The TWIST1 oncogene is a direct target of hypoxia-inducible factor-2α

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Oncogene

• Publication date

  2008-03-06

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1038/sj.onc.1210795PMID 17873906
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Hypoxia-Inducible Factor-1α Is a Key Regulator of Metastasis in a Transgenic Model of Cancer Initiation and Progression

  2007cited by this paper
• Hypoxia-inducible factor-1alpha is a key regulator of metastasis in a transgenic model of cancer initiation and progression.

  2007cited by this paper
• Regulation of E-cadherin expression by VHL and hypoxia-inducible factor.

  2006cited by this paper
• Recruitment of HIF-1alpha and HIF-2alpha to common target genes is differentially regulated in neuroblastoma: HIF-2alpha promotes an aggressive phenotype.

  2006cited by this paper
• The Caenorhabditis elegans rhy-1 Gene Inhibits HIF-1 Hypoxia-Inducible Factor Activity in a Negative Feedback Loop That Does Not Include vhl-1

  2006influential reference
• Hypoxia-inducible factor-1alpha expression requires PI 3-kinase activity and correlates with Akt1 phosphorylation in invasive breast carcinomas.

  2006cited by this paper
• Fer kinase sustains the activation level of ERK1/2 and increases the production of VEGF in hypoxic cells.

  2005cited by this paper
• Differential Gene Up-Regulation by Hypoxia-Inducible Factor-1α and Hypoxia-Inducible Factor-2α in HEK293T Cells

  2005cited by this paper
• Suppression of Hypoxia-inducible Factor 1α (HIF-1α) Transcriptional Activity by the HIF Prolyl Hydroxylase EGLN1*

  2005cited by this paper
• Roles of the HIF-1 Hypoxia-inducible Factor during Hypoxia Response in Caenorhabditis elegans*

  2005cited by this paper
• Contrasting Properties of Hypoxia-Inducible Factor 1 (HIF-1) and HIF-2 in von Hippel-Lindau-Associated Renal Cell Carcinoma

  2005cited by this paper
• Differential gene up-regulation by hypoxia-inducible factor-1alpha and hypoxia-inducible factor-2alpha in HEK293T cells.

  2005cited by this paper
• Hypoxia and anemia: effects on tumor biology and treatment resistance.

  2005cited by this paper
• Up‐regulation of gene expression by hypoxia is mediated predominantly by hypoxia‐inducible factor 1 (HIF‐1)

  2005cited by this paper
• The insulin-PI3K/TOR pathway induces a HIF-dependent transcriptional response in Drosophila by promoting nuclear localization of HIF-α/Sima

  2005cited by this paper
• Suppression of hypoxia-inducible factor 1alpha (HIF-1alpha) transcriptional activity by the HIF prolyl hydroxylase EGLN1.

  2005cited by this paper
• Gene interactions in the DNA damage-response pathway identified by genome-wide RNA-interference analysis of synthetic lethality.

  2004cited by this paper
• Hypoxia‐inducible factor‐1 and oncogenic signalling

  2004cited by this paper
• Hydroxylation of HIF-1: oxygen sensing at the molecular level.

  2004cited by this paper
• Genetic Analysis of Pathways Regulated by the von Hippel-Lindau Tumor Suppressor in Caenorhabditis elegans

  2004cited by this paper
• Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis.

  2004cited by this paper
• Genetic Analysis of Hypoxia Signaling and Response in C. elegans

  2003cited by this paper
• Targeting HIF-1 for cancer therapy

  2003cited by this paper
• Inhibition of HIF2α Is Sufficient to Suppress pVHL-Defective Tumor Growth

  2003cited by this paper
• Molecular signature associated with bone marrow micrometastasis in human breast cancer.

  2003cited by this paper
• Genome-wide RNAi screening in Caenorhabditis elegans.

  2003cited by this paper
• Systematic functional analysis of the Caenorhabditis elegans genome using RNAi

  2003cited by this paper
• Regulation of Hypoxia-inducible Factor-1α Protein Level during Hypoxic Conditions by the Phosphatidylinositol 3-Kinase/Akt/Glycogen Synthase Kinase 3β Pathway in HepG2 Cells*

  2003cited by this paper
• Structural basis for PAS domain heterodimerization in the basic helix–loop–helix-PAS transcription factor hypoxia-inducible factor

  2003cited by this paper
• Levels of hypoxia‐inducible factor‐1α independently predict prognosis in patients with lymph node negative breast carcinoma

  2003cited by this paper
• Characterization of a dominant negative C. elegans Twist mutant protein with implications for human Saethre-Chotzen syndrome.

  2002cited by this paper
• Dephosphorylation of cell cycle-regulated proteins correlates with anoxia-induced suspended animation in Caenorhabditis elegans.

  2002influential reference
• Biological consequences of tumor hypoxia.

  2001cited by this paper
• Oxygen status of malignant tumors: pathogenesis of hypoxia and significance for tumor therapy.

  2001cited by this paper
• The Caenorhabditis elegans hif-1 gene encodes a bHLH-PAS protein that is required for adaptation to hypoxia

  2001influential reference
• Genetics of craniofacial development and malformation

  2001cited by this paper
• C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation.

  2001influential reference
• HIF-1, O(2), and the 3 PHDs: how animal cells signal hypoxia to the nucleus.

  2001cited by this paper
• Regulation of tumor angiogenesis by p53-induced degradation of hypoxia-inducible factor 1alpha.

  2000cited by this paper
• Twist is a potential oncogene that inhibits apoptosis.

  1999cited by this paper
• Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha.

  1998cited by this paper
• Analysis of a Caenorhabditis elegans Twist homolog identifies conserved and divergent aspects of mesodermal patterning.

  1998influential reference
• Expression of hypoxia-inducible genes in tumor cells

  1998cited by this paper
• Enhancement of gene expression under hypoxic conditions using fragments of the human vascular endothelial growth factor and the erythropoietin genes.

  1998cited by this paper
• cDNA cloning and tissue-specific expression of a novel basic helix-loop-helix/PAS protein (BMAL1) and identification of alternatively spliced variants with alternative translation initiation site usage.

  1997cited by this paper
• Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.

  1997cited by this paper
• A novel bHLH-PAS factor with close sequence similarity to hypoxia-inducible factor 1alpha regulates the VEGF expression and is potentially involved in lung and vascular development.

  1997cited by this paper
• The Role of the Aryl Hydrocarbon Receptor Nuclear Translocator (ARNT) in Hypoxic Induction of Gene Expression

  1996cited by this paper
• Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

  1996cited by this paper
• Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

  1995cited by this paper
• Multiple modes of dorsal‐bHLH transcriptional synergy in the Drosophila embryo.

  1995cited by this paper
• General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia.

  1993cited by this paper
• The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo.

  1992cited by this paper
• Functional analysis of an oxygen-regulated transcriptional enhancer lying 3' to the mouse erythropoietin gene.

  1991cited by this paper
• Egg-laying defective mutants of the nematode Caenorhabditis elegans.

  1983cited by this paper
• The FASEB Journal express article 10.1096/fj.02-0445fje. Published online December 17, 2002. Widespread, hypoxia-inducible expression of HIF-2α in distinct cell populations of different organs

  year unknowncited by this paper

• Development of small molecule inhibitors of hypoxia-inducible factors for cancer therapy.

  2025cites this paper
• Twist-related protein 1 promotes transforming growth factor β receptor 1 in keloid fibroblasts via regulating the stability of myocyte enhancer factor 2A

  2024cites this paper
• Emerging biological functions of Twist1 in cell differentiation

  2024cites this paper
• A tumor metastasis‐associated molecule TWIST1 is a favorable target for cancer immunotherapy due to its immunogenicity

  2022cites this paper
• Hypoxia-inducible factor (HIF) as a bridge between healthy barrier function, wound healing, and fibrosis.

  2022cites this paper
• Hypoxia-inducible factors: cancer progression and clinical translation

  2022cites this paper
• Single-cell and spatial analysis reveal interaction of FAP+ fibroblasts and SPP1+ macrophages in colorectal cancer

  2022cites this paper
• Regulation of epithelial-mesenchymal transition by tumor microenvironmental signals and its implication in cancer therapeutics

  2022cites this paper
• Advances of Tumorigenesis, Diagnosis at Early Stage, and Cellular Immunotherapy in Gastrointestinal Malignancies

  2021cites this paper
• ATG12 deficiency results in intracellular glutamine depletion, abrogation of tumor hypoxia and a favorable prognosis in cancer

  2021cites this paper
• Hypoxia-inducible factor-1β is essential for upregulation of the hypoxia‐induced FLT1 gene in placental trophoblasts

  2021cites this paper
• Exacerbation of Liver Tumor Metastasis in twist1a+/xmrk+ Double Transgenic Zebrafish following Lipopolysaccharide or Dextran Sulphate Sodium Exposure

  2021cites this paper
• Towards a global investigation of transcriptomic signatures through co-expression networks and pathway knowledge for the identification of disease mechanisms

  2021cites this paper
• TWIST1-overexpression induces glycolytic reprogramming and ATP production in 293T cells

  2020cites this paper
• A lineage-tracing tool to map the fate of hypoxic tumour cells

  2020cites this paper
• A lineage-tracing tool to map the fate of post-hypoxic H1299 NSCLC tumour cells

  2020cites this paper
• Twist1: A Double-Edged Sword in Kidney Diseases

  2020cites this paper
• RETRACTED ARTICLE: Blocking C-Raf alleviated high-dose small-volume radiation-induced epithelial mesenchymal transition in mice lung

  2020cites this paper
• Identification of LIMK2 as a therapeutic target in castration resistant prostate cancer.

  2019cites this paper
• The hypoxia-response pathway modulates RAS/MAPK–mediated cell fate decisions in Caenorhabditis elegans

  2019cites this paper
• Biomarkers of epithelial-mesenchymal transition in localized, surgically treated clear-cell renal cell carcinoma.

  2019cites this paper
• Hypoxia: Overview on Hypoxia-Mediated Mechanisms with a Focus on the Role of HIF Genes

  2019cites this paper
• HIF 1 a and HIF 2 a independently activate SRC to promote melanoma metastases

  2018cites this paper
• Luteolin inhibits ER-α expression through ILK inhibition is regulated by a pathway involving Twist and YB-1

  2018cites this paper
• Amendment history : Corrigendum ( October 2009 ) HIF 2 a cooperates with RAS to promote lung tumorigenesis in mice

  2018cites this paper
• Identification of novel regulators of HIFs for use in anti-cancer target development

  2018cites this paper
• HIF-α factors as potential therapeutic targets in leukemia

  2018cites this paper
• Combined analysis of gene expression and genome binding profiles identified potential therapeutic targets of ciclopirox in Ewing sarcoma

  2018cites this paper
• Hypoxia and Inflammation in Cancer, Focus on HIF and NF-κB

  2017cites this paper
• Le phénotype mésenchymateux et la réponse aux agents anti-VEGF dans le cancer colorectal

  2017cites this paper
• Human steroid sulfatase induces Wnt/β-catenin signaling and epithelial-mesenchymal transition by upregulating Twist1 and HIF-1α in human prostate and cervical cancer cells

  2017cites this paper
• Artemin promotes oncogenicity, metastasis and drug resistance in cancer cells

  2017cites this paper
• Benzo(a)pyrene enhances the EMT-associated migration of lung adenocarcinoma A549 cells by upregulating Twist1

  2017cites this paper
• Epithelial-to-Mesenchymal Transition and MicroRNAs in Lung Cancer

  2017cites this paper
• Composition of TWIST1 dimers regulates fibroblast activation and tissue fibrosis

  2016cites this paper
• Forcing through Tumor Metastasis: The Interplay between Tissue Rigidity and Epithelial-Mesenchymal Transition.

  2016cites this paper
• Glioma: Tryptophan Catabolite and Melatoninergic Pathways Link microRNA, 14-3- 3, Chromosome 4q35, Epigenetic Processes and other Glioma Biochemical Changes.

  2016cites this paper
• Hypoxia promotes production of neural crest cells in the embryonic head

  2016cites this paper
• [HIF-2α/Notch3 pathway mediates CoCl2-induced migration and invasion in human breast cancer MCF-7 cells].

  2016cites this paper
• High nuclear expression of Twist1 in the skeletal extramedullary disease of myeloma patients predicts inferior survival.

  2016cites this paper
• The p38 MAP kinase pathway modulates the hypoxia response and glutamate receptor trafficking in aging neurons

  2016cites this paper
• CAP protein superfamily members in

  2016cites this paper
• Régulation de l'agressivité tumorale mammaire par la protéine tyrosine phosphatase PTPL1/PTPN13

  2016cites this paper
• CAP protein superfamily members in Toxocara canis

  2016cites this paper
• 1-1-2016 Tripartite motif containing 28 ( TRIM 28 ) promotes breast cancer metastasis by stabilizing TWIST 1 protein

  2016cites this paper
• Total Synthesis and Biological Evaluation of Rakicidin A and Discovery of a Simplified Bioactive Analogue.

  2016cites this paper
• Reduce, Reuse, Recycle: The tale of two Wnts and the lone C. elegans Syndecan, SDN-1

  2015cites this paper
• Sustained proliferation in cancer: Mechanisms and novel therapeutic targets.

  2015cites this paper
• Inflammation and Lung Cancer: The Role of Epithelial–Mesenchymal Transition

  2015cites this paper
• Regulation of histone demethylase KDM6B by hypoxia-inducible factor-2α.

  2015cites this paper
• A Synthetic Lethal Screen Identifies a Role for Lin-44/Wnt in C. elegans Embryogenesis

  2015cites this paper
• The barber's pole worm CAP protein superfamily--A basis for fundamental discovery and biotechnology advances.

  2015cites this paper
• ustained proliferation in cancer : Mechanisms and novel therapeutic argets ark

  2015cites this paper
• The role of hypoxia in inflammatory disease (Review)

  2015cites this paper
• The emerging role of Twist proteins in hematopoietic cells and hematological malignancies

  2014cites this paper
• The emerging role of Twist proteins in hematopoietic cells and hematological malignancies

  2014cites this paper
• The hypoxic tumor microenvironment: driving the tumorigenesis of non-small-cell lung cancer.

  2014cites this paper
• Partial bladder outlet obstruction in mice may cause E-cadherin repression through hypoxia induced pathway.

  2014cites this paper
• SPE-8, a protein-tyrosine kinase, localizes to the spermatid cell membrane through interaction with other members of the SPE-8 group spermatid activation signaling pathway in C. elegans

  2014cites this paper
• Microenvironment and Immunology Twist 1 Induces CCL 2 and Recruits Macrophages to Promote Angiogenesis

  2013influential citation
• TWIST1 hypermethylation is observed in pancreatic cancer.

  2013cites this paper
• The Proto-Oncogene TWIST1 Is Regulated by MicroRNAs

  2013cites this paper
• Dysregulated pH in Tumor Microenvironment Checkmates Cancer Therapy.

  2013cites this paper
• The hypoxia factor Hif-1α controls neural crest chemotaxis and epithelial to mesenchymal transition

  2013cites this paper
• Overexpression of HIF-2α, TWIST, and CXCR4 Is Associated with Lymph Node Metastasis in Papillary Thyroid Carcinoma

  2013cites this paper
• Enrichment of ovarian cancer stem‐like cells is associated with epithelial to mesenchymal transition through an miRNA‐activated AKT pathway

  2013cites this paper
• Clinicopathological and prognostic significance of HIF-1α and HIF-2α expression in small cell lung cancer.

  2013cites this paper
• Hypoxia inducible NOD2 interacts with 3-O-sulfogalactoceramide and regulates vesicular homeostasis.

  2013cites this paper
• Twist: a molecular target in cancer therapeutics

  2013cites this paper
• Twist1 induces CCL2 and recruits macrophages to promote angiogenesis.

  2013influential citation
• Technical considerations for analyzing EMT-MET data from surgical samples.

  2013cites this paper
• HIF1α and HIF2α independently activate SRC to promote melanoma metastases.

  2013cites this paper
• Oncogenic functions of ARTEMIN in ER negative mammary carcinoma

  2013cites this paper
• ADENOSINE AS AN ENVIRONMENTAL STRESSOR AFFECTING HSP27 AND CXCR4 IN EPITHELIAL CELLS

  2013cites this paper
• HIF1α and HIF2α independently activate SRC to promote melanoma invasion and metastasis

  2013cites this paper
• TWIST1 promoter methylation is associated with prognosis in tonsillar squamous cell carcinoma.

  2013cites this paper
• Hypoxia regulates glutamate receptor trafficking through an HIF‐independent mechanism

  2012cites this paper
• The Inflammatory Tumor Microenvironment, Epithelial Mesenchymal Transition and Lung Carcinogenesis

  2012cites this paper
• Coexpression of hypoxia-inducible factor-2α, TWIST2, and SIP1 may correlate with invasion and metastasis of salivary adenoid cystic carcinoma.

  2012cites this paper
• Attenuation of reactive oxygen species by antioxidants suppresses hypoxia-induced epithelial-mesenchymal transition and metastasis of pancreatic cancer cells

  2012cites this paper
• A tale with a Twist: a developmental gene with potential relevance for metabolic dysfunction and inflammation in adipose tissue

  2012cites this paper
• CCN5/WISP-2: A micromanager of breast cancer progression

  2012cites this paper
• Parasite neuropeptide biology: Seeding rational drug target selection?

  2012cites this paper
• EMT and Stem Cell-Like Properties Associated with HIF-2α Are Involved in Arsenite-Induced Transformation of Human Bronchial Epithelial Cells

  2012cites this paper
• CD133: holy of grail of neuro‐oncology or promiscuous red‐herring?

  2012cites this paper
• Constitutive Proteasomal Degradation of TWIST-1 in Epithelial Ovarian Cancer Stem Cells Impacts Differentiation and Metastatic Potential

  2012cites this paper
• New insights into the regulation of epithelial-mesenchymal transition and tissue fibrosis.

  2012cites this paper
• E-Cadherin loss associated with EMT promotes radioresistance in human tumor cells.

  2011cites this paper
• Twist1 is up-regulated in gastric cancer-associated fibroblasts with poor clinical outcomes.

  2011cites this paper
• Étude du profil mutationnel K-RAS, EGFR, LKB1 et de la transition épithélio-mésenchymateuse dans une série de 22 carcinomes sarcomatoïdes pulmonaires

  2011cites this paper
• C. elegans homologs of insect clock proteins: a tale of many stories

  2011cites this paper
• Epithelial-mesenchymal transition and anoikis resistance: two mechanisms promoting metastasis

  2011cites this paper
• Hypoxia-inducible factors--regulation, role and comparative aspects in tumourigenesis.

  2011cites this paper
• The role of epithelial-mesenchymal transition in pancreatic cancer.

  2011cites this paper
• Advanced prostate cancer: reinforcing the strings between inflammation and the metastatic behavior

  2011cites this paper
• Artificially Induced Epithelial-Mesenchymal Transition in Surgical Subjects: Its Implications in Clinical and Basic Cancer Research

  2011cites this paper
• ARTEMIN synergizes with TWIST1 to promote metastasis and poor survival outcome in patients with ER negative mammary carcinoma

  2011cites this paper
• Hypoxia-inducible factor-1 alpha, in association with TWIST2 and SNIP1, is a critical prognostic factor in patients with tongue squamous cell carcinoma.

  2011cites this paper
• Hypoxia‐mediated biological control

  2011influential citation
• Gastrointestinal , Hepatobiliary , and Pancreatic Pathology Twist 1 Is Up-Regulated in Gastric Cancer-Associated Fibroblasts with Poor Clinical Outcomes

  2011cites this paper