical Localization After Hyperthermia In Vivo

  1990cited by this paper
• Selective sparing of NADPH‐diaphorase–somatostatin–neuropeptide Y neurons in ischemic gerbil striatum

  1990cited by this paper
• Interaction of Hsp 70 with newly synthesized proteins: implications for protein folding and assembly.

  1990cited by this paper
• Hypoxia-ischemia induces heat shock protein-like (HSP72) immunoreactivity in neonatal rat brain.

  1990cited by this paper
• 'Ischemic tolerance' phenomenon found in the brain.

  1990cited by this paper
• The pattern of 72-kDa heat shock protein-like immunoreactivity in the rat brain following flurothyl-induced status epilepticus.

  1990cited by this paper
• A Semiautomated Method for Measuring Brain Infarct Volume

  1990cited by this paper
• Heat Shock RNA Levels in Brain and Other Tissues After Hyperthermia and Transient Ischemia

  1990cited by this paper
• Activation of the heat shock transcription factor by hypoxia in mammalian cells.

  1990cited by this paper
• N‐Methyl‐D‐Aspartate antagonist reduces stroke size and regional glucose metabolism

  1990cited by this paper
• Correlation between cerebral blood flow and histologic changes in a new rat model of middle cerebral artery occlusion.

  1989cited by this paper
• Reversible middle cerebral artery occlusion without craniectomy in rats.

  1989cited by this paper
• Mitochondrial heat-shock protein hsp60 is essential for assembly of proteins imported into yeast mitochondria

  1989cited by this paper
• Induction of stress protein HSP70 in nerve cells after status epilepticus in the rat.

  1989cited by this paper
• Sequential Metabolic Changes in Rat Brain following Middle Cerebral Artery Occlusion: A 2-Deoxyglucose Study

  1989cited by this paper
• Spinal cord injury and the stress protein response.

  1989cited by this paper
• Synthesis of the major inducible heat shock protein in rat hippocampus after neonatal hypoxia-ischemia.

  1989cited by this paper
• A role for a 70-kilodalton heat shock protein in lysosomal degradation of intracellular proteins.

  1989cited by this paper
• Heat shock proteins as markers of neural injury.

  1989cited by this paper
• Induction of a heat shock gene at the site of tissue injury in the rat brain.

  1989cited by this paper
• Glutamate neurotoxicity and diseases of the nervous system.

  1988cited by this paper
• Competitive inhibition of hsp70 gene expression causes thermosensitivity.

  1988cited by this paper
• Coexistence and gene expression of phenylethanolamine N-methyltransferase, tyrosine hydroxylase, and neuropeptide tyrosine in the rat and bovine adrenal gland: effects of reserpine.

  1988cited by this paper
• 70K heat shock related proteins stimulate protein translocation into microsomes

  1988cited by this paper
• Germline transformation used to define key features of heat-shock response elements.

  1988cited by this paper
• Heat shock is lethal to fibroblasts microinjected with antibodies against hsp70.

  1988cited by this paper
• Characterization of the thermotolerant cell. I. Effects on protein synthesis activity and the regulation of heat-shock protein 70 expression

  1988cited by this paper
• Stereotaxic injection of kainic acid into the striatum of rats induces synthesis of mRNA for heat shock protein 70

  1988cited by this paper
• Selective sparing of NADPH‐diaphorase neurons in neonatal hypoxia‐ischemia

  1988cited by this paper
• The induction of the major heat‐stress protein in purified rat glial cells

  1988cited by this paper
• The role of stress proteins in membrane biogenesis.

  1988cited by this paper
• Hyperthermia protects against light damage in the rat retina.

  1988cited by this paper
• Selective induction of a heat shock gene in fibre tracts and cerebellar neurons of the rabbit brain detected by in situ hybridization.

  1987cited by this paper
• Excitotoxity and the NMDA receptor

  1987cited by this paper
• Protection against hypoxic/ischaemic brain damage with excitatory amino acid antagonists.

  1987cited by this paper
• Proteins as molecular chaperones

  1987cited by this paper
• Cellular and biochemical events in mammalian cells during and after recovery from physiological stress

  1986cited by this paper
• Uncoating ATPase is a member of the 70 kilodalton family of stress proteins.

  1986cited by this paper
• Heat shock-like protein is transferred from glia to axon.

  1986cited by this paper
• Speculations on the functions of the major heat shock and glucose-regulated proteins.

  1986cited by this paper
• Synthesis of Heat Shock Proteins in Rat Brain Cortex after Transient Ischemia

  1986cited by this paper
• Protein Synthesis in Postischemic Rat Brain: A Two-Dimensional Electrophoretic Analysis

  1986cited by this paper
• Conserved features of eukaryotic hsp70 genes revealed by comparison with the nucleotide sequence of human hsp70.

  1985cited by this paper
• Synthesis of a Stress Protein Following Transient Ischemia in the Gerbil

  1985cited by this paper
• Hyperthermia Induces the Synthesis of a Heat Shock Protein by Polysomes Isolated from the Fetal and Neonatal Mammalian Brain

  1983cited by this paper
• Heat shock, from bacteria to man

  1982cited by this paper
• Trauma-induced protein in rat tissues: a physiological role for a "heat shock" protein?

  1981cited by this paper
• Differences in protein synthesized in vivo and in vitro by cells associated with the cerebral microvasculature. A protein synthesized in response to trauma?

  1980cited by this paper
• Journal of Cerebral Blood Flow and Metabolism Localization of 70 Kda Stress Protein Mrna Induction in Gerbil Brain after Ischemia

  year unknowncited by this paper

• Inducible HSP72 protein as a marker of neuronal vulnerability in brain research: A potential biomarker for clinical psychiatry?

  2025cites this paper
• New Candidates for Biomarkers and Drug Targets of Ischemic Stroke—A First Dynamic LC-MS Human Serum Proteomic Study

  2022cites this paper
• Valproic Acid Inhibits Glial Scar Formation after Ischemic Stroke

  2022cites this paper
• Stoichiometric Analysis of Shifting in Subcellular Compartmentalization of HSP70 within Ischemic Penumbra

  2021cites this paper
• The Autophagy-Related Organelle Autophagoproteasome Is Suppressed within Ischemic Penumbra

  2021cites this paper
• MRI for prediction of hemorrhagic transformation in acute ischemic stroke: a systematic review and meta-analysis

  2019cites this paper
• Neuronal PirB Upregulated in Cerebral Ischemia Acts as an Attractive Theranostic Target for Ischemic Stroke

  2018cites this paper
• Understanding the Role of Innate Immunity in the Response to Intracortical Microelectrodes.

  2018cites this paper
• Protective Role of Hypothermia Against Heat Stress in Differentiated and Undifferentiated Human Neural Precursor Cells: A Differential Approach for the Treatment of Traumatic Brain Injury

  2017cites this paper
• Hypothermia decreased the expression of heat shock proteins in neonatal rat model of hypoxic ischemic encephalopathy

  2017cites this paper
• Elevation of brain-enriched miRNAs in cerebrospinal fluid of patients with acute ischemic stroke

  2017cites this paper
• EXPERIMENTAL FOCAL CEREBRAL ISCHEMIA

  2016cites this paper
• Inflammation: the Common Link in Brain Pathologies

  2016cites this paper
• Neuroinflammation in Ischaemic Stroke: Utilizing the Biphasic Niche of Neuroprotection and Neurotoxicity for Clinic

  2016cites this paper
• Cerebral collateral circulation in experimental ischemic stroke: from molecular penumbra to collateral therapeutics

  2015cites this paper
• Neuroprotective effects of a glutathione depletor in rat post-ischemic reperfusion brain damage.

  2015cites this paper
• Functional up‐regulation of endopeptidase neurolysin during post‐acute and early recovery phases of experimental stroke in mouse brain

  2014cites this paper
• Protective Effects of Inducible HO-1 on Oxygen Toxicity in Rat Brain Endothelial Microvessel Cells

  2014cites this paper
• Presence of heat shock protein 70 in secondary lymphoid tissue correlates with stroke prognosis.

  2014influential citation
• miRNA Expression Profiles in Cerebrospinal Fluid and Blood of Patients with Acute Ischemic Stroke

  2014cites this paper
• MicroRNAs Regulate the Chaperone Network in Cerebral Ischemia

  2013cites this paper
• Chronic social isolation induces NF-κB activation and upregulation of iNOS protein expression in rat prefrontal cortex.

  2013cites this paper
• The regulation of ER stress induced cell death by HSPB1 (hsp27)

  2013influential citation
• Clinical Evaluation of a Neuroprotective Drug in Patients With Cervical Spondylotic Myelopathy Undergoing Surgical Treatment: Design and Rationale for the CSM-Protect Trial

  2013cites this paper
• Tsc1 (hamartin) confers neuroprotection against ischemia by inducing autophagy

  2013cites this paper
• Spine ROLE OF NON-SURGICAL MANAGEMENT IN CERVICAL SPONDYLOTIC MYELOPATHY Clinical Evaluation ofa Neuroprotective Drug in Patients With Cervical Spondylotic Myelopathy Undergoing Surgical Treatnnent Design and Rationale for the CSM-Protect Trial

  2013cites this paper
• Cervical Spondylotic Myelopathy

  2013cites this paper
• In vivo imaging of induction of heat-shock protein-70 gene expression with fluorescence reflectance imaging and intravital confocal microscopy following brain ischaemia in reporter mice

  2013cites this paper
• Role of Inflammation and Its Mediators in Acute Ischemic Stroke

  2013cites this paper
• Endogenous Agents That Contribute to Generate or Prevent Ischemic Damage

  2012cites this paper
• Mannitol-facilitated perfusion staining with 2,3,5-triphenyltetrazolium chloride (TTC) for detection of experimental cerebral infarction and biochemical analysis.

  2012cites this paper
• A new method for focal transient cerebral ischaemia by distal compression of the middle cerebral artery

  2012cites this paper
• Oxygen challenge MRI: development of a novel technique and application to acute stroke patients

  2012cites this paper
• miR-181 regulates GRP78 and influences outcome from cerebral ischemia in vitro and in vivo.

  2012cites this paper
• Temperature- and time-dependent changes in TLR2-activated microglial NF-κB activity and concentrations of inflammatory and anti-inflammatory factors

  2012cites this paper
• ER-Mitochondria Crosstalk during Cerebral Ischemia: Molecular Chaperones and ER-Mitochondrial Calcium Transfer

  2012cites this paper
• Heterogeneity in the penumbra

  2011cites this paper
• GRP 78 and in fl uences outcome from cerebral ischemia in vitro and in vivo

  2011cites this paper
• Post stroke intervention: is the window widening?

  2011cites this paper
• Thrombin antithrombin complex and IL-18 serum levels in stroke patients

  2010cites this paper
• Dealing with Misfolded Proteins: Examining the Neuroprotective Role of Molecular Chaperones in Neurodegeneration

  2010cites this paper
• Expression of HSP70 in cerebral ischemia and neuroprotetive action of hypothermia and ketoprofen.

  2010cites this paper
• Systemic Lipopolysaccharide Protects the Brain from Ischemic Injury by Reprogramming the Response of the Brain to Stroke: A Critical Role for IRF3

  2009cites this paper
• CRITICAL ROLE OF EUKARYOTIC TRANSLATION INITIATION FACTOR 4G IN MEDIATING ISCHEMIA-INDUCED NEURONAL DEATH

  2009cites this paper
• Identification of Ischemic Regions in a Rat Model of Stroke

  2009cites this paper
• Toll-like receptor signaling in endogenous neuroprotection and stroke.

  2009cites this paper
• Critical role of eukaryotic translation initiation factor 4g degradation in mediating ischemia-induced neuronal death

  2009cites this paper
• Very brief focal ischemia simulating transient ischemic attacks (TIAs) can injure brain and induce Hsp70 protein.

  2008cites this paper
• Toll-like receptors: novel pharmacological targets for the treatment of neurological diseases.

  2008cites this paper
• Preconditioning reprograms TLR signaling following cerebral ischemia the emergence of a neuroprotective program

  2008cites this paper
• Global profiling of influence of intra-ischemic brain temperature on gene expression in rat brain.

  2008cites this paper
• Endothelial heat shock response in cerebral ischemia.

  2007cites this paper
• Experimental focal cerebral ischemia

  2007cites this paper
• Prediction of hemorrhagic transformation after recanalization therapy using T2*‐permeability magnetic resonance imaging

  2007cites this paper
• Ischemia-Induced Neuronal Cell Death and Stress Response

  2007cites this paper
• Heat-shock protein regulation of protein folding, protein degradation, protein function, and apoptosis

  2007cites this paper
• Blood content modulates the induction of heat shock proteins in the neurovascular network.

  2006cites this paper
• Molecular Identification of the Ischemic Penumbra

  2004cites this paper
• Effects of Hsp70.1 Gene Knockout on the Mitochondrial Apoptotic Pathway After Focal Cerebral Ischemia

  2004cites this paper
• The induction of heat shock proteins as a potential strategy to treat neurodegenerative disorders.

  2004cites this paper
• Expression of NALP1 in cerebellar granule neurons stimulates apoptosis.

  2004cites this paper
• Characterization of spinal HSP72 induction and development of ischemic tolerance after spinal ischemia in rats.

  2004cites this paper
• Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein induction

  2004cites this paper
• Restriction-mediated Differential Display (RMDD) Identifies pip92 as a Pro-Apoptotic Gene Product Induced during Focal Cerebral Ischemia

  2004cites this paper
• IVAN SALVADOR BONILLO CONTRERAS PRÉ-CONDICIONAMENTO ISQUÊMICO IMEDIATO BASEADO NA MONITORIZAÇÃO DOS POTENCIAIS EVOCADOS SOMATO-SENSORIAIS NA PREVENÇÃO DA LESÃO DA MEDULA ESPINHAL

  2004cites this paper
• Effects of Hsp 70 . 1 Gene Knockout on the Mitochondrial Apoptotic Pathway After Focal Cerebral Ischemia

  2004cites this paper
• Differential Cerebral Protein Synthesis and Heat Shock Protein 70 Expression in the Core and Penumbra of Rat Brain after Transient Focal Ischemia

  2003cites this paper
• Induction of heat shock protein 40 and GrpE mRNAs following transient focal cerebral ischemia in the rat.

  2003cites this paper
• Les protéines de choc thermique (heat shock proteins-Hsps). II. Hsp70 : biomarqueur et acteur du stress cellulaire.

  2003cites this paper
• Cyclooxygenase-2 mRNA expression is associated with c-fos mRNA expression and transient water ADC reduction detected with diffusion MRI during acute focal ischemia in rats.

  2003cites this paper
• Heat shock proteins and neuroprotection.

  2002cites this paper
• Transgenic mice expressing human copper-zinc superoxide dismutase exhibit attenuated apparent diffusion coefficient reduction during reperfusion following focal cerebral ischemia.

  2002cites this paper
• Induction of heat shock proteins (HSPs) by sodium arsenite in cultured astrocytes and reduction of hydrogen peroxide‐induced cell death

  2002cites this paper
• Correlation between changes in apparent diffusion coefficient and induction of heat shock protein, cell-specific injury marker expression, and protein synthesis reduction on diffusion-weighted magnetic resonance images after temporary focal cerebral ischemia in rats.

  2002cites this paper
• Hypoxia-inducible factor in brain.

  2001cites this paper
• Reversal of Early Diffusion-Weighted Magnetic Resonance Imaging Abnormalities Does Not Necessarily Reflect Tissue Salvage in Experimental Cerebral Ischemia

  2001cites this paper
• Targeted hsp70.1 Disruption Increases Infarction Volume After Focal Cerebral Ischemia in Mice

  2001cites this paper
• Decrease in level of APG-2, a member of the heat shock protein 110 family, in murine brain following systemic administration of kainic acid.

  2001cites this paper
• Expression of c-fos, Heat Shock Protein 70, Neurotrophins, and Cyclooxygenase-2 mRNA in Response to Focal Cerebral Ischemia/Reperfusion in Rats and Their Modification by Magnesium Sulfate

  2001cites this paper
• Measurement of Expression of the HSP70 Protein Family

  2001cites this paper
• Targeted hsp 70 . 1 Disruption Increases Infarction Volume After Focal Cerebral Ischemia in Mice

  2001cites this paper
• Cerebral activation and distribution of inducible hsp110 and hsp70 mRNAs following focal ischemia in rat.

  2001cites this paper
• Induction of mitochondrial heat shock protein 60 and 10 mRNAs following transient focal cerebral ischemia in the rat.

  2001cites this paper
• Attenuation of Ischemic Brain EDEMA and Cerebrovascular Injury after Ischemic Preconditioning in the Rat

  2001cites this paper
• Cerebral Ischemia Reversal of Early Diffusion-Weighted Magnetic Resonance Imaging Abnormalities Does

  2001cites this paper
• Thromboembolic Events Lead to Cortical Spreading Depression and Expression of c-fos, Brain-Derived Neurotrophic Factor, Glial Fibrillary Acidic Protein, and Heat Shock Protein 70 mRNA in Rats

  2000cites this paper
• Atheroemboli to the brain: size threshold for causing acute neuronal cell death.

  2000cites this paper
• Preconditioning the Brain and Heart: Implications for Cardiac Surgery

  2000cites this paper
• Oxygen-glucose deprivation induces inducible nitric oxide synthase and nitrotyrosine expression in cerebral endothelial cells.

  2000cites this paper
• Multiple Molecular Penumbras after Focal Cerebral Ischemia

  2000cites this paper
• The Heat Shock Response Inhibits NF-κB Activation, Nitric Oxide Synthase Type 2 Expression, and Macrophage/Microglial Activation in Brain

  2000cites this paper
• Nuclear factor-κB activation in permanent intraluminal focal cerebral ischemia in the rat

  2000cites this paper
• Nuclear factor-kappa B activation in permanent intraluminal focal cerebral ischemia in the rat.

  2000cites this paper
• Stress Proteins as Molecular Markers of Neurotoxicity

  2000cites this paper
• Mild hypothermia decreases the incidence of transient ADC reduction detected with diffusion MRI and expression of c-fos and hsp70 mRNA during acute focal ischemia in rats.

  2000cites this paper
• Simultaneous induction of mitochondrial heat shock protein mRNAs in rat forebrain ischemia.

  2000cites this paper
• Reprogramming of Gene Expression After Ischemia

  1999cites this paper
• Heat-shock protein protection.

  1999cites this paper
• Activation of nuclear factor-kappaB in the rat brain after transient focal ischemia.

  1999cites this paper
• The neuroprotective potential of heat shock protein 70 (HSP70).

  1999cites this paper