Rapid Adaptation of Rat Brain and Liver Metabolism to a Ketogenic Diet: An Integrated Study Using 1H- and 13C-NMR Spectroscopy

No abstract is available for this paper.

• Publication year

  2015

• Venue

  Journal of Cerebral Blood Flow and Metabolism

• Publication date

  2015-03-18

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1038/jcbfm.2015.29PMID 25785828PMCID PMC4640267
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• The Contribution of Ketone Bodies to Basal and Activity-Dependent Neuronal Oxidation in Vivo

  2014cited by this paper
• Acute exercise increases brain region-specific expression of MCT1, MCT2, MCT4, GLUT1, and COX IV proteins.

  2014cited by this paper
• Ketosis Proportionately Spares Glucose Utilization in Brain

  2013cited by this paper
• Long-term calorie restriction has minimal impact on brain metabolite and fatty acid profiles in aged rats on a Western-style diet.

  2013cited by this paper
• Role of branched chain amino acids in cerebral ammonia homeostasis related to hepatic encephalopathy

  2013cited by this paper
• Glucose and lactate metabolism in the awake and stimulated rat: a 13C-NMR study

  2013cited by this paper
• Sweet Sixteen for ANLS

  2012cited by this paper
• The ketogenic diet increases brain glucose and ketone uptake in aged rats: a dual tracer PET and volumetric MRI study.

  2012cited by this paper
• Cortical Substrate Oxidation during Hyperketonemia in the Fasted Anesthetized Rat in Vivo

  2011cited by this paper
• Brain fuel metabolism, aging, and Alzheimer's disease.

  2011cited by this paper
• Mild experimental ketosis increases brain uptake of 11C-acetoacetate and 18F-fluorodeoxyglucose: a dual-tracer PET imaging study in rats

  2011cited by this paper
• Branched Chain Amino Acids as Adjunctive Therapy to Ketogenic Diet in Epilepsy: Pilot Study and Hypothesis

  2009cited by this paper
• Ketogenic diets: Evidence for short- and long-term efficacy

  2009cited by this paper
• Ketosis and brain handling of glutamate, glutamine, and GABA

  2008cited by this paper
• Intrahepatic Glucose Flux as a Mechanism for Defective Intrahepatic Islet α-Cell Response to Hypoglycemia

  2008cited by this paper
• Diet-induced ketosis increases capillary density without altered blood flow in rat brain.

  2007cited by this paper
• Neuronal-glial interactions in rats fed a ketogenic diet.

  2006cited by this paper
• Mitochondrial biogenesis in the anticonvulsant mechanism of the ketogenic diet

  2006cited by this paper
• Acetoacetate protects neuronal cells from oxidative glutamate toxicity

  2006cited by this paper
• Despite transient ketosis, the classic high-fat ketogenic diet induces marked changes in fatty acid metabolism in rats.

  2005cited by this paper
• Response of brain amino acid metabolism to ketosis.

  2005cited by this paper
• Ketogenic diet, brain glutamate metabolism and seizure control.

  2004cited by this paper
• A cDNA microarray analysis of gene expression profiles in rat hippocampus following a ketogenic diet.

  2004cited by this paper
• High plasma branched-chain amino acids:aromatic amino acids ratio in children on the ketogenic diet: a mechanism in controlling epilepsy.

  2004cited by this paper
• Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry.

  2004cited by this paper
• Short Communication The ketogenic diet in children, adolescents and young adults with refractory epilepsy: an Italian multicentric experience

  2002cited by this paper
• Ontogeny and subcellular localization of rat liver mitochondrial branched chain amino-acid aminotransferase.

  2001cited by this paper
• Ketogenic diet, amino acid metabolism, and seizure control

  2001cited by this paper
• Diet-induced ketosis increases monocarboxylate transporter (MCT1) levels in rat brain.

  2001cited by this paper
• The Metabolism of [3‐13C]Lactate in the Rat Brain Is Specific of a Pyruvate Carboxylase‐Deprived Compartment

  2000cited by this paper
• Blood—Brain Barrier Glucose Transporter

  1999cited by this paper
• Brain metabolism of branched‐chain amino acids

  1997cited by this paper
• Upregulation of Blood-Brain Barrier GLUT1 Glucose Transporter Protein and mRNA in Experimental Chronic Hypoglycemia

  1995cited by this paper
• Cerebral metabolism of [1,2‐13C2]glucose and [U‐13C4]3‐hydroxybutyrate in rat brain as detected by 13C NMR spectroscopy

  1993cited by this paper
• NMR Determination of the TCA Cycle Rate and α-Ketoglutarate/Glutamate Exchange Rate in Rat Brain

  1992cited by this paper
• NMR determination of the TCA cycle rate and alpha-ketoglutarate/glutamate exchange rate in rat brain.

  1992cited by this paper
• Pyruvate car☐ylase: an astrocyte-specific enzyme implicated in the replenishment of amino acid neurotransmitter pools

  1985cited by this paper
• Brain metabolism: a perspective from the blood-brain barrier.

  1983cited by this paper
• Glutamine synthetase: glial localization in brain

  1977cited by this paper
• Utilization of L(+)-3-hydroxybutyrate, D(-)-3-hydroxybutyrate, acetoacetate, and glucose for respiration and lipid synthesis in the 18-day-old rat.

  1977cited by this paper
• Uptake of ketone bodies by rat brain in vivo.

  1971cited by this paper
• Brain metabolism during fasting.

  1967cited by this paper
• The effects of ketonemia on the course of epilepsy

  year unknowncited by this paper

• Acute Supplementation of Beta‐Hydroxybutyrate Increases Visual Cortical Excitability in Humans: A Combined Electro‐EncephaloGraphy and Magnetic Resonance Spectroscopy Study

  2025cites this paper
• Energy metabolism in health and diseases

  2025cites this paper
• Neuroprotective effects of lactate and ketone bodies in acute brain injury

  2024cites this paper
• Linking mitochondrial dysfunction, neurotransmitter, neural network abnormalities and mania: Elucidating neurobiological mechanisms of the therapeutic effect of the ketogenic diet in Bipolar Disorder.

  2024cites this paper
• Case for supporting astrocyte energetics in glucose transporter 1 deficiency syndrome

  2024cites this paper
• Ketogenic diet time-dependently prevents NAFLD through upregulating the expression of antioxidant protein metallothionein-2.

  2024cites this paper
• Association of Circulating Caprylic Acid with Risk of Mild Cognitive Impairment and Alzheimer’s Disease in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) Cohort

  2023cites this paper
• In vivo assessment of β‐hydroxybutyrate metabolism in mouse brain using deuterium (2H) MRS

  2023cites this paper
• Cognitive, Sleep, and Autonomic Responses to Induction of a Ketogenic Diet in Military Personnel: A Pilot Study.

  2022cites this paper
• Aberrant Energy Metabolism in Alzheimer’s Disease

  2022cites this paper
• Ketogenic diet uncovers differential metabolic plasticity of brain cells

  2022cites this paper
• Metabolism of Exogenous [2,4-13C]β-Hydroxybutyrate following Traumatic Brain Injury in 21-22-Day-Old Rats: An Ex Vivo NMR Study

  2022cites this paper
• Ameliorating effect of ketogenic diet on acute status epilepticus: Insights into biochemical and histological changes in rat hippocampus.

  2022cites this paper
• Acutely increased β-hydroxybutyrate plays a role in the prefrontal cortex to escape stressful conditions during the acute stress response.

  2021cites this paper
• Ketogenic diets and the nervous system: a scoping review of neurological outcomes from nutritional ketosis in animal studies

  2021cites this paper
• Brain energy rescue: an emerging therapeutic concept for neurodegenerative disorders of ageing

  2020cites this paper
• Metabolism and epilepsy: Ketogenic diets as a homeostatic link.

  2019cites this paper
• Inflammation, insulin resistance and neuroprogression in depression

  2019cites this paper
• Loss of ACOT7 potentiates seizures and metabolic dysfunction.

  2019cites this paper
• β -H YDROXYBUTYRATE : A S IGNALING M ETABOLITE

  2019cites this paper
• Feasibility of in vivo measurement of glucose metabolism in the mouse hypothalamus by 1H‐[13C] MRS at 14.1T

  2018cites this paper
• The lived experience of healthy adults following a ketogenic diet: A qualitative study

  2018cites this paper
• The use of nutritional supplements to induce ketosis and reduce symptoms associated with keto-induction: a narrative review

  2018cites this paper
• A Systematic Review Comparison of Ketogenic Dietary Treatment Efficacy for Alzheimer’s Disease

  2018cites this paper
• Effects of Systemic Metabolic Fuels on Glucose and Lactate Levels in the Brain Extracellular Compartment of the Mouse

  2017cites this paper
• β-Hydroxybutyrate: A Signaling Metabolite.

  2017cites this paper
• Ketogenic diet or BHB improves epileptiform spikes, memory, survival in Alzheimer’s model

  2017cites this paper
• Can Ketones Help Rescue Brain Fuel Supply in Later Life? Implications for Cognitive Health during Aging and the Treatment of Alzheimer’s Disease

  2016cites this paper
• Is ketogenic diet treatment hepatotoxic for children with intractable epilepsy?

  2016cites this paper
• Glucose, Lactate, β-Hydroxybutyrate, Acetate, GABA, and Succinate as Substrates for Synthesis of Glutamate and GABA in the Glutamine-Glutamate/GABA Cycle.

  2016cites this paper
• Can ketones compensate for deteriorating brain glucose uptake during aging? Implications for the risk and treatment of Alzheimer's disease

  2016cites this paper