Genome Editing by Targeted Nucleases and the CRISPR/Cas Revolution

No abstract is available for this paper.

• Publication year

  2020

• Venue

  Liver

• Publication date

  2020-01-24

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1002/9781119436812.ch71
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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• No unexpected CRISPR-Cas9 off-target activity revealed by trio sequencing of gene-edited mice

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• The Human Transcription Factors.

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• Repair Pathway Choices and Consequences at the Double-Strand Break.

  2016cited by this paper
• CRISPR/Cas9 Platforms for Genome Editing in Plants: Developments and Applications.

  2016cited by this paper
• GoldyTALEN Vectors with Improved Efficiency for Golden Gate TALEN Assembly

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• Biology and Applications of CRISPR Systems: Harnessing Nature's Toolbox for Genome Engineering.

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  2016cited by this paper
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  2016cited by this paper
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  2016cited by this paper
• Enhancing homology-directed genome editing by catalytically active and inactive CRISPR-Cas9 using asymmetric donor DNA

  2016cited by this paper
• A high-throughput functional genomics workflow based on CRISPR/Cas9-mediated targeted mutagenesis in zebrafish

  2016cited by this paper
• Increasing the efficiency of homology-directed repair for CRISPR-Cas9-induced precise gene editing in mammalian cells

  2015cited by this paper
• Cpf1 is a single RNA-guided endonuclease of a class 2 CRISPR-Cas system.

  2015cited by this paper
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  2015cited by this paper
• High-fidelity CRISPR-Cas9 variants with undetectable genome-wide off-targets

  2015cited by this paper
• Rationally engineered Cas9 nucleases with improved specificity

  2015cited by this paper
• An updated evolutionary classification of CRISPR–Cas systems

  2015cited by this paper
• Digenome-seq: genome-wide profiling of CRISPR-Cas9 off-target effects in human cells

  2015cited by this paper
• Structural basis of PAM-dependent target DNA recognition by the Cas9 endonuclease

  2014cited by this paper
• Improving CRISPR-Cas nuclease specificity using truncated guide RNAs

  2014cited by this paper
• Crystal structure of Cas9 in complex with guide RNA and target DNA.

  2014cited by this paper
• Fusion of catalytically inactive Cas9 to FokI nuclease improves the specificity of genome modification

  2014cited by this paper
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  2013cited by this paper
• Multiplex Genome Engineering Using CRISPR/Cas Systems

  2013cited by this paper
• Genome engineering in Saccharomyces cerevisiae using CRISPR-Cas systems

  2013cited by this paper
• Double nicking by RNA-guided CRISPR Cas9 for enhanced genome editing specificity.

  2013cited by this paper
• CRISPR-mediated modular RNA-guided regulation of transcription in eukaryotes.

  2013cited by this paper
• Genome Engineering of Drosophila with the CRISPR RNA-Guided Cas9 Nuclease

  2013cited by this paper
• A large-scale in vivo analysis reveals that TALENs are significantly more mutagenic than ZFNs generated using context-dependent assembly

  2013cited by this paper
• One-step generation of mice carrying reporter and conditional alleles by CRISPR/Cas-mediated genome engineering.

  2013cited by this paper
• DNA targeting specificity of RNA-guided Cas9 nucleases

  2013cited by this paper
• FLASH Assembly of TALENs Enables High-Throughput Genome Editing

  2012cited by this paper
• A Programmable Dual-RNA–Guided DNA Endonuclease in Adaptive Bacterial Immunity

  2012cited by this paper
• A novel TALE nuclease scaffold enables high genome editing activity in combination with low toxicity

  2011cited by this paper
• Modularly assembled designer TAL effector nucleases for targeted gene knockout and gene replacement in eukaryotes

  2011cited by this paper
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  2011cited by this paper
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  2011cited by this paper
• Targeting DNA Double-Strand Breaks with TAL Effector Nucleases

  2010cited by this paper
• Xanthomonas AvrBs3 family-type III effectors: discovery and function.

  2010cited by this paper
• A Simple Cipher Governs DNA Recognition by TAL Effectors

  2009cited by this paper
• Breaking the Code of DNA Binding Specificity of TAL-Type III Effectors

  2009cited by this paper
• Oligomerized pool engineering (OPEN): an 'open-source' protocol for making customized zinc-finger arrays

  2009cited by this paper
• Genotype Analysis Identifies the Cause of the “Royal Disease”

  2009cited by this paper
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  2007cited by this paper
• CRISPR Provides Acquired Resistance Against Viruses in Prokaryotes

  2007cited by this paper
• Identification of a new subfamily of HNH nucleases and experimental characterization of a representative member, HphI restriction endonuclease

  2006cited by this paper
• Intervening Sequences of Regularly Spaced Prokaryotic Repeats Derive from Foreign Genetic Elements

  2005cited by this paper
• CRISPR elements in Yersinia pestis acquire new repeats by preferential uptake of bacteriophage DNA, and provide additional tools for evolutionary studies.

  2005cited by this paper
• Clustered regularly interspaced short palindrome repeats (CRISPRs) have spacers of extrachromosomal origin.

  2005cited by this paper
• Binding of two zinc finger nuclease monomers to two specific sites is required for effective double-strand DNA cleavage.

  2005cited by this paper
• Structural classification of zinc fingers: survey and summary.

  2003cited by this paper
• Engineering polydactyl zinc-finger transcription factors

  2002cited by this paper
• Identification of genes that are associated with DNA repeats in prokaryotes

  2002cited by this paper
• Initial sequencing and analysis of the human genome

  2001cited by this paper
• In vitro reconstitution of the late steps of genetic recombination in E. coli.

  1997cited by this paper
• Two different but related mechanisms are used in plants for the repair of genomic double-strand breaks by homologous recombination.

  1996cited by this paper
• Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain.

  1996cited by this paper
• Induction of homologous recombination in mammalian chromosomes by using the I-SceI system of Saccharomyces cerevisiae

  1995cited by this paper
• Characterization of double-strand break-induced recombination: homology requirements and single-stranded DNA formation

  1992cited by this paper
• Zinc finger-DNA recognition: crystal structure of a Zif268-DNA complex at 2.1 A

  1991cited by this paper
• Site-directed mutagenesis by gene targeting in mouse embryo-derived stem cells.

  1987cited by this paper
• Nucleotide sequence of the iap gene, responsible for alkaline phosphatase isozyme conversion in Escherichia coli, and identification of the gene product

  1987cited by this paper
• Sequence the Human Genome

  1986cited by this paper
• Replacement of chromosome segments with altered DNA sequences constructed in vitro.

  1979cited by this paper
• Transformation of yeast.

  1978cited by this paper
• Molecular evolution of human and rabbit beta-globin mRNAs.

  1977cited by this paper
• Abnormal human haemoglobins. III. The chemical difference between normal and sickle cell haemoglobins.

  1959cited by this paper

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