Post-translational Modifications: A Mystery to Unravel Huntington’s Disease Prognosis

No abstract is available for this paper.

• Publication year

  2019

• Venue

  Insights into Human Neurodegeneration: Lessons Learnt from Drosophila

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/978-981-13-2218-1_11
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Dynamic recruitment of ubiquitin to mutant huntingtin inclusion bodies

  2018cited by this paper
• Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease

  2018cited by this paper
• Post-translational modifications clustering within proteolytic domains decrease mutant huntingtin toxicity

  2017cited by this paper
• Phosphorylation of huntingtin at residue T3 is decreased in Huntington’s disease and modulates mutant huntingtin protein conformation

  2017cited by this paper
• Post-Translational Modifications (PTMs), Identified on Endogenous Huntingtin, Cluster within Proteolytic Domains between HEAT Repeats.

  2017cited by this paper
• Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity

  2017cited by this paper
• A human huntingtin SNP alters post-translational modification and pathogenic proteolysis of the protein causing Huntington disease

  2017cited by this paper
• What is the main mechanism of the origin of phosphorylation sites? Still an open question

  2017cited by this paper
• The Biology of Huntingtin.

  2016cited by this paper
• Acetylation within the First 17 Residues of Huntingtin Exon 1 Alters Aggregation and Lipid Binding.

  2016cited by this paper
• Comparative study of naturally occurring huntingtin fragments in Drosophila points to exon 1 as the most pathogenic species in Huntington's disease.

  2015cited by this paper
• Molecular, cellular, and physiological significance of N-terminal acetylation.

  2015cited by this paper
• Post-translational myristoylation at the cross roads of cell death, autophagy and neurodegeneration.

  2015cited by this paper
• The emerging role of the first 17 amino acids of huntingtin in Huntington’s disease

  2015cited by this paper
• Drosophila as an In Vivo Model for Human Neurodegenerative Disease

  2015cited by this paper
• An organellar nα-acetyltransferase, naa60, acetylates cytosolic N termini of transmembrane proteins and maintains Golgi integrity.

  2015cited by this paper
• Scalable Production in Human Cells and Biochemical Characterization of Full-Length Normal and Mutant Huntingtin

  2015cited by this paper
• 50 years of protein acetylation: from gene regulation to epigenetics, metabolism and beyond

  2014cited by this paper
• The Ubiquitination Machinery of the Ubiquitin System

  2014cited by this paper
• The physiological role of reversible methionine oxidation.

  2014cited by this paper
• Identification of a post-translationally myristoylated autophagy-inducing domain released by caspase cleavage of huntingtin.

  2014cited by this paper
• Neuronal SUMOylation: mechanisms, physiology, and roles in neuronal dysfunction.

  2014cited by this paper
• Phosphorylation of Mutant Huntingtin at Serine 116 Modulates Neuronal Toxicity

  2014cited by this paper
• Hip14l-deficient mice develop neuropathological and behavioural features of Huntington disease.

  2013cited by this paper
• Huntingtin: Here, There, Everywhere!

  2013cited by this paper
• Proteolytic Post-translational Modification of Proteins: Proteomic Tools and Methodology*

  2013cited by this paper
• A multifunctional, multi-pathway intracellular localization signal in Huntingtin

  2013cited by this paper
• Ubiquitin-like proteins.

  2012cited by this paper
• Mass spectrometric identification of novel posttranslational modification sites in Huntingtin

  2012cited by this paper
• Caspase-6 does not contribute to the proteolysis of mutant huntingtin in the HdhQ150 knock-in mouse model of Huntington’s disease

  2012cited by this paper
• Why nature chose phosphate to modify proteins

  2012cited by this paper
• Understanding protein palmitoylation: Biological significance and enzymology

  2011cited by this paper
• Kinase inhibitors modulate huntingtin cell localization and toxicity.

  2011cited by this paper
• Huntington's disease: from molecular pathogenesis to clinical treatment

  2011cited by this paper
• Proteome-derived Peptide Libraries Allow Detailed Analysis of the Substrate Specificities of Nα-acetyltransferases and Point to hNaa10p as the Post-translational Actin Nα-acetyltransferase*

  2011cited by this paper
• Wild-type HTT modulates the enzymatic activity of the neuronal palmitoyl transferase HIP14.

  2011cited by this paper
• Altered palmitoylation and neuropathological deficits in mice lacking HIP14.

  2011cited by this paper
• Bioinformatics analysis of a Saccharomyces cerevisiae N-terminal proteome provides evidence of alternative translation initiation and post-translational N-terminal acetylation.

  2011cited by this paper
• Preferential accumulation of N-terminal mutant huntingtin in the nuclei of striatal neurons is regulated by phosphorylation.

  2011cited by this paper
• Small Changes, Big Impact

  2011cited by this paper
• Profiling of N-Acetylated Protein Termini Provides In-depth Insights into the N-terminal Nature of the Proteome*

  2010cited by this paper
• Does Huntingtin play a role in selective macroautophagy?

  2010cited by this paper
• Protein palmitoylation in neuronal development and synaptic plasticity

  2010cited by this paper
• Design principles of insect and vertebrate visual systems.

  2010cited by this paper
• Valproic Acid is Neuroprotective in the Rotenone Rat Model of Parkinson’s Disease: Involvement of α-Synuclein

  2010cited by this paper
• Inhibitors of Class 1 Histone Deacetylases Reverse Contextual Memory Deficits in a Mouse Model of Alzheimer's Disease

  2010cited by this paper
• Proteolysis of Mutant Huntingtin Produces an Exon 1 Fragment That Accumulates as an Aggregated Protein in Neuronal Nuclei in Huntington Disease*

  2010cited by this paper
• Post-translational modifications of expanded polyglutamine proteins: impact on neurotoxicity.

  2009cited by this paper
• IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome

  2009cited by this paper
• Neuronal palmitoyl acyl transferases exhibit distinct substrate specificity

  2009cited by this paper
• Acetylation targets mutant huntingtin to autophagosomes for degradation.

  2009cited by this paper
• Beyond the brain: widespread pathology in Huntington's disease.

  2009cited by this paper
• Proteomics analyses reveal the evolutionary conservation and divergence of N-terminal acetyltransferases from yeast and humans

  2009cited by this paper
• Single Neuron Ubiquitin-Proteasome Dynamics Accompanying Inclusion Body Formation in Huntington Disease*

  2009cited by this paper
• Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice.

  2009cited by this paper
• Huntingtin facilitates polycomb repressive complex 2

  2009cited by this paper
• Secondary structure of Huntingtin amino-terminal region.

  2009cited by this paper
• Rhes, a Striatal Specific Protein, Mediates Mutant-Huntingtin Cytotoxicity

  2009cited by this paper
• Phosphorylation of Threonine 3

  2009cited by this paper
• Global sequencing of proteolytic cleavage sites in apoptosis by specific labeling of protein N termini.

  2008cited by this paper
• Global mapping of the topography and magnitude of proteolytic events in apoptosis.

  2008cited by this paper
• Identification of G Protein α Subunit-Palmitoylating Enzyme

  2008cited by this paper
• Activated caspase-6 and caspase-6-cleaved fragments of huntingtin specifically colocalize in the nucleus.

  2008cited by this paper
• The first 17 amino acids of Huntingtin modulate its sub-cellular localization, aggregation and effects on calcium homeostasis.

  2007cited by this paper
• Co-chaperone CHIP promotes aggregation of ataxin-1.

  2007cited by this paper
• Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity.

  2007cited by this paper
• CHIP Overexpression Reduces Mutant Androgen Receptor Protein and Ameliorates Phenotypes of the Spinal and Bulbar Muscular Atrophy Transgenic Mouse Model

  2007cited by this paper
• Phosphorylation of Huntingtin by Cyclin-Dependent Kinase 5 Is Induced by DNA Damage and Regulates Wild-Type and Mutant Huntingtin Toxicity in Neurons

  2007cited by this paper
• Cleavage at the caspase-6 site is required for neuronal dysfunction and degeneration due to mutant huntingtin.

  2006cited by this paper
• Huntingtin Phosphorylation Sites Mapped by Mass Spectrometry

  2006cited by this paper
• Palmitoylation of huntingtin by HIP14is essential for its trafficking and function

  2006cited by this paper
• CHIP Protects from the Neurotoxicity of Expanded and Wild-type Ataxin-1 and Promotes Their Ubiquitination and Degradation*

  2006cited by this paper
• Substrate and functional diversity of lysine acetylation revealed by a proteomics survey.

  2006cited by this paper
• Differential Contributions of Caenorhabditis elegans Histone Deacetylases to Huntingtin Polyglutamine Toxicity

  2006cited by this paper
• Modification of proteins by ubiquitin and ubiquitin-like proteins.

  2006cited by this paper
• Drosophila models of neurodegenerative disease

  2005cited by this paper
• Huntingtin phosphorylation on serine 421 is significantly reduced in the striatum and by polyglutamine expansion in vivo.

  2005cited by this paper
• Ataxin-3 suppresses polyglutamine neurodegeneration in Drosophila by a ubiquitin-associated mechanism.

  2005cited by this paper
• A proline-90 residue unique to SUMO-4 prevents maturation and sumoylation.

  2005cited by this paper
• Global impairment of the ubiquitin-proteasome system by nuclear or cytoplasmic protein aggregates precedes inclusion body formation.

  2005cited by this paper
• Protein modification by SUMO.

  2004cited by this paper
• Cellular toxicity of polyglutamine expansion proteins: mechanism of transcription factor deactivation.

  2004cited by this paper
• SUMO Modification of Huntingtin and Huntington's Disease Pathology

  2004cited by this paper
• The Role of Palmitoylation in Functional Expression of Nicotinic α7 Receptors

  2004cited by this paper
• Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease

  2004cited by this paper
• The diverse superfamily of lysine acetyltransferases and their roles in leukemia and other diseases.

  2004cited by this paper
• Inhibition of Calpain Cleavage of Huntingtin Reduces Toxicity

  2004cited by this paper
• A M55V Polymorphism in a Novel SUMO Gene (SUMO-4) Differentially Activates Heat Shock Transcription Factors and Is Associated with Susceptibility to Type I Diabetes Mellitus*

  2004cited by this paper
• Huntingtin and the molecular pathogenesis of Huntington's disease

  2004cited by this paper
• Different sensitivities of bromodomain factors 1 and 2 to histone H4 acetylation.

  2003cited by this paper
• Human and mouse proteases: a comparative genomic approach

  2003cited by this paper
• Huntingtin contains a highly conserved nuclear export signal.

  2003cited by this paper
• Fly models of Huntington's disease.

  2003cited by this paper
• Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates

  2003cited by this paper
• Characterization of a Nuclear Export Signal within the Human T Cell Leukemia Virus Type I Transactivator Protein Tax*

  2003cited by this paper
• Bromodomains mediate an acetyl-histone encoded antisilencing function at heterochromatin boundaries.

  2003cited by this paper
• The IGF-1/Akt pathway is neuroprotective in Huntington's disease and involves Huntingtin phosphorylation by Akt.

  2002cited by this paper
• Regulation and Destabilization of HIF-1 by ARD1-Mediated Acetylation

  2002cited by this paper
• Calpain Activation in Huntington's Disease

  2002cited by this paper
• Enhanced SUMOylation in polyglutamine diseases.

  2002cited by this paper

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