Flavonoids as Phospholipase A2 Inhibitors: Importance of Their Structure for Selective Inhibition of Group II Phospholipase A2

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Inflammation

• Publication date

  1997-06-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1023/A:1027306118026PMID 9246576
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Structure-antioxidant activity relationships of flavonoids and phenolic acids.

  1996cited by this paper
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  1996cited by this paper
• Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2

  1995cited by this paper
• Rapid assay of phospholipase A2 activity in plasma and synovial fluid.

  1995cited by this paper
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  1995cited by this paper
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  1995cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1994cited by this paper
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  1993cited by this paper
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  1993cited by this paper
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  1993cited by this paper
• Induction of group II phospholipase A2 expression and pathogenesis of the sepsis syndrome.

  1993cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1992cited by this paper
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  1991cited by this paper
• Anti-inflammatory activity and inhibition of arachidonic acid metabolism by flavonoids

  1991cited by this paper
• Evaluation of antirheumatic drugs for their effect in vitro on purified human synovial fluid phospholipase A2.

  1991cited by this paper
• Hydrogen peroxide stimulates phospholipase A2-mediated arachidonic acid release in cultured intestinal epithelial cells (INT 407).

  1991cited by this paper
• Phospholipase A2--a mediator between proximal and distal effectors of inflammation.

  1991influential reference
• Role of phospholipases in generating lipid second messengers in signal transduction 1

  1991cited by this paper
• Evolutionary relationships and implications for the regulation of phospholipase A2 from snake venom to human secreted forms

  1990cited by this paper
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  1990cited by this paper
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  1990cited by this paper
• Isolation and characterization of phospholipase A2 from rat lung with affinity chromatography and two-dimensional gel electrophoresis.

  1989cited by this paper
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  1988cited by this paper
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  1986cited by this paper
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  1982cited by this paper
• Effect of quercetin on human polymorphonuclear leukocyte lysosomal enzyme release and phospholipid metabolism.

  1982cited by this paper
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