Negative regulation of the human epsilon-globin gene by transcriptional interference: role of an Alu repetitive element

No abstract is available for this paper.

• Publication year

  1990

• Venue

  Molecular and Cellular Biology

• Publication date

  1990-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1128/mcb.10.3.1209-1216.1990PMID 2304465PMCID PMC360999
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Correlation between patterns of DNase I-hypersensitive sites and upstream promoter activity of the human epsilon-globin gene at different stages of erythroid development

  1990cited by this paper
• Identification of a transcriptional silencer in the 5'-flanking region of the human epsilon-globin gene.

  1989cited by this paper
• Role of transcriptional interference in the Drosophila melanogaster Adh promoter switch

  1989cited by this paper
• Promoter occlusion during ribosomal RNA transcription.

  1988cited by this paper
• Position-independent, high-level expression of the human beta-globin gene in transgenic mice.

  1987cited by this paper
• A cellular DNA-binding protein that activates eukaryotic transcription and DNA replication.

  1987cited by this paper
• Transcriptional interference and termination between duplicated α-globin gene constructs suggests a novel mechanism for gene regulation

  1986influential reference
• Tissue specific transcription of the human epsilon-globin gene following transfection into the embryonic erythroid cell line K562.

  1985cited by this paper
• Transcription unit of the rabbit beta 1 globin gene

  1985cited by this paper
• Characterization of an unique RNA initiated immediately upstream from human alpha 1 globin gene in vivo and in vitro: polymerase II-dependence, tissue specificity, and subcellular location.

  1985cited by this paper
• Transcription in vivo of an Alu family member upstream from the human epsilon-globin gene.

  1984cited by this paper
• The chromatin structure of the human epsilon globin gene: nuclease hypersensitive sites correlate with multiple initiation sites of transcription.

  1984cited by this paper
• Transcriptional interference in avian retroviruses—implications for the promoter insertion model of leukaemogenesis

  1984cited by this paper
• Differential response of multiple ϵ-globin cap sites to cis- and trans-acting controls

  1984cited by this paper
• Two protein-binding sites in chromatin implicated in the activation of heat-shock genes

  1984cited by this paper
• Transcription in vivo of an Alu family member upstream from the human ε-globin gene

  1984cited by this paper
• Alternative sites of transcription initiation upstream of the canonical cap site in human gamma-globin and beta-globin genes.

  1984cited by this paper
• Specific factor conferring nuclease hypersensitivity at the 5' end of the chicken adult beta-globin gene.

  1984cited by this paper
• Differential response of multiple epsilon-globin cap sites to cis- and trans-acting controls.

  1984cited by this paper
• Mapping of DNase I-hypersensitive sites in the upstream DNA of human embryonic epsilon-globin gene in K562 leukemia cells.

  1984cited by this paper
• Alu family members in the human alpha-like globin-gene cluster.

  1983cited by this paper
• Multiple origins of transcription in the 4.5 Kb upstream of the epsilon-globin gene.

  1983cited by this paper
• Far upstream initiation sites for adenovirus early region 1A transcription are utilized after the onset of viral DNA replication

  1983cited by this paper
• A transcriptional function for the repetitive ribosomal spacer in Xenopus laevis

  1983cited by this paper
• Characterization of productive and sterile transcripts from the immunoglobulin heavy-chain locus: processing of micron and muS mRNA

  1983cited by this paper
• Multiple origins of transcription in the 4.5 Kb upstream of the ϵ-globin gene

  1983influential reference
• Isolation of transcription factors that discriminate between different promoters recognized by RNA polymerase II.

  1983cited by this paper
• Construction and expression in vivo of an internally deleted mouse alpha-fetoprotein gene: presence of a transcribed Alu-like repeat within the first intervening sequence.

  1982cited by this paper
• Transcriptional control signals of a eukaryotic protein-coding gene.

  1982cited by this paper
• Epsilon globin gene transcripts originating upstream of the mRNA cap site in K562 cells and normal human embryos.

  1982cited by this paper
• Repetitive sequences in eukaryotic DNA and their expression.

  1982cited by this paper
• Evidence for the direct involvement of DNA replication origin in synthesis of late SV40 RNA

  1982cited by this paper
• Selective in vitro transcription of one of the two Alu family repeats present in the 5' flanking region of the human epsilon-globin gene.

  1981cited by this paper
• DNA sequence of the rat growth hormone gene: location of the 5' terminus of the growth hormone mRNA and identification of an internal transposon-like element.

  1981cited by this paper
• Characterization ofAlu family repetitive sequences which flank human β-type globin genes

  1981cited by this paper
• Identification of DNA sequences required for transcription of the human α1-globin gene in a new SV40 host-vector system

  1981cited by this paper
• Identification of DNA sequences required for transcription of the human alpha 1-globin gene in a new SV40 host-vector system.

  1981cited by this paper
• Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

  1979cited by this paper
• Transformation of mammalian cells with genes from procaryotes and eucaryotes.

  1979cited by this paper
• K562 human leukaemic cells synthesise embryonic haemoglobin in response to haemin

  1979cited by this paper
• Analysis of erythropoeisis at the molecular level

  1976cited by this paper

• Role of Transposable Elements in Gene Regulation in the Human Genome

  2020cites this paper
• Characterization of the cHS4 insulator in mouse embryonic stem cells

  2020cites this paper
• Massive contribution of transposable elements to mammalian regulatory sequences.

  2016cites this paper
• This paper was presented at a colloquium entitled "Biology of Developmental Transcription Control, " organized by Eric

  2016cites this paper
• Gene structure variation in segmental duplication block C of human chromosome 7q 11.23 during primate evolution.

  2015cites this paper
• Dynamic Alu Methylation during Normal Development, Aging, and Tumorigenesis

  2014cites this paper
• Identification and characterization of transposable elements inserted into the coding sequences of horse genes

  2013cites this paper
• β‐Thalassemia Due to Intronic LINE‐1 Insertion in the β‐Globin Gene (HBB): Molecular Mechanisms Underlying Reduced Transcript Levels of the β‐GlobinL1 Allele

  2013cites this paper
• Transposable Elements: No More 'Junk DNA'

  2012cites this paper
• Aberrant DNA Methylation in Ependymomas

  2012cites this paper
• The dynamic Eukaryote Genome: Evolution, mobile DNA, and the TE-Thrust hypothesis

  2012cites this paper
• Mobile DNA and the TE-Thrust hypothesis: supporting evidence from the primates

  2011cites this paper
• Genomic Structure and Expression Analyses of the PYGM Gene in the Thoroughbred Horse

  2011cites this paper
• Genetic and epigenetic variations contributed by Alu retrotransposition

  2011cites this paper
• Impact of Alu repeats on the evolution of human p53 binding sites

  2011cites this paper
• Does DNA methylation in the promoter region of the ATXN3 gene modify age at onset in MJD (SCA3) patients?

  2011cites this paper
• Expression Vector Engineering for Recombinant Protein Production

  2009cites this paper
• Evolutionary rate heterogeneity of Alu repeats upstream of the APOA5 gene: do they regulate APOA5 expression?

  2008cites this paper
• Influence of the transposable element neighborhood on human gene expression in normal and tumor tissues.

  2007cites this paper
• cHS4 insulator-mediated alleviation of promoter interference during cell-based expression of tandemly associated transgenes.

  2007cites this paper
• The human growth hormone gene contains a silencer embedded within an Alu repeat in the 3'-flanking region.

  2006cites this paper
• COMMENTARY Negative regulation of eukaryotic transcription

  2005cites this paper
• Expression of thelacZ gene targeted to the HPRT locus in embryonic stem cells and their derivatives

  2005cites this paper
• DrosophilaP element: Transposition, regulation and evolution

  2005cites this paper
• Short retroposons in eukaryotic genomes.

  2005cites this paper
• Genomes were forged by massive bombardments with retroelements and retrosequences

  2004cites this paper
• Genome canalization: the coevolution of transposable and interspersed repetitive elements with single copy DNA

  2004cites this paper
• Bovine αs1-casein gene sequences direct high level expression of human granulocyte-macrophage colony-stimulating factor in the milk of transgenic mice

  2004cites this paper
• Species- and tissue-specific transcription of complex, highly repeated satellite-like Bsp elements in the fox genome

  2004cites this paper
• Molecular cloning and characterization of the human orthologue of the oppo 1 gene encoding a sperm tail protein.

  2003cites this paper
• Contrasting Effects of the SATBI Core Nuclear Matrix Attachment Region and Flanking Sequences of the Keratin 18 Gene in Transgenic Mice

  2003cites this paper
• The human MJD gene: genomic structure and functional characterization of the promoter region.

  2003cites this paper
• Transcriptional Interference by Independently Regulated Genes Occurs in Any Relative Arrangement of the Genes and Is Influenced by Chromosomal Integration Position

  2002cites this paper
• A direct repeat of N-type Ca2+ channel alpha1B gene functions as a negative regulatory element in HeLa cells.

  2002cites this paper
• A Direct Repeat of N-Type Ca2+ Channel α1B Gene Functions as a Negative Regulatory Element in HeLa Cells

  2002cites this paper
• Molecular cloning and identification of naturally occurring human antisenseangiopoietin-1: Gna-1

  2001cites this paper
• The endothelin receptor B (EDNRB) promoter displays heterogeneous, site specific methylation patterns in normal and tumor cells.

  2001cites this paper
• Promoter suppression in cultured mammalian cells can be blocked by the chicken beta-globin chromatin insulator 5'HS4 and matrix/scaffold attachment regions.

  2001cites this paper
• Sequence analysis of the human glycoprotein hormone alpha-subunit gene 5'-flanking DNA and identification of a potential regulatory element as an alu repetitive sequence.

  2000cites this paper
• Identification and characterization of a transcriptional silencer upstream of the human BRCA2 gene.

  1999cites this paper
• Tissue-specific alternative splicing in the human INK4a/ARF cell cycle regulatory locus

  1999cites this paper
• Control of genes by mammalian retroposons.

  1999cites this paper
• An RNA polymerase III transcription unit located in the upstream control regions of the human proliferating-cell nucleolar protein p120 gene is transcribed in vitro and in vivo.

  1999cites this paper
• Genomes were forged by massive bombardments with retroelements and retrosequences.

  1999cites this paper
• RNAs from all categories generate retrosequences that may be exapted as novel genes or regulatory elements.

  1999cites this paper
• Antisense expression of the human pro-melanin-concentrating hormone genes.

  1998cites this paper
• Repetitive DNA Sequences in the Common Vole: Cloning, Characterization and Chromosome Localization of Two Novel Complex Repeats MS3 and MS4 from the Genome of the East European Vole Microtus Rossiaemeridionalis

  1998cites this paper
• Components and Reactivity

  1998cites this paper
• The Complement System

  1998cites this paper
• Isolation of an Alu repetitive DNA binding protein and effect of CpG methylation on binding to its recognition sequence.

  1998cites this paper
• The Human ARF Cell Cycle Regulatory Gene Promoter Is a CpG Island Which Can Be Silenced by DNA Methylation and Down-Regulated by Wild-Type p53

  1998cites this paper
• Recent evolutionary acquisition of alternative pre-mRNA splicing and 3' processing regulations induced by intronic B2 SINE insertion.

  1997cites this paper
• Bovine alpha s1-casein gene sequences direct high level expression of human granulocyte-macrophage colony-stimulating factor in the milk of transgenic mice.

  1997cites this paper
• Structural and functional characterization of the human alpha3 nicotinic subunit gene promoter.

  1997cites this paper
• Transcriptional Induction of Collagenase-1 in Differentiated Monocyte-like (U937) Cells is Regulated by AP-1 and an Upstream C/EBP-β Site*

  1997cites this paper
• Distinct mechanisms regulate TIMP-1 expression at different stages of phorbol ester-mediated differentiation of U937 cells.

  1997cites this paper
• Structural and Functional Characterization of the Human (cid:97) 3 Nicotinic Subunit Gene Promoter

  1997cites this paper
• Enrichment of middle repetitive element Bm-1 transcripts in translationally active RNA fractions of the silkmoth, Bombyx mori

  1996cites this paper
• Retro-Vectors for Human Gene Therapy

  1996cites this paper
• Focal altered compartmentation of repetitive B2 (Alu-like) sequences in rat liver following hepatocarcinogen exposure.

  1996cites this paper
• Independence and interdependence of the three human aldolase A promoters in transgenic mice.

  1996cites this paper
• Alu: structure, origin, evolution, significance and function of one-tenth of human DNA.

  1996cites this paper
• Tissue-specific Expression of the Nonneuronal Promoter of the Aromatic L-Amino Acid Decarboxylase Gene Is Regulated by Hepatocyte Nuclear Factor 1 (*)

  1996cites this paper
• DNA sequence insertion and evolutionary variation in gene regulation.

  1996cites this paper
• Contrasting effects of the SATB1 core nuclear matrix attachment region and flanking sequences of the keratin 18 gene in transgenic mice.

  1996cites this paper
• Complex patterns of transcription of a Drosophila retrotransposon in vivo and in vitro by RNA polymerases II and III.

  1995cites this paper
• Complex patternsoftranscription ofa D

  1995cites this paper
• Use of a mammalian interspersed repetitive (MIR) element in the coding and processing sequences of mammalian genes.

  1995cites this paper
• Transposable elements: possible catalysts of organismic evolution.

  1995cites this paper
• Analysis of the Neuronal Promoter of the Rat Aromatic l‐Amino Acid Decarboxylase Gene

  1995cites this paper
• The consensus sequence of a major Alu subfamily contains a functional retinoic acid response element.

  1995cites this paper
• The human myelin oligodendrocyte glycoprotein (MOG) gene: complete nucleotide sequence and structural characterization.

  1995cites this paper
• Computer assisted promoter analysis of a human sperm specific nucleoprotein gene cluster.

  1995cites this paper
• Tissue-specific regulation of the rabbit 15-lipoxygenase gene in erythroid cells by a transcriptional silencer.

  1995cites this paper
• Transcriptional Silencer of the Wilms Tumor Gene WT1 Contains an Alu Repeat (*)

  1995cites this paper
• Evolutionary selection against change in many Alu repeat sequences interspersed through primate genomes.

  1994cites this paper
• Induction of heat-stable enterotoxin receptor activity by a human Alu repeat.

  1994cites this paper
• Eukaryotic transcription termination factor La mediates transcript release and facilitates reinitiation by RNA polymerase III

  1994cites this paper
• Genomic organization of HLA-DMA and HLA-DMB. Comparison of the gene organization of all six class II families in the human major histocompatibility complex.

  1994cites this paper
• Different domains regulate the human erythropoietin receptor gene transcription.

  1994cites this paper
• Specific combinations of human serum albumin introns direct high level expression of albumin in transfected COS cells and in the milk of transgenic mice

  1994cites this paper
• [Glucocorticoids specifically regulate the expression of dispersed repeating sequences in liver cells. Detection of small ID-like antisense RNA].

  1994cites this paper
• Identification and chromosomal localization of a DNA fragment implicated in the partial correction of the Fanconi anemia group D cellular defect.

  1994cites this paper
• Extracellular superoxide dismutase (SOD3): tissue-specific expression, genomic characterization, and computer-assisted sequence analysis of the human EC SOD gene.

  1994cites this paper
• Positive and negative regulatory elements of the rabbit embryonic epsilon-globin gene revealed by an improved multiple alignment program and functional analysis.

  1993cites this paper
• Alu sequence involvement in transcriptional insulation of the keratin 18 gene in transgenic mice

  1993cites this paper
• Evolution and consequences of transposable elements.

  1993cites this paper
• Activation of RNA polymerase III transcription of human Alu repetitive elements by adenovirus type 5: requirement for the E1b 58-kilodalton protein and the products of E4 open reading frames 3 and 6

  1993cites this paper
• The genes of major lysosomal membrane glycoproteins, lamp-1 and lamp-2. 5'-flanking sequence of lamp-2 gene and comparison of exon organization in two genes.

  1993cites this paper
• Transposable Elements and Evolution

  1993cites this paper
• The topographic organization of repetitive DNA in the human nucleolus.

  1993cites this paper
• Transcriptional inhibition of the murine erythropoietin receptor gene by an upstream repetitive element

  1993cites this paper
• cis regulation of the keratin 18 gene in transgenic mice

  1993cites this paper
• Genomic structure and chromosomal mapping of the human CD22 gene.

  1993cites this paper
• A novel and atypical type one interferon gene expressed by trophoblast during early pregnancy.

  1993cites this paper
• Comparison of the human and mouse erythropoietin genes shows extensive homology in the flanking regions.

  1993cites this paper
• Expression of the lacZ gene targeted to the HPRT locus in embryonic stem cells and their derivatives.

  1993cites this paper
• Positive and negative regulatory elements of the rabbit embryonic eglobin gene revealed by an improved multiple alignment program and functional analysis

  1993cites this paper
• Werner syndrome and biological ageing: a molecular genetic hypothesis.

  1993cites this paper
• Transcriptional regulation of the human insulin receptor promoter.

  1992cites this paper