Silver nanoparticles: a promising nanoplatform for targeted delivery of therapeutics and optimized therapeutic efficacy

Abstract In recent decades, nanotechnology-employed nanomaterials have gained remarkable recognition due to their unique physicochemical features (nanoscopic size, zeta potential, and high entrapment efficiency), target-specific delivery of diagnostic and therapeutic payload, alleviated systemic toxicity, and improved therapeutic outcomes. Amongst various nanomaterials, silver nanoparticles (SNPs) have widely been employed in various fields including medicine and healthcare. In this chapter, we have mainly emphasized upon biological and biomedical applications of SNPs such as wound healing, tissue regenerating, antibacterial, antifungal, anticancer, antiproliferative, antiinflammatory, antioxidant, and antidiabetic efficacies. As a promising antimicrobial agent, SNPs have numerously been utilized for the development of wound dressings, bone fracture artificial ligaments, women hygienic products, disinfectants, and antiseptics. SNPs have also been well acclaimed as an efficient nanoplatform for target-specific delivery of imaging and anticancer agents for efficient screening and rational treatment of human cancer. Pharmaceutical and therapeutic feasibility of SNPs has been investigated in the form of nanocomposites, sponges, hydrogels, nanodispersion, nanosuspension, gels, colloidal solution, creams, ointment, and topical sprays. This chapter also recaps on recent development and progress made in designing the SNP-based hybrid nanomaterials, their superior biomedical efficacies, current challenges to their clinical transition, and future prospects.

• Publication year

  2020

• Venue

  Metal Nanoparticles for Drug Delivery and Diagnostic Applications

• Publication date

  Unknown publication date

• Fields of study

  Medicine, Materials Science

• Identifiers
  DOI 10.1016/b978-0-12-816960-5.00009-4
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Hyaluronic acid-modified betamethasone encapsulated polymeric nanoparticles: fabrication, characterisation, in vitro release kinetics, and dermal targeting

  2019cited by this paper
• Carbon nanotube scaffolds as emerging nanoplatform for myocardial tissue regeneration: A review of recent developments and therapeutic implications.

  2018cited by this paper
• Enhancement of Equid Distal Limb Wounds Healing by Topical Application of Silver Nanoparticles

  2018cited by this paper
• Graphene Oxide–Silver Nanocomposite Enhances Cytotoxic and Apoptotic Potential of Salinomycin in Human Ovarian Cancer Stem Cells (OvCSCs): A Novel Approach for Cancer Therapy

  2018cited by this paper
• A novel use of cellulose based filter paper containing silver nanoparticles for its potential application as wound dressing agent.

  2018cited by this paper
• ANTIDIABETIC EFFECT OF SILVER NANOPARTICLES SYNTHESIZED USING LEMONGRASS (CYMBOPOGON CITRATUS) THROUGH CONVENTIONAL HEATING AND MICROWAVE IRRADIATION APPROACH

  2018cited by this paper
• Nanoencapsulation of betamethasone valerate using high pressure homogenization–solvent evaporation technique: optimization of formulation and process parameters for efficient dermal targeting

  2018cited by this paper
• A novel wound dressing based on a Konjac glucomannan/silver nanoparticle composite sponge effectively kills bacteria and accelerates wound healing.

  2018cited by this paper
• Domperidone nanocrystals with boosted oral bioavailability: fabrication, evaluation and molecular insight into the polymer-domperidone nanocrystal interaction

  2018cited by this paper
• Bio fabrication of silver nanoparticles as an effective wound healing agent in the wound care after anorectal surgery.

  2018cited by this paper
• Nanomedicines as emerging platform for simultaneous delivery of cancer therapeutics: new developments in overcoming drug resistance and optimizing anticancer efficacy

  2018cited by this paper
• Biomedical Applications of Silver Nanoparticles: An Up-to-Date Overview

  2018cited by this paper
• Curcumin based nanomedicines as efficient nanoplatform for treatment of cancer: New developments in reversing cancer drug resistance, rapid internalization, and improved anticancer efficacy

  2018cited by this paper
• Design and development of novel hyaluronate-modified nanoparticles for combo-delivery of curcumin and alendronate: fabrication, characterization, and cellular and molecular evidences of enhanced bone regeneration.

  2018cited by this paper
• Caspase-3/MAPK pathways as main regulators of the apoptotic effect of the phyto-mediated synthesized silver nanoparticle from dried stem of Eleutherococcus senticosus in human cancer cells.

  2018cited by this paper
• Development of biosynthesized silver nanoparticles based formulation for treating wounds during nursing care in hospitals.

  2018cited by this paper
• Hyaluronic acid decorated tacrolimus-loaded nanoparticles: Efficient approach to maximize dermal targeting and anti-dermatitis efficacy.

  2018cited by this paper
• Injectable methylcellulose hydrogel containing silver oxide nanoparticles for burn wound healing.

  2018cited by this paper
• Characterization, antibacterial, antioxidant, antidiabetic, anti-inflammatory and antityrosinase activity of green synthesized silver nanoparticles using Calophyllum tomentosum leaves extract

  2018cited by this paper
• Silver oxide nanoparticles embedded silk fibroin spuns: Microwave mediated preparation, characterization and their synergistic wound healing and anti-bacterial activity.

  2018cited by this paper
• Biogenic synthesis, characterization of gold and silver nanoparticles from Coleus forskohlii and their clinical importance.

  2018cited by this paper
• In situ reduction of silver nanoparticles by chitosan-l-glutamic acid/hyaluronic acid: Enhancing antimicrobial and wound-healing activity.

  2017cited by this paper
• Exploring recent developments to improve antioxidant, anti-inflammatory and antimicrobial efficacy of curcumin: A review of new trends and future perspectives.

  2017cited by this paper
• Novel biomolecule lycopene-reduced graphene oxide-silver nanoparticle enhances apoptotic potential of trichostatin A in human ovarian cancer cells (SKOV3)

  2017cited by this paper
• Graphene Oxide–Silver Nanoparticles Nanocomposite Stimulates Differentiation in Human Neuroblastoma Cancer Cells (SH-SY5Y)

  2017cited by this paper
• Biosynthesis of silver nanoparticles using aqueous extract of Phyllanthus acidus L. fruits and characterization of its anti-inflammatory effect against H2O2 exposed rat peritoneal macrophages

  2017cited by this paper
• Quercetin-mediated synthesis of graphene oxide–silver nanoparticle nanocomposites: a suitable alternative nanotherapy for neuroblastoma

  2017cited by this paper
• In vitro and in vivo anti-inflammatory properties of green synthesized silver nanoparticles using Viburnum opulus L. fruits extract.

  2017cited by this paper
• Silver-nanoparticles increase bactericidal activity and radical oxygen responses against bacterial pathogens in human osteoclasts.

  2017cited by this paper
• Silver nanoparticles enhance the apoptotic potential of gemcitabine in human ovarian cancer cells: combination therapy for effective cancer treatment

  2017cited by this paper
• Combination of graphene oxide–silver nanoparticle nanocomposites and cisplatin enhances apoptosis and autophagy in human cervical cancer cells

  2017cited by this paper
• Bioengineered mannan sulphate capped silver nanoparticles for accelerated and targeted wound healing: Physicochemical and biological investigations.

  2017cited by this paper
• Green Biosynthesis, Characterization, In vitro Antidiabetic Activity, and Investigational Acute Toxicity Studies of Some Herbal-mediated Silver Nanoparticles on Animal Models

  2017cited by this paper
• Enhanced antibacterial and wound healing activities of microporous chitosan-Ag/ZnO composite dressing.

  2017cited by this paper
• Silver Inlaid with Gold Nanoparticle/Chitosan Wound Dressing Enhances Antibacterial Activity and Porosity, and Promotes Wound Healing.

  2017cited by this paper
• An in vitro study on the burn wound healing activity of cotton fabrics incorporated with phytosynthesized silver nanoparticles in male Wistar albino rats

  2017cited by this paper
• Nanoencapsulation, an efficient and promising approach to maximize wound healing efficacy of curcumin: A review of new trends and state-of-the-art.

  2017cited by this paper
• Spongy bilayer dressing composed of chitosan-Ag nanoparticles and chitosan-Bletilla striata polysaccharide for wound healing applications.

  2017cited by this paper
• Evaluation of antidiabetic activity of biologically synthesized silver nanoparticles using Pouteria sapota in streptozotocin‐induced diabetic rats

  2017cited by this paper
• Dual functions of silver nanoparticles in F9 teratocarcinoma stem cells, a suitable model for evaluating cytotoxicity- and differentiation-mediated cancer therapy

  2017cited by this paper
• Aceclofenac nanocrystals with enhanced in vitro, in vivo performance: formulation optimization, characterization, analgesic and acute toxicity studies

  2017cited by this paper
• Long-term anti-inflammatory efficacy in intestinal anastomosis in mice using silver nanoparticle-coated suture.

  2017cited by this paper
• Synthesis, characterization, and antimicrobial properties of novel double layer nanocomposite electrospun fibers for wound dressing applications

  2017cited by this paper
• In vivo diabetic wound healing potential of nanobiocomposites containing bamboo cellulose nanocrystals impregnated with silver nanoparticles.

  2017cited by this paper
• New developments and clinical transition of hyaluronic acid-based nanotherapeutics for treatment of cancer: reversing multidrug resistance, tumour-specific targetability and improved anticancer efficacy

  2017cited by this paper
• Antidiabetic activity of silver nanoparticles from green synthesis using Lonicera japonica leaf extract

  2016cited by this paper
• Differential Cytotoxic Potential of Silver Nanoparticles in Human Ovarian Cancer Cells and Ovarian Cancer Stem Cells

  2016cited by this paper
• Synthesis, characterization, biocompatible and anticancer activity of green and chemically synthesized silver nanoparticles - A comparative study.

  2016cited by this paper
• Combination of salinomycin and silver nanoparticles enhances apoptosis and autophagy in human ovarian cancer cells: an effective anticancer therapy

  2016cited by this paper
• Fabrication of electrospun polycaprolactone coated withchitosan-silver nanoparticles membranes for wound dressing applications

  2016cited by this paper
• Rapid green synthesis of silver and gold nanoparticles using Dendropanax morbifera leaf extract and their anticancer activities

  2016cited by this paper
• Enhanced bactericidal toxicity of silver nanoparticles by the antibiotic gentamicin

  2016cited by this paper
• Chitosan wound dressing with hexagonal silver nanoparticles for hyperthermia and enhanced delivery of small molecules.

  2016cited by this paper
• Bifunctional Therapeutic High-Valence Silver-Pyridoxine Nanoparticles with Proliferative and Antibacterial Wound-Healing Activities.

  2016cited by this paper
• Amelioration of excision wounds by topical application of green synthesized, formulated silver and gold nanoparticles in albino Wistar rats.

  2016cited by this paper
• Silver nanoparticles from Dendropanax morbifera Léveille inhibit cell migration, induce apoptosis, and increase generation of reactive oxygen species in A549 lung cancer cells

  2016cited by this paper
• Sulfanilamide and silver nanoparticles-loaded polyvinyl alcohol-chitosan composite electrospun nanofibers: Synthesis and evaluation on synergism in wound healing

  2016cited by this paper
• Antibacterial properties and mechanisms of gold-silver nanocages.

  2016cited by this paper
• Anticancer activity of silver nanoparticles from Panax ginseng fresh leaves in human cancer cells.

  2016cited by this paper
• Synthesis, characterization and biocompatibility of silver nanoparticles synthesized from Nigella sativa leaf extract in comparison with chemical silver nanoparticles.

  2015cited by this paper
• Photochemical synthesis of biocompatible and antibacterial silver nanoparticles embedded within polyurethane polymers

  2015cited by this paper
• Green synthesis of silver nanoparticles using cranberry powder aqueous extract: characterization and antimicrobial properties

  2015cited by this paper
• Reduced graphene oxide–silver nanoparticle nanocomposite: a potential anticancer nanotherapy

  2015cited by this paper
• Antibacterial and cytotoxic effect of biologically synthesized silver nanoparticles using aqueous root extract of Erythrina indica lam.

  2015cited by this paper
• Biosynthesis of silver nanoparticles using ethanolic petals extract of Rosa indica and characterization of its antibacterial, anticancer and anti-inflammatory activities.

  2015cited by this paper
• Evaluation of biomaterial containing regenerated cellulose and chitosan incorporated with silver nanoparticles.

  2015cited by this paper
• Electrospun Polycaprolactone Membrane Incorporated with Biosynthesized Silver Nanoparticles as Effective Wound Dressing Material

  2015cited by this paper
• Construction of Silver Nanoparticle-Loaded Micelles Via Coordinate Interaction and Their Antibacterial Activity

  2015cited by this paper
• Susceptibility of Candida albicans and Candida glabrata biofilms to silver nanoparticles in intermediate and mature development phases.

  2015cited by this paper
• Prompt and synergistic antibacterial activity of silver nanoparticle-decorated silica hybrid particles on air filtration.

  2014cited by this paper
• Green synthesis of silver nanoparticles with Dalbergia spinosa leaves and their applications in biological and catalytic activities

  2014cited by this paper
• Dendrimer encapsulation enhances anti-inflammatory efficacy of silver nanoparticles.

  2014cited by this paper
• Antimicrobial and antioxidant activities of Mimusops elengi seed extract mediated isotropic silver nanoparticles.

  2014cited by this paper
• Silver nanoparticles alter proteoglycan expression in the promotion of tendon repair.

  2014cited by this paper
• In situ synthesis of silver-nanoparticles/bacterial cellulose composites for slow-released antimicrobial wound dressing.

  2014cited by this paper
• Silver colloidal nanoparticle stability: influence on Candida biofilms formed on denture acrylic.

  2014cited by this paper
• Silver nanoparticle-coated suture effectively reduces inflammation and improves mechanical strength at intestinal anastomosis in mice.

  2014cited by this paper
• Antimicrobial wound dressing and anti-inflammatory efficacy of silver nanoparticles.

  2014cited by this paper
• APPLICATION OF SILVER NANOPARTICLES AS ANTIFUNGAL AND ANTIAFLATOXIN B1 PRODUCED BY ASPERGILLUS FLAVUS

  2014cited by this paper
• Green synthesis, characterization and anti-inflammatory activity of silver nanoparticles using European black elderberry fruits extract.

  2014cited by this paper
• Silver nanoparticle/chitosan oligosaccharide/poly(vinyl alcohol) nanofibers as wound dressings: a preclinical study

  2013cited by this paper
• Bactericidal Effect of Poly(Acrylamide/Itaconic Acid)–Silver Nanoparticles Synthesized by Gamma Irradiation Against Pseudomonas Aeruginosa

  2013cited by this paper
• Stepwise Embryonic Toxicity of Silver Nanoparticles on Oryzias latipes

  2013cited by this paper
• Sesbania grandiflora leaf extract mediated green synthesis of antibacterial silver nanoparticles against selected human pathogens.

  2013cited by this paper
• Green synthesis of silver nanoparticles from leaf extract of Mimusops elengi, Linn. for enhanced antibacterial activity against multi drug resistant clinical isolates.

  2013cited by this paper
• Citrate-capped silver nanoparticles showing good bactericidal effect against both planktonic and sessile bacteria and a low cytotoxicity to osteoblastic cells.

  2013cited by this paper
• Antifungal activity of silver nanoparticles in combination with nystatin and chlorhexidine digluconate against Candida albicans and Candida glabrata biofilms

  2013cited by this paper
• Silver nanoparticle production by the fungus Fusarium oxysporum: nanoparticle characterisation and analysis of antifungal activity against pathogenic yeasts

  2013cited by this paper
• In vitro cytotoxicity and genotoxicity studies of titanium dioxide (TiO2) nanoparticles in Chinese hamster lung fibroblast cells.

  2013cited by this paper
• Silver as antibacterial agent: ion, nanoparticle, and metal.

  2013cited by this paper
• Chitosan-hyaluronic acid/nano silver composite sponges for drug resistant bacteria infected diabetic wounds.

  2013cited by this paper
• Extracellular biosynthesis of silver nanoparticles using Bacillus sp. GP-23 and evaluation of their antifungal activity towards Fusarium oxysporum.

  2013cited by this paper
• Preparation, characterization and evaluation of biocomposite films containing chitosan and sago starch impregnated with silver nanoparticles.

  2012cited by this paper
• Negligible particle-specific antibacterial activity of silver nanoparticles.

  2012cited by this paper
• Evaluation of biocomposite films containing alginate and sago starch impregnated with silver nano particles.

  2012cited by this paper
• Silver nanoparticles: influence of stabilizing agent and diameter on antifungal activity against Candida albicans and Candida glabrata biofilms

  2012cited by this paper
• Antifungal Effects of Silver Nanoparticles (AgNPs) against Various Plant Pathogenic Fungi

  2012cited by this paper
• Green synthesis of silver nanoparticles using Ocimum sanctum (Tulashi) and study of their antibacterial and antifungal activities

  2012cited by this paper
• Cytocompatible antifungal acrylic resin containing silver nanoparticles for dentures

  2012cited by this paper
• Biogenic Silver Nanoparticles by Gelidiella acerosa Extract and their Antifungal Effects

  2011cited by this paper

• Laser Generated MoS2 Nanomaterials and Its Applications: A Review

  2025cites this paper
• Doxorubicin-sanguinarine nanoparticles: formulation and evaluation of breast cancer cell apoptosis and cell cycle

  2024cites this paper
• Surface Engineering of AgNPs-Decorated Polyetheretherketone

  2023cites this paper
• PENENTUAN KANDUNGAN ANTIOKSIDAN DAN FENOLIK TOTAL DARI EKSTRAK TUMBUHAN SEBAGAI BIOREDUKTOR DALAM PEMBENTUKAN NANOPARTIKEL PERAK

  2023cites this paper
• Green Synthesis Silver Nanoparticles Using Sembung (Blumea balsamifera) Leaf Extract as an Antibacterial and Antioxidant

  2023cites this paper
• Green Synthesis and Characterization of Silver Nanoparticles Using Myrsine africana Leaf Extract for Their Antibacterial, Antioxidant and Phytotoxic Activities

  2022cites this paper
• Treating colon cancers with a non-conventional yet strategic approach: An overview of various nanoparticulate systems.

  2021cites this paper
• Silver nanoparticles: Advanced and promising technology in diabetic wound therapy.

  2020cites this paper
• In Situ and Ex Situ Designed Hydroxyapatite: Bacterial Cellulose Materials with Biomedical Applications

  2020cites this paper
• Prospects for Further Development of Face Masks to Minimize Pandemics Functionalization of Textile Materials with Biocide Inorganic Nanoparticles: A Review

  2020cites this paper
• Preparation and antioxidant study of silver nanoparticles of Microsorum pteropus methanol extract.

  2020cites this paper
• A hybrid lipid membrane coating “shape-locks” silver nanoparticles to prevent surface oxidation and silver ion dissolution

  2020cites this paper