Drug-induced Hepatotoxicity and Hepatoprotective Medicinal Plants: A Review

The Liver, a paramount organ is the Chief site for metabolism of nutrients and energy production in the human body. It is also necessary for metabolism and elimination of exogenous drugs and harmful substances via kidney. Hepatotoxicity caused by a variety of environmental pollutants, pathogenic micro-organism, viruses, drugs and chemical agents may account for various hepatic diseases such as jaundice, necrosis, hepatitis, fibrosis and cirrhosis etc. Ayurveda is a traditional medicinal system of India and is being practiced continuously since ancient times and at present for the treatment of various human diseases. Medicinal plants as a significant source of therapeutic compounds used for the development of effective drugs against a variety of human diseases include liver ailments. Hence, therapeutic plants are becoming popular in the pharmaceutical industry to develop a safe and effective medicine for the treatment of the emerging new human diseases. Therefore, the present review is aimed to compiling data on hepatoprotective medicinal plants which have been investigated against drug-induced hepatotoxicity.

• Publication year

  2020

• Venue

  Indian Journal of Pharmaceutical Education and Research

• Publication date

  2020-03-03

• Fields of study

  Medicine, Environmental Science

• Identifiers
  DOI 10.5530/ijper.54.2.28
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar

• No claims are published for this paper.

• No concepts are published for this paper.

• Presence of gallic acid and rutin improve the hepatoprotective strength of Withania coagulans.

  2019cited by this paper
• Solanum nigrum confers protection against CCl4-induced experimental hepatotoxicity by increasing hepatic protein synthesis and regulation of energy metabolism

  2019cited by this paper
• AMELIORATIVE POTENTIALS OF NYMPHAEA ALBA ON HEPATOTOXICITY AND OXIDATIVE DAMAGE INDUCED BY CHRONIC EXPOSURE TO ISONIAZID IN RATS

  2019cited by this paper
• Pathophysiological, Molecular and Therapeutic Issues of Nonalcoholic Fatty Liver Disease: An Overview

  2019cited by this paper
• Evaluation of Hepatoprotective Effect of Curcumin on Liver Cirrhosis Using a Combination of Biochemical Analysis and Magnetic Resonance-Based Electrical Conductivity Imaging

  2018cited by this paper
• Silymarin prevents acetaminophen-induced hepatotoxicity in mice

  2018cited by this paper
• Dyslipidemia and Fatty Liver Disease in Overweight and Obese Children

  2018cited by this paper
• Novel Effects of Rosa damascena Extract on Patients with Neurocognitive Disorder and Depression: A Clinical Trial Study

  2018cited by this paper
• Liver toxicity associated with tuberculosis chemotherapy in the REMoxTB study

  2018cited by this paper
• MEDICINAL PLANTS WITH ANTI-ULCER AND HEPATOPROTECTIVE ACTIVITY : A REVIEW

  2018cited by this paper
• Hepatoprotective influence of quercetin and ellagic acid on thioacetamide-induced hepatotoxicity in rats.

  2018cited by this paper
• Overview of pharmacological activities of Andrographis paniculata and its major compound andrographolide

  2018cited by this paper
• An overview of the hepatoprotective potentials of Phyllanthus amarus

  2018cited by this paper
• Hepatoprotective Effects of Cichorium Intybus against Paracetamol Induced Hepatotoxicity in Broiler. J. World Poult. Res., 8(2): 25-30.;

  2018cited by this paper
• Mechanisms of acetaminophen-induced liver injury and its implications for therapeutic interventions

  2018cited by this paper
• Boerhavia diffusa: One plant with many functions

  2018cited by this paper
• Antioxidant activity and hepatoprotective effect of Cichorium intybus (Kasni) seed extract against carbon tetrachloride-induced liver toxicity in rats

  2018cited by this paper
• Paracetamol: overdose-induced oxidative stress toxicity, metabolism, and protective effects of various compounds in vivo and in vitro

  2017cited by this paper
• Profile of bioactive compounds in Nymphaea alba L. leaves growing in Egypt: hepatoprotective, antioxidant and anti-inflammatory activity

  2017cited by this paper
• Drug-induced liver injury: recent advances in diagnosis and risk assessment

  2017cited by this paper
• Hepatoprotective effects of Gentianella turkestanerum extracts on acute liver injury induced by carbon tetrachloride in mice.

  2017cited by this paper
• Medicinal, biological and phytochemical properties of Gentiana species

  2017cited by this paper
• HEPATOPROTECTIVE ACTIVITY OF ETHANOLIC EXTRACT OF TERMINALIA CHEBULA FRUIT AGAINST ETHANOL INDUCED HEPATOTOXICITY IN RATS

  2017cited by this paper
• Exploratory Studies of (-)-Epicatechin, a Bioactive Compound of Phyllanthus niruri, on the Antioxidant Enzymes and Oxidative Stress Markers in D-galactosamine-induced Hepatitis in Rats: A Study with Reference to Clinical Prospective

  2017cited by this paper
• Pharmacognostic review of medicinal plant Aerva lanata

  2017cited by this paper
• Modulations of Hibiscus sabdariffa Extract on Ethanol Induced Hepatotoxicity

  2017cited by this paper
• The impact of sterile inflammation in acute liver injury

  2017cited by this paper
• Hepatoprotective Efficacy of Cichorium intybus L. Extract Against Carbon Tetrachloride-induced Liver Damage in Rats

  2016cited by this paper
• Hepatoprotective properties of oleanolic and ursolic acids in antitubercular drug-induced liver damage.

  2016cited by this paper
• Drug-Induced Liver Toxicity and Prevention by Herbal Antioxidants: An Overview

  2016cited by this paper
• Acetaminophen-Induced Hepatotoxicity: a Comprehensive Update

  2016cited by this paper
• Medicinal plants: Future source of new drugs

  2016cited by this paper
• Genistein Produces Hepatoprotection through Modulating EGFR Expression and Phosphorylation in Experimental Fibrosis

  2016cited by this paper
• Therapeutic use of Adhatoda vasica

  2016cited by this paper
• Protective effect of wedelolactone against CCl4-induced acute liver injury in mice.

  2016cited by this paper
• Isolation, identification, and in vivoevaluation of flavonoid fractions of chloroform/methanol extracts of Rheum emodi roots for their hepatoprotective activity in Wistar rats

  2016cited by this paper
• Hepatoprotective Effects of a Proprietary Glycyrrhizin Product during Alcohol Consumption: A Randomized, Double‐Blind, Placebo‐Controlled, Crossover Study

  2016cited by this paper
• Protective Role of Grape Seed Proanthocyanidins Against Ccl4 Induced Acute Liver Injury in Mice

  2016cited by this paper
• Histopathology of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.

  2016cited by this paper
• Experimental hepatotoxicity Inducing agents: A Review

  2016cited by this paper
• A Review on Phytochemistry and Biological Activities of Aerva

  2015cited by this paper
• Protective Effect of Procyanidin B2 against CCl4-Induced Acute Liver Injury in Mice

  2015cited by this paper
• Resveratrol and liver: A systematic review

  2015cited by this paper
• A Study on Hepatoprotective Activity of Mimosa pudica in Albino Rats

  2015cited by this paper
• Cancer-specific chemoprevention and anti-metastatic potentials of Rheum emodi rhizome ethyl acetate extracts and identification of active principles through HPLC and GC-MS analysis.

  2015cited by this paper
• Cichorium intybus Linn: its Role in Hepatoprotection

  2014cited by this paper
• Carbon tetrachloride (CCl4)-induced hepatic damage in experimental Sprague Dawley rats: Antioxidant potential of Xylopia aethiopica

  2014cited by this paper
• Current status of the field of obesity.

  2014cited by this paper
• Acetaminophen‐induced liver injury in obesity and nonalcoholic fatty liver disease

  2014cited by this paper
• Hepatoprotective activity of Tephrosia purpurea against arsenic induced toxicity in rats

  2014cited by this paper
• Enhancement of Hepatoprotective Effect of Herbal Formulation (F1) on Carbon tetrachloride and Ethanol Induced Liver Toxicity in Albino Rats

  2014cited by this paper
• Acetaminophen-induced Liver Injury: from Animal Models to Humans

  2014cited by this paper
• Hepatoprotective effect of Cichorium intybus L., a traditional Uighur medicine, against carbon tetrachloride-induced hepatic fibrosis in rats.

  2014cited by this paper
• The impact of obesity and metabolic syndrome on alcoholic liver disease.

  2014cited by this paper
• Hepatoprotective effect of silymarin.

  2014cited by this paper
• Acetaminophen-related hepatotoxicity.

  2013cited by this paper
• Evaluation of hepatoprotective activity of ethanolic extract of Aquilaria agallocha leaves (EEAA) against CCl4 induced hepatic damage in rat

  2013cited by this paper
• The hepato-ameliorating effect of Solanum nigrum against CCl4 induced liver toxicity in Albino rats

  2013cited by this paper
• Therapeutic potential of thymoquinone against anti-tuberculosis drugs induced liver damage.

  2013cited by this paper
• Hepatoprotective, Antioxidant, and Ameliorative Effects of Ginger (Zingiber officinale Roscoe) and Vitamin E in Acetaminophen Treated Rats

  2013cited by this paper
• ANTI INFLAMMATORY ACTIVITY OF ETHANOLIC EXTRACT OF NYMPHAEA ALBA FLOWER IN SWISS ALBINO MICE

  2013cited by this paper
• Antiobesity Pharmacotherapy: New Drugs and Emerging Targets

  2013cited by this paper
• Hepatoprotective Effect Of ADHATODA VASICA Leaves Extract Against Paracetamol Induced Hepatic Damage In Rats

  2013cited by this paper
• A Review on Hepatoprotective Activity of Medicinal Plants

  2012cited by this paper
• Protective effect of pre-recovery surfactant inhalation on lungs donated after cardiac death in a canine lung transplantation model.

  2012cited by this paper
• Hepatoprotection of emodin and Polygonum multiflorum against CCl4-induced liver injury

  2012cited by this paper
• Therapeutic efficacy of Rosa damascena Mill. on acetaminophen-induced oxidative stress in albino rats.

  2012cited by this paper
• Hepatoprotective Activity of Cassia fistula root against Carbon tetrachloride-Induced Hepatic Injury in rats ( Wistar )

  2012cited by this paper
• S-Allyl-Cysteines Reduce Amelioration of Aluminum Induced Toxicity in Rats

  2011cited by this paper
• Antioxidant and anti-neoplastic activities of Picrorhiza kurroa extracts.

  2011cited by this paper
• Zingiber officinale acts as a nutraceutical agent against liver fibrosis

  2011cited by this paper
• Protective effect of ethyl acetate fraction of Rhododendron arboreum flowers against carbon tetrachloride-induced hepatotoxicity in experimental models

  2011cited by this paper
• EVALUATION OF HEPATOPROTECTIVE ACTIVITY OF CAPPARIS SEPIARIA LEAVES

  2011cited by this paper
• Solanum nigrum: current perspectives on therapeutic properties.

  2011cited by this paper
• Boerhaavia diffusa Linn.: A Review on its Phytochemical and Pharmacological Profile

  2011cited by this paper
• Invitro Antioxidant and Free Radical Scavenging Activity of Aqueous and Ethanolic Flower Extract of Nymphaea Alba

  2011cited by this paper
• Antioxidant and Hepatoprotective Effects of Silibinin in a Rat Model of Nonalcoholic Steatohepatitis

  2011cited by this paper
• Hepatoprotective effects of methanol extract of Carissa opaca leaves on CCl4-induced damage in rat

  2011cited by this paper
• Aerva lanata: A review on phytochemistry and pharmacological aspects

  2011cited by this paper
• Phytocompounds from Vitis kelungensis stem prevent carbon tetrachloride-induced acute liver injury in mice

  2011cited by this paper
• Current issues with acetaminophen hepatotoxicity--a clinically relevant model to test the efficacy of natural products.

  2011cited by this paper
• Mechanisms of acetaminophen-induced liver necrosis.

  2010cited by this paper
• Hepatoprotective activity of Morus alba (Linn.) leaves extract against carbon tetrachloride induced hepatotoxicity in rats.

  2010cited by this paper
• Hygrophila spinosa: A comprehensive review

  2010cited by this paper
• Hepatoprotective activity of ethanolic extracts of bark of Zanthoxylum armatum DC in CCl4 induced hepatic damage in rats.

  2010cited by this paper
• Acetaminophen: Old drug, new warnings

  2010cited by this paper
• Enhancing bioavailability and hepatoprotective activity of andrographolide from Andrographis paniculata, a well-known medicinal food, through its herbosome.

  2010cited by this paper
• Hepatoprotective effects of Sedum sarmentosum on D-galactosamine/lipopolysaccharide-induced murine fulminant hepatic failure.

  2010cited by this paper
• Hepatoprotective effects of apple polyphenols on CCl4-induced acute liver damage in mice.

  2010cited by this paper
• Effect of Clausena dentata (Willd.) M. Roem. against paracetamol induced hepatotoxicity in rats.

  2009cited by this paper
• Hepatoprotective effect of Carissa carandas Linn root extract against CCl4 and paracetamol induced hepatic oxidative stress.

  2009cited by this paper
• Carbon tetrachloride-induced liver disease in rats: the potential effect of supplement oils with vitamins E and C on the nutritional status

  2009cited by this paper
• Estimation of Tissue Lipid Peroxidation Level and Organ Weight in Litters of Wistar Rats Exposed to Prenatal Alcohol Ingestion

  2009cited by this paper
• Hepatoprotective activity of Mimosa pudica leaves against carbontetrachloride induced toxicity.

  2009cited by this paper
• Hepatoprotective studies on Sida acuta Burm. f.

  2009cited by this paper
• Pharmacology and chemistry of a potent hepatoprotective compound Picroliv isolated from the roots and rhizomes of Picrorhiza kurroa royle ex benth. (kutki).

  2009cited by this paper
• Protective effect of Cichorium glandulosum root extract on carbon tetrachloride-induced and galactosamine-induced hepatotoxicity in mice.

  2009cited by this paper
• Hepatoprotective effect of Azadirachta indica (Neem) leaves against alcohol induced liver injury in Albino rats.

  2009cited by this paper
• DEMAND OF HERBAL HEPATOPROTECTIVE FORMULATIONS IN LUCKNOW - A SURVEY

  2009cited by this paper
• Hepatoprotective effect of Morus alba L. in carbon tetrachloride-induced hepatotoxicity in mice.

  2009cited by this paper

• Protective Effect of Silymarin on Monosodium Glutamate-induced Liver Toxicity in Rats

  2025cites this paper
• Synergistic Neuroprotective Effects of Hesperetin and Naringenin against Benzo[a]pyrene-induced Brain Injury

  2025cites this paper
• Herbal Defenders of the Liver: Exploring Pakistan’s Medicinal Flora for Hepatoprotection

  2025cites this paper
• Hepatoprotective Effect of Bersama abyssinica Fresen Leaf Methanolic Extract on Paracetamol-Induced Hepatotoxicity in Swiss Albino Mice

  2025cites this paper
• Liver protective effect of Indonesian bay leaf on liver injury in alloxan-induced diabetic Wistar rats

  2025cites this paper
• Chemical Profiling and Hepatoprotective Potential of Chloroform–Methanolic Extract of Salvia sclarea L.: GC–MS Analysis and In Vivo Studies

  2025cites this paper
• Role of Milk Thistle (Silybum marianum) as a Therapeutic Feed Additive in Livestock, Poultry and Humans

  2024cites this paper
• Impact of Traditional Chinese Medicine Antioxidants on Oxidative Stress and Drug-Induced Liver Injury: A Review

  2024cites this paper
• Hepatoprotective activity of medicinal plants, their phytochemistry, and safety concerns: a systematic review

  2024cites this paper
• Phosphodiesterase 5 and Arginase Inhibitory Activities of the Extracts from Some Members of Nelumbonaceae and Nymphaeaceae Families

  2023cites this paper
• Biomarkers of liver diseases

  2023cites this paper
• Role of Mesenchymal Stem Cells (MSCs) individually and with combination of Cherry Extract against Antiepileptic Drug Induced Hepatotoxicity

  2023cites this paper
• Silymarin: a review on paving the way towards promising pharmacological agent

  2023cites this paper
• Mixed leaf meal supplemented with exogenous enzyme and limiting amino acids can completely replace DORB (de-oiled rice bran) in the diet of Labeo rohita

  2022influential citation
• A REVIEW ON HEPATOPROTECTIVE PLANTS AND COMPOUNDS

  2022cites this paper
• Protective role of Avena fatua against drug-induced liver toxicity.

  2022cites this paper
• Medical and medicinal importance of Rheum spp. collected from different altitudes of the Kashmir Himalayan range

  2022influential citation
• Improvement of liver injury induced by acetaminophen using black cherry (Prunus serotina Ehrh) powder and extract in rats

  2021cites this paper
• Medicinal plants with hepatoprotective potentials against carbon tetrachloride-induced toxicity: a review

  2021cites this paper
• Herbal and dietary supplement induced liver injury: Highlights from the recent literature

  2021cites this paper
• Hepatoprotective plants role in human health: A cross-kingdom review

  2021cites this paper
• Hepatoprotective Activity of Helicteres isora Ethanol Extract Against Paracetamol-Induced Liver Injury in Mice

  2021influential citation
• Protective Effects of Aqueous and Hydroethanolic Extracts of Secamone afzelii (Asclepiadaceae) Leaves on Liver Transaminases, Serum Vitamin D and Zinc Levels against Carbon Tetrachloride (CCl4)- Induced Hepatotoxicity in Rats

  2020cites this paper
• Hepatoprotective and Nephroprotective Effect of Aegle marmelos and Andrographis paniculata in Aflatoxicosis of Broiler Chicken

  2020cites this paper
• ROLE OF NUTRACEUTICALS IN MANAGEMENT OF LIVER DISEASE: A COMPREHENSIVE REVIEW

  year unknowncites this paper