Autocatakinesis systems in drug discovery

Abstract Achieving self-organization in a biological system allows for the constitution of metabolic networks for the sharing of entropy, as well as consolidating mechanisms to maintain homeostasis in the face of environmental challenges. This ability makes the system evolve by virtue of the structural function and allows plasticity in biological forms, as well as allowing coevolution in the interaction. For this process, it is important to maintain protein homeostasis or proteostasis in order to have stability in both primary and secondary metabolic systems. Molecular chaperones, therefore, perform this task of regulation in the synthesis of enzymes and structural proteins, as well as introducing conformational changes that boost the chemical diversity of metabolic networks; all this in order to support the replicative and autopoietic capacity of the biological system and the cellular communities involved. That is why proteostasis becomes a therapeutic target of interest in order to apply evolutionary models in the search for new drugs for metabolic diseases, cancer, and degenerative and infectious diseases. For the above reasons, in this chapter we will analyze the importance of self-organization in the maintenance of metabolic networks in biological systems and how they can be applied in the development of pharmacologically active products.

• Publication year

  2020

• Venue

  Unknown venue

• Publication date

  Unknown publication date

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/b978-0-12-817613-9.00009-2
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

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