Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Nature Structural &Molecular Biology

• Publication date

  2004-05-09

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/nsmb776PMID 15133503
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• RACK1, A multifaceted scaffolding protein: Structure and function

  2011cited by this paper
• Structure and mechanism of BRCA1 BRCT domain recognition of phosphorylated BACH1 with implications for cancer

  2004cited by this paper
• Detection of Protein Folding Defects Caused by BRCA1-BRCT Truncation and Missense Mutations*

  2003cited by this paper
• The BRCT Domain Is a Phospho-Protein Binding Domain

  2003cited by this paper
• BRCT Repeats As Phosphopeptide-Binding Modules Involved in Protein Targeting

  2003cited by this paper
• Structural Consequences of a Cancer-causing BRCA1-BRCT Missense Mutation*

  2003cited by this paper
• SOLVE and RESOLVE: automated structure solution and density modification.

  2003cited by this paper
• Phosphopeptide Binding Specificities of BRCA1 COOH-terminal (BRCT) Domains*

  2003cited by this paper
• Structure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure.

  2002cited by this paper
• Review Cancer Susceptibility and the Functions of BRCA1 and BRCA2

  2002cited by this paper
• Characterisation of the BRCT domains of the breast cancer susceptibility gene product BRCA1.

  2002cited by this paper
• Crystal structure of human 53BP1 BRCT domains bound to p53 tumour suppressor

  2002cited by this paper
• Characterization of Common BRCA1 and BRCA2 Variants

  2002cited by this paper
• Cancer susceptibility and the functions of BRCA1 and BRCA2.

  2002cited by this paper
• Breast cancer genetics: What we know and what we need

  2001cited by this paper
• BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function.

  2001cited by this paper
• Crystal structure of the BRCT repeat region from the breast cancer-associated protein BRCA1

  2001cited by this paper
• Solution structure and backbone dynamics of the human DNA ligase IIIalpha BRCT domain.

  2001cited by this paper
• Breast cancer genetics: what we know and what we need

  2001cited by this paper
• Functional analysis of BRCA1 C-terminal missense mutations identified in breast and ovarian cancer families.

  2001cited by this paper
• Use of TLS parameters to model anisotropic displacements in macromolecular refinement.

  2001cited by this paper
• PhosphoSerine/threonine binding domains: you can't pSERious?

  2001cited by this paper
• Crystal structure of an Xrcc4–DNA ligase IV complex

  2001cited by this paper
• The BRCA1 C-terminal domain: structure and function.

  2000cited by this paper
• Genetic analysis of BRCA1 function in a defined tumor cell line.

  1999cited by this paper
• BRCA1 interacts with components of the histone deacetylase complex.

  1999cited by this paper
• Structure of an XRCC1 BRCT domain: a new protein–protein interaction module

  1998cited by this paper
• The C-terminal (BRCT) Domains of BRCA1 Interact in Vivo with CtIP, a Protein Implicated in the CtBP Pathway of Transcriptional Repression*

  1998cited by this paper
• Validation of protein models derived from experiment.

  1998cited by this paper
• Raster3D: photorealistic molecular graphics.

  1997cited by this paper
• A superfamily of conserved domains in DNA damage‐ responsive cell cycle checkpoint proteins

  1997cited by this paper
• MOLREP: an Automated Program for Molecular Replacement

  1997cited by this paper
• An extensively modified version of MolScript that includes greatly enhanced coloring capabilities.

  1997cited by this paper
• [20] Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• Processing of X-ray diffraction data collected in oscillation mode.

  1997cited by this paper
• From BRCA1 to RAP1: a widespread BRCT module closely associated with DNA repair

  1997cited by this paper
• …Functional motifs…

  1996cited by this paper
• BRCA1 protein products ... Functional motifs...

  1996cited by this paper
• A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.

  1994cited by this paper
• Improved methods for building protein models in electron density maps and the location of errors in these models.

  1991cited by this paper
• The BRCT Domain Is a PhosphoProtein Binding Domain

  year unknowncited by this paper

• Dynamic assemblies and coordinated reactions of non-homologous end joining

  2025cites this paper
• Distinct mechanisms of recognition of phosphorylated RNAPII C-terminal domain by BRCT repeats of the BRCA1–BARD1 complex

  2025cites this paper
• Functional characterization of BRCA1 variants of unknown significance using homologous recombination repair assays

  2025cites this paper
• HSP90 buffers deleterious genetic variations in BRCA1.

  2025cites this paper
• Engineered chromatin readers track damaged chromatin dynamics in live cells and animals

  2025cites this paper
• Profiling BRCA1-BRCT interactions and their functional relevance at amino acid resolution

  2025cites this paper
• BRCA1 and Its Vulnerable C-Terminal BRCT Domain: Structure, Function, Genetic Mutations and Links to Diagnosis and Treatment of Breast and Ovarian Cancer

  2024cites this paper
• BLM and BRCA1-BARD1 coordinate complementary mechanisms of joint DNA molecule resolution.

  2024cites this paper
• Protein-folding chaperones predict structure-function relationships and cancer risk in BRCA1 mutation carriers

  2024cites this paper
• Spectrum of BRCA1 interacting helicase 1 aberrations and potential prognostic and therapeutic implication: a pan cancer analysis

  2023cites this paper
• Functional Analyses of Rare Germline Missense BRCA1 Variants Located within and outside Protein Domains with Known Functions

  2023cites this paper
• Structure/function studies of the NAD+-dependent DNA ligase from the poly-extremophile Deinococcus radiodurans reveal importance of the BRCT domain for DNA binding

  2023cites this paper
• Why to target G‐quadruplexes using peptides: Next‐generation G4‐interacting ligands

  2023cites this paper
• Inter-BRCT linker is probably the most intolerant region of the BRCA1 BRCT domain

  2023cites this paper
• Protein-Folding Chaperones Predict Structure-Function Relationships and Cancer Risk in BRCA1 Mutation Carriers

  2023cites this paper
• Regulation of DNA damage response by trimeric G-proteins

  2023cites this paper
• Structural insights into Rad18 targeting by the SLF1 BRCT domains

  2023cites this paper
• The functional impact of BRCA1 BRCT domain variants using multiplexed DNA double-strand break repair assays.

  2022cites this paper
• Computed cancer interactome explains the effects of somatic mutations in cancers

  2022cites this paper
• The BRCA1 BRCT promotes antisense RNA production and double-stranded RNA formation to suppress ribosomal R-loops

  2022cites this paper
• Molecular Characterization of BRCA1 c.5339T>C Missense Mutation in DNA Damage Response of Triple-Negative Breast Cancer

  2022cites this paper
• Coupled MD simulations and NMR reveal that the intrinsically disordered domain of the breast-cancer susceptibility 1 protein (BRCA1) binds head-on to DNA double-strand ends

  2022cites this paper
• Phosphorylation-dependent assembly of DNA damage response systems and the central roles of TOPBP1

  2021cites this paper
• UBQLN4 is an ATM substrate that stabilizes the anti‐apoptotic proteins BCL2A1 and BCL2L10 in mesothelioma

  2021cites this paper
• The fellowship of the RING: BRCA1, its partner BARD1 and their liaison in DNA repair and cancer.

  2021cites this paper
• Structural insights into DNA double-strand break signaling.

  2021cites this paper
• GIV/Girdin binds BRCA1 and links trimeric G-proteins to DNA damage response

  2021cites this paper
• Fanconi anemia pathway as a prospective target for cancer intervention

  2020cites this paper
• A fifth of the protein world: Rossmann-like proteins as an evolutionarily successful structural unit.

  2020cites this paper
• Structural characterization of KKT4, an unconventional microtubule-binding kinetochore protein

  2020influential citation
• Classification of VUS and unclassified variants in BRCA1 BRCT repeats by molecular dynamics simulation

  2020cites this paper
• Identification of regulatory crosstalks between RKIP and BRCA1 tumor suppressors in healthy tissues and cancer (breast and ovarian): Therapeutic implications

  2020cites this paper
• Functional Investigation of the Novel BRCA1variant (Glu1661Gly) byComputationalTools andYeastTranscription Activation Assay

  2019cites this paper
• Efficient Single-Strand Break Repair Requires Binding to Both Poly(ADP-Ribose) and DNA by the Central BRCT Domain of XRCC1

  2019cites this paper
• Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107.

  2019cites this paper
• Characterizing BRCA1 Variants Using Multiplex Functional Assays

  2019cites this paper
• β-Hairpins as peptidomimetics of human phosphoprotein-binding domains.

  2019cites this paper
• Structural features underlying the activity of benzimidazole derivatives that target phosphopeptide recognition by the tandem BRCT domain of the BRCA1 protein

  2019cites this paper
• Distinct associations of the Saccharomyces cerevisiae Rad9 protein link Mac1-regulated transcription to DNA repair

  2019cites this paper
• Efficient Single-Strand Bre ak Repair Requires Binding to Both Poly ( ADP-Ribose ) and DNA by the Central BRCT Domain of XRCC 1 Graphical Abstract Highlights

  2019influential citation
• Nuclear Phosphatidylinositol 5-Phosphatase Is Essential for Allelic Exclusion of Variant Surface Glycoprotein Genes in Trypanosomes

  2018cites this paper
• Human DNA ligase IV is able to use NAD+ as an alternative adenylation donor for DNA ends ligation

  2018cites this paper
• Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and Cancer.

  2018cites this paper
• Combining Homologous Recombination and Phosphopeptide-binding Data to Predict the Impact of BRCA1 BRCT Variants on Cancer Risk

  2018cites this paper
• The BRCT Domains of the BRCA1 and BARD1 Tumor Suppressors Differentially Regulate Homology-Directed Repair and Stalled Fork Protection.

  2018cites this paper
• Targeting Phosphopeptide Recognition by the Human BRCA1 Tandem BRCT Domain to Interrupt BRCA1-Dependent Signaling

  2018cites this paper
• A novel model to characterize structure and function of BRCA1

  2018cites this paper
• The BARD1 BRCT Domain in Tumor Suppression and Genome Stability

  2018cites this paper
• Chapter 7 The BRCA 1 and BRCA 2 Breast and Ovarian Cancer Susceptibility Genes — Implications for DNA Damage Response , DNA Repair and Cancer Therapy

  2018influential citation
• Mechanism of APTX nicked DNA sensing and pleiotropic inactivation in neurodegenerative disease

  2018cites this paper
• Integrating plant and animal biology for the search of novel DNA damage biomarkers.

  2018cites this paper
• Dealing With BRCA1/2 Unclassified Variants in a Cancer Genetics Clinic: Does Cosegregation Analysis Help?

  2018cites this paper
• CtIP/Ctp1/Sae2, molecular form fit for function.

  2017cites this paper
• A Novel Model to Characterize Structure and Function of BRCA 1 † Short running title : A Model of Characterization of BRCA 1

  2017cites this paper
• PHOPSPHORYLATION AND UBIQUITIN MODIFICATION AT DNA DAMAGE SITES IN RESPONSE TO DOUBLE-STRAND BREAKS

  2017influential citation
• The BRCA 1 and BRCA 2 Breast and Ovarian Cancer Susceptibility Genes — Implications for DNA Damage Response , DNA Repair and Cancer Therapy

  2017cites this paper
• “DNA Binding Region” of BRCA1 Affects Genetic Stability through modulating the Intra-S-Phase Checkpoint

  2016cites this paper
• Structure of BRCA1-BRCT/Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites

  2016influential citation
• Recent advances in the research for the homolog of breast cancer associated gene AtROW1 in higher plants

  2016influential citation
• Beyond DNA: An Integrated and Functional Approach for Classifying Germline Variants in Breast Cancer Genes

  2016cites this paper
• Characterization of Promiscuous Binding of Phosphor Ligands to Breast-Cancer-Gene 1 (BRCA1) C-Terminal (BRCT): Molecular Dynamics, Free Energy, Entropy and Inhibitor Design

  2016cites this paper
• Structure of BRCA 1-BRCT / Abraxas Complex Reveals Phosphorylation-Dependent BRCT Dimerization at DNA Damage Sites Graphical

  2016influential citation
• Síndrome de cáncer de mama y ovario hereditario: Estudio in vitro de variantes BRCA1 y BRCA2 de significado biológico desconocido y búsqueda de nuevos genes responsables de este síndrome

  2016cites this paper
• The Role of BRCA 1 in DNA Double-strand Break Repair

  2016cites this paper
• The dynamic organization of fungal acetyl-CoA carboxylase

  2016cites this paper
• Petasis-Ugi ligands: New affinity tools for the enrichment of phosphorylated peptides.

  2016cites this paper
• The BRCA1 and BRCA2 Breast and Ovarian Cancer Susceptibility Genes — Implications for DNA Damage Response, DNA Repair and Cancer Therapy

  2015cites this paper
• Splicing analysis of 14 BRCA1 missense variants classifies nine variants as pathogenic

  2015cites this paper
• Recognition and repair of chemically heterogeneous structures at DNA ends

  2015cites this paper
• RAD9A Stabilization and Destabilization Processes in Checkpoint Maintenance and Checkpoint Recovery

  2015cites this paper
• Phosphopeptide interactions with BRCA1 BRCT domains: More than just a motif

  2015influential citation
• The Role of BRCT-Containing Proteins BRCA1 and PAXIP1 in Cancer

  2015cites this paper
• ROW1 maintains quiescent centre identity by confining WOX5 expression to specific cells

  2015cites this paper
• Identification of a Variety of Mutations in Cancer Predisposition Genes in Patients With Suspected Lynch Syndrome.

  2015cites this paper
• Breast Cancer: Basic and Clinical Research

  2014cites this paper
• Crystal structure of triple‐BRCT‐domain of ECT2 and insights into the binding characteristics to CYK‐4

  2014cites this paper
• Computational Modeling of Biomolecular Systems: Insights Into Protein Dynamics, Free Energy and Peptide/Ligand Binding

  2014influential citation
• Development and validation of a new algorithm for the reclassification of genetic variants identified in the BRCA1 and BRCA2 genes

  2014cites this paper
• Phosphorylation of ribosomal protein S6 confers PARP inhibitor resistance in BRCA1-deficient cancers

  2014cites this paper
• The breast cancer susceptibility genes (BRCA) in breast and ovarian cancers.

  2014cites this paper
• The BRCA1-interacting protein Abraxas is required for genomic stability and tumor suppression.

  2014cites this paper
• The role of the BARD1 BRCT domains in the DNA damage response

  2014cites this paper
• DNA Methylierung ausgewählter BRCA- und Fanconi Anämie-Gene beim familiären Mammakarzinom

  2014cites this paper
• Poly(ADP-ribosyl)ation is recognized by ECT2 during mitosis

  2014cites this paper
• Triapine Disrupts CtIP-Mediated Homologous Recombination Repair and Sensitizes Ovarian Cancer Cells to PARP and Topoisomerase Inhibitors

  2014influential citation
• Screening of young and/or familial African breast cancer patients for the presence of BRCA mutations

  2014cites this paper
• The Role of Poly(ADP-ribosyl)ation in DNA Damage Response and Cancer Chemotherapy

  2014cites this paper
• The BRCA1 Variant p.Ser36Tyr Abrogates BRCA1 Protein Function and Potentially Confers a Moderate Risk of Breast Cancer

  2014cites this paper
• Host Cell Reactivation and Transcriptional Activation of Carboplatin-Modified BRCA1

  2014cites this paper
• A common structural scaffold in CTD phosphatases that supports distinct catalytic mechanisms

  2014cites this paper
• Centralspindlin assembly and 2 phosphorylations on MgcRacGAP by Polo-like kinase 1 initiate Ect2 binding in early cytokinesis

  2014cites this paper
• BRCA1 and FancJ cooperatively promote interstrand crosslinker induced centrosome amplification through the activation of polo-like kinase 1

  2014influential citation
• Achieving Peptide Binding Specificity and Promiscuity by Loops: Case of the Forkhead-Associated Domain

  2014cites this paper
• Characterization of Dbf4 structure and function in Saccharomyces cerevisiae DNA replication and checkpoint responses.

  2014cites this paper
• Pulling the Trigger to Fire Origins of DNA Replication

  2013cites this paper
• Structural basis of the interaction of the breast cancer oncogene LMO4 with the tumour suppressor CtIP/RBBP8.

  2013cites this paper
• H2AX a Promising Biomarker for Lung Cancer: A Review

  2013cites this paper
• A Novel Non-canonical Forkhead-associated (FHA) Domain-binding Interface Mediates the Interaction between Rad53 and Dbf4 Proteins*

  2013cites this paper
• Extending the Interaction Repertoire of FHA and BRCT Domains

  2013cites this paper
• Structural mechanisms underlying signaling in the cellular response to DNA double strand breaks.

  2013cites this paper