A carrier fusion significantly induces unfolded protein response in heterologous protein production by Aspergillus oryzae

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Applied Microbiology and Biotechnology

• Publication date

  2011-08-07

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/s00253-011-3487-9PMID 21822643
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Autophagy delivers misfolded secretory proteins accumulated in endoplasmic reticulum to vacuoles in the filamentous fungus Aspergillus oryzae.

  2011cited by this paper
• Disruption of ten protease genes in the filamentous fungus Aspergillus oryzae highly improves production of heterologous proteins

  2011cited by this paper
• Enhanced Production and Secretion of Heterologous Proteins by the Filamentous Fungus Aspergillus oryzae via Disruption of Vacuolar Protein Sorting Receptor Gene Aovps10

  2010cited by this paper
• Construction of quintuple protease gene disruptant for heterologous protein production in Aspergillus oryzae

  2009cited by this paper
• Isolation of Aspergillus oryzae mutants for heterologous protein production from a double proteinase gene disruptant

  2009influential reference
• Improvement of Heterologous Protein Production in Aspergillus oryzae by RNA Interference with α-Amylase Genes

  2009influential reference
• Monitoring Global Gene Expression of Proteases and Improvement of Human Lysozyme Production in the nptB Gene Disruptant of Aspergillus oryzae

  2008influential reference
• Multiple gene disruptions by marker recycling with highly efficient gene-targeting background (ΔligD) in Aspergillus oryzae

  2008cited by this paper
• Double disruption of the proteinase genes, tppA and pepE, increases the production level of human lysozyme by Aspergillus oryzae

  2007influential reference
• Analysis of Expressed Sequence Tags from the Fungus Aspergillus oryzae Cultured Under Different Conditions

  2007cited by this paper
• Microbial production of sensory-active miraculin.

  2007cited by this paper
• Genomic analysis of the secretion stress response in the enzyme-producing cell factory Aspergillus niger

  2007influential reference
• Identification and Characterization of an Intracellular Lectin, Calnexin, from Aspergillus oryzae Using N-Glycan-Conjugated Beads

  2007cited by this paper
• Signal integration in the endoplasmic reticulum unfolded protein response

  2007cited by this paper
• Common features and interesting differences in transcriptional responses to secretion stress in the fungi Trichoderma reesei and Saccharomyces cerevisiae

  2006cited by this paper
• Development of a Versatile Expression Plasmid Construction System for Aspergillus oryzae and Its Application to Visualization of Mitochondria

  2006cited by this paper
• Extracellular Production of Neoculin, a Sweet-Tasting Heterodimeric Protein with Taste-Modifying Activity, by Aspergillus oryzae

  2006influential reference
• HACA, the transcriptional activator of the unfolded protein response (UPR) in Aspergillus niger, binds to partly palindromic UPR elements of the consensus sequence 5'-CAN(G/A)NTGT/GCCT-3'.

  2006influential reference
• Transcriptome Analysis of Recombinant Protein Secretion by Aspergillus nidulans and the Unfolded-Protein Response In Vivo

  2005cited by this paper
• Genome sequencing and analysis of Aspergillus oryzae

  2005cited by this paper
• Development of a novel quadruple auxotrophic host transformation system by argB gene disruption using adeA gene and exploiting adenine auxotrophy in Aspergillus oryzae.

  2004cited by this paper
• Isolation and characterisation of a calnexin homologue, clxA, from Aspergillus niger

  2003influential reference
• Improvement of Foreign-Protein Production in Aspergillus niger var. awamori by Constitutive Induction of the Unfolded-Protein Response

  2003cited by this paper
• The role of the Aspergillus niger furin-type protease gene in processing of fungal proproteins and fusion proteins. Evidence for alternative processing of recombinant (fusion-) proteins.

  2003cited by this paper
• Molecular biology of the Koji molds.

  2002cited by this paper
• Characterization of the Kexin-Like Maturase ofAspergillus niger

  2000cited by this paper
• Characterization of a Foldase, Protein Disulfide Isomerase A, in the Protein Secretory Pathway ofAspergillus niger

  2000cited by this paper
• Molecular characterization of a PDI-related gene prpA in Aspergillus niger var. awamori

  2000cited by this paper
• Cloning and functional analysis of the Aspergillus oryzae conidiation regulator gene brlA by its disruption and misscheduled expression.

  1999cited by this paper
• Cloning and characterization of the bipA gene encoding ER chaperone BiP from Aspergillus oryzae.

  1999cited by this paper
• Analysis of the role of the gene bipA, encoding the major endoplasmic reticulum chaperone protein in the secretion of homologous and heterologous proteins in black Aspergilli

  1998cited by this paper
• Glucoamylase gene fusions alleviate limitations for protein production in Aspergillus awamori at the transcriptional and (post) translational levels

  1997cited by this paper
• The ER chaperone encoding bipA gene of black Aspergilli is induced by heat shock and unfolded proteins.

  1997cited by this paper
• Cloning, characterization and overexpression of a gene (pdiA) encoding protein disulfide isomerase of Aspergillus oryzae

  1996cited by this paper
• Deletion analysis of promoter elements of the Aspergillus oryzae agdA gene encoding α-glucosidase

  1996cited by this paper
• High level secretion of calf chymosin using a glucoamylase-prochymosin fusion gene in Aspergillus oryzae.

  1994cited by this paper
• Immunoisolation of Kex2p-containing organelles from yeast demonstrates colocalisation of three processing proteinases to a single Golgi compartment.

  1993cited by this paper
• Investigations on the activation of bovine prochymosin.

  1979cited by this paper

• AI-directed gene fusing prolongs the evolutionary half-life of synthetic gene circuits

  2025cites this paper
• From Fungal Cell Factories to Mycoproteins: Alternative Protein Production for Human Diets

  2025cites this paper
• Spatiotemporal regulation of endoplasmic reticulum stress visualized by live imaging of bipA mRNA in Aspergillus oryzae

  2025influential citation
• Construction of a heterologous protein secretion system using the protein disulfide isomerase Pdi1p in Schizosaccharomycespombe.

  2025cites this paper
• Synthetic Biology Tools for Engineering Aspergillus oryzae

  2024cites this paper
• Genetic Engineering in Bacteria, Fungi, and Oomycetes, Taking Advantage of CRISPR

  2024cites this paper
• Genetic Engineering of Filamentous Fungi: Prospects for Obtaining Fourth-Generation Biological Products

  2024cites this paper
• Unlocking the magic in mycelium: Using synthetic biology to optimize filamentous fungi for biomanufacturing and sustainability

  2023cites this paper
• Physiological ER stress caused by amylase production induces regulated Ire1-dependent mRNA decay in Aspergillus oryzae

  2023cites this paper
• FungalBraid 2.0: expanding the synthetic biology toolbox for the biotechnological exploitation of filamentous fungi

  2023cites this paper
• Heterologous protein production in filamentous fungi

  2023influential citation
• Advances in Genetic Engineering Technology and Its Application in the Industrial Fungus Aspergillus oryzae

  2021cites this paper
• Engineering interventions in industrial filamentous fungal cell factories for biomass valorization.

  2021cites this paper
• Delivering the goods: Fungal secretion modulates virulence during host–pathogen interactions

  2021cites this paper
• Characterization and functional analysis of ERAD-related AAA+ ATPase Cdc48 in Aspergillus oryzae.

  2020cites this paper
• Aspergillus: A Powerful Protein Production Platform

  2020cites this paper
• 10 Filamentous Fungi as Hosts for Heterologous Production of Proteins and Secondary Metabolites in the Post-Genomic Era

  2020cites this paper
• Genetic Engineering of Filamentous Fungi for Efficient Protein Expression and Secretion

  2020cites this paper
• Harnessing the knowledge of protein secretion for enhanced protein production in filamentous fungi

  2019cites this paper
• Filamentous fungi-like secretory pathway strayed in a yeast system: peculiarities of Yarrowia lipolytica secretory pathway underlying its extraordinary performance

  2018cites this paper
• Cellular responses to the expression of unstable secretory proteins in the filamentous fungus Aspergillus oryzae

  2017cites this paper
• Genetic Tools for Production of Proteins in Fungi

  2016cites this paper
• Searching for an hiv vaccine: a heterologous prime-boost system using replicating vaccinia virus and plant-produced virus-like particles

  2016cites this paper
• Heterologous Protein Expression in the Aspergilli: Overcoming Obstacles in the Secretory Pathway

  2016cites this paper
• Comparative genomic analysis identified a mutation related to enhanced heterologous protein production in the filamentous fungus Aspergillus oryzae

  2016cites this paper
• Unfolded protein response is required for Aspergillus oryzae growth under conditions inducing secretory hydrolytic enzyme production.

  2015cites this paper
• Stress Responses of Koji Mold Cells with Highly Polarized and Multicellular Morphology

  2015cites this paper
• 9 Transcriptomics of Industrial Filamentous Fungi: A New View on Regulation, Physiology, and Application

  2014cites this paper
• Modulating Endoplasmic Reticulum-Golgi Cargo Receptors for Improving Secretion of Carrier-Fused Heterologous Proteins in the Filamentous Fungus Aspergillus oryzae

  2014cites this paper
• Endoplasmic reticulum stress and fungal pathogenesis.

  2014cites this paper
• Strategies for Increasing the Production Level of Heterologous Proteins in Aspergillus oryzae

  2014cites this paper
• Studies on gene expression and promoter analyses for protein production in Aspergillus oryzae

  2013cites this paper
• Further enhanced production of heterologous proteins by double-gene disruption (ΔAosedD ΔAovps10) in a hyper-producing mutant of Aspergillus oryzae

  2013cites this paper
• Presence and Functionality of Mating Type Genes in the Supposedly Asexual Filamentous Fungus Aspergillus oryzae

  2012cites this paper
• Heterologous gene expression in filamentous fungi.

  2012cites this paper
• Produção e caracterização de proteínas do complexo celulolítico de Trichoderma harzianum, envolvidas na hidrólise enzimática da biomassa

  2012cites this paper
• High production of llama variable heavy-chain antibody fragment (VHH) fused to various reader proteins by Aspergillus oryzae

  2012cites this paper
• Transcripts of a heterologous gene encoding mite allergen Der f 7 are stabilized by codon optimization in Aspergillus oryzae

  2012cites this paper