Transcriptome Analysis of Recombinant Protein Secretion by Aspergillus nidulans and the Unfolded-Protein Response In Vivo

No abstract is available for this paper.

• Publication year

  2005

• Venue

  Applied and Environmental Microbiology

• Publication date

  2005-05-01

• Fields of study

  Biology, Medicine, Environmental Science

• Identifiers
  DOI 10.1128/AEM.71.5.2737-2747.2005PMID 15870366PMCID PMC1087583
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Combining transcriptome data with genomic and cDNA sequence alignments to make confident functional assignments for Aspergillus nidulans genes.

  2004cited by this paper
• The transcription factor HACA mediates the unfolded protein response in Aspergillus niger, and up-regulates its own transcription

  2004cited by this paper
• Glutamic protease distribution is limited to filamentous fungi.

  2004cited by this paper
• Negative Subtraction Hybridization: An efficient method to isolate large numbers of condition-specific cDNAs

  2004cited by this paper
• Use of expressed sequence tag analysis and cDNA microarrays of the filamentous fungus Aspergillus nidulans.

  2004cited by this paper
• Global analysis of nutrient control of gene expression in Saccharomyces cerevisiae during growth and starvation.

  2004cited by this paper
• Rapid prefractionation of complex protein lysates with centrifugal membrane adsorber units improves the resolving power of 2D-PAGE-based proteome analysis

  2004cited by this paper
• Identification of a novel gene hbrB required for polarised growth in Aspergillus nidulans.

  2004cited by this paper
• Characterization of the protein processing and secretion pathways in a comprehensive set of expressed sequence tags from Trichoderma reesei.

  2004cited by this paper
• Activation mechanisms of the HACI‐mediated unfolded protein response in filamentous fungi

  2003cited by this paper
• Genomic Analysis of the Unfolded Protein Response in Arabidopsis Shows Its Connection to Important Cellular Processes Online version contains Web-only data. Article, publication date, and citation information can be found at www.plantcell.org/cgi/doi/10.1105/tpc.007609.

  2003cited by this paper
• Isolation and characterisation of a calnexin homologue, clxA, from Aspergillus niger

  2003cited by this paper
• Mcm1p-Induced DNA Bending Regulates the Formation of Ternary Transcription Factor Complexes

  2003cited by this paper
• Improvement of Foreign-Protein Production in Aspergillus niger var. awamori by Constitutive Induction of the Unfolded-Protein Response

  2003cited by this paper
• The Effects of Drugs Inhibiting Protein Secretion in the Filamentous Fungus Trichoderma reesei

  2003cited by this paper
• Filamentous fungi as cell factories for heterologous protein production.

  2002cited by this paper
• Role of the unfolded protein response pathway in regulation of INO1 and in the sec14 bypass mechanism in Saccharomyces cerevisiae.

  2002influential reference
• Hybridization array technology coupled with chemostat culture: Tools to interrogate gene expression in Saccharomyces cerevisiae.

  2002cited by this paper
• Identification and characterization of a family of secretion‐related small GTPase‐encoding genes from the filamentous fungus Aspergillus niger : a putative SEC4 homologue is not essential for growth

  2001cited by this paper
• Production of tissue plasminogen activator (t-PA) in Aspergillus niger.

  2001cited by this paper
• The foldase CYPB is a component of the secretory pathway of Aspergillus niger and contains the endoplasmic reticulum retention signal HEEL

  2001cited by this paper
• Small GTP-binding proteins.

  2001cited by this paper
• The secretion pathway in filamentous fungi: a biotechnological view.

  2001influential reference
• A defined level of protein disulfide isomerase expression is required for optimal secretion of thaumatin by Aspergillus awamori

  2001cited by this paper
• Functional and genomic analyses reveal an essential coordination between the unfolded protein response and ER-associated degradation.

  2000cited by this paper
• Genomic expression programs in the response of yeast cells to environmental changes.

  2000influential reference
• Functional implications of disulfide bond, Cys206-Cys210, in recombinant prochymosin (chymosin).

  2000cited by this paper
• Glucoamylase::green fluorescent protein fusions to monitor protein secretion in Aspergillus niger.

  2000cited by this paper
• A concise guide to cDNA microarray analysis.

  2000cited by this paper
• Functional and Genomic Analyses Reveal an Essential Coordination between the Unfolded Protein Response and ER-Associated Degradation

  2000cited by this paper
• A glucoamylase::GFP gene fusion to study protein secretion by individual hyphae of Aspergillus niger.

  2000cited by this paper
• Degradation of proteins from the ER of S. cerevisiae requires an intact unfolded protein response pathway.

  2000cited by this paper
• Molecular characterization of a PDI-related gene prpA in Aspergillus niger var. awamori

  2000cited by this paper
• Filamentous fungi as microbial cell factories for food use.

  2000cited by this paper
• Molecular cloning and characterization of Aspergillus nidulans cyclophilin B.

  1999cited by this paper
• Protein targeting to the endoplasmic reticulum in yeast. 1997 Fleming Lecture.

  1999cited by this paper
• Analysis of the role of the gene bipA, encoding the major endoplasmic reticulum chaperone protein in the secretion of homologous and heterologous proteins in black Aspergilli

  1998cited by this paper
• Hydrolysis of GTP on rab11 is required for the direct delivery of transferrin from the pericentriolar recycling compartment to the cell surface but not from sorting endosomes.

  1998cited by this paper
• Vesicular transport: how many Ypt/Rab-GTPases make a eukaryotic cell?

  1997cited by this paper
• Efficient production of secreted proteins by Aspergillus : progress, limitations and prospects

  1997cited by this paper
• Molecular evidence for an ancient duplication of the entire yeast genome

  1997cited by this paper
• The ER chaperone encoding bipA gene of black Aspergilli is induced by heat shock and unfolded proteins.

  1997cited by this paper
• Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites.

  1997cited by this paper
• SHORT COMMUNICATION Identification of prokaryotic and eukaryotic signal peptides and prediction of their cleavage sites

  1997influential reference
• Isolation and characterisation of a gene encoding protein disulphide isomerase, pdiA, from Aspergillus niger

  1997cited by this paper
• Overexpression of binding protein and disruption of the PMR1 gene synergistically stimulate secretion of bovine prochymosin but not plant Thaumatin in yeast

  1996cited by this paper
• From DNA sequence to biological function

  1996cited by this paper
• Nucleotide sequence of the Aspergillus niger srpA gene.

  1995cited by this paper
• Protein disulfide isomerase mutant lacking its isomerase activity accelerates protein folding in the cell

  1995cited by this paper
• CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice.

  1994cited by this paper
• Secretion of calf chymosin from the filamentous fungus Aspergillus oryzae

  1993cited by this paper
• Use of Aspergillus overproducing mutants, cured for intergrated plasmid, to overproduce heterologous proteins

  1993cited by this paper
• Small GTP-binding proteins.

  1992cited by this paper
• Production of extracellular proteins by the filamentous fungusAspergillus

  1992cited by this paper
• Commercial Levels of Chymosin Production by Aspergillus

  1991cited by this paper
• Improved Production of Chymosin in Aspergillus by Expression as a Glucoamylase-Chymosin Fusion

  1990influential reference
• A GTP-binding protein required for secretion rapidly associates with secretory vesicles and the plasma membrane in yeast.

  1988cited by this paper
• Controlled Expression and Secretion of Bovine Chymosin in Aspergillus Nidulans

  1987influential reference
• Expression of calf prochymosin in Saccharomyces cerevisiae.

  1984cited by this paper
• Synthesis of calf prochymosin (prorennin) in Escherichia coli.

  1983cited by this paper
• Efficient synthesis of enzymatically active calf chymosin in Saccharomyces cerevisiae.

  1983cited by this paper
• Expression of cloned calf prochymosin gene sequence in Escherichia coli.

  1982cited by this paper
• Expression of cloned calf prochymosin gene sequence in Escherichia coli.

  1982cited by this paper

• Deciphering the role of ThHSF1 in the differential expression regulation of laccase isozymes in the white-rot fungus Trametes hirsuta

  2025cites this paper
• From Fungal Cell Factories to Mycoproteins: Alternative Protein Production for Human Diets

  2025cites this paper
• Protein secretion and associated stress in industrially employed filamentous fungi

  2024cites this paper
• Thiol reductive stress activates the hypoxia response pathway

  2023cites this paper
• Anticancer Asparaginases: Perspectives in Using Filamentous Fungi as Cell Factories

  2023cites this paper
• Physiological ER stress caused by amylase production induces regulated Ire1-dependent mRNA decay in Aspergillus oryzae

  2023cites this paper
• Proteomic analysis on Aspergillus strains that are useful for industrial enzyme production

  2020cites this paper
• Improvement of homologous GH10 xylanase production by deletion of genes with predicted function in the Aspergillus nidulans secretion pathway

  2020cites this paper
• Plasma‐mediated enhancement of enzyme secretion in Aspergillus oryzae

  2020cites this paper
• Redesigning N-glycosylation sites in a GH3 β-xylosidase improves the enzymatic efficiency

  2019cites this paper
• Verticillium dahliae transcription factors Som1 and Vta3 control microsclerotia formation and sequential steps of plant root penetration and colonisation to induce disease.

  2018cites this paper
• Protein profile in Aspergillus nidulans recombinant strains overproducing heterologous enzymes

  2018cites this paper
• Heterologous Expression of Lignocellulolytic Enzymes in Aspergillus niger

  2018cites this paper
• Comparative RNA-seq based transcriptomic analysis of Aspergillus nidulans recombinant strains overproducing heterologous glycoside hydrolases

  2018cites this paper
• Fungal Cellulolytic Enzymes

  2018cites this paper
• Cellular responses to the expression of unstable secretory proteins in the filamentous fungus Aspergillus oryzae

  2017cites this paper
• Exploring the potential of Saccharomyces cerevisiae for biopharmaceutical protein production.

  2017cites this paper
• Title Regulation of the lignocellulolytic response in filamentous fungi Permalink

  2016cites this paper
• Effect of secretory pathway gene overexpression on secretion of a fluorescent reporter protein in Aspergillus nidulans

  2016cites this paper
• Regulation of the lignocellulolytic response in filamentous fungi

  2016cites this paper
• Coping with Physiological Stress During Recombinant Protein Production by Bioreactor Design and Operation

  2016cites this paper
• Yeast Expression Systems for Industrial Biotechnology

  2016cites this paper
• Microbial Models: From Environmental to Industrial Sustainability

  2016cites this paper
• Functional and transcriptomic analysis of the key unfolded protein response transcription factor HacA in Aspergillus oryzae.

  2016cites this paper
• Gene Expression Systems in Fungi: Advancements and Applications

  2016cites this paper
• Heterologous Protein Expression in the Aspergilli: Overcoming Obstacles in the Secretory Pathway

  2016cites this paper
• Identification of functional cis-elements required for repression of the Taka-amylase A gene under secretion stress in Aspergillus oryzae

  2015cites this paper
• Ultrastructural features of the early secretory pathway in Trichoderma reesei

  2015cites this paper
• The bZIP Transcription Factor HAC-1 Is Involved in the Unfolded Protein Response and Is Necessary for Growth on Cellulose in Neurospora crassa

  2015cites this paper
• Expression and characterization of camel chymosin in Pichia pastoris.

  2015cites this paper
• Monitoring and control of protein production in fungi

  2015cites this paper
• Towards defining the substrate of orphan P5A-ATPases.

  2015cites this paper
• Unfolded protein response in filamentous fungi—implications in biotechnology

  2014cites this paper
• Identification of Interphase Functions for the NIMA Kinase Involving Microtubules and the ESCRT Pathway

  2014cites this paper
• Genome-scale analysis of the high-efficient protein secretion system of Aspergillus oryzae

  2014cites this paper
• Heterologous Expression of Proteins in Trichoderma

  2014cites this paper
• Investigation of protein secretion and secretion stress in Ashbya gossypii

  2014influential citation
• Effect of earlier unfolded protein response and efficient protein disposal system on cellulase production in Rut C30

  2014cites this paper
• The importance of connections between the cell wall integrity pathway and the unfolded protein response in filamentous fungi.

  2014cites this paper
• Stress effects caused by the expression of a mutant cellobiohydrolase I and proteasome inhibition in Trichoderma reesei Rut-C30.

  2013cites this paper
• Understanding the biotechnological potential of Ashbya gossypii

  2013influential citation
• The Aspergillus nidulans Peripheral ER: Disorganization by ER Stress and Persistence during Mitosis

  2013cites this paper
• Proteome analysis of the farnesol-induced stress response in Aspergillus nidulans--The role of a putative dehydrin.

  2012cites this paper
• Physiological characterization of Ashbya gossypii and strain development for recombinant protein production

  2012cites this paper
• High-yield secretion of multiple client proteins in Aspergillus.

  2012cites this paper
• Heterologous gene expression in filamentous fungi.

  2012cites this paper
• Heterologous expression systems for lipases: a review.

  2012cites this paper
• Genome-wide expression analysis upon constitutive activation of the HacA bZIP transcription factor in Aspergillus niger reveals a coordinated cellular response to counteract ER stress

  2012cites this paper
• Adaptation d'Alternaria brassicicola à son hôte : étude de composantes moléculaires impliquées dans la protection du champignon pathogène vis-à-vis des phytoalexines indoliques des Brassicaceae

  2011cites this paper
• HacA-Independent Functions of the ER Stress Sensor IreA Synergize with the Canonical UPR to Influence Virulence Traits in Aspergillus fumigatus

  2011cites this paper
• A carrier fusion significantly induces unfolded protein response in heterologous protein production by Aspergillus oryzae

  2011cites this paper
• Methods for investigating the UPR in filamentous fungi.

  2011cites this paper
• Recent advances in milk clotting enzymes

  2011cites this paper
• Survey of the transcriptome of Aspergillus oryzae via massively parallel mRNA sequencing

  2010cites this paper
• Effects of a defective ERAD pathway on growth and heterologous protein production in Aspergillus niger

  2010cites this paper
• In vivo imaging of endoplasmic reticulum and distribution of mutant α-amylase in Aspergillus oryzae.

  2010cites this paper
• Sense and nonsense from a systems biology approach to microbial recombinant protein production

  2010cites this paper
• Systems biology of industrial microorganisms.

  2010cites this paper
• Structural divergence between the two subgroups of P5 ATPases.

  2010cites this paper
• Transcriptomic response of the mycoparasitic fungus Trichoderma atroviride to the presence of a fungal prey

  2009cites this paper
• Current status of systems biology in Aspergilli.

  2009cites this paper
• HacA-Dependent Transcriptional Switch Releases hacA mRNA from a Translational Block upon Endoplasmic Reticulum Stress

  2009cites this paper
• Yeast systems biotechnology for the production of heterologous proteins.

  2009cites this paper
• NOVEL PROCESSES AND PRODUCTS FOR RECOMBINANT PRODUCTION OFBIOPHARMACEUTICALS

  2009cites this paper
• Developing Aspergillus as a host for heterologous expression.

  2009cites this paper
• Effective lead selection for improved protein production in Aspergillus niger based on integrated genomics.

  2009cites this paper
• Impact of the unfolded protein response upon genome-wide expression patterns, and the role of Hac1 in the polarized growth, of Candida albicans.

  2008cites this paper
• [Recent advances in the production of heterologous proteins in filamentous fungi].

  2008cites this paper
• Assessment of the pectinolytic network of Aspergillus niger by functional genomics : insights from the transcriptome

  2008cites this paper
• Isolation of four pepsin-like protease genes from Aspergillus niger and analysis of the effect of disruptions on heterologous laccase expression.

  2008cites this paper
• Novel insights into the unfolded protein response using Pichia pastoris specific DNA microarrays

  2008cites this paper
• Systems biology studies of Aspergilli - from sequence to science

  2008cites this paper
• The first fifty microarray studies in filamentous fungi.

  2007cites this paper
• Select what you need: a comparative evaluation of the advantages and limitations of frequently used expression systems for foreign genes.

  2007cites this paper
• Comparative and functional genome analysis of fungi for development of the protein production host Trichoderma reesei

  2007influential citation
• Circadian rhythmicity during prolonged chemostat cultivation of Neurospora crassa.

  2007cites this paper
• Functional expression of amine oxidase from Aspergillus niger (AO-I) in Saccharomyces cerevisiae

  2007cites this paper
• Genomic analysis of the secretion stress response in the enzyme-producing cell factory Aspergillus niger

  2007cites this paper
• Selection of reference genes for normalisation of specific gene quantification data of Aspergillus niger.

  2007cites this paper
• Comparative genome analysis across a kingdom of eukaryotic organisms: specialization and diversification in the fungi.

  2007cites this paper
• Proteome mapping of the Trichoderma reesei 20S proteasome

  2007influential citation
• Monitoring of transcriptional regulation in Pichia pastoris under protein production conditions

  2007cites this paper
• Common features and interesting differences in transcriptional responses to secretion stress in the fungi Trichoderma reesei and Saccharomyces cerevisiae

  2006cites this paper
• Transcriptional monitoring of steady state and effects of anaerobic phases in chemostat cultures of the filamentous fungus Trichoderma reesei

  2006cites this paper
• HACA, the transcriptional activator of the unfolded protein response (UPR) in Aspergillus niger, binds to partly palindromic UPR elements of the consensus sequence 5'-CAN(G/A)NTGT/GCCT-3'.

  2006cites this paper
• Metabolic network driven analysis of genome-wide transcription data from Aspergillus nidulans

  2006cites this paper
• Genomics of Protein Secretion and Hyphal Growth in Aspergillus

  2006cites this paper
• UPR-independent dithiothreitol stress-induced genes in Aspergillus niger

  2005cites this paper