A Ca2+‐activated Cl− conductance in interstitial cells of Cajal linked to slow wave currents and pacemaker activity

No abstract is available for this paper.

• Publication year

  2009

• Venue

  Journal of Physiology

• Publication date

  2009-10-01

• Fields of study

  Biology, Medicine, Chemistry

• Identifiers
  DOI 10.1113/jphysiol.2009.176206PMID 19703958PMCID PMC2770155
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Mathematical Model

  2020cited by this paper
• Expression of anoctamin 1/TMEM16A by interstitial cells of Cajal is fundamental for slow wave activity in gastrointestinal muscles

  2009cited by this paper
• Anoctamin/TMEM16 family members are Ca2+‐activated Cl− channels

  2009cited by this paper
• Biophysically based mathematical modeling of interstitial cells of Cajal slow wave activity generated from a discrete unitary potential basis.

  2009cited by this paper
• Ano1 is a selective marker of interstitial cells of Cajal in the human and mouse gastrointestinal tract.

  2009influential reference
• Nitric oxide decreases the excitability of interstitial cells of Cajal through activation of the BK channel

  2008cited by this paper
• TMEM16A confers receptor-activated calcium-dependent chloride conductance

  2008influential reference
• TMEM16A, A Membrane Protein Associated with Calcium-Dependent Chloride Channel Activity

  2008cited by this paper
• A biophysically based mathematical model of unitary potential activity in interstitial cells of Cajal.

  2008cited by this paper
• A Novel Monoclonal Antibody Against DOG1 is a Sensitive and Specific Marker for Gastrointestinal Stromal Tumors

  2008cited by this paper
• Expression cloning of TMEM16A as a calcium-activated chloride channel subunit.

  2008influential reference
• Differential gene expression in functional classes of interstitial cells of Cajal in murine small intestine.

  2007cited by this paper
• Action of imipramine on activated ATP-sensitive K(+) channels in interstitial cells of Cajal from murine small intestine.

  2006cited by this paper
• Characterization of depolarization‐evoked ERG K+ currents in interstitial cells of Cajal

  2006cited by this paper
• Interstitial cells of cajal as pacemakers in the gastrointestinal tract.

  2006cited by this paper
• A mathematical model of pacemaker activity recorded from mouse small intestine

  2006cited by this paper
• Inwardly rectifying chloride channel activity in intestinal pacemaker cells.

  2005cited by this paper
• Melastatin-type transient receptor potential channel 7 is required for intestinal pacemaking activity.

  2005cited by this paper
• The novel marker, DOG1, is expressed ubiquitously in gastrointestinal stromal tumors irrespective of KIT or PDGFRA mutation status.

  2004cited by this paper
• Two types of spontaneous depolarizations in the interstitial cells freshly prepared from the murine small intestine

  2004influential reference
• ERG K+ currents regulate pacemaker activity in ICC.

  2003cited by this paper
• Excitation of smooth muscles isolated from the guinea‐pig gastric antrum in response to depolarization

  2002cited by this paper
• High-conductance chloride channels generate pacemaker currents in interstitial cells of Cajal.

  2002cited by this paper
• A Ca2+‐inhibited non‐selective cation conductance contributes to pacemaker currents in mouse interstitial cell of Cajal

  2002cited by this paper
• Regenerative component of slow waves in the guinea‐pig gastric antrum involves a delayed increase in [Ca2+]i and Cl− channels

  2002influential reference
• Voltage‐dependent inward currents of interstitial cells of Cajal from murine colon and small intestine

  2002cited by this paper
• Expression of Ca(2+)-activated K(+) channels, SK3, in the interstitial cells of Cajal in the gastrointestinal tract.

  2001cited by this paper
• Functional and molecular expression of a voltage‐dependent K+ channel (Kv1.1) in interstitial cells of Cajal

  2001cited by this paper
• Pacemaking in interstitial cells of Cajal depends upon calcium handling by endoplasmic reticulum and mitochondria

  2000cited by this paper
• Identification of rhythmically active cells in guinea‐pig stomach

  1999influential reference
• Unitary nature of regenerative potentials recorded from circular smooth muscle of guinea‐pig antrum

  1999cited by this paper
• Interstitial cells of Cajal generate a rhythmic pacemaker current

  1998cited by this paper
• Spontaneous electrical rhythmicity in cultured interstitial cells of Cajal from the murine small intestine

  1998cited by this paper
• Calcium‐activated chloride channels in bovine pulmonary artery endothelial cells.

  1997cited by this paper
• W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity

  1995cited by this paper
• Rhythmic Cl− current and physiological roles of the intestinal c-kit-positive cells

  1995cited by this paper
• Mutation of the proto‐oncogene c‐kit blocks development of interstitial cells and electrical rhythmicity in murine intestine.

  1994cited by this paper
• Characterization of the calcium-activated chloride channel in isolated guinea-pig hepatocytes

  1994cited by this paper
• Membrane potential modulates inositol 1,4,5‐trisphosphate‐mediated Ca2+ transients in guinea‐pig coronary myocytes.

  1993cited by this paper
• Spontaneous electrical activity of interstitial cells of Cajal isolated from canine proximal colon.

  1989cited by this paper
• Effects of frequency on the wave form of propagated slow waves in canine gastric antral muscle.

  1986cited by this paper

• Absence of Interstitial Cells of Cajal in Human Colonic Muscularis Mucosae: Implications for Mucosal Motility Control.

  2026cites this paper
• Slow Transit Constipation: Pathophysiological Perspectives and Management Updates.

  2026cites this paper
• Conformational changes upon pore blocker removal reveal conductive states of TMEM16A

  2026influential citation
• TMEM16A in gastrointestinal and vascular smooth muscle contractility.

  2025cites this paper
• EXPRESSION OF ANO1 IN HUMAN GASTROINTESTINAL TRACT DURING EMBRYONIC AND FETAL DEVELOPMENT

  2025cites this paper
• Neuronal regulation of myenteric interstitial cells of Cajal (ICC-MY) in the proximal colon.

  2025cites this paper
• Atractylodes macrocephala Koidzumi modulates human colonic motility via ICCs pacemaker suppression and cAMP/ATP-sensitive K⁺ channel pathways

  2025cites this paper
• Cellular characterization of the mouse collecting lymphatic vessels reveals that lymphatic muscle cells are the innate pacemaker cells

  2025cites this paper
• A specialized population of intramuscular interstitial cells of Cajal regulates motility within the mouse oesophagogastric junction.

  2025cites this paper
• Role of ANO1 Ca2+-activated Cl− channels in the generation of propagating spontaneous Ca2+ transients of mouse bladder suburothelial pericytes

  2025cites this paper
• ANO1 channels are expressed in mouse urethral smooth muscle but do not contribute to agonist or neurally evoked contractions

  2025cites this paper
• ER morphological analysis associated with interstitial cells of Cajal and smooth muscle cells in the murine stomach

  2025cites this paper
• Modulation of intracellular calcium activity in interstitial cells of Cajal by inhibitory neural pathways within the internal anal sphincter.

  2024cites this paper
• Attenuation of Ampullary Anoctamin 1 by the peritoneal fluid in rhesus macaques with spontaneous endometriosis

  2024cites this paper
• Pacemaking in the lymphatic system.

  2024cites this paper
• Cells and ionic conductances contributing to spontaneous activity in bladder and urethral smooth muscle.

  2024cites this paper
• Electrogastrography measurement systems and analysis methods used in clinical practice and research: comprehensive review

  2024cites this paper
• Qi Lang formula relieves constipation via targeting SCF/c-kit signaling pathway: An integrated study of network pharmacology and experimental validation

  2024cites this paper
• A bibliometric analysis of interstitial cells of Cajal research

  2024cites this paper
• Cellular characterization of the mouse collecting lymphatic vessels reveals that lymphatic muscle cells are the innate pacemaker cells

  2023cites this paper
• Plasticity of colonic enteric nervous system following spinal cord injury in male and female rats

  2023cites this paper
• Functional and Transcriptomic Characterization of Postnatal Maturation of ENS and SIP Syncytium in Mice Colon

  2023cites this paper
• Expression and clinical implications of PARs in the stenotic tissue of ureteropelvic junction obstruction

  2023cites this paper
• Ca2+ dynamics in interstitial cells: foundational mechanisms for the motor patterns in the gastrointestinal tract.

  2023cites this paper
• ANO1, CaV1.2, and IP3R form a localized unit of EC-coupling in mouse pulmonary arterial smooth muscle

  2023cites this paper
• A Study on the Effects of Muscarinic and Serotonergic Regulation by Bojanggunbi-tang on the Pacemaker Potential of the Interstitial Cells of Cajal in the Murine Small Intestine

  2023cites this paper
• Smooth muscle cells, interstitial cells and neurons in the gallbladder (GB): Functional syncytium of electrical rhythmicity and GB motility (Review)

  2023cites this paper
• Transcriptome and Proteome Profiling of Primary Human Gastric Interstitial Cells of Cajal Predicts Pacemaker Networks

  2023cites this paper
• Interstitial cells of Cajal - pacemakers of the gastrointestinal tract.

  2023cites this paper
• Lymphatic Collecting Vessel: New Perspectives on Mechanisms of Contractile Regulation and Potential Lymphatic Contractile Pathways to Target in Obesity and Metabolic Diseases

  2022cites this paper
• Ca2+ Signaling Is the Basis for Pacemaker Activity and Neurotransduction in Interstitial Cells of the GI Tract.

  2022cites this paper
• The enteric nervous system.

  2022cites this paper
• PDGFRα+ Interstitial Cells are Effector Cells of PACAP Signaling in Mouse and Human Colon

  2022cites this paper
• Altered functional responses by PAR1 agonist in murine dextran sodium sulphate-treated colon

  2022cites this paper
• Corticotropin‐releasing factor receptor agonists decrease interstitial cells of Cajal in murine colon

  2022cites this paper
• Function and Regulation of the Calcium-Activated Chloride Channel Anoctamin 1 (TMEM16A).

  2022cites this paper
• Treatment of Gastrointestinal Disorders—Plants and Potential Mechanisms of Action of Their Constituents

  2022cites this paper
• Inhibitory Effects of Jakyakgamcho-Tang (Glycyrrhiza uralensis and Paeonia lactiflora) on the Pacemaker Potential of the Interstitial Cells of Cajal in the Murine Small Intestine

  2022cites this paper
• Insights on gastrointestinal motility through the use of optogenetic sensors and actuators

  2022cites this paper
• Propulsive colonic contractions are mediated by inhibition-driven poststimulus responses that originate in interstitial cells of Cajal

  2022influential citation
• Grape seed powder increases gastrointestinal motility

  2022influential citation
• Calcium transients in intramuscular interstitial cells of Cajal of the murine gastric fundus and their regulation by neuroeffector transmission

  2022cites this paper
• Hyperpolarization‐activated cyclic nucleotide‐gated channels working as pacemaker channels in colonic interstitial cells of Cajal

  2021cites this paper
• Specific PIP2 binding promotes calcium activation of TMEM16A chloride channels

  2021cites this paper
• Light-Mediated Inhibition of Colonic Smooth Muscle Constriction and Colonic Motility via Opsin 3

  2021cites this paper
• Manifestazioni non classiche dell’iperparatiroidismo primario: nuove evidenze?

  2021cites this paper
• Ca2+ transients in ICC-MY define the basis for the dominance of the corpus in gastric pacemaking.

  2021cites this paper
• Identification of evodiamine and rutecarpine as novel TMEM16A inhibitors and their inhibitory effects on peristalsis in isolated Guinea-pig ileum.

  2021cites this paper
• The Gastric Conduction System in Health and Disease: A Translational Review.

  2021cites this paper
• The groovy TMEM16 family: molecular mechanisms of lipid scrambling and ion conduction.

  2021cites this paper
• Low-voltage activated (LVA) inward current in murine antral smooth muscle cells is an artifact.

  2021cites this paper
• The Calcium-Activated Chloride Channel TMEM16A is Inhibitied by Liquiritigenin

  2021cites this paper
• Ca2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the murine colon

  2021influential citation
• Molecular mechanisms of activation and regulation of ANO1-Encoded Ca2+-Activated Cl- channels

  2021cites this paper
• Role of Ano1 Ca2+ activated Cl channels in generating urethral tone.

  2021cites this paper
• Neurotransmitters responsible for purinergic motor neurotransmission and regulation of GI motility.

  2021cites this paper
• Cucumis sativus extract elicits chloride secretion by stimulation of the intestinal TMEM16A ion channel

  2021cites this paper
• A novel intramuscular Interstitial Cell of Cajal is a candidate for generating pacemaker activity in the mouse internal anal sphincter

  2020cites this paper
• Excitatory cholinergic responses in mouse colon intramuscular interstitial cells of Cajal are due to enhanced Ca2+ release via M3 receptor activation

  2020cites this paper
• INVESTIGATION INTO THE DEVELOPMENT AND FUNCTION OF THE GASTROINTESTINAL TRACT OF ZEBRAFISH A Thesis by SAVANNA SHERIDAN

  2020influential citation
• Norepinephrine Has Dual Effects on Human Colonic Contractions Through Distinct Subtypes of Alpha 1 Adrenoceptors

  2020cites this paper
• Identification and classification of interstitial cells in the mouse renal pelvis

  2020cites this paper
• Specific PIP2 binding promotes calcium activation of TMEM16A chloride channels

  2020cites this paper
• Understanding the Biology of Human Interstitial Cells of Cajal in Gastrointestinal Motility

  2020influential citation
• Hesperidin depolarizes the pacemaker potentials through 5-HT4 receptor in murine small intestinal interstitial cells of Cajal

  2020cites this paper
• Depolarization of pacemaker potentials by caffeic acid phenethyl ester in interstitial cells of Cajal from the murine small intestine.

  2020cites this paper
• Association between interstitial cells of Cajal and anti-vinculin antibody in human stomach

  2020cites this paper
• Co-expression network analysis identified specific miRNAs and genes in association with slow-transit constipation

  2020cites this paper
• Ca2+ signaling driving pacemaker activity in submucosal interstitial cells of Cajal in the colon

  2020cites this paper
• Na+/Ca2 + Exchange and Pacemaker Activity of Interstitial Cells of Cajal

  2020cites this paper
• A high throughput machine-learning driven analysis of Ca2+ spatio-temporal maps.

  2020cites this paper
• Extracellular metabolism of the enteric inhibitory neurotransmitter β‐nicotinamide adenine dinucleotide (β‐NAD) in the murine colon

  2020cites this paper
• The Ca2+-activated chloride channel ANO1/TMEM16A: An emerging therapeutic target for epithelium-originated diseases?

  2020cites this paper
• Differential sensitivity of gastric and small intestinal muscles to inducible knockdown of anoctamin 1 and the effects on gastrointestinal motility

  2019influential citation
• Smooth Muscle Spontaneous Activity

  2019cites this paper
• The roles of PDGFRα signaling in the postnatal development and functional maintenance of the SMC‐ICC‐PDGFRα+ cell (SIP) syncytium in the colon

  2019cites this paper
• Control of Motility in the Internal Anal Sphincter

  2019cites this paper
• Venous Vasomotion.

  2019cites this paper
• Applications of Spatio-temporal Mapping and Particle Analysis Techniques to Quantify Intracellular Ca2+ Signaling In Situ.

  2019cites this paper
• Mechanics of the stomach: A review of an emerging field of biomechanics

  2019cites this paper
• Colonic Transit Disorder Mediated by Downregulation of Interstitial Cells of Cajal/Anoctamin-1 in Dextran Sodium Sulfate-induced Colitis Mice

  2019cites this paper
• Effects of Olanzapine on the Pacemaker Potentials of Interstitial Cells of Cajal in Murine Small Intestine

  2019cites this paper
• Colonic Dysmotility in Murine Partial Colonic Obstruction Due to Functional Changes in Interstitial Cells

  2019cites this paper
• Neuromodulation of central pattern generators and its role in the functional recovery of central pattern generator activity.

  2019cites this paper
• Spontaneous Electrical Activity and Rhythmicity in Gastrointestinal Smooth Muscles.

  2019cites this paper
• The Traditional Medicine Banhasasim-Tang Depolarizes Pacemaker Potentials of Cultured Interstitial Cells of Cajal through M3 Muscarinic and 5-HT3 Receptors in Murine Small Intestine

  2019cites this paper
• Pacemaker Mechanisms Driving Pyeloureteric Peristalsis: Modulatory Role of Interstitial Cells.

  2019cites this paper
• Generation and Regulation of Spontaneous Contractions in the Prostate.

  2019cites this paper
• Na-K-2Cl Cotransporter and Store-Operated Ca2+ Entry in Pacemaking by Interstitial Cells of Cajal.

  2019cites this paper
• Anoctamin-1 affects the migration and invasion of anaplastic thyroid carcinoma cells

  2019cites this paper
• Tonic inhibition of murine proximal colon is due to nitrergic suppression of Ca2+ signaling in interstitial cells of Cajal

  2019cites this paper
• Myosalpinx Contractions Are Essential for Egg Transport Along the Oviduct and Are Disrupted in Reproductive Tract Diseases.

  2019cites this paper
• Rikkunshito Depolarizes Pacemaker Potentials of Cultured Interstitial Cells of Cajal through Ghrelin Receptors in Murine Small Intestine

  2019cites this paper
• Modulation of Pacemaker Potentials in Murine Small Intestinal Interstitial Cells of Cajal by Gamisoyo-San, a Traditional Chinese Herbal Medicine

  2018cites this paper
• Excitatory Neuronal Responses of Ca2+ Transients in Interstitial Cells of Cajal in the Small Intestine

  2018cites this paper
• Inhibitory Neural Regulation of the Ca2+ Transients in Intramuscular Interstitial Cells of Cajal in the Small Intestine

  2018cites this paper
• Effects of Ca2+-Activated Cl- Channel ANO1inhibitors on Pacemaker Activity in Interstitial Cells of Cajal

  2018cites this paper
• Bioengineering functional smooth muscle with spontaneous rhythmic contraction in vitro

  2018cites this paper
• Colonic Hypermotility in a Rat Model of Irritable Bowel Syndrome Is Associated with Upregulation of TMEM16A in Myenteric Plexus

  2018cites this paper
• Regulation of Intracellular Calcium by Endoplasmic Reticulum Proteins in Small Intestinal Interstitial Cells of Cajal

  2018cites this paper