The mechanism of elevated toxicity in HepG2 cells due to combined exposure to ethanol and ionizing radiation

No abstract is available for this paper.

• Publication year

  2008

• Venue

  Journal of Applied Toxicology

• Publication date

  2008-04-01

• Fields of study

  Medicine, Chemistry, Environmental Science

• Identifiers
  DOI 10.1002/JAT.1285PMID 17631663
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Glutathione

  2011cited by this paper
• alpha-Lipoic acid attenuates x-irradiation-induced oxidative stress in mice.

  2007cited by this paper
• α-Lipoic acid attenuates x-irradiation-induced oxidative stress in mice

  2007cited by this paper
• Topoisomerase II trapping agent teniposide induces apoptosis and G2/M or S phase arrest of oral squamous cell carcinoma

  2006cited by this paper
• Quantitative measurements of oxidative stress in mouse skin induced by X-ray irradiation.

  2005influential reference
• A simple technique for quantifying apoptosis in 96-well plates

  2005cited by this paper
• Melatonin prevents hyperhomocysteinemia and neural lipid peroxidation induced by methionine intake.

  2005cited by this paper
• Role for Membrane Fluidity in Ethanol-Induced Oxidative Stress of Primary Rat Hepatocytes

  2005cited by this paper
• Antioxidants and radiation therapy.

  2004influential reference
• Measuring the genetic damage in cancer patients during radiotherapy with three genetic end-points.

  2004influential reference
• Cytokines—Central Factors in Alcoholic Liver Disease

  2003cited by this paper
• Melatonin protects rat liver against irradiation-induced oxidative injury.

  2003cited by this paper
• Dilinoleoylphosphatidylcholine is responsible for the beneficial effects of polyenylphosphatidylcholine on ethanol-induced mitochondrial injury in rats.

  2002cited by this paper
• Contribution of mitochondria to oxidative stress associated with alcoholic liver disease.

  2002influential reference
• Nitric oxide levels and lipid peroxidation in plasma of patients with gastric cancer.

  2002cited by this paper
• Combined effect of radiation and other agents: is there a synergism trap?

  2001cited by this paper
• Signal Transduction and Cellular Radiation Responses

  2000cited by this paper
• Activation of neutral sphingomyelinase participates in ethanol-induced apoptosis in Hep G2 cells.

  2000cited by this paper
• Ionizing Radiation and Chemotherapeutic Drugs Induce Apoptosis in Lymphocytes in the Absence of FAS or Fadd/Mort1 Signaling Implications for Cancer Therapy

  2000cited by this paper
• Ethanol-induced free radicals and hepatic DNA strand breaks are prevented in vivo by antioxidants: effects of acute and chronic ethanol exposure.

  2000cited by this paper
• Ionizing Radiation and Chemotherapeutic Drugs Induce Apoptosis in Lymphocytes in the Absence of FAS or Fadd/Mort1 Signaling

  2000cited by this paper
• Characterization of adducts of ethanol metabolites with cytochrome c.

  1999influential reference
• Contribution of antioxidant enzymes to the adaptive response to ionizing radiation of human lymphoblasts.

  1999cited by this paper
• Ethanol-induced apoptosis to stable HepG2 cell lines expressing human cytochrome P-4502E1.

  1999cited by this paper
• Role of antioxidant enzymes on ionizing radiation resistance.

  1998cited by this paper
• Role of cytokines in ethanol-induced cytotoxicity in vitro in Hep G2 cells.

  1998cited by this paper
• Protein kinase mutants of human ATR increase sensitivity to UV and ionizing radiation and abrogate cell cycle checkpoint control.

  1998cited by this paper
• Chemopreventive effects of carotenoids and curcumins on mouse colon carcinogenesis after 1,2-dimethylhydrazine initiation.

  1998cited by this paper
• Mechanisms involved in the generation of free radicals.

  1996cited by this paper
• Ethanol-induced oxidative stress in the liver.

  1996cited by this paper
• Effect of tauroursodeoxycholic and ursodeoxycholic acid on ethanol-induced cell injuries in the human Hep G2 cell line.

  1995cited by this paper
• Glutathione metabolism.

  1995cited by this paper
• [1] Glutathione metabolism

  1995cited by this paper
• Analysis of glutathione, glutathione disulfide, cysteine, homocysteine, and other biological thiols by high-performance liquid chromatography following derivatization by n-(1-pyrenyl)maleimide.

  1995cited by this paper
• Radiotherapy‐Induced Lung Cancer among Women Who Smoke

  1994cited by this paper
• Introduction to clinical radiation oncology

  1994cited by this paper
• Pulmonary retention and tissue distribution of {sup 239}Pu nitrate in F344 rats and syrian hamsters inhaling carbon tetrachloride

  1994cited by this paper
• Dose-response effects of acute ultraviolet irradiation on antioxidants and molecular markers of oxidation in murine epidermis and dermis.

  1993cited by this paper
• Carcinogenesis induced by combined neonatal exposure to 5-bromo-2'-deoxyuridine and subsequent total-body X-ray irradiation in rats.

  1993cited by this paper
• Effect of ethanol on rat fetal hepatocytes: Studies on cell replication, lipid peroxidation and glutathione

  1993cited by this paper
• Ethanol-inducible cytochrome P4502E1: genetic polymorphism, regulation, and possible role in the etiology of alcohol-induced liver disease.

  1993cited by this paper
• [Glutathione metabolism].

  1993cited by this paper
• In vitro assessment of the ethanol-induced hepatotoxicity on HepG2 cell line.

  1993cited by this paper
• Comparison of MTT, XTT, and a novel tetrazolium compound MTS for in vitro proliferation and chemosensitivity assays

  1992cited by this paper
• Hepatic mitochondrial glutathione depletion and progression of experimental alcoholic liver disease in rats

  1992cited by this paper
• Use of an aqueous soluble tetrazolium/formazan assay for cell growth assays in culture.

  1991cited by this paper
• Glutathione metabolism and its role in hepatotoxicity.

  1991cited by this paper
• Effect of ethanol in vivo on enzymes which detoxify oxygen free radicals.

  1989cited by this paper
• Mammary carcinogenesis in different rat strains after irradiation and hormone administration.

  1987cited by this paper
• [Effect of ionizing radiation on the turnover of catalase-degrading proteinase in rat hepatocytes].

  1987cited by this paper
• [Effect of ionizing radiation on the turnover of catalase-degrading proteinase in rat hepatocytes]

  1987cited by this paper
• The regulation of hepatic glutathione.

  1985cited by this paper
• Discrepancy between the different subcellular activities of rat liver catalase and superoxide dismutases in response to acute ethanol administration.

  1985cited by this paper
• Catalase in vitro.

  1984influential reference
• Paraquat and radiation effects on mouse C3H 10T1/2 cells.

  1984cited by this paper
• The Liver: Biology and Pathobilogy

  1983cited by this paper
• Superoxide radical inhibits catalase.

  1982cited by this paper
• A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.

  1976cited by this paper
• The use of standards for malonyldialdehyde.

  1975cited by this paper

• Ethanol Enhances Hyperthermia-Induced Cell Death in Human Leukemia Cells

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• The Radiosensitizing Effect of Olanzapine as an Antipsychotic Medication in Glioblastoma Cell.

  2021cites this paper
• Ethnopharmacological Applications Targeting Alcohol Abuse: Overview and Outlook

  2020influential citation
• Radiation-Induced Reactions in the Liver—Modulation of Radiation Effects by Lifestyle-Related Factors—

  2018cites this paper
• Effects of Toxic Stimuli Combinations on Determination of Exposure Limits

  2018cites this paper
• Chronic ethanol treatment depletes glutathione regeneration capacity in hepatoma cell line HepG2

  2016cites this paper
• Protective role of onion oil on hepato-testicular oxidative damage induced by gamma irradiation in rats.

  2014cites this paper
• A hipótese do citocromo P450 na etiologia do suicídio

  2014cites this paper
• Effect of N-acetylcysteine on γ-radiation-induced cytotoxicity in human hepatocellular carcinoma cells

  2014cites this paper
• Genetic Polymorphisms in CYP2E1: Association with Schizophrenia Susceptibility and Risperidone Response in the Chinese Han Population

  2012cites this paper
• Potential in vitro Protective Effect of Quercetin, Catechin, Caffeic Acid and Phytic Acid against Ethanol-Induced Oxidative Stress in SK-Hep-1 Cells

  2012cites this paper
• Cytochrome P450 2E1 and hyperglycemia-induced liver injury

  2011cites this paper
• Antroquinonol from ethanolic extract of mycelium of Antrodia cinnamomea protects hepatic cells from ethanol-induced oxidative stress through Nrf-2 activation.

  2011cites this paper
• Alcohol as a potential contributing factor in radiation complications.

  2009cites this paper
• Current world literature. Pain: cancer.

  2009cites this paper
• Alcohol dependence syndrome in chernobyl npp Accident cleAn-up workers

  year unknowncites this paper