Resveratrol in Human Hepatoma HepG2 Cells: Metabolism and Inducibility of Detoxifying Enzymes

No abstract is available for this paper.

• Publication year

  2007

• Venue

  Drug Metabolism And Disposition

• Publication date

  2007-05-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  DOI 10.1124/dmd.106.013664PMID 17287390
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Correction to “Stereoselective Metabolism of Endosulfan by Human Liver Microsomes and Human Cytochrome P540 Isoforms”

  2007cited by this paper
• Metabolic Profile of a Peptide-Conjugated Chlorin-Type Photosensitizer Targeting Neuropilin-1: An in Vivo and in Vitro Study

  2007cited by this paper
• Resveratrol as a chemopreventive agent: a promising molecule for fighting cancer.

  2006cited by this paper
• Toxicogenomics of resveratrol in rat liver.

  2005cited by this paper
• Resveratrol: preventing properties against vascular alterations and ageing.

  2005cited by this paper
• Bioavailability of trans-resveratrol from red wine in humans.

  2005cited by this paper
• Bioactivity and metabolism of trans-resveratrol orally administered to Wistar rats.

  2005cited by this paper
• Differential modulation of ochratoxin A absorption across Caco-2 cells by dietary polyphenols, used at realistic intestinal concentrations.

  2005cited by this paper
• Sulfation of resveratrol in human liver: Evidence of a major role for the sulfotransferases SULT1A1 and SULT1E1

  2005cited by this paper
• Metabolism and bioavailability of trans-resveratrol.

  2005cited by this paper
• Cellular uptake and efflux of trans-piceid and its aglycone trans-resveratrol on the apical membrane of human intestinal Caco-2 cells.

  2005cited by this paper
• HIGH ABSORPTION BUT VERY LOW BIOAVAILABILITY OF ORAL RESVERATROL IN HUMANS

  2004cited by this paper
• Redistribution of CD95, DR4 and DR5 in rafts accounts for the synergistic toxicity of resveratrol and death receptor ligands in colon carcinoma cells

  2004cited by this paper
• Human hepatic cell uptake of resveratrol: involvement of both passive diffusion and carrier-mediated process.

  2004cited by this paper
• Resveratrol-induced Apoptosis Is Associated with Fas Redistribution in the Rafts and the Formation of a Death-inducing Signaling Complex in Colon Cancer Cells*

  2003cited by this paper
• Resveratrol transport and metabolism by human intestinal Caco‐2 cells

  2003cited by this paper
• UDP glucuronosyltransferase mRNA levels in human liver disease.

  2002cited by this paper
• Relative expression software tool (REST©) for group-wise comparison and statistical analysis of relative expression results in real-time PCR

  2002cited by this paper
• Metabolism and Disposition of Resveratrol in Rats: Extent of Absorption, Glucuronidation, and Enterohepatic Recirculation Evidenced by a Linked-Rat Model

  2002cited by this paper
• Regioselective and stereospecific glucuronidation of trans- and cis-resveratrol in human.

  2001cited by this paper
• Sulphation of resveratrol, a natural product present in grapes and wine, in the human liver and duodenum

  2000influential reference
• Glucuronidation of resveratrol, a natural product present in grape and wine, in the human liver

  2000influential reference
• Stilbene content of mature Vitis vinifera berries in response to UV-C elicitation.

  2000cited by this paper
• Determination of trans-resveratrol in human plasma by high-performance liquid chromatography.

  1999influential reference

• Natural products targeting cancer stem cells: a promising therapeutic approach

  2025cites this paper
• Spectroscopic, antioxidant and cytotoxicity studies of vanillic acids

  2025cites this paper
• Resveratrol Bioavailability After Oral Administration: A Meta‐Analysis of Clinical Trial Data

  2024cites this paper
• The in vitro intestinal cell model: different co-cultured cells create different applications

  2024cites this paper
• The Drug Transporter P-Glycoprotein and Its Impact on Ceramide Metabolism—An Unconventional Ally in Cancer Treatment

  2024cites this paper
• Non-cytotoxic levels of resveratrol enhance the anticancer effects of cisplatin by increasing the methyltransferase activity of CARM1 in human cancer cells.

  2024cites this paper
• Effects of Functional and Nutraceutical Foods in the Context of the Mediterranean Diet in Patients Diagnosed with Breast Cancer

  2023cites this paper
• Plants-based medicine implication in the evolution of chronic liver diseases.

  2023cites this paper
• Between the Devil and the Deep Blue Sea—Resveratrol, Sulfotransferases and Sulfatases—A Long and Turbulent Journey from Intestinal Absorption to Target Cells

  2023cites this paper
• Hepatocellular cancer cell lines, Hep-3B and Hep-G2 display the pleiotropic response to resveratrol and berberine.

  2022cites this paper
• Applications of resveratrol in the treatment of gastrointestinal cancer.

  2022cites this paper
• Resveratrol’ biotechnological applications: enlightening its antimicrobial and antioxidant properties

  2022cites this paper
• The Protective Effect of Trichosanthes kirilowii Peel Polysaccharide on the Oxidative Damaged HepG2 and HUASMC Cells

  2022cites this paper
• Targeting microbiota-host interactions with resveratrol on cancer: Effects and potential mechanisms of action

  2022cites this paper
• Chemo-Preventive Action of Resveratrol: Suppression of p53—A Molecular Targeting Approach

  2021cites this paper
• Metabolism of Phenolic

  2021cites this paper
• PD-1/PD-L1 Checkpoints and Resveratrol: A Controversial New Way for a Therapeutic Strategy

  2021cites this paper
• Resveratrol as Chemosensitizer Agent: State of Art and Future Perspectives

  2021cites this paper
• Diabetes and Cancer: Metabolic Association, Therapeutic Challenges, and the Role of Natural Products

  2021cites this paper
• Polyphenols of the Mediterranean Diet and Their Metabolites in the Prevention of Colorectal Cancer

  2021cites this paper
• Toxicity of Ozonated Wastewater to HepG2 Cells: Taking Full Account of Nonvolatile, Volatile, and Inorganic Byproducts.

  2021cites this paper
• Resveratrol Modulates Transforming Growth Factor-Beta (TGF-β) Signaling Pathway for Disease Therapy: A New Insight into Its Pharmacological Activities

  2020cites this paper
• Pharmacokinetics and Bioavailability Enhancement of Natural Products

  2020cites this paper
• Xenobiotic Metabolic Enzymes: Bioactivation and Antioxidant Defense

  2020cites this paper
• 4-Aminobiphenyl inhibits the DNA homologous recombination repair in human liver cells: The role of miR-630 in downregulating RAD18 and MCM8.

  2020cites this paper
• Diversity of Metabolic Enzyme Modulators

  2020cites this paper
• Resveratrol promotes mammary cell proliferation and antioxidation capacity during pregnancy and lactation in mice

  2020cites this paper
• Dietary polyphenols for managing cancers: What have we ignored?

  2020cites this paper
• Resveratrol isoforms and conjugates: A review from biosynthesis in plants to elimination from the human body

  2020cites this paper
• New insights into ethionamide metabolism: influence of oxidized methionine on its degradation path.

  2020cites this paper
• Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation

  2020cites this paper
• The Potential Use of Resveratrol for Cancer Prevention

  2019cites this paper
• Resveratrol Treatment Enhances the Cellular Response to Leptin by Increasing OBRb Content in Palmitate-Induced Steatotic HepG2 Cells

  2019cites this paper
• Resveratrol: Review on its discovery, anti-leukemia effects and pharmacokinetics.

  2019cites this paper
• Resveratrol is a promising agent for colorectal cancer prevention and treatment: focus on molecular mechanisms

  2019cites this paper
• Synthesis of Non‐Symmetrical Nitrogen‐Containing Curcuminoids in the Pursuit of New Anticancer Candidates

  2019cites this paper
• Absorption and Metabolism of Phenolics from Digests of Polyphenol-Rich Potato Extracts Using the Caco-2/HepG2 Co-Culture System

  2018cites this paper
• Comparison of protein expression between human livers and the hepatic cell lines HepG2, Hep3B, and Huh7 using SWATH and MRM-HR proteomics: Focusing on drug-metabolizing enzymes.

  2018cites this paper
• Therapeutic Versatility of Resveratrol Derivatives

  2017cites this paper
• Avaliação da ecotoxicidade do resveratrol no estágio embriolarval de peixes da espécie Danio rerio

  2017cites this paper
• The importance of studying cell metabolism when testing the bioactivity of phenolic compounds

  2017influential citation
• Metabolic activity of tree saps of different origin towards cultured human cells in the light of grade correspondence analysis and multiple regression modeling

  2017cites this paper
• Endocytic pathways of optimized resveratrol cubosomes capturing into human hepatoma cells.

  2017cites this paper
• Enhanced absorption and inhibited metabolism of emodin by 2, 3, 5, 4'-tetrahydroxystilbene-2-O-β-D-glucopyranoside: Possible mechanisms for Polygoni Multiflori Radix-induced liver injury.

  2017cites this paper
• Mechanisms and therapeutic prospects of polyphenols as modulators of the aryl hydrocarbon receptor.

  2017cites this paper
• Resveratrol and inflammatory bowel disease: the evidence so far

  2017cites this paper
• Cancer Chemoprevention by Resveratrol: The p53 Tumor Suppressor Protein as a Promising Molecular Target

  2017cites this paper
• The effects of dietary and herbal phytochemicals on drug transporters☆

  2017cites this paper
• Differentiated Caco-2 cell monolayers exhibit adaptation in the transport and metabolism of flavan-3-ols with chronic exposure to both isolated flavan-3-ols and enriched extracts.

  2017cites this paper
• Antidiabetic Effects of Resveratrol: The Way Forward in Its Clinical Utility

  2016cites this paper
• Les polyphénols du vin rouge : des propriétés pour prévenir les cancers ?

  2016cites this paper
• Research progress on chemopreventive effects of phytochemicals on colorectal cancer and their mechanisms.

  2016cites this paper
• Ethanol extract of Terminalia chebula fruit protects against UVB-induced skin damage

  2016influential citation
• Intestinal Adaptation to Repeated Exposure of Flavonoid-rich Foods: In Vitro and Clinical Data

  2016cites this paper
• N-Monosubstituted Methoxy-oligo(ethylene glycol) Carbamate Ester Prodrugs of Resveratrol

  2015cites this paper
• Exploring new ways of regulation by resveratrol involving miRNAs, with emphasis on inflammation

  2015cites this paper
• Screening and Purification of Resveratrol from Endophytic Fungi

  2015cites this paper
• The phytoalexin, resveratrol ameliorates Ochratoxin A genotoxicity in Human Embryonic Kidney (HEK293) cells

  2015cites this paper
• Interplay of Breast Cancer Resistance Protein (BCRP) and Metabolizing Enzymes.

  2015cites this paper
• Systematic Evaluation of the Metabolism and Toxicity of Thiazolidinone and Imidazolidinone Heterocycles.

  2015cites this paper
• Herb–Drug Interactions: Challenges and Opportunities for Improved Predictions

  2014cites this paper
• Bioreactivity of Resveratrol Toward Inflammation Processes

  2014cites this paper
• Metabolism of Skin-Absorbed Resveratrol into Its Glucuronized Form in Mouse Skin

  2014cites this paper
• Synthesis of doxorubicin α-linolenic acid conjugate and evaluation of its antitumor activity.

  2014cites this paper
• Modulation of Drug-Metabolizing Enzymes and Transporters by Polyphenols as an Anticarcinogenic Effect

  2014cites this paper
• Stilbenes and resveratrol metabolites improve mitochondrial fatty acid oxidation defects in human fibroblasts

  2014cites this paper
• α-Mangostin: Friend or Foe of the Immune System and the Gut Microbiota?

  2014cites this paper
• Cellular Uptake and Antitumor Activity of DOX-hyd-PEG-FA Nanoparticles

  2014cites this paper
• Curcumin and trans-resveratrol exert cell cycle-dependent radioprotective or radiosensitizing effects as elucidated by the PCC and G2-assay.

  2014cites this paper
• Resveratrol metabolites inhibit human metastatic colon cancer cells progression and synergize with chemotherapeutic drugs to induce cell death.

  2013cites this paper
• Chinese herbal medicine-derived compounds for cancer therapy: a focus on hepatocellular carcinoma.

  2013cites this paper
• Bioactive polyphenols from grapes and wine emphasized with resveratrol.

  2013cites this paper
• Marcadores citogenéticos aplicados en biomedicina = Cytogentic biomarkers applied in biomedicine

  2013cites this paper
• Stilbene glucoside inhibits the glucuronidation of emodin in rats through the down-regulation of UDP-glucuronosyltransferases 1A8: application to a drug-drug interaction study in Radix Polygoni Multiflori.

  2013cites this paper
• Neuroprotective properties and mechanisms of resveratrol in in vitro and in vivo experimental cerebral stroke models.

  2013cites this paper
• Anticancer bioactivity of compounds from medicinal plants used in European medieval traditions.

  2013cites this paper
• Bioactive form of resveratrol in glioblastoma cells and its safety for normal brain cells

  2013cites this paper
• Comparision of Piceid and Resveratrol in Antioxidation and Antiproliferation Activities In Vitro

  2013cites this paper
• Resveratrol: French Paradox Revisited

  2012cites this paper
• New trends for the medical treatment of endometriosis

  2012cites this paper
• Natural prenylated resveratrol analogs arachidin-1 and -3 demonstrate improved glucuronidation profiles and have affinity for cannabinoid receptors

  2012cites this paper
• Biotechnologically produced secondary plant metabolites for cancer treatment and prevention.

  2012cites this paper
• A transcriptomics-based in vitro assay for predicting chemical genotoxicity in vivo.

  2012cites this paper
• Effects of resveratrol on HepG2 cells as revealed by (1)H-NMR based metabolic profiling.

  2012cites this paper
• The bioavailability and distribution of trans-resveratrol are constrained by ABC transporters.

  2012cites this paper
• The role of ABC and SLC transporters in the pharmacokinetics of dietary and herbal phytochemicals and their interactions with xenobiotics.

  2012cites this paper
• Biological activity of piceatannol: leaving the shadow of resveratrol.

  2012cites this paper
• Penetration of resveratrol into bovine aortic endothelial cells (BAEC): a possible passive diffusion.

  2012cites this paper
• Induction and Inhibition Compounds

  2012cites this paper
• Dietary hydroxycinnamates and their bioavailability

  2012cites this paper
• Effets des polyphénols de vin rouge sur la prolifération cellulaire et sur le métabolisme du resvératrol

  2011cites this paper
• Estudi de la biodisponibilitat del trans-resveratrol i el seu efecte quimiopreventiu del càncer de còlon induït per 1,2-dimetilhidrazina en rata

  2011influential citation
• Predictive toxicogenomics for the identification of chemical carcinogens : application to human hepatic cell lines

  2011cites this paper
• From Natural Polyphenols to Synthetic Antitumor Agents

  2011cites this paper
• POTENTIAL CANCER CHEMOPREVENTIVE PROPERTIES OF

  2011cites this paper
• Activation and Detoxification Enzymes

  2011cites this paper
• Resveratrol against Major Pathologies: From Diet Prevention to Possible Alternative Chemotherapies with New Structural Analogues

  2011cites this paper
• ACTION OF RESVERATROL ANALOGS AND HYPERTHERMIA IN CANCER CHEMOPREVENTION AND CHEMOTHERAPY

  2011cites this paper
• Pro-apoptotic versus anti-apoptotic properties of dietary resveratrol on tumoral and normal cardiac cells

  2011cites this paper
• Resveratrol in combination with other dietary polyphenols concomitantly enhances antiproliferation and UGT1A1 induction in Caco-2 cells.

  2011cites this paper