Growth factor-like effects of lysophosphatidic acid, a novel lipid mediator.

No abstract is available for this paper.

• Publication year

  1994

• Venue

  Biochimica et Biophysica Acta

• Publication date

  1994-12-30

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1016/0304-419X(94)90013-2PMID 7819274
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Protein tyrosine phosphorylation induced by lysophosphatidic acid in Rat-1 fibroblasts. Evidence that phosphorylation of map kinase is mediated by the Gi-p21ras pathway.

  1994cited by this paper
• Lysophosphatidic acid possesses dual action in cell proliferation.

  1994cited by this paper
• Diversity in function and regulation of MAP kinase pathways.

  1994cited by this paper
• Ras-dependent activation of MAP kinase pathway mediated by G-protein βγ subunits

  1994cited by this paper
• Biochemical characterization of the interaction of lipid phosphoric acids with human platelets: comparison with platelet activating factor.

  1994cited by this paper
• Lysophosphatidic acid stimulates tyrosine phosphorylation of focal adhesion kinase, paxillin, and p130. Signaling pathways and cross-talk with platelet-derived growth factor.

  1994cited by this paper
• Identification and characterization of a lysophosphatidic acid receptor.

  1994cited by this paper
• Inhibition of lysophosphatidate- and thrombin-induced neurite retraction and neuronal cell rounding by ADP ribosylation of the small GTP-binding protein Rho

  1994cited by this paper
• Signal transduction pathways regulating Rho‐mediated stress fibre formation: requirement for a tyrosine kinase.

  1994cited by this paper
• cAMP abrogates the p21ras-mitogen-activated protein kinase pathway in fibroblasts.

  1994cited by this paper
• Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK

  1994cited by this paper
• Lysophosphatidic acid stimulates mitogen-activated protein kinase activation via a G-protein-coupled pathway requiring p21ras and p74raf-1.

  1993cited by this paper
• Inhibition of PMA-induced, LFA-1-dependent lymphocyte aggregation by ADP ribosylation of the small molecular weight GTP binding protein, rho

  1993cited by this paper
• Neurotransmitter release from lysophosphatidic acid stimulated PC12 cells: involvement of lysophosphatidic acid receptors.

  1993cited by this paper
• cAMP antagonizes p21ras‐directed activation of extracellular signal‐regulated kinase 2 and phosphorylation of mSos nucleotide exchange factor.

  1993cited by this paper
• Platelet-activating factor: a phospholipid autacoid with diverse actions.

  1993cited by this paper
• Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in fibroblasts.

  1993cited by this paper
• Inhibition by cAMP of Ras-dependent activation of Raf.

  1993cited by this paper
• Involvement of Ras and Raf in the Gi-coupled acetylcholine muscarinic m2 receptor activation of mitogen-activated protein (MAP) kinase kinase and MAP kinase.

  1993cited by this paper
• Induction of in vitro tumor cell invasion of cellular monolayers by lysophosphatidic acid or phospholipase D.

  1993cited by this paper
• Lysophosphatidic acid is a chemoattractant for Dictyostelium discoideum amoebae.

  1993cited by this paper
• The bioactive phospholipid lysophosphatidic acid is released from activated platelets.

  1993cited by this paper
• RapV12 antagonizes Ras‐dependent activation of ERK1 and ERK2 by LPA and EGF in Rat‐1 fibroblasts.

  1993cited by this paper
• ADP-ribosylation of rho p21 inhibits lysophosphatidic acid-induced protein tyrosine phosphorylation and phosphatidylinositol 3-kinase activation in cultured Swiss 3T3 cells.

  1993cited by this paper
• Differentiation and apoptosis of murine neuroblastoma cells N1E115.

  1993cited by this paper
• Pertussis toxin-sensitive activation of p21ras by G protein-coupled receptor agonists in fibroblasts.

  1993cited by this paper
• Lysophosphatidic acid induces neuronal shape changes via a novel, receptor-mediated signaling pathway: similarity to thrombin action.

  1993cited by this paper
• Thrombin causes neurite retraction in neuronal cells through activation of cell surface receptors.

  1992cited by this paper
• Phosphatidic acid that accumulates in platelet-derived growth factor-stimulated Balb/c 3T3 cells is a potential mitogenic signal.

  1992cited by this paper
• Lysophosphatidates bound to serum albumin activate membrane currents in Xenopus oocytes and neurite retraction in PC12 pheochromocytoma cells.

  1992cited by this paper
• The biologically active phospholipid, lysophosphatidic acid, induces phosphatidylcholine breakdown in fibroblasts via activation of phospholipase D. Comparison with the response to endothelin.

  1992cited by this paper
• Lysophosphatidic acid induces inward currents in Xenopus laevis oocytes; evidence for an extracellular site of action.

  1992cited by this paper
• The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors.

  1992cited by this paper
• Mitogenic action of lysophosphatidic acid and phosphatidic acid on fibroblasts. Dependence on acyl-chain length and inhibition by suramin.

  1992cited by this paper
• Metabolic conversion of the biologically active phospholipid, lysophosphatidic acid, in fibroblasts.

  1992cited by this paper
• Extracellular calcium mimics the actions of platelet-derived growth factor on mouse fibroblasts.

  1992cited by this paper
• Thrombin receptor activation causes rapid neural cell rounding and neurite retraction independent of classic second messengers

  1992cited by this paper
• Tyrosine phosphorylation of paxillin and pp125FAK accompanies cell adhesion to extracellular matrix: a role in cytoskeletal assembly

  1992cited by this paper
• Ras-related GTPases and the cytoskeleton.

  1992cited by this paper
• Bombesin, vasopressin, and endothelin stimulation of tyrosine phosphorylation in Swiss 3T3 cells. Identification of a novel tyrosine kinase as a major substrate.

  1992cited by this paper
• Identification of a putative membrane receptor for the bioactive phospholipid, lysophosphatidic acid.

  1992cited by this paper
• Differences in the regulation of endothelin-1- and lysophosphatidic-acid-stimulated Ins(1,4,5)P3 formation in rat-1 fibroblasts.

  1991cited by this paper
• G-protein-coupled receptors, phosphoinositide hydrolysis, and cell proliferation.

  1991cited by this paper
• Sphingosine-1-phosphate, a novel lipid, involved in cellular proliferation

  1991cited by this paper
• P2-purinoceptor-activated membrane currents and inositol tetrakisphosphate formation are blocked by suramin.

  1990cited by this paper
• Ascitic fluid from human ovarian cancer patients contains growth factors necessary for intraperitoneal growth of human ovarian adenocarcinoma cells.

  1990cited by this paper
• A serum factor that activates the phosphatidylinositol phosphate signaling system in Xenopus oocytes.

  1990cited by this paper
• Lysophosphatidic acid, but not phosphatidic acid, is a potent Ca2(+)-mobilizing stimulus for fibroblasts. Evidence for an extracellular site of action.

  1990cited by this paper
• Identification of the molecular species of lysophosphatidic acid produced when platelets are stimulated by thrombin.

  1989cited by this paper
• Lysophosphatidate-induced cell proliferation: identification and dissection of signaling pathways mediated by G proteins.

  1989cited by this paper
• Assembly of phospholipids into cellular membranes: biosynthesis, transmembrane movement and intracellular translocation.

  1988cited by this paper
• A putative new growth factor in ascitic fluid from ovarian cancer patients: identification, characterization, and mechanism of action.

  1988cited by this paper
• Suramin inhibition of growth factor receptor binding and mitogenicity in AKR‐2B cells

  1987cited by this paper
• Involvement of lysophospholipase D in the production of lysophosphatidic acid in rat plasma.

  1986cited by this paper
• Growth factor-like action of phosphatidic acid

  1986cited by this paper
• Involvement of lysophospholipase D in the production of lysophosphatidic acid in rat plasma.

  1986cited by this paper
• Effects of lysophosphatidic acids and their structural analogs on arterial blood pressure of cats.

  1985cited by this paper
• Decanoyl lysophosphatidic acid induces platelet aggregation through an extracellular action. Evidence against a second messenger role for lysophosphatidic acid.

  1985cited by this paper
• Human platelet aggregation induced by 1-alkyl-lysophosphatidic acid and its analogs: a new group of phospholipid mediators?

  1982cited by this paper
• Purification of the low density lipoprotein receptor, an acidic glycoprotein of 164,000 molecular weight.

  1982cited by this paper
• Lysophosphatidic acid-induced aggregation of human and feline platelets: structure-activity relationship.

  1981cited by this paper
• Phospholipase A2 activity specific for phosphatidic acid. A possible mechanism for the production of arachidonic acid in platelets.

  1981cited by this paper
• Stimulatory effect of lysophosphatidic acids on uterine smooth muscles of non-pregant rats.

  1980cited by this paper
• Lysophosphatidic acids. Influence on platelet aggregation and intracellular calcium flux.

  1979cited by this paper
• Platelet Aggregation Evoked In Vitro and In Vivo by Phosphatidic Acids and Lysoderivatives: Identity with Substances in Aged Serum (DAS)

  1979cited by this paper
• Effects of synthetic and natural lysophosphatidic acids on the arterial blood pressure of different animal species

  1978cited by this paper
• Spectroscopic studies on the complex formation of suramin with bovine and human serum albumin.

  1976cited by this paper
• Phosphoglyceride metabolism.

  1974cited by this paper
• Neurotransmitter synthesis by neuroblastoma clones (neuroblast differentiation-cell culture-choline acetyltransferase-acetylcholinesterase-tyrosine hydroxylase-axons-dendrites).

  1972cited by this paper
• Regulation of axon formation by clonal lines of a neural tumor.

  1970cited by this paper
• Pharamacologically active acidic phospholipids and glycolipids.

  1963cited by this paper

• Volatilomics and Lipidomics revealed flavoring mechanism in baijiu brewed from diverse Sorghum varieties.

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• Beyond cell cycle regulation: the pleiotropic function of CDK4 in cancer.

  2023cites this paper
• Effects of lysophosphatidic acid on sling and clasp fibers of the human lower esophageal sphincter

  2022cites this paper
• Mammary tissue proteomics in a pig model indicates that dietary valine supplementation increases milk fat content via increased de novo synthesis of fatty acid

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• LPA1, LPA2, LPA4, and LPA6 receptor expression during mouse brain development

  2019cites this paper
• The role of lysophosphatidic acid in the physiology and pathology of the skin

  2019cites this paper
• Lysophosphatidic acid triggers cathepsin B-mediated invasiveness of human endometriotic cells.

  2018cites this paper
• Biofunctionalized Lysophosphatidic Acid/Silk Fibroin Film for Cornea Endothelial Cell Regeneration

  2018cites this paper
• P2Y1 Receptors - Properties and Functional Activities.

  2017cites this paper
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  2015cites this paper
• Translational research on autotaxin-LPA-LPA receptors and drug discovery

  2015cites this paper
• Mitigation of the Hematopoietic and Gastrointestinal Acute Radiation Syndrome by Octadecenyl Thiophosphate, a Small Molecule Mimic of Lysophosphatidic Acid

  2015cites this paper
• The regulations of miR-30c-3-3p and its antitumor mechanism in ovarian cancer

  2015cites this paper
• Lysophosphatidic acid induces YAP-promoted proliferation of human corneal endothelial cells via PI3K and ROCK pathways

  2015cites this paper
• Addition of lysophosphatidic acid to mouse oocyte maturation media can enhance fertilization and developmental competence.

  2014cites this paper
• The potential protective role of lysophospholipid mediators in nephrotoxicity induced by chronically exposed cadmium.

  2014cites this paper
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  2013cites this paper
• Expression of lysophosphatidic acid receptors in the human lower esophageal sphincter

  2013cites this paper
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• L1 cell adhesion molecule promotes resistance to alcohol-induced silencing of growth cone responses to guidance cues.

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  2010cites this paper
• Atrial natriuretic peptide and oxidative stress.

  2010cites this paper
• Phospholipids and a phospholipid-rich diet alter the in vitro amyloid-beta peptide levels and amyloid-beta 42/40 ratios.

  2010cites this paper
• Activatory properties of lysophosphatidic acid (LPA) on human THP-1 monocytes

  2009cites this paper
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• Epithelial restitution and wound healing in inflammatory bowel disease.

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• Lysophosphatidic acid induced nuclear translocation of nuclear factor-kappaB in Panc-1 cells by mobilizing cytosolic free calcium.

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• Lysophosphatidic acid promoting corneal epithelial wound healing by transactivation of epidermal growth factor receptor.

  2007cites this paper
• "ACTIVATORY PROPERTIES OF LYSOPHOSPHATIDIC ACID (LPA) ON HUMAN THP-1 MONOCYTES"

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• [Phosphodiesterases that extracellularly produces a lysolipid mediator].

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• Beeinflussung der LPA-Signalübertragung in Xenopus Oozyten durch Lokalanästhetika

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• The signaling pathways linking to lysophosphatidic acid-promoted meiotic maturation in mice.

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• Functional lipidomics: Lysophosphatidic acid as a target for molecular diagnosis and therapy of ovarian cancer

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• Role of atrial natriuretic peptide in the suppression of lysophosphatydic acid-induced rat aortic smooth muscle (RASM) cell growth

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