Dual-response oxygen-generating MnO2 nanoparticles with polydopamine modification for combined photothermal-photodynamic therapy

Abstract Photonic therapy (e.g., photodynamic therapy (PDT) and photothermal therapy (PTT)), features easy handling, good targeting, high curative effect and lower side effects compared to other treatments, thus showing considerable potential in cancer treatment. However, adverse tumor microenvironment, low light conversion efficiency, and inherent toxicity of photonic agents limit their further application in clinic. In this work, hollow mesoporous MnO2 nanoparticles (NPs) loaded with photosensitizer chlorin e6 and coated with folic acid-functionalized polydopamine were fabricated, and used as a platform for photonic therapy. The NPs enabled accurately controlled drug release, and sustainable and extensive O2 production by reacting with endogenous H2O2 in vitro. In addition, the NPs allowed efficient NIR light-to-heat conversion, owing to the core-shell MnO2/polydopamine structure. With the synergy of folic acid mediated active targeting and enhanced permeability and retention effect mediated passive targeting, a pronounced NPs accumulation at the tumor sites of mouse model was observed. The NPs also exhibited excellent biodegradation properties, alleviating the possible concerns about the long-term safety of photonic agents. Finally, a combination of O2-strengthened PDT and PTT resulted in effective tumor growth inhibition upon irradiation with 660 nm and 808 nm laser in vivo treatment. The above features of the devised NPs highlight their potential for improved cancer therapy and imaging.

• Publication year

  2020

• Venue

  Chemical Engineering Journal

• Publication date

  2020-06-01

• Fields of study

  Medicine, Materials Science, Chemistry, Engineering

• Identifiers
  DOI 10.1016/j.cej.2020.124494
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Biomimetic Metal–Organic Framework Nanoparticles for Cooperative Combination of Antiangiogenesis and Photodynamic Therapy for Enhanced Efficacy

  2019cited by this paper
• An Extendable Star-Like Nanoplatform for Functional and Anatomical Imaging-Guided Photothermal Oncotherapy.

  2019cited by this paper
• Glucose Oxidase‐Instructed Multimodal Synergistic Cancer Therapy

  2019cited by this paper
• Wet/Sono‐Chemical Synthesis of Enzymatic Two‐Dimensional MnO2 Nanosheets for Synergistic Catalysis‐Enhanced Phototheranostics

  2019cited by this paper
• Versatile Polydopamine Platforms: Synthesis and Promising Applications for Surface Modification and Advanced Nanomedicine.

  2019cited by this paper
• SnTe@MnO2‐SP Nanosheet–Based Intelligent Nanoplatform for Second Near‐Infrared Light–Mediated Cancer Theranostics

  2019cited by this paper
• Boosting the photodynamic therapy efficiency with a mitochondria-targeted nanophotosensitizer

  2019cited by this paper
• Near-infrared light-controllable on-demand antibiotics release using thermo-sensitive hydrogel-based drug reservoir for combating bacterial infection.

  2019cited by this paper
• A biomimetic nanoreactor for synergistic chemiexcited photodynamic therapy and starvation therapy against tumor metastasis

  2018cited by this paper
• Simultaneous Fenton-like Ion Delivery and Glutathione Depletion by MnO2 -Based Nanoagent to Enhance Chemodynamic Therapy.

  2018cited by this paper
• Oxygen‐Generating MnO2 Nanodots‐Anchored Versatile Nanoplatform for Combined Chemo‐Photodynamic Therapy in Hypoxic Cancer

  2018cited by this paper
• Perfluorohexane-cored nanodroplets for stimulations-responsive ultrasonography and O2-potentiated photodynamic therapy.

  2018cited by this paper
• Oxygen-boosted immunogenic photodynamic therapy with gold nanocages@manganese dioxide to inhibit tumor growth and metastases.

  2018cited by this paper
• Biomimetic Nanoemulsions for Oxygen Delivery In Vivo

  2018cited by this paper
• Chemo-photothermal therapy combination elicits anti-tumor immunity against advanced metastatic cancer

  2018cited by this paper
• Near‐Infrared‐Light‐Activatable Nanomaterial‐Mediated Phototheranostic Nanomedicines: An Emerging Paradigm for Cancer Treatment

  2018cited by this paper
• Photosensitizer-crosslinked in-situ polymerization on catalase for tumor hypoxia modulation & enhanced photodynamic therapy.

  2018cited by this paper
• O2-generating MnO2 nanoparticles for enhanced photodynamic therapy of bladder cancer by ameliorating hypoxia

  2018cited by this paper
• Combining photothermal therapy and immunotherapy against melanoma by polydopamine-coated Al2O3 nanoparticles

  2018cited by this paper
• A multifunctional nanoplatform for cancer chemo-photothermal synergistic therapy and overcoming multidrug resistance.

  2018cited by this paper
• Magnetic Targeting, Tumor Microenvironment-Responsive Intelligent Nanocatalysts for Enhanced Tumor Ablation.

  2018cited by this paper
• Theranostic 2D ultrathin MnO2 nanosheets with fast responsibility to endogenous tumor microenvironment and exogenous NIR irradiation.

  2018cited by this paper
• Polydopamine‐Modified Black Phosphorous Nanocapsule with Enhanced Stability and Photothermal Performance for Tumor Multimodal Treatments

  2018cited by this paper
• Hollow MnO2 as a tumor-microenvironment-responsive biodegradable nano-platform for combination therapy favoring antitumor immune responses

  2017cited by this paper
• Cancer Cell Membrane Camouflaged Cascade Bioreactor for Cancer Targeted Starvation and Photodynamic Therapy.

  2017cited by this paper
• pH-Sensitive Delivery Vehicle Based on Folic Acid-Conjugated Polydopamine-Modified Mesoporous Silica Nanoparticles for Targeted Cancer Therapy.

  2017cited by this paper
• A Polydopamine Nanoparticle-Knotted Poly(ethylene glycol) Hydrogel for On-Demand Drug Delivery and Chemo-photothermal Therapy

  2017cited by this paper
• Rethinking cancer nanotheranostics.

  2017cited by this paper
• Highly biocompatible BSA-MnO2 nanoparticles as an efficient near-infrared photothermal agent for cancer therapy

  2017cited by this paper
• TPGS-Functionalized Polydopamine-Modified Mesoporous Silica as Drug Nanocarriers for Enhanced Lung Cancer Chemotherapy against Multidrug Resistance.

  2017cited by this paper
• A Multifunctional Nanoplatform against Multidrug Resistant Cancer: Merging the Best of Targeted Chemo/Gene/Photothermal Therapy

  2017cited by this paper
• In vivo covalent cross-linking of photon-converted rare-earth nanostructures for tumour localization and theranostics

  2016cited by this paper
• Polydopamine coated manganese oxide nanoparticles with ultrahigh relaxivity as nanotheranostic agents for magnetic resonance imaging guided synergetic chemo-/photothermal therapy

  2016cited by this paper
• Modulation of Hypoxia in Solid Tumor Microenvironment with MnO2 Nanoparticles to Enhance Photodynamic Therapy

  2016cited by this paper
• Multi-responsive photothermal-chemotherapy with drug-loaded melanin-like nanoparticles for synergetic tumor ablation.

  2016cited by this paper
• Bioconjugated Manganese Dioxide Nanoparticles Enhance Chemotherapy Response by Priming Tumor-Associated Macrophages toward M1-like Phenotype and Attenuating Tumor Hypoxia.

  2016cited by this paper
• Hypoxia Induced by Upconversion-Based Photodynamic Therapy: Towards Highly Effective Synergistic Bioreductive Therapy in Tumors.

  2015cited by this paper
• Intelligent MnO2 Nanosheets Anchored with Upconversion Nanoprobes for Concurrent pH‐/H2O2‐Responsive UCL Imaging and Oxygen‐Elevated Synergetic Therapy

  2015cited by this paper
• Porphyrin-based photosensitizers and the corresponding multifunctional nanoplatforms for cancer-imaging and phototherapy

  2015cited by this paper
• Chlorin e6 Conjugated Poly(dopamine) Nanospheres as PDT/PTT Dual-Modal Therapeutic Agents for Enhanced Cancer Therapy.

  2015cited by this paper
• Break‐up of Two‐Dimensional MnO2 Nanosheets Promotes Ultrasensitive pH‐Triggered Theranostics of Cancer

  2014cited by this paper
• Robust ICG theranostic nanoparticles for folate targeted cancer imaging and highly effective photothermal therapy.

  2014cited by this paper
• Surface plasmon resonance enhanced light absorption and photothermal therapy in the second near-infrared window.

  2014cited by this paper
• Activatable fluorescence/MRI bimodal platform for tumor cell imaging via MnO2 nanosheet-aptamer nanoprobe.

  2014cited by this paper
• The EPR effect for macromolecular drug delivery to solid tumors: Improvement of tumor uptake, lowering of systemic toxicity, and distinct tumor imaging in vivo.

  2013cited by this paper
• Synergistic effect of folate-mediated targeting and verapamil-mediated P-gp inhibition with paclitaxel -polymer micelles to overcome multi-drug resistance.

  2011cited by this paper
• Tumor delivery of macromolecular drugs based on the EPR effect.

  2011cited by this paper
• Drug resistance and the solid tumor microenvironment.

  2007cited by this paper
• Photodynamic therapy and anti-tumour immunity

  2006cited by this paper
• Photodynamic therapy for cancer

  2003cited by this paper
• Oxygen consumption and diffusion effects in photodynamic therapy.

  1991cited by this paper

• Hollow nanoarchitectures: Materials engineering, nanochemistry, and biomedical applications

  2026cites this paper
• Enhanced sono-radio dynamic therapy of non-small cell lung cancer using a polydopamine coated manganese dioxide-gold nanosystem: reactive oxygen species amplification and tumor microenvironment modulation

  2026cites this paper
• Nano-in-Micro GelMA depots assist electro-thermal-immuno orchestral treatment for solid triple negative breast tumor

  2026cites this paper
• Photothermal effect-reinforced cancer treatment: Materials and strategies

  2026cites this paper
• Advanced Strategies for Surface Modifications of Manganese oxide Nanoparticles for Cancer Diagnosis and Therapy

  2026cites this paper
• Alkali-controlled one-pot synthesis of ultrasmall PEGylated polydopamine nanoparticles for diverse biological applications

  2026cites this paper
• Near-infrared light-driven nanomotors-based microneedles for the active therapy of bacterial infected acne

  2026cites this paper
• Synthesis, catalytic mechanisms, and biomedical applications of manganese-based nanozymes: A review.

  2026cites this paper
• Atomic-valence engineering of a Mn(III)-tuned sonozyme system for multimodal tumor immunotherapy.

  2026cites this paper
• Innovative applications of silicon dioxide nanoparticles for targeted liver cancer treatment

  2025cites this paper
• Responsive nanomaterials in biomedicine, patent path and prospect analysis

  2025cites this paper
• Logic-gated approach for targeted delivery and site-selective activation of photothermal agents in precision cancer treatment

  2025cites this paper
• Photoactive Nanomaterials Containing Metals for Biomedical Applications: A Comprehensive Literature Review

  2025cites this paper
• Oxygen-Generating Metal Peroxide Particles for Cancer Therapy, Diagnosis, and Theranostics

  2025cites this paper
• Chiral metal nanozyme-enabled SOD2 activation and siRNA delivery cooperatively mitigating chronic heart failure

  2025cites this paper
• Construction of Multifunctional Hyaluronic Acid Modified Gold Nanoparticles Clocked with Irinotecan and Indocyanine Green: Investigation of Chemotherapy and Cancer Cell Imaging

  2025cites this paper
• Octa-Cationic Porphyrin-Functionalized Biocompatible Nanocomposite: A Promising Candidate for Enhanced Combinatorial Photodynamic and Photothermal Tumor Therapy.

  2025cites this paper
• Multifunctional Near Infrared Polymer Dots for Enhanced Synergistic Photodynamic/Photothermal Effect In Vitro.

  2025cites this paper
• ROS-responsive MnO2 mesoporous hydrogel to modulate liver-muscle crosstalk and mitigate NAFLD-associated sarcopenia via exosomal miR-582-5p delivery

  2025cites this paper
• Reducing the availability of endogenous copper and glucose for cascade starvation therapy and chemodynamic therapy

  2025cites this paper
• Intelligent Hierarchical Targeting Near-Infrared Persistent Luminescence Nanosystem for Improved Nuclear Delivery and Simultaneous Visualization/Therapy of EBV-Associated Cancer.

  2025cites this paper
• Biomimetic multifunctional nanoparticles for improved radiotherapy and immunotherapy in cancer treatment

  2025influential citation
• An artificial cascade-nanozyme-loaded hydrogel with robust revascularization and macrophage remodulation for diabetic foot ulcers therapy

  2025cites this paper
• Synergistic induction of immunogenic cell death by icaritin, JQ1, and doxorubicin to enhance immunotherapy in hepatocellular carcinoma

  2025cites this paper
• Homotypic biomimetic nanotheranostics enhance locoregional Cherenkov radiation-induced photodynamic therapy and ferroptosis in early bone metastases.

  2025cites this paper
• Self-oxygenated biomimetic nano-heterojunction combats bacterial biofilm infections via near-infrared triggered ROS storms

  2025cites this paper
• ATP-Exhausted Strategy Induced Anti-Tumor Low-Temperature Photothermal Therapy Based on Rare Earth Nanocrystals Modified Hollow Porous MnOx Nanozyme with TME-Activated NIR-II Imaging.

  2025cites this paper
• Manganese Dioxide-Based pH-Responsive Multifunctional Nanoparticles Deliver Methotrexate for Targeted Rheumatoid Arthritis Treatment

  2025cites this paper
• An intelligent responsive ZIF-8 co-delivery nanoplatform with multimodal synergistic technologies for closed-loop therapy of tumors.

  2025cites this paper
• Functional nanomaterials for enhanced tumor photothermal therapy - the mechanisms and applications

  2025cites this paper
• Ultrasensitive Bi-Mode Lateral-Flow Assay via UCNPs-Based Host-Guest Assembly of Fluorescent-Colorimetric Nanoparticles.

  2025cites this paper
• Cu/Au-doped nanopolymers with multiple catalytic activities for NIR II laser-promoted nanocatalytic tumor therapy

  2025cites this paper
• Copper-Based Bio-Coordination Nanoparticle for Enhanced Pyroptosis-Cuproptosis Cancer Immunotherapy through Redox Modulation and Glycolysis Inhibition.

  2025cites this paper
• A Nucleobase‐Driven Self‐Gelled Hyaluronic Acid‐Based Injectable Adhesive Hydrogel Enhances Intervertebral Disc Repair

  2024cites this paper
• Dual biomarkers-activatable hollow MnO2-Based theranostic nanoplatform for efficient breast cancer-specific multisite fluorescence imaging and synergistic therapy.

  2024cites this paper
• Hetastarch-stabilized polypyrrole with hyperthermia-enhanced release and catalytic activity for synergistic antitumor therapy

  2024cites this paper
• Enzyme‐Empowered “Two Birds with One Stone” Strategy for Amplifying Tumor Apoptosis and Metabolic Clearance

  2024cites this paper
• Tumor microenvironment activated mussel-inspired hollow mesoporous nanotheranostic for enhanced synergistic photodynamic/chemodynamic therapy.

  2024cites this paper
• Engineering Synthetic Erythrocytes as Next‐Generation Blood Substitutes

  2024cites this paper
• Beyond the promise: Exploring the complex interactions of nanoparticles within biological systems.

  2024cites this paper
• MoS2 Nanocomposites Loaded with Zinc Phthalocyanine for NIR Light-Triggered Photothermal/Photodynamic Therapy of Breast Cancer

  2024cites this paper
• Tumor microenvironment-responsive intelligent nanoplatform with oxygen self-supply for synergistic chemotherapy/photodynamic therapy/photothermal therapy against hypoxic tumors

  2024cites this paper
• Functional inorganic nanomaterials for optical cancer theranostics

  2024cites this paper
• Synergistic Effect of Polydopamine and Gallium Ion Doping on Photothermal and Antibacterial Properties of Hydroxyapatite

  2024cites this paper
• Hollow Manganese Dioxide Nanoparticles for Drug Delivery and Imaging

  2024cites this paper
• Harnessing the power of targeted metal nanocarriers mediated photodynamic and photothermal therapy.

  2024cites this paper
• Integrating Photothermal, Photodynamic, and Chemodynamic Therapies: The Innovative Design Based on Copper Sulfide Nanoparticles for Enhanced Tumor Therapy.

  2024cites this paper
• Synthesis of theranostic aptamer targeted polydopamine-coated gold nanocages for chemo-photothermal therapy against melanoma

  2024cites this paper
• Manganese oxide nanomaterials: bridging synthesis and therapeutic innovations for cancer treatment

  2024cites this paper
• A Multi-Functional Cascade Nanoreactor for Remodeling Tumor Microenvironment to Realize Mitochondria Dysfunction via ROS/Zn2+ Ions Overload.

  2024cites this paper
• Platelet Membrane-Camouflaged Copper Doped CaO2 Biomimetic Nanomedicines for Breast Cancer Combination Treatment.

  2024cites this paper
• Photothermal Nanozyme‐Encapsulating Microneedles for Synergistic Treatment of Infected Wounds

  2024cites this paper
• Tri-Responsive Drug Delivery System for Lung Cancer Treatment: Enhanced Photothermal Conversion and Targeted Apoptosis in H1299 Cells

  2024cites this paper
• Oxygen‐Supplying Piezocatalytic Therapy of Hypoxic Tumors by Intratumoral Delivery of pH‐Responsive Multicompartmental Carriers with Sequential Drug Release Capability

  2024cites this paper
• Progress on oxygen-releasing bioactive polymeric scaffolds in tissue engineering and biomedical treatment: A review.

  2024cites this paper
• TiO2@Ti MOFs hollow double-shell structure by in-situ self-sacrificial hydrolytic etching for enhanced photocatalytic hydrogen evolution

  2024cites this paper
• (Nano)biotechnological approaches in the treatment of cervical cancer: integration of engineering and biology

  2024cites this paper
• Theranostic Nanoplatform Based on Polydopamine-Coated Magnetic Mesoporous Silicon for Precise Cancer Triplex Nanotherapy and Multimodal Imaging.

  2024cites this paper
• Zeolitic imidazolate framework-8@polydopamine decorated carboxylated chitosan hydrogel with photocatalytic and photothermal antibacterial activity for infected wound healing.

  2024cites this paper
• Photothermally Reconfigurable Biomimetic Photonic Structures Prepared via Crystallization of Polydopamine‐Incorporated Core–Shell Nanoparticles

  2024cites this paper
• Paclitaxel-Loaded PLGA/Au Nanocylinders for the Photothermal-Chemotherapy Treatment of Cancer

  2024cites this paper
• Biomimetic Copper-Containing Nanogels for Imaging-Guided Tumor Chemo-Chemodynamic-Immunotherapy.

  2024cites this paper
• Codelivery of Dual Gases with Metal-Organic Supramolecular Cage-Based Microenvironment-Responsive Nanomedicine for Atherosclerosis Therapy.

  2024cites this paper
• Tumor Cell-Targeting and Tumor Microenvironment–Responsive Nanoplatforms for the Multimodal Imaging-Guided Photodynamic/Photothermal/Chemodynamic Treatment of Cervical Cancer

  2024cites this paper
• Dual-targeted delivery of temozolomide by multi-responsive nanoplatform via tumor microenvironment modulation for overcoming drug resistance to treat glioblastoma

  2024cites this paper
• Carbon dots-based nanoclusters for sonodynamic therapy of bacterial infection enhanced by deep biofilm penetration and hypoxia alleviation

  2024cites this paper
• Nanoparticle-mediated thermal Cancer therapies: Strategies to improve clinical translatability.

  2024cites this paper
• Tea polyphenol-derived nanomedicine for targeted photothermal thrombolysis and inflammation suppression

  2024cites this paper
• Layered MnO2@PDA as cathode material toward high-performance aqueous zinc-ion batteries

  2024cites this paper
• Surface functionalized mesoporous polydopamine nanocomposites for killing tumor cells through collaborative chemo/photothermal/chemodynamic treatment

  2023cites this paper
• An ultrasensitive split-type electrochemical immunosensor based on controlled-release strategy for detection of CA19-9.

  2023cites this paper
• Biodegradable and Efficient Charge-Migrated Z-Scheme Heterojunction Amplifies Cancer Ferroptosis by Blocking Defensive Redox System.

  2023cites this paper
• Multifunctional Self-Assembled Nanoplatform with AIEgen and Rapamycin-Mediated Tumor Microenvironment Remodeling via mTOR Axis to Enhance Photodynamic Therapy

  2023cites this paper
• Iron-polydopamine coated multifunctional nanoparticle SiO2@PDA/Fe3+-FA mediated low temperature photothermal for chemodynamic therapy of cisplatin-insensitive osteosarcoma

  2023cites this paper
• Photothermal Fibrous Chitosan/Polydopamine Sponge for Intraoperative Hemostasis and Prevention of Tumor Recurrence in Hepatocellular Carcinoma Resection

  2023cites this paper
• Smiple preparation and high activity for cancer therapy via Zr(IO3)4 nanozyme

  2023cites this paper
• Nanoparticles for imaging-guided photothermal therapy of colorectal cancer

  2023cites this paper
• Two-Pronged Microenvironmental Modulation of Metal-Oxidase Cascade Catalysis and Metabolic Intervention for Synergistic Tumor Immunotherapy.

  2023cites this paper
• Dual-Template Induced Interfacial Assembly of Yolk-Shell Magnetic Mesoporous Polydopamine Vesicles with Tunable Cavity For Enhanced Photothermal Antibacterial

  2023cites this paper
• Recent Advances in Bio-Inspired Versatile Polydopamine Platforms for “Smart” Cancer Photothermal Therapy

  2023cites this paper
• Superhydrophobic coating with a micro- and nano-sized MnO2/PDMS composite structure for passive anti-icing/active de-icing and photothermal applications

  2023cites this paper
• Redox regulation and its emerging roles in cancer treatment

  2023cites this paper
• A photoluminescence strategy for detection nanoplastics in water and biological imaging in cells and plants.

  2023cites this paper
• Redox/pH-responsive hollow manganese dioxide nanoparticles for thyroid cancer treatment

  2023cites this paper
• Multifunctional nanogel based on carboxymethyl cellulose interfering with cellular redox homeostasis enhances phycocyanobilin photodynamic therapy.

  2023cites this paper
• A mesoporous MnO2-based nanoplatform with near infrared light-controlled nitric oxide delivery and tumor microenvironment modulation for enhanced antitumor therapy.

  2023cites this paper
• A hyperthermia-enhanced nanocatalyst based on asymmetric Au@polypyrrole for synergistic cancer Fenton/photothermal therapy

  2023cites this paper
• In Situ Cancer-Cell-Triggered Visible Changes in Mechanical Properties, Electroconductivity, and Adhesiveness of a MnO2@PD-Based Mineralized Hydrogel.

  2023cites this paper
• Research progress of nanomaterials in tumor-targeted drug delivery and imaging therapy

  2023cites this paper
• Some synergetic therapy strategies for overcoming hypoxia for photodynamic therapy of cancer

  2023cites this paper
• Surface engineering Salmonella with pH‐responsive polyserotonin and self‐activated DNAzyme for better microbial therapy of tumor

  2023cites this paper
• Poly-thymine DNA templated MnO2 biomineralization as a high-affinity anchoring enabling tumor targeting delivery.

  2023cites this paper
• Mussel-inspired "plug-and-play" hydrogel glue for postoperative tumor recurrence and wound infection inhibition.

  2023cites this paper
• Investigation into the Photochemical Properties of Methylene Blue-Immobilized Hydroxyapatite Nanoparticles for Theranostic Application.

  2023cites this paper
• CeO2@CuS@PDA-FA as targeted near-infrared PTT/CDT therapeutic agents for cancer cells

  2023cites this paper
• A General and Efficient Strategy for Gene Delivery Based on Tea Polyphenols Intercalation and Self‐Polymerization

  2023cites this paper
• Efficient in vitro delivery of paclitaxel by a nanocellulose-coated dendritic mesoporous organosilica nanoparticle for enhanced chemodynamic cancer therapy

  2023cites this paper
• An NIR-II light-responsive nanoplatform for photothermal and enhanced photodynamic synergistic therapy toward drug-resistant bacterial infection and hypoxia relief in subcutaneous wound healing

  2023cites this paper
• Molecularly Stimuli-Responsive Self-Assembled Peptide Nanoparticles for Targeted Imaging and Therapy.

  2023cites this paper
• Biodegradable FePS3 nanoplatform for efficient treatment of osteosarcoma by combination of gene and NIR-II photothermal therapy

  2023cites this paper