Hyperglycemia promotes tissue plasminogen activator‐induced hemorrhage by Increasing superoxide production

No abstract is available for this paper.

• Publication year

  2011

• Venue

  Annals of Neurology

• Publication date

  2011-10-01

• Fields of study

  Medicine

• Identifiers
  DOI 10.1002/ana.22538PMID 22002675PMCID PMC4554391
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Digitally quantifying cerebral hemorrhage using Photoshop and Image J.

  2010cited by this paper
• Thrombolysis for acute stroke in Australia: outcomes from the Safe Implementation of Thrombolysis in Stroke registry (2002–2008)

  2010cited by this paper
• Diabetes Mellitus, Acute Hyperglycemia, and Ischemic Stroke

  2010cited by this paper
• NADPH oxidase is the primary source of superoxide induced by NMDA receptor activation

  2009cited by this paper
• Glucose Regulation in Acute Stroke Patients (GRASP) Trial: A Randomized Pilot Trial

  2009cited by this paper
• Patterns and Predictors of Blood–Brain Barrier Permeability Derangements in Acute Ischemic Stroke

  2009cited by this paper
• Baseline Diabetic Status and Admission Blood Glucose Were Poor Prognostic Factors in the EPITHET Trial

  2009cited by this paper
• HIF-1 alpha inhibition ameliorates neonatal brain damage after hypoxic-ischemic injury.

  2008cited by this paper
• Glucose and NADPH oxidase drive neuronal superoxide formation in stroke

  2008cited by this paper
• Priming of neutrophil oxidative burst in diabetes requires preassembly of the NADPH oxidase

  2008cited by this paper
• Hemorrhagic transformation of ischemic brain tissue after t-PA thrombolysis as detected by MRI may be asymptomatic, but impair neurological recovery.

  2008cited by this paper
• Apocynin improves outcome in experimental stroke with a narrow dose range.

  2008cited by this paper
• Hyperglycemia in Acute Ischemic Stroke: A Vascular Perspective

  2007cited by this paper
• Effect of Sustained-Mild and Transient-Severe Hyperglycemia on Ischemia-Induced Blood–Brain Barrier Opening

  2007cited by this paper
• Asymptomatic Hemorrhage After Thrombolysis May Not Be Benign: Prognosis by Hemorrhage Type in the Canadian Alteplase for Stroke Effectiveness Study Registry

  2007cited by this paper
• Symptomatic Intracerebral Hemorrhage following Thrombolytic Therapy for Acute Ischemic Stroke: A Review of the Risk Factors

  2007cited by this paper
• Glucose-potassium-insulin infusions in the management of post-stroke hyperglycaemia: the UK Glucose Insulin in Stroke Trial (GIST-UK).

  2007cited by this paper
• Influence of Hyperglycemia on Oxidative Stress and Matrix Metalloproteinase-9 Activation After Focal Cerebral Ischemia/Reperfusion in Rats: Relation to Blood-Brain Barrier Dysfunction

  2007cited by this paper
• NADPH Oxidase Plays a Central Role in Blood-Brain Barrier Damage in Experimental Stroke

  2007cited by this paper
• Hypoglycemic neuronal death is triggered by glucose reperfusion and activation of neuronal NADPH oxidase.

  2007cited by this paper
• Hyperglycemia increases superoxide production in the CA1 pyramidal neurons after global cerebral ischemia.

  2006cited by this paper
• Glucose-6-phosphate dehydrogenase-derived NADPH fuels superoxide production in the failing heart.

  2006cited by this paper
• Influence of age on the response to fibroblast growth factor-2 treatment in a rat model of stroke.

  2006cited by this paper
• Regulation and termination of NADPH oxidase activity

  2005cited by this paper
• Damage to the Endoplasmic Reticulum and Activation of Apoptotic Machinery by Oxidative Stress in Ischemic Neurons

  2005cited by this paper
• Role of NADPH oxidase in the brain injury of intracerebral hemorrhage

  2005cited by this paper
• Thrombolysis for acute ischemic stroke: results of the Canadian Alteplase for Stroke Effectiveness Study

  2005cited by this paper
• Matrix metalloproteinases and free radicals in cerebral ischemia.

  2005cited by this paper
• Intravenous Administration of a GPIIb/IIIa Receptor Antagonist Extends the Therapeutic Window of Intra-Arterial Tenecteplase–Tissue Plasminogen Activator in a Rat Stroke Model

  2004cited by this paper
• Brain lactic acidosis and ischemic cell damage: Quantitative ultrastructural changes in capillaries of rat cerebral cortex

  2004cited by this paper
• Protein Glycation: A Firm Link to Endothelial Cell Dysfunction

  2004cited by this paper
• Mechanisms of Hemorrhagic Transformation After Tissue Plasminogen Activator Reperfusion Therapy for Ischemic Stroke

  2004cited by this paper
• Effects of Admission Hyperglycemia on Stroke Outcome in Reperfused Tissue Plasminogen Activator–Treated Patients

  2003cited by this paper
• Admission glucose level and clinical outcomes in the NINDS rt-PA Stroke Trial

  2002cited by this paper
• Delayed induction and long-term effects of mild hypothermia in a focal model of transient cerebral ischemia: neurological outcome and infarct size.

  2001cited by this paper
• Cerebral hemorrhage after intra-arterial thrombolysis for ischemic stroke

  2001cited by this paper
• Stress Hyperglycemia and Prognosis of Stroke in Nondiabetic and Diabetic Patients: A Systematic Overview

  2001cited by this paper
• Serum glucose level and diabetes predict tissue plasminogen activator-related intracerebral hemorrhage in acute ischemic stroke.

  1999cited by this paper
• Overexpression of SOD1 in Transgenic Rats Protects Vulnerable Neurons Against Ischemic Damage After Global Cerebral Ischemia and Reperfusion

  1998cited by this paper
• Nitric oxide- and superoxide-mediated toxicity in cerebral endothelial cells.

  1997cited by this paper
• Tissue plasminogen activator for acute ischemic stroke.

  1996cited by this paper
• Tissue plasminogen activator for acute ischemic stroke. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group.

  1995cited by this paper
• Tissue plasminogen activator for acute ischemic stroke.

  1995cited by this paper
• Characteristics of the inhibition of NADPH oxidase activation in neutrophils by apocynin, a methoxy-substituted catechol.

  1994cited by this paper
• Predictors of mortality and recurrence after hospitalized cerebral infarction in an urban community

  1994cited by this paper
• Effect of plasma glucose on infarct size in focal cerebral ischemia‐reperfusion

  1991cited by this paper
• What causes infarction in ischemic brain?

  1983cited by this paper
• Brain Lactic Acidosis and Ischemic Cell Damage: 1. Biochemistry and Neurophysiology

  1981cited by this paper
• Studies on the Specific Fibrinolytic Effect of Human Extrinsic (Tissue-Type) Plasminogen Activator in Human Blood and in Various Animal Species in Vitro

  1981cited by this paper
• “Model”

  1981cited by this paper

• Postoperative Blood Glucose Trajectories are Associated with Inflammatory Markers and Functional Outcomes in Acute Ischemic Stroke Treated by Thrombectomy.

  2026cites this paper
• Propolis alleviates brain tissue damage and oxidative abnormalities in streptozotocin (STZ)-induced diabetes

  2026cites this paper
• Myrtenal Ameliorates Ischemic Brain Injury Diabetic and Non-Diabetic Rats

  2025cites this paper
• Association Between Internal Carotid Artery Tortuosity and Hemorrhagic Transformation in Patients with Acute Ischemic Stroke.

  2025cites this paper
• Stress Hyperglycemia Ratio and Adverse Outcomes in Acute Mild Ischemic Stroke or High-Risk Transient Ischemic Attack: A Secondary Analysis of the INSPIRES Trial

  2025cites this paper
• Cardiovascular Risk Factors Involved in Hemorrhagic Transformation After Intravenous Thrombolytic Therapy in Patients with Acute Ischemic Stroke

  2025cites this paper
• Correlation between systemic inflammatory response index and post-stroke epilepsy based on multiple logistic regression analysis

  2025cites this paper
• Effect of stress hyperglycaemia on the occurrence of haemorrhagic transformation after thrombolysis in patients with acute ischaemic stroke

  2025cites this paper
• Computed Tomography Based Analysis of Impact of Diabetes On the Severity of Subdural Hematoma: Correlation with Glycemic Control and Hematoma Volume

  2025cites this paper
• Relative Hyperglycemia and In-Hospital Bleeding Across Glycemic Status in Patients on High-Intensity Antithrombotic Therapy.

  2025cites this paper
• Association between the stress hyperglycemia ratio and all-cause mortality in patients with hemorrhagic stroke: a retrospective analysis based on MIMIC-IV database

  2025cites this paper
• Transcriptional and neuroprotective effects of hexokinase-2 inhibitors administered after stroke

  2025cites this paper
• Stress hyperglycemia could influence futile recanalization in patients who undergo mechanical thrombectomy for stroke caused by large vessel occlusion.

  2025cites this paper
• Review of Associations of Diabetes and Insulin Resistance With Brain Health in Three Harmonised Cohort Studies of Ageing and Dementia

  2025cites this paper
• Futile recanalization after mechanical thrombectomy in patients with acute ischemic stroke and large ischemic core.

  2025cites this paper
• Prognostic significance of the stress hyperglycemia ratio and admission blood glucose in diabetic and nondiabetic patients with spontaneous intracerebral hemorrhage

  2024cites this paper
• Secondary Brain Injury After Parenchymal Cerebral Hemorrhage in Humans: The Role of NOX2-Mediated Oxidative Stress and Endothelin-1

  2024cites this paper
• Ischemia-induced endogenous Nrf2/HO-1 axis activation modulates microglial polarization and restrains ischemic brain injury

  2024cites this paper
• Admission hyperglycemia effect on symptomatic intracranial hemorrhage in tenecteplase versus alteplase before large vessel occlusion stroke thrombectomy

  2024cites this paper
• Impact of stress hyperglycemia on outcomes in patients with large ischemic stroke

  2024cites this paper
• Hyperglycemia in a NOD Mice Model of Type-I Diabetes Aggravates Collagenase-Induced Intracerebral Hemorrhagic Injury

  2024cites this paper
• Misprogramming of glucose metabolism impairs recovery of hippocampal slices from neuronal GLT‐1 knockout mice and contributes to excitotoxic injury through mitochondrial superoxide production

  2024cites this paper
• Relationship between stress hyperglycemia ratio and prognosis in patients with aneurysmal subarachnoid hemorrhage: a two-center retrospective study

  2024cites this paper
• Stress hyperglycemia exacerbates inflammatory brain injury after stroke

  2024cites this paper
• Triglyceride-glucose index as a potential predictor for in-hospital mortality in critically ill patients with intracerebral hemorrhage: a multicenter, case–control study

  2024cites this paper
• Glucose Control and Risk of Symptomatic Intracerebral Hemorrhage Following Thrombolysis for Acute Ischemic Stroke: A SHINE Trial Analysis.

  2024cites this paper
• Diffusion-weighted Imaging Detection of Acute Ischemia Brain Lesions in Spontaneous Intracerebral Hemorrhage Associated with White Matter Hyperintensities, Enlarged Perivascular Spaces and Diabetes Mellitus.

  2024cites this paper
• Development and validation of a random forest model to predict functional outcome in patients with intracerebral hemorrhage

  2023cites this paper
• Glucose-albumin ratio as new biomarker for predicting mortality after intracerebral hemorrhage

  2023cites this paper
• Risk factors of hemorrhagic transformation in acute ischaemic stroke: A systematic review and meta-analysis

  2023cites this paper
• Polymeric nanomaterial strategies to encapsulate and deliver biological drugs: points to consider between methods.

  2023cites this paper
• A 6-month prognostic nomogram incorporating hemoglobin level for intracerebral hemorrhage in younger adults

  2023cites this paper
• Hypoperfusion Intensity Ratio Is Correlated With the Risk of Parenchymal Hematoma After Endovascular Stroke Treatment

  2022cites this paper
• Association of preoperative glucose concentration with mortality in patients undergoing craniotomy for brain tumor.

  2022cites this paper
• Association between hyperglycemia at admission and mortality in aneurysmal subarachnoid hemorrhage.

  2022cites this paper
• Potential application of intranasal insulin delivery for treatment of intracerebral hemorrhage: A review of the literature.

  2022cites this paper
• Verapamil, a possible repurposed therapeutic candidate for stroke under hyperglycemia

  2022cites this paper
• Diabetic and stress‐induced hyperglycemia in spontaneous intracerebral hemorrhage: A multicenter prospective cohort (CHEERY) study

  2022cites this paper
• Changes in hippocampal volume during a preceding 10-year period do not correlate with cognitive performance and hippocampal blood‒brain barrier permeability in cognitively normal late-middle-aged men

  2022cites this paper
• Hemorrhagic Transformation in Ischemic Stroke and the Role of Inflammation

  2021cites this paper
• The Stress Hyperglycemia Ratio is Associated with Hemorrhagic Transformation in Patients with Acute Ischemic Stroke

  2021cites this paper
• Clinical perspectives on ischemic stroke.

  2021cites this paper
• Verapamil as an Adjunct Therapy to Reduce tPA Toxicity in Hyperglycemic Stroke: Implication of TXNIP/NLRP3 Inflammasome

  2021cites this paper
• Stress Hyperglycemia in Patients With Acute Ischemic Stroke Due to Large Vessel Occlusion Undergoing Mechanical Thrombectomy

  2021cites this paper
• Association of early glycemic change with short-term mortality in lobar and non-lobar intracerebral hemorrhage

  2021cites this paper
• Cav-1 Protein Levels in Serum and Infarcted Brain Correlate with Hemorrhagic Volume in a Mouse Model of Thromboembolic Stroke, Independently of rt-PA Administration

  2021cites this paper
• Hyperglycemia in acute ischemic stroke: physiopathological and therapeutic complexity

  2021cites this paper
• A Nomogram to Predict Symptomatic Intracranial Hemorrhage After Intravenous Thrombolysis in Chinese Patients

  2021cites this paper
• Effects of β-Adrenergic Blockade on Metabolic and Inflammatory Responses in a Rat Model of Ischemic Stroke

  2020cites this paper
• Diabetes mellitus: A common comorbidity increasing hemorrhagic transformation after tPA thrombolytic therapy for ischemic stroke

  2020cites this paper
• Quantitative Proteomics Reveals the Beneficial Effects of Low Glucose on Neuronal Cell Survival in an in vitro Ischemic Penumbral Model

  2020cites this paper
• NOX Inhibitors: From Bench to Naxibs to Bedside.

  2020cites this paper
• Dynamic Hyperglycemic Patterns Predict Adverse Outcomes in Patients with Acute Ischemic Stroke Undergoing Mechanical Thrombectomy

  2020cites this paper
• Cerebral ischemia in diabetics and oxidative stress

  2020cites this paper
• The treament of hyperglycemia in acute ischemic stroke with incretin-based drugs.

  2020cites this paper
• Cardiogenic cerebral infarction in the parietal lobe predicts the development of post-stroke epilepsy.

  2020cites this paper
• Tissue Plasminogen Activator Promotes TXNIP-NLRP3 Inflammasome Activation after Hyperglycemic Stroke in Mice

  2020cites this paper
• Dynamic Detection of Thrombolysis in Embolic Stroke Rats by Synchrotron Radiation Angiography

  2019cites this paper
• Blood-brain barrier disturbances in diabetes-associated dementia: Therapeutic potential for cannabinoids.

  2019cites this paper
• Multi-parameters of Magnetic Resonance Imaging to Estimate Ischemia-Reperfusion Injury after Stroke in Hyperglycemic Rats

  2019cites this paper
• Nicotinamide adenine dinucleotide phosphate oxidase activation and neuronal death after ischemic stroke

  2019cites this paper
• Association between neutrophil to lymphocyte ratio and blood glucose level at admission in patients with spontaneous intracerebral hemorrhage

  2019cites this paper
• Postoperative hyperglycemia predicts symptomatic intracranial hemorrhage after endovascular treatment in patients with acute anterior circulation large artery occlusion.

  2019cites this paper
• Blood-Brain Barrier Disruption, Vascular Impairment, and Ischemia/Reperfusion Damage in Diabetic Stroke

  2019cites this paper
• Tissue Plasminogen Activator Causes Brain Microvascular Endothelial Cell Injury After Oxygen Glucose Deprivation by Inhibiting Sonic Hedgehog Signaling

  2018cites this paper
• The more effective treatment of atrial fibrillation applying the natural compounds; as NADPH oxidase and ion channel inhibitors

  2018cites this paper
• Ischemia/Reperfusion Damage in Diabetic Stroke

  2018cites this paper
• A hemorrhagic transformation model of mechanical stroke therapy with acute hyperglycemia in mice

  2018cites this paper
• Beta adrenoceptor blockade ameliorates impaired glucose tolerance and alterations of the cerebral ceramide metabolism in an experimental model of ischemic stroke

  2018cites this paper
• Association Between Blood Glucose and Functional Outcome in Intracerebral Hemorrhage: A Systematic Review and Meta-Analysis.

  2018cites this paper
• Targeting Reperfusion Injury in the Age of Mechanical Thrombectomy

  2018cites this paper
• Bioenergetic regulation of microglia

  2018cites this paper
• Autophagy- and MMP-2/9-mediated Reduction and Redistribution of ZO-1 Contribute to Hyperglycemia-increased Blood-Brain Barrier Permeability During Early Reperfusion in Stroke.

  2018cites this paper
• Influence of Admission Blood Glucose in Predicting Outcome in Patients With Spontaneous Intracerebral Hematoma

  2018cites this paper
• Hyperglycemia Predicts Blend Sign in Patients with Intracerebral Hemorrhage

  2018cites this paper
• Suppressing Interferon-γ Stimulates Microglial Responses and Repair of Microbleeds in the Diabetic Brain

  2018cites this paper
• Efficacy of Novel Carbon Nanoparticle Antioxidant Therapy in a Severe Model of Reversible Middle Cerebral Artery Stroke in Acutely Hyperglycemic Rats

  2018cites this paper
• Diabetes Worsens Functional Outcomes in Young Female Rats: Comparison of Stroke Models, Tissue Plasminogen Activator Effects, and Sexes

  2017cites this paper
• Cerebral ischemic damage in diabetes: an inflammatory perspective

  2017cites this paper
• Exendin-4 inhibits MMP-9 activation and reduces infarct growth after focal cerebral ischemia in hyperglycemic mice

  2017cites this paper
• Reconsidering Neuroprotection in the Reperfusion Era

  2017cites this paper
• The Role of Diabetes, Obesity, and Metabolic Syndrome in Stroke

  2017cites this paper
• Diabetic aggravation of stroke and animal models

  2017cites this paper
• Involvement of Nox2 and Nox4 NADPH oxidases in early brain injury after subarachnoid hemorrhage

  2017cites this paper
• Hemorrhagic transformation of ischemic stroke

  2017cites this paper
• Hematoma Expansion Following Intracerebral Hemorrhage: Mechanisms Targeting the Coagulation Cascade and Platelet Activation.

  2017cites this paper
• Blood-brain barrier dysfunction and recovery after ischemic stroke.

  2017cites this paper
• Hyperglycemia decreases preoxiredoxin-2 expression in a middle cerebral artery occlusion model

  2017cites this paper
• Effect of pregabalin administration upon reperfusion in a rat model of hyperglycemic stroke: Mechanistic insights associated with high-mobility group box 1

  2017cites this paper
• Reconsidering Neuroprotection in the Reperfusion Era

  2017cites this paper
• NOX Activation by Subunit Interaction and Underlying Mechanisms in Disease

  2017influential citation
• Blood–Brain Barrier Disruption, Vascular Impairment, and Ischemia/Reperfusion Damage in Diabetic Stroke

  2017cites this paper
• Hyperbaric Oxygen Reduces Infarction Volume and Hemorrhagic Transformation Through ATP/NAD+/Sirt1 Pathway in Hyperglycemic Middle Cerebral Artery Occlusion Rats

  2017cites this paper
• Diabetes, adult neurogenesis and brain remodeling: New insights from rodent and zebrafish models

  2017cites this paper
• Reconsidering Neuroprotection in the Reperfusion Era.

  2017cites this paper
• Admission hyperglycemia and outcome after intravenous thrombolysis

  2016cites this paper
• Long non-coding RNA HOTAIR promotes ischemic infarct induced by hypoxia through up-regulating the expression of NOX2.

  2016cites this paper
• Exendin-4 Inhibits Matrix Metalloproteinase-9 Activation and Reduces Infarct Growth After Focal Cerebral Ischemia in Hyperglycemic Mice

  2016cites this paper
• Improving Reperfusion Therapies in the Era of Mechanical Thrombectomy

  2016cites this paper
• Uric Acid Is Protective After Cerebral Ischemia/Reperfusion in Hyperglycemic Mice

  2016cites this paper