Ketogenic diet, brain glutamate metabolism and seizure control.

No abstract is available for this paper.

• Publication year

  2004

• Venue

  Prostaglandins, Leukotrienes and Essential Fatty Acids

• Publication date

  2004-03-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1016/J.PLEFA.2003.07.005PMID 14769486
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Ketogenic Diet

  2005cited by this paper
• MCT2 is a Major Neuronal Monocarboxylate Transporter in the Adult Mouse Brain

  2002cited by this paper
• Diet-induced ketosis increases monocarboxylate transporter (MCT1) levels in rat brain.

  2001cited by this paper
• Ketogenic diet, amino acid metabolism, and seizure control

  2001cited by this paper
• Human L-type amino acid transporter 1 (LAT1): characterization of function and expression in tumor cell lines.

  2001cited by this paper
• Transfer of glutamine between astrocytes and neurons

  2001cited by this paper
• Compartmentation of TCA cycle metabolism in cultured neocortical neurons revealed by 13C MR spectroscopy.

  2000cited by this paper
• A Ketogenic Diet Increases the Resistance to Pentylenetetrazole‐Induced Seizures in the Rat

  1999cited by this paper
• Ketosis and Epilepsy: 31P Spectroscopic Imaging at 4.1 T

  1999cited by this paper
• Selective expression of the large neutral amino acid transporter at the blood-brain barrier.

  1999cited by this paper
• Circulation and Energy Metabolism of the Brain

  1999cited by this paper
• Energy on Demand

  1999cited by this paper
• Cellular distribution and kinetic properties of high-affinity glutamate transporters.

  1998cited by this paper
• Monocarboxylate transporter expression in mouse brain.

  1998cited by this paper
• A multicenter study of the efficacy of the ketogenic diet.

  1998cited by this paper
• Preferential Utilization of Acetate by Astrocytes Is Attributable to Transport

  1998cited by this paper
• Ketone Bodies and Brain Glutamate and GABA Metabolism

  1998cited by this paper
• Rate of Glutamate Synthesis from Leucine in Rat Brain Measured In Vivo by 15N NMR

  1998cited by this paper
• Excitatory amino acids.

  1998cited by this paper
• Monocarboxylate transporter expression in mouse brain.

  1998cited by this paper
• The role of glutamate transporters in glutamate homeostasis in the brain.

  1997cited by this paper
• Expression of monocarboxylate transporter MCT1 by brain endothelium and glia in adult and suckling rats.

  1997cited by this paper
• Mice devoid of γ-aminobutyrate type A receptor β3 subunit have epilepsy, cleft palate, and hypersensitive behavior

  1997cited by this paper
• Effects of Ketone Bodies on Astrocyte Amino Acid Metabolism

  1997influential reference
• The ketogenic diet: 1997.

  1997cited by this paper
• GABA and Epileptogenesis

  1997cited by this paper
• Clinical Significance of Animal Seizure Models and Mechanism of Action Studies of Potential Antiepileptic Drugs

  1997cited by this paper
• Cellular Distribution of Branched-chain Amino Acid Aminotransferase Isoenzymes Among Rat Brain Glial Cells in Culture

  1997cited by this paper
• Epilepsy and the Ketogenic diet

  1997cited by this paper
• Mice devoid of gamma-aminobutyrate type A receptor beta3 subunit have epilepsy, cleft palate, and hypersensitive behavior.

  1997cited by this paper
• Enzymes of Ketone Body Utilization in Human Tissues: Protein and Messenger RNA Levels of Succinyl-Coenzyme A (CoA):3-Ketoacid CoA Transferase and Mitochondrial and Cytosolic Acetoacetyl-CoA Thiolases

  1997cited by this paper
• Ketogenic Diet: Effects on Expression of Kindled Seizures and Behavior in Adult Rats

  1997cited by this paper
• Diet‐Induced Ketosis Does Not Cause Cerebral Acidosis

  1996cited by this paper
• Low brain GABA level is associated with poor seizure control

  1996cited by this paper
• Update on the Mechanism of Action of Antiepileptic Drugs

  1996cited by this paper
• Elevation of amino acids in the interstitial space of the rat brain following infusion of large neutral amino and keto acids by microdialysis: leucine infusion.

  1996cited by this paper
• Regulation of GABA Level in Rat Brain Synaptosomes: Fluxes Through Enzymes of the GABA Shunt and Effects of Glutamate, Calcium, and Ketone Bodies

  1996cited by this paper
• Neuronal Metabolism of Branched‐Chain Amino Acids: Flux Through the Aminotransferase Pathway in Synaptosomes

  1996cited by this paper
• Simultaneous Determination of the Rates of the TCA Cycle, Glucose Utilization, α-Ketoglutarate/Glutamate Exchange, and Glutamine Synthesis in Human Brain by NMR

  1995cited by this paper
• The role of GABAA receptors in the subsensitivity of Purkinje neurons to GABA in genetic epilepsy prone rats.

  1995cited by this paper
• Tricarboxylic acid cycle in rat brain synaptosomes. Fluxes and interactions with aspartate aminotransferase and malate/aspartate shuttle.

  1994cited by this paper
• The Epilepsy Diet Treatment: : An Introduction to The Ketogenic Diet

  1994cited by this paper
• The role of glutamate in epilepsy and other CNS disorders

  1994cited by this paper
• Diminished potassium-stimulated GABA release in vivo in genetically epilepsy-prone rats.

  1994cited by this paper
• Glucose and ketone body utilization by the brain of neonatal rats.

  1993cited by this paper
• Potassium-induced stimulation of oxidative metabolism of glucose in cultures of intact cerebellar granule cells but not in corresponding cells with dendritic degeneration.

  1993cited by this paper
• Extracellular amino acid levels in hippocampus during pilocarpine-induced seizures.

  1993cited by this paper
• Regulation of energy metabolism in synaptic terminals and cultured rat brain astrocytes: differences revealed using aminooxyacetate.

  1993cited by this paper
• Aspartate and glutamate mediate excitatory synaptic transmission in area CA1 of the hippocampus

  1993cited by this paper
• Direct demonstration by [13C]NMR spectroscopy that glutamine from astrocytes is a precursor for GABA synthesis in neurons.

  1993cited by this paper
• Efficacy of the Ketogenic Diet for Intractable Seizure Disorders: Review of 58 Cases

  1992cited by this paper
• Identification of mitochondrial branched chain aminotransferase and its isoforms in rat tissues.

  1992cited by this paper
• Brain uptake and release of amino acids in nondiabetic and insulin-dependent diabetic subjects: important role of glutamine release for nitrogen balance.

  1992cited by this paper
• Seizure related elevations of extracellular amino acids in human focal epilepsy.

  1992cited by this paper
• Enhanced Aspartate Release from Hippocampal Slices of Epileptic (El) Mice

  1991cited by this paper
• Autoreceptor Regulation of Glutamate and Aspartate Release from Slices of the Hippocampal CA1 Area

  1991cited by this paper
• Metabolism and role of glutamate in mammalian brain.

  1990cited by this paper
• Use of the traditional ketogenic diet for treatment of intractable epilepsy.

  1990cited by this paper
• Cerebral metabolism of [1,2-13C2]acetate as detected by in vivo and in vitro 13C NMR.

  1990cited by this paper
• Neuronal Glutamine Utilization: Glutamine/Glutamate Homeostasis in Synaptosomes

  1990cited by this paper
• Relationships between the neuronal sodium/potassium pump and energy metabolism. Effects of K+, Na+, and adenosine triphosphate in isolated brain synaptosomes

  1990cited by this paper
• Endogenous aspartate release in the rat hippocampus is inhibited by M2 'cardiac' muscarinic receptors.

  1990cited by this paper
• Stimulation of Synaptosomal γ‐Aminobutyric Acid Synthesis by Glutamate and Glutamine

  1990cited by this paper
• Stimulation of synaptosomal gamma-aminobutyric acid synthesis by glutamate and glutamine.

  1990cited by this paper
• Epilepsy and the GABA-hypothesis a brief review and some examples.

  1990cited by this paper
• Activities of pyruvate dehydrogenase, enzymes of citric acid cycle, and aminotransferases in the subcellular fractions of cerebral cortex in normal and hyperammonemic rats

  1989cited by this paper
• Lactate, 3-hydroxybutyrate, and glucose as substrates for the early postnatal rat brain

  1989cited by this paper
• Role of Glial Cells for the Basal and Ca2+‐Dependent K+‐Evoked Release of Transmitter Amino Acids Investigated by Microdialysis

  1989cited by this paper
• Basic Neurochemistry: Molecular, Cellular and Medical Aspects

  1989cited by this paper
• Transport of 3-hydroxy[3-14C]butyrate by dissociated cells from rat brain.

  1988cited by this paper
• Stability and Activation of Glutamate Apodecarboxylase from Pig Brain

  1988cited by this paper
• Kinetics of Neutral Amino Acid Transport Across the Blood‐Brain Barrier

  1987cited by this paper
• Neurohistochemistry, modern methods and applications

  1986cited by this paper
• β-Hydroxybutyrate reverses insulin-induced hypoglycemic coma in suckling-weanling mice despite low blood and brain glucose levels

  1986cited by this paper
• Evidence for impaired GABAergic activity in the substantia nigra of amygdaloid kindled rats.

  1985cited by this paper
• Nutritional management. The Johns Hopkins handbook.

  1984cited by this paper
• Acetoacetate is a cholesterogenic precursor for myelinating rat brain and spinal cord. Incorporation of label from [3-14C]acetoacetate, [14C]glucose and 3H2O.

  1984cited by this paper
• First visualization of glutamate and GABA in neurones by immunocytochemistry

  1983cited by this paper
• Use of β‐Methylene‐D,L‐Aspartate to Assess the Role of Aspartate Aminotransferase in Cerebral Oxidative Metabolism

  1983cited by this paper
• Preferential utilization of ketone bodies for the synthesis of myelin cholesterol in vivo.

  1981cited by this paper
• Present status and significance of the glutamine cycle in neural tissues.

  1981cited by this paper
• Fine structural localization of glutamine synthetase in astrocytes of rat brain.

  1979cited by this paper
• The metabolic fate of 13N-labeled ammonia in rat brain.

  1979cited by this paper
• Brain energy metabolism

  1978cited by this paper
• A rapid method for the preparation of relatively pure metabolically competent synaptosomes from rat brain.

  1978cited by this paper
• Glutamine synthetase: glial localization in brain

  1977cited by this paper
• CHRONIC KETOSIS AND CEREBRAL METABOLISM

  1977cited by this paper
• Starvation and Seizures

  1976cited by this paper
• GABA in nervous system function

  1976cited by this paper
• Starvation and seizures. Observation on the electroconvulsive threshold and cerebral metabolism of the starved adult rat.

  1975cited by this paper
• Induction processes in blood-brain transfer of ketone bodies during starvation.

  1975cited by this paper
• Metabolic compartmentation of glutamate associated with the formation of gamma-aminobutyrate.

  1974cited by this paper
• METABOLIC COMPARTMENTATION OF GLUTAMATE ASSOCIATED WITH THE FORMATION OF γ‐AMINOBUTYRATE

  1974cited by this paper
• Contribution of the GABA Bypath to Glucose Oxidation, and the Development of Compartmentation in the Brain

  1970cited by this paper
• Brain metabolism during fasting.

  1967cited by this paper
• Metabolic compartments in vivo. Ammonia and glutamic acid metabolism in brain and liver.

  1962cited by this paper
• Epilepsy in childhood: II. The incidence of remissions*

  1937cited by this paper
• Ketosis and Epilepsy

  1933cited by this paper

• Ketogenic diet dampens excitatory neurotransmission by shrinking synaptic vesicle pools.

  2026cites this paper
• ACETATO: MECANISMOS CELULARES E POTENCIAL TERAPÊUTICO EM DOENÇAS NEUROIMUNOLÓGICAS E NEURODEGENERATIVAS

  2025cites this paper
• Clinical Insights Into the Mechanistic Crossroads of Lamotrigine and Therapeutic Ketosis in Bipolar Depression

  2025cites this paper
• Ketogenic diet dampens excitatory neurotransmission by shrinking synaptic vesicle pools

  2025cites this paper
• Pentylenetetrazole-Induced Seizures in Wistar Male Albino Rats with Reference to Glutamate Metabolism

  2024cites this paper
• Pathway mapping of exhaled volatile organic compounds associated with blood and ruminal fluid metabolites to describe the nutritional and metabolic status of lactating dairy cows.

  2024cites this paper
• Ketogenic-Mimicking Diet as a Therapeutic Modality for Bipolar Disorder: Biomechanistic Rationale and Protocol for a Pilot Clinical Trial

  2023cites this paper
• Defining ketone supplementation: the evolving evidence for post-exercise ketone supplementation to improve recovery and adaptation to exercise.

  2023cites this paper
• Novel Ketamine and Zinc Treatment for Anorexia Nervosa and the Potential Beneficial Interactions With the Gut Microbiome.

  2023cites this paper
• A ketogenic intervention improves dorsal attention network functional and structural connectivity in mild cognitive impairment.

  2022cites this paper
• Fructose 1,6-bisphosphate is anticonvulsant and improves oxidative glucose metabolism within the hippocampus and liver in the chronic pilocarpine mouse epilepsy model.

  2021cites this paper
• Acetylation Profiles in the Metabolic Process of Glioma-Associated Seizures

  2021cites this paper
• Acutely increased β-hydroxybutyrate plays a role in the prefrontal cortex to escape stressful conditions during the acute stress response.

  2021cites this paper
• Ketogenic diet as a metabolic therapy for bipolar disorder: Clinical developments

  2021cites this paper
• The use of a low carbohydrate, ketogenic diet in bipolar disorder: systematic review

  2021cites this paper
• Dietary medium chain triglycerides for management of epilepsy: New data from human, dog, and rodent studies

  2021cites this paper
• Neuroanesthesiology Update.

  2020cites this paper
• Nutritional ketosis as an intervention to relieve astrogliosis: Possible therapeutic applications in the treatment of neurodegenerative and neuroprogressive disorders

  2020cites this paper
• An Examination of Serum Acylcarnitine and Amino Acid Profiles at Different Time Point of Ketogenic Diet Therapy and Their Association of Ketogenic Diet Effectiveness

  2020cites this paper
• Gamma-Aminobutyric Acid (GABA)

  2020cites this paper
• Analgesic activity of some aroylhydrazone-based molecular hybrids with antiseizure activity: in vivo and in silico evaluations

  2019cites this paper
• Effects of Branched-Chain Amino Acid Supplementation on Spontaneous Seizures and Neuronal Viability in a Model of Mesial Temporal Lobe Epilepsy

  2019cites this paper
• Therapeutic alternative of the ketogenic Mediterranean diet to improve mitochondrial activity in Amyotrophic Lateral Sclerosis (ALS): A Comprehensive Review

  2019cites this paper
• The distribution and density of monocarboxylate transporter 2 in cerebral cortex, hippocampus and cerebellum of wild‐type mice

  2019cites this paper
• Ketogenic diet attenuates cerebellar atrophy progression in a subject with a biallelic variant at the ATAD3A locus [Response to Letter]

  2019cites this paper
• Branched-Chain Amino Acids and Seizures: A Systematic Review of the Literature

  2019cites this paper
• Exogenous β-Hydroxybutyrate Treatment and Neuroprotection in a Suckling Rat Model of Hypoxic-Ischemic Encephalopathy

  2018cites this paper
• Ketogenic Diet Based on Extra Virgin Coconut Oil Has No Effects in Young Wistar Rats With Pilocarpine-Induced Epilepsy.

  2018cites this paper
• The Antiepileptic Ketogenic Diet Alters Hippocampal Transporter Levels and Reduces Adiposity in Aged Rats

  2018cites this paper
• Insect models of central nervous system energy metabolism and its links to behavior

  2018cites this paper
• γ-Aminobutyric Acid (GABA): Biosynthesis, Role, Commercial Production, and Applications

  2018cites this paper
• Astrocytes and Glutamine Synthetase in Epileptogenesis

  2018cites this paper
• Automated synthesis of 1-[11C]acetoacetate on a TRASIS AIO module.

  2017cites this paper
• Various ketogenic diets can differently support brain resistance against experimentally evoked seizures and seizure-induced elemental anomalies of hippocampal formation.

  2017cites this paper
• Alternative Fuels in Epilepsy and Amyotrophic Lateral Sclerosis

  2017cites this paper
• The pleiotropic effects of decanoic acid treatment on mitochondrial function in fibroblasts from patients with complex I deficient Leigh syndrome

  2016cites this paper
• How effective is the ketogenic diet for electrical status epilepticus of sleep?

  2016cites this paper
• Anaplerosis for Glutamate Synthesis in the Neonate and in Adulthood.

  2016cites this paper
• An Initial Analysis of a Long-Term Ketogenic Diet’s Impact on Motor Behavior, Brain Purine Systems, and Nigral Dopamine Neurons in a New Genetic Rodent Model of Parkinson’s Disease

  2016cites this paper
• The Glutamate-Glutamine Cycle in Epilepsy.

  2016cites this paper
• Possible relationship between amino acids, aggression and psychopathy

  2016cites this paper
• Metabolic Dysfunctions in Epilepsy and Novel Metabolic Treatment Approaches

  2015cites this paper
• Elemental changes in the hippocampal formation following two different formulas of ketogenic diet: an X-ray fluorescence microscopy study

  2015cites this paper
• Rapid Adaptation of Rat Brain and Liver Metabolism to a Ketogenic Diet: An Integrated Study Using 1H- and 13C-NMR Spectroscopy

  2015cites this paper
• The influence of the ketogenic diet on the elemental and biochemical compositions of the hippocampal formation.

  2015cites this paper
• Synthesis of alkyl 2-aminomethyl-5-(1,2,3-thiadiazol-4-yl)furan-3-carboxylate and pseudopeptides on its basis

  2015cites this paper
• Neuroactive Peptides as Putative Mediators of Antiepileptic Ketogenic Diets

  2014cites this paper
• Triheptanoin partially restores levels of tricarboxylic acid cycle intermediates in the mouse pilocarpine model of epilepsy

  2014cites this paper
• Brain to blood glutamate scavenging as a novel therapeutic modality: a review

  2014cites this paper
• Ketogenic diet alters dopaminergic activity in the mouse cortex.

  2014cites this paper
• KETOGENIC DIET IN EPILEPSY: TIME FOR NIGERIA AND AFRICA ACCESS.

  2014cites this paper
• Glucose uptake by the brain on chronic high-protein weight-loss diets with either moderate or low amounts of carbohydrate

  2013cites this paper
• Monocarboxylate transporters in temporal lobe epilepsy: roles of lactate and ketogenic diet

  2013cites this paper
• Astrocytic regulation of glutamate homeostasis in epilepsy

  2012cites this paper
• Characteristics of ketogenic diet and its therapeutic properties in central nervous system disorders

  2012cites this paper
• Altered expression of brain monocarboxylate transporter 1 in models of temporal lobe epilepsy.

  2012cites this paper
• Monocarboxylate transporters in temporal lobe epilepsy

  2012cites this paper
• The ketogenic diet increases brain glucose and ketone uptake in aged rats: a dual tracer PET and volumetric MRI study.

  2012influential citation
• The Ketogenic Diet and Brain Metabolism

  2012cites this paper
• Efeito de dieta cetogênica à base de óleo de coco sobre as crises convulsivas de ratos portadores de epilepsia induzida por pilocarpina

  2011cites this paper
• Monocarboxylate transporter 1 is deficient on microvessels in the human epileptogenic hippocampus.

  2011cites this paper
• Efficacy of Diet Therapies in the Treatment of Neurological and Neurodegenerative Diseases

  2010cites this paper
• Mitochondrial energetics and therapeutics.

  2010cites this paper
• Potential of Anaplerotic Triheptanoin for the Treatment of Long-chain Fatty Acid Oxidation Disorders

  2010cites this paper
• LONG-CHAIN FATTY ACID OXIDATION DISORDERS

  2010cites this paper
• PET study of 11C-acetoacetate kinetics in rat brain during dietary treatments affecting ketosis.

  2009cites this paper
• Branched Chain Amino Acids as Adjunctive Therapy to Ketogenic Diet in Epilepsy: Pilot Study and Hypothesis

  2009cites this paper
• Ketosis and brain handling of glutamate, glutamine, and GABA

  2008cites this paper
• The effect of several antiepileptic treatments on the fatty acid metabolism of Sprague-Dawley rats

  2008cites this paper
• Cerebral Metabolic Adaptation and Ketone Metabolism after Brain Injury

  2008cites this paper
• The ketogenic diet and brain metabolism of amino acids: relationship to the anticonvulsant effect.

  2007cites this paper
• Ketogenic diet and astrocyte/neuron metabolic interactions

  2007influential citation
• NEUROMODULATION OF SEIZURES , EPILEPTOGENESIS , AND EPILEPSY

  2007cites this paper
• [Ketogenic diet for the treatment of refractory epilepsy].

  2007cites this paper
• Widespread neuronal expression of branched‐chain aminotransferase in the CNS: implications for leucine/glutamate metabolism and for signaling by amino acids

  2007cites this paper
• The Ketogenic Diet: One Decade Later

  2007cites this paper
• Ketogenic Diet: Electrophysiological Effects on the Normal Human Cortex

  2007cites this paper
• Ketogenic Diet as a Treatment for Refractory Epilepsy

  2007cites this paper
• The neuropharmacology of the ketogenic diet.

  2007cites this paper
• Ketogenic diet. Update and application.

  2006cites this paper
• Short-term fasting, seizure control and brain amino acid metabolism.

  2006cites this paper
• State of the ketogenic diet(s) in epilepsy

  2006cites this paper
• Neuronal-glial interactions in rats fed a ketogenic diet.

  2006cites this paper
• The role of fatty acids in drug resistant epilepsy

  2006cites this paper
• The ketogenic diet: from molecular mechanisms to clinical effects.

  2006cites this paper
• The Ketogenic Diet

  2005cites this paper
• Response of brain amino acid metabolism to ketosis.

  2005cites this paper
• Transitory gliosis in the CA3 hippocampal region in rats fed on a ketogenic diet

  2005influential citation
• Ketogenic diet decreases circulating concentrations of neuroactive steroids of female rats.

  2005cites this paper
• Gamma-Aminobutyric Acid ( GABA ) Introduction

  year unknowncites this paper