Thermodynamic study of the BRCT domain of BARD1 and its interaction with the -pSER-X-X-Phe- motif-containing BRIP1 peptide.

No abstract is available for this paper.

• Publication year

  2010

• Venue

  Biochimica et Biophysica Acta

• Publication date

  2010-09-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/j.bbapap.2010.04.012PMID 20451671
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Fluorescence Spectroscopy In Vivo

  2011cited by this paper
• Comparison of the structures and peptide binding specificities of the BRCT domains of MDC1 and BRCA1.

  2010cited by this paper
• Cancer predisposing missense and protein truncating BARD1 mutations in non‐BRCA1 or BRCA2 breast cancer families

  2010cited by this paper
• Negative feedback loop of BRCA1-BARD1 ubiquitin ligase on estrogen receptor alpha stability and activity antagonized by cancer-associated isoform of BARD1.

  2010cited by this paper
• BARD1, a possible biomarker for breast and ovarian cancer.

  2010cited by this paper
• The BARD1 C-Terminal Domain Structure and Interactions with Polyadenylation Factor CstF-50, by R. A. Edwards

  2009cited by this paper
• Structural evidence for direct interactions between the BRCT domains of human BRCA1 and a phospho-peptide from human ACC1.

  2008cited by this paper
• Kinetic analysis of interaction of BRCA1 tandem breast cancer c-terminal domains with phosphorylated peptides reveals two binding conformations.

  2008cited by this paper
• The BARD1 C-Terminal Domain Structure and Interactions with Polyadenylation Factor CstF-50

  2008cited by this paper
• Crystal Structure of the BARD1 Ankyrin Repeat Domain and Its Functional Consequences*♦

  2008cited by this paper
• Very fast prediction and rationalization of pKa values for protein–ligand complexes

  2008cited by this paper
• Oncogenic BARD1 isoforms expressed in gynecological cancers.

  2007cited by this paper
• Structural Requirements for the BARD1 Tumor Suppressor in Chromosomal Stability and Homology-directed DNA Repair*

  2007cited by this paper
• Crystal structure of the BARD1 BRCT domains.

  2007cited by this paper
• Thermal unfolding of human BRCA1 BRCT-domain variants.

  2007cited by this paper
• Is there more to BARD1 than BRCA1?

  2006cited by this paper
• A homologue of the breast cancer‐associated gene BARD1 is involved in DNA repair in plants

  2006cited by this paper
• Fluorescence techniques for studying protein structure.

  2006cited by this paper
• A truncated splice variant of human BARD1 that lacks the RING finger and ankyrin repeats.

  2006cited by this paper
• MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks.

  2005cited by this paper
• Thermal denaturation of the BRCT tandem repeat region of human tumour suppressor gene product BRCA1.

  2005cited by this paper
• Identification and characterization of missense alterations in the BRCA1 associated RING domain (BARD1) gene in breast and ovarian cancer

  2005cited by this paper
• Very fast empirical prediction and rationalization of protein pKa values

  2005cited by this paper
• Structure of the BRCT Repeat Domain of MDC1 and Its Specificity for the Free COOH-terminal End of the γ-H2AX Histone Tail*

  2005cited by this paper
• Structural basis for cell cycle checkpoint control by the BRCA1-CtIP complex.

  2005cited by this paper
• Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling.

  2004cited by this paper
• Comparison of BRCT domains of BRCA1 and 53BP1: A biophysical analysis

  2004cited by this paper
• Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer

  2004cited by this paper
• BRCA1/BARD1 orthologs required for DNA repair in Caenorhabditis elegans.

  2004cited by this paper
• Finite size effects on thermal denaturation of globular proteins.

  2004cited by this paper
• BARD1 regulates BRCA1 apoptotic function by a mechanism involving nuclear retention.

  2004cited by this paper
• Nuclear–cytoplasmic shuttling of BARD1 contributes to its proapoptotic activity and is regulated by dimerization with BRCA1

  2004cited by this paper
• BARD1 Expression During Spermatogenesis Is Associated with Apoptosis and Hormonally Regulated1

  2004cited by this paper
• Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1

  2004cited by this paper
• Phosphopeptide Binding Specificities of BRCA1 COOH-terminal (BRCT) Domains*

  2003cited by this paper
• BARD1 Participates with BRCA1 in Homology-Directed Repair of Chromosome Breaks

  2003cited by this paper
• Loss of Bard1, the Heterodimeric Partner of the Brca1 Tumor Suppressor, Results in Early Embryonic Lethality and Chromosomal Instability

  2003cited by this paper
• The BRCT Domain Is a Phospho-Protein Binding Domain

  2003cited by this paper
• BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

  2003cited by this paper
• The BRCA1/BARD1 heterodimer, a tumor suppressor complex with ubiquitin E3 ligase activity.

  2002cited by this paper
• Characterisation of the BRCT domains of the breast cancer susceptibility gene product BRCA1.

  2002cited by this paper
• Variability in the pKa of histidine side‐chains correlates with burial within proteins

  2002cited by this paper
• Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1

  2001cited by this paper
• Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development

  2001cited by this paper
• Identification of BARD1 as mediator between proapoptotic stress and p53-dependent apoptosis.

  2001cited by this paper
• The RING Heterodimer BRCA1-BARD1 Is a Ubiquitin Ligase Inactivated by a Breast Cancer-derived Mutation*

  2001cited by this paper
• Mutations in the BRCA1-associated RING domain (BARD1) gene in primary breast, ovarian and uterine cancers.

  1998cited by this paper
• Structure and mechanism in protein science

  1998cited by this paper
• A new ultrasensitive scanning calorimeter.

  1997cited by this paper
• Fluorescence methods for studying kinetics of protein-folding reactions.

  1997cited by this paper
• Fluorescence methods for studying equilibrium macromolecule-ligand interactions.

  1997cited by this paper
• Identification of a RING protein that can interact in vivo with the BRCA1 gene product

  1996cited by this paper
• Fluorescence spectroscopy.

  1995cited by this paper
• Circular dichroism.

  1995cited by this paper
• [4] Circular dichroism

  1995cited by this paper
• Engineered disulfide bonds as probes of the folding pathway of barnase: increasing the stability of proteins against the rate of denaturation.

  1993cited by this paper
• Rapid measurement of binding constants and heats of binding using a new titration calorimeter.

  1989cited by this paper
• Principles of fluorescence spectroscopy

  1983cited by this paper
• Fluorescence of proteins in aqueous neutral salt solutions. I. Influence of anions

  1977cited by this paper

• Distinct mechanisms of recognition of phosphorylated RNAPII C-terminal domain by BRCT repeats of the BRCA1–BARD1 complex

  2025cites this paper
• Identification of the most common BRCA alterations through analysis of germline mutation databases: Is droplet digital PCR an additional strategy for the assessment of such alterations in breast and ovarian cancer families?

  2022cites this paper
• Biophysical evaluation to categorize pathogenicity of cancer-predisposing mutations identified in the BARD1 BRCT domain

  2018cites this paper
• Multimodal approach to explore the pathogenicity of BARD1, ARG 658 CYS, and ILE 738 VAL mutants

  2016cites this paper
• New concepts on BARD1: Regulator of BRCA pathways and beyond.

  2016cites this paper
• The stability of the TIM-barrel domain of a psychrophilic chitinase

  2015cites this paper
• Characterization of LGALS3 (galectin-3) as a player in DNA damage response

  2014cites this paper
• Applications of isothermal titration calorimetry in pure and applied research—survey of the literature from 2010

  2012cites this paper
• The BRCT Signaling 'Landscape': Emerging Concepts and Implications in Tumorigenesis and Cancer Diagnostics

  2012cites this paper
• Pathogenicity of Mutations Discovered in BRCA1 BRCT Domains is Characterized by Destabilizing the Hydrophobic Interactions

  2012cites this paper
• BRCT domains

  2011cites this paper
• Impact of BRCA1 BRCT Domain Missense Substitutions on Phosphopeptide Recognition

  2011cites this paper
• Thermal and chemical denaturation of the BRCT functional module of human 53BP1.

  2011cites this paper