Computational modeling of anoctamin 1 calcium-activated chloride channels as pacemaker channels in interstitial cells of Cajal.

No abstract is available for this paper.

• Publication year

  2014

• Venue

  American Journal of Physiology - Gastrointestinal and Liver Physiology

• Publication date

  2014-04-15

• Fields of study

  Biology, Medicine, Computer Science

• Identifiers
  DOI 10.1152/ajpgi.00449.2013PMID 24481603PMCID PMC3989704
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Physiology and Pathology of Chloride Transporters and Channels in the Nervous System

  2015cited by this paper
• Activation of the Cl− Channel ANO1 by Localized Calcium Signals in Nociceptive Sensory Neurons Requires Coupling with the IP3 Receptor

  2013cited by this paper
• L-type calcium channel targeting and local signalling in cardiac myocytes.

  2013cited by this paper
• 256 Identification and Characterization of a Human Ano1 Gene Promoter

  2013cited by this paper
• Anoctamins are a family of Ca2+-activated Cl− channels

  2012cited by this paper
• Maxi-channels recorded in situ from ICC and pericytes associated with the mouse myenteric plexus.

  2012cited by this paper
• Targeting ion channels for the treatment of gastrointestinal motility disorders

  2012cited by this paper
• Systemic Hypertension: The Roles of Salt, Vascular Na+/K+ ATPase and the Endogenous Glycosides, Ouabain and Marinobufagenin

  2012cited by this paper
• Involvement of Na+-leak Channel in Substance P-induced Depolarization of Pacemaking Activity in Interstitial Cells of Cajal

  2012cited by this paper
• Activation of Ca2+-activated Cl- channels by store-operated Ca2+ entry in arterial smooth muscle cells does not require reverse-mode Na+/Ca2+ exchange.

  2012cited by this paper
• Ca2+ sensitivity of the maxi chloride channel in interstitial cells of Cajal

  2012cited by this paper
• Data‐based theoretical identification of subcellular calcium compartments and estimation of calcium dynamics in cardiac myocytes

  2012cited by this paper
• On the origin of rhythmic calcium transients in the ICC-MP of the mouse small intestine.

  2011cited by this paper
• TEAD1-dependent expression of the FoxO3a gene in mouse skeletal muscle

  2011cited by this paper
• Altered Expression of Ano1 Variants in Human Diabetic Gastroparesis*

  2011cited by this paper
• STIM1L is a new actin-binding splice variant involved in fast repetitive Ca2+ release

  2011cited by this paper
• Voltage- and calcium-dependent gating of TMEM16A/Ano1 chloride channels are physically coupled by the first intracellular loop

  2011cited by this paper
• The role of store-operated calcium influx in skeletal muscle signaling.

  2011cited by this paper
• Biophysically Based Modeling of the Interstitial Cells of Cajal: Current Status and Future Perspectives

  2011cited by this paper
• Increased complexity of Tmem16a/Anoctamin 1 transcript alternative splicing

  2011cited by this paper
• STIM1L is a new actin-binding splice variant involved in fast repetitive Ca2+release

  2011cited by this paper
• A mathematical analysis of agonist- and KCl-induced Ca(2+) oscillations in mouse airway smooth muscle cells.

  2010cited by this paper
• Mechanosensitivity of Nav1.5, a voltage‐sensitive sodium channel

  2010cited by this paper
• Ultra-rapid activation and deactivation of store-operated Ca(2+) entry in skeletal muscle.

  2010cited by this paper
• Spatio-temporal calcium dynamics in pacemaking units of the interstitial cells of Cajal.

  2010cited by this paper
• Measurement of intracellular chloride ion concentration in ICC in situ and in explant culture

  2010cited by this paper
• Activation and regulation of store-operated calcium entry

  2010cited by this paper
• TRPC1 and STIM1 mediate capacitative Ca2+ entry in mouse pulmonary arterial smooth muscle cells

  2009cited by this paper
• Calcium-Activated Chloride Channels

  2009cited by this paper
• Biophysically based mathematical modeling of interstitial cells of Cajal slow wave activity generated from a discrete unitary potential basis.

  2009cited by this paper
• A Ca2+‐activated Cl− conductance in interstitial cells of Cajal linked to slow wave currents and pacemaker activity

  2009cited by this paper
• Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract.

  2009cited by this paper
• Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles

  2009cited by this paper
• Quantitative cellular description of gastric slow wave activity.

  2008cited by this paper
• Oligomerization of STIM1 couples ER calcium depletion to CRAC channel activation

  2008cited by this paper
• The α1H Ca2+ channel subunit is expressed in mouse jejunal interstitial cells of Cajal and myocytes

  2008cited by this paper
• Differential expression of ionic conductances in interstitial cells of Cajal in the murine gastric antrum

  2008cited by this paper
• Expression cloning of TMEM16A as a calcium-activated chloride channel subunit.

  2008cited by this paper
• Structural and mechanistic insights into STIM1-mediated initiation of store-operated calcium entry.

  2008cited by this paper
• Ether-a-go-go-related gene 3 is the main candidate for the E-4031-sensitive potassium current in the pacemaker interstitial cells of Cajal.

  2008cited by this paper
• Interstitial cells of Cajal in health and disease

  2008cited by this paper
• Orai1 subunit stoichiometry of the mammalian CRAC channel pore

  2008cited by this paper
• TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

  2008cited by this paper
• TMEM16A confers receptor-activated calcium-dependent chloride conductance

  2008cited by this paper
• STIM2 is a feedback regulator that stabilizes basal cytosolic and endoplasmic reticulum Ca2+ levels.

  2007cited by this paper
• Differential gene expression in functional classes of interstitial cells of Cajal in murine small intestine.

  2007cited by this paper
• A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function

  2006cited by this paper
• A mathematical model of pacemaker activity recorded from mouse small intestine

  2006cited by this paper
• Subtractive hybridization unravels a role for the ion cotransporter NKCC1 in the murine intestinal pacemaker.

  2006cited by this paper
• Interstitial cells of cajal as pacemakers in the gastrointestinal tract.

  2006cited by this paper
• STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane

  2005cited by this paper
• Volume-activated chloride currents in interstitial cells of Cajal.

  2005cited by this paper
• Block of TRPC5 channels by 2‐aminoethoxydiphenyl borate: a differential, extracellular and voltage‐dependent effect

  2005cited by this paper
• KCl leakage from microelectrodes and its impact on the membrane parameters of a nonexcitable cell

  2005cited by this paper
• Co-contribution of IP₃R and Ca²⁺ Influx Pathways to Pacemaker Ca²⁺ Activity in Stomach ICC

  2005cited by this paper
• STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx.

  2005cited by this paper
• Melastatin-type transient receptor potential channel 7 is required for intestinal pacemaking activity.

  2005cited by this paper
• Two types of spontaneous depolarizations in the interstitial cells freshly prepared from the murine small intestine

  2004cited by this paper
• Pharmacological profile of store‐operated channels in cerebral arteriolar smooth muscle cells

  2003cited by this paper
• Properties of Pacemaker Potentials Recorded from Myenteric Interstitial Cells of Cajal Distributed in the Mouse Small Intestine

  2003cited by this paper
• Physiological study of interstitial cells of Cajal identified by vital staining

  2002cited by this paper
• Calcium Oscillation Linked to Pacemaking of Interstitial Cells of Cajal

  2002cited by this paper
• 2‐Aminoethoxydiphenyl borate (2‐APB) is a reliable blocker of store‐operated Ca2+ entry but an inconsistent inhibitor of InsP3‐induced Ca2+ release

  2002cited by this paper
• Voltage‐dependent inward currents of interstitial cells of Cajal from murine colon and small intestine

  2002cited by this paper
• A Ca2+‐inhibited non‐selective cation conductance contributes to pacemaker currents in mouse interstitial cell of Cajal

  2002cited by this paper
• Potentiation and inhibition of Ca2+ release‐activated Ca2+ channels by 2‐aminoethyldiphenyl borate (2‐APB) occurs independently of IP3 receptors

  2001cited by this paper
• Mitochondrial modulation of intracellular Ca(2+) signaling.

  2001cited by this paper
• Regulation of slow wave frequency by IP(3)-sensitive calcium release in the murine small intestine.

  2001cited by this paper
• Pacemaking in interstitial cells of Cajal depends upon calcium handling by endoplasmic reticulum and mitochondria

  2000cited by this paper
• Cannabinoid receptor activation in CA1 pyramidal cells in adult rat hippocampus.

  2000cited by this paper
• Bimodal Control of a Ca 2 Ϩ -activated Cl Ϫ Channel by Different Ca 2 Ϩ Signals Key Words: Ion Channels @bullet Electrophysiology @bullet Ion Channel Gating @bullet Calcium Signaling @bullet Ion Transport

  2000cited by this paper
• Properties of gastric smooth muscles obtained from mice which lack inositol trisphosphate receptor

  2000cited by this paper
• Bimodal Control of a Ca2+-Activated Cl− Channel by Different Ca2+ Signals

  2000cited by this paper
• Dynamics of calcium regulation of chloride currents in Xenopus oocytes.

  1999cited by this paper
• Dynamics of calcium regulation of chloride currents in Xenopus oocytes.

  1999cited by this paper
• Interstitial cells of Cajal generate a rhythmic pacemaker current

  1998cited by this paper
• 2APB, 2-aminoethoxydiphenyl borate, a membrane-penetrable modulator of Ins(1,4,5)P3-induced Ca2+ release.

  1997cited by this paper
• Analytical steady-state solution to the rapid buffering approximation near an open Ca2+ channel.

  1996cited by this paper
• Rhythmic Cl− current and physiological roles of the intestinal c-kit-positive cells

  1995cited by this paper
• The patch clamp technique.

  1995cited by this paper
• A single-pool inositol 1,4,5-trisphosphate-receptor-based model for agonist-stimulated oscillations in Ca2+ concentration.

  1992cited by this paper

• Gastrointestinal motility disorders: from pathogenesis to therapeutic strategies

  2026cites this paper
• Modelling pacemaker oscillations in lymphatic muscle cells: lengthened action potentials by two distinct system effects

  2025cites this paper
• ER morphological analysis associated with interstitial cells of Cajal and smooth muscle cells in the murine stomach

  2025cites this paper
• Burst-patterned stimulation restores colonic motility in preclinical models.

  2025cites this paper
• A Compartmental Model for Simulating the Gut-Brain Axis in Gastric Function Regulation

  2025cites this paper
• Utilisation of Deep Neural Networks for Estimation of Cajal Cells in the Anal Canal Wall of Patients with Advanced Haemorrhoidal Disease Treated by LigaSure Surgery

  2025cites this paper
• Loss of anoctamin 1 reveals a subtle role for BK channels in lymphatic muscle action potentials

  2024cites this paper
• Modulatory Impact of Oxidative Stress on Action Potentials in Pathophysiological States: A Comprehensive Review

  2024cites this paper
• Correction: A dual-clock-driven model of lymphatic muscle cell pacemaking to emulate knock-out of Ano1 or IP3R

  2024cites this paper
• Neural regulation of slow waves and phasic contractions in the distal stomach: a mathematical model

  2023cites this paper
• A dual-clock-driven model of lymphatic muscle cell pacemaking to emulate knock-out of Ano1 or IP3R

  2023cites this paper
• Computational models of autonomic regulation in gastric motility: Progress, challenges, and future directions

  2023cites this paper
• Spatially resolved multiomics of human cardiac niches

  2023cites this paper
• Computational modeling of anoctamin 1 calcium-activated chloride channels as pacemaker channels in interstitial cells of Cajal

  2023influential citation
• A dual-clock-driven model emulating the effects of either Ano1 or IP3R knock-out on lymphatic muscle cell pace-making

  2022cites this paper
• Effect of Calcium-Sensitive Receptor Agonist R568 on Gastric Motility and the Underlying Mechanism

  2022cites this paper
• Three-dimensional multi-field modelling of gastric arrhythmias and their effects on antral contractions

  2022cites this paper
• Modelling the coupling of the M-clock and C-clock in lymphatic muscle cells

  2021cites this paper
• Relationships between serum electrolyte concentrations and ileus: A joint clinical and mathematical modeling study

  2021influential citation
• The Gastric Conduction System in Health and Disease: A Translational Review.

  2021cites this paper
• Reciprocal Correlations of Inflammatory and Calcium Signaling in Asthma Pathogenesis.

  2021cites this paper
• Current applications of mathematical models of the interstitial cells of Cajal in the gastrointestinal tract.

  2020cites this paper
• Interstitial Cells of Cajal

  2020cites this paper
• Recent progress in electrophysiology and motility mapping of the gastrointestinal tract using multi-channel devices

  2020cites this paper
• A novel intramuscular Interstitial Cell of Cajal is a candidate for generating pacemaker activity in the mouse internal anal sphincter

  2020cites this paper
• Modeling of Slow Waves in the Stomach

  2020cites this paper
• Na-K-2Cl Cotransporter and Store-Operated Ca2+ Entry in Pacemaking by Interstitial Cells of Cajal.

  2019influential citation
• Conversion of Ca2+ oscillation into propagative electrical signals by Ca2+-activated ion channels and connexin as a reconstituted Ca2+ clock model for the pacemaker activity.

  2019cites this paper
• Mechanics of the stomach: A review of an emerging field of biomechanics

  2019cites this paper
• Role of the Plasma Membrane Ca2+-ATPase Pump in the Regulation of Rhythm Generation by an Interstitial Cell of Cajal: A Computational Study

  2019cites this paper
• Methods for High-Resolution Electrical Mapping in the Gastrointestinal Tract

  2019cites this paper
• Computational motility models of neurogastroenterology and neuromodulation.

  2018cites this paper
• Computational model of gastric motility with active‐strain electromechanics

  2018cites this paper
• EAVK segment "c" sequence confers Ca2+-dependent changes to the kinetics of full-length human Ano1.

  2017cites this paper
• ANO1 in intramuscular interstitial cells of Cajal plays a key role in the generation of slow waves and tone in the internal anal sphincter

  2017cites this paper
• SCF-KIT signaling induces endothelin-3 synthesis and secretion: Thereby activates and regulates endothelin-B-receptor for generating temporally- and spatially-precise nitric oxide to modulate SCF- and or KIT-expressing cell functions

  2017cites this paper
• A mathematical model of the effects of anoctamin-1 loss on intestinal slow wave entrainment

  2017cites this paper
• The virtual intestine: in silico modeling of small intestinal electrophysiology and motility and the applications

  2016cites this paper
• Original Research: Combined model of bladder detrusor smooth muscle and interstitial cells

  2016cites this paper
• High performance computational simulations of gastrointestinal electrical activity

  2015cites this paper
• Slow wave conduction patterns in the stomach: from Waller's Foundations to Current Challenges

  2015cites this paper
• Normal and abnormal electrical propagation in the small intestine

  2015cites this paper
• Experimental evidence and mathematical modeling of thermal effects on human colonic smooth muscle contractility.

  2014cites this paper
• Modeling of stochastic behavior of pacemaker potential in interstitial cells of Cajal.

  2014cites this paper
• A theoretical study of the initiation, maintenance and termination of gastric slow wave re-entry.

  2014cites this paper
• Keeping Pace with Interstitial Cells of Cajal: Modelling Gastrointestinal Electrophysiology

  2014cites this paper