Insulin receptor kinase defects as a possible cause of cellular insulin resistance.

No abstract is available for this paper.

• Publication year

  1987

• Venue

  Diabete & metabolisme

• Publication date

  1987-07-01

• Fields of study

  Medicine, Chemistry

• Identifiers
  PMID 2820811
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

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  1987cited by this paper
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  1987cited by this paper
• Phosphorylation of Purified Insulin Receptor by cAMP Kinase

  1987cited by this paper
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  1987cited by this paper
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  1986cited by this paper
• Characterization of phosphatidylinositol kinase activity associated with the insulin receptor.

  1986cited by this paper
• Decreased tyrosine kinase activity of insulin receptor isolated from rat adipocytes rendered insulin-resistant by catecholamine treatment in vitro.

  1986cited by this paper
• Comparative Studies on Insulin-Like Growth Factor II and Insulin Processing by Vascular Endothelial Cells

  1986cited by this paper
• Insulin stimulates the generation from hepatic plasma membranes of modulators derived from an inositol glycolipid.

  1986cited by this paper
• Further Evidence Implicating Diacylglycerol Generation and Protein Kinase C Activation in Agonist-Induced Increases in Glucose Uptake: Insulin-Like Effects of Phenylephrine in BC3H-1 Myocytes

  1986cited by this paper
• Increasing the cAMP content of IM-9 cells alters the phosphorylation state and protein kinase activity of the insulin receptor.

  1986cited by this paper
• Tumor-promoting phorbol esters increase the Km of the ATP-binding site of the insulin receptor kinase from rat adipocytes.

  1986cited by this paper
• Studies and perspectives of protein kinase C.

  1986cited by this paper
• Insulin receptor kinase in human skeletal muscle

  1985cited by this paper
• Differences in the sites of phosphorylation of the insulin receptor in vivo and in vitro.

  1985cited by this paper
• Insulin receptor tyrosine kinase is defective in skeletal muscle of insulin-resistant obese mice

  1985cited by this paper
• Identification of a cellular 110 000-Da protein substrate for the insulin-receptor kinase.

  1985cited by this paper
• Tumour-promoting phorbol esters increase basal and inhibit insulin-stimulated lipogenesis in rat adipocytes without decreasing insulin binding.

  1985cited by this paper
• Phorbolesters enhance basal D-glucose transport but inhibit insulin stimulation of D-glucose transport and insulin binding in isolated rat adipocytes.

  1985cited by this paper
• Interaction of the insulin receptor kinase with serine/threonine kinases in vitro

  1985cited by this paper
• An endogenous substrate for the insulin receptor-associated tyrosine kinase.

  1985cited by this paper
• Tyrosine phosphorylation of the insulin receptor beta subunit activates the receptor-associated tyrosine kinase activity.

  1984cited by this paper
• Phosphorylation and dephosphorylation of the insulin receptor: evidence against an intrinsic phosphatase activity.

  1984cited by this paper
• Abnormality of insulin binding and receptor phosphorylation in an insulin-resistant melanoma cell line

  1984cited by this paper
• Defect in insulin receptor phosphorylation in erythrocytes and fibroblasts associated with severe insulin resistance.

  1984cited by this paper
• Phorbol esters modulate insulin receptor phosphorylation and insulin action in cultured hepatoma cells.

  1984cited by this paper
• Protein kinase activity of the insulin receptor from muscle

  1984cited by this paper
• Decreased autophosphorylation of the insulin receptor-kinase in streptozotocin-diabetic rats.

  1984cited by this paper
• Defect in phosphorylation of insulin receptors in cells from an insulin-resistant patient with normal insulin binding.

  1984cited by this paper
• Kinetic properties and sites of autophosphorylation of the partially purified insulin receptor from hepatoma cells.

  1984cited by this paper
• Two different protein kinase activities are associated with the insulin receptor.

  1983cited by this paper
• Receptor-mediated phosphorylation of the hepatic insulin receptor: evidence that the Mr 95,000 receptor subunit is its own kinase.

  1983cited by this paper
• Catecholamine-induced insulin resistance of glucose transport in isolated rat adipocytes.

  1983cited by this paper
• Tyrosine-specific protein kinase activity is associated with the purified insulin receptor.

  1983cited by this paper
• Phorbol esters stimulate the phosphorylation of receptors for insulin and somatomedin C.

  1983cited by this paper
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  1982cited by this paper
• Phosphorylation of the hepatic insulin receptor

  1982cited by this paper
• Insulin receptor phosphorylation in intact adipocytes and in a cell-free system.

  1982cited by this paper
• Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor.

  1982cited by this paper
• Insulin receptor: structure and function.

  1981cited by this paper
• Inhibition of proliferation of cloudman S91 melanoma cells by insulin and characterization of some insulin‐resistant variants

  1980cited by this paper

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• Mechanisms of Insulin Resistance Leading to Hypertension: What We Can Learn from Experimental Models

  1997cites this paper
• [Insulin resistance, calcium cell metabolism, and essential arterial hypertension. Role of skeletal muscle].

  1996cites this paper
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  1996cites this paper
• Tumor Necrosis Factor- (cid:97) – and Hyperglycemia-induced Insulin Resistance Evidence for Different Mechanisms and Different Effects on Insulin Signaling

  1996cites this paper
• Mechanism of insulin receptor kinase inhibition in non-insulin-dependent diabetes mellitus patients. Phosphorylation of serine 1327 or threonine 1348 is unaltered.

  1995cites this paper
• [The value of metformin in therapy of type 2 diabetes: effect on insulin resistance, diabetic control and cardiovascular risk factors].

  1994cites this paper
• Regulation of human insulin receptor RNA splicing in vivo.

  1994cites this paper
• Pathogenesis of Type 2 (non-insulin-dependent) diabetes mellitus: candidates for a signal transmitter defect causing insulin resistance of the skeletal muscle

  1993cites this paper
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  1992cites this paper
• Theoretische und klinische Grundlagen des Typ-I-Diabetes

  1992cites this paper
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• Normal insulin receptor tyrosine kinase activity and glucose transporter (GLUT 4) levels in the skeletal muscle of hyperinsulinaemic hypertensive rats

  1992cites this paper
• Reduced glycogen synthase activity in skeletal muscle from obese patients with and without Type 2 (non-insulin-dependent) diabetes mellitus

  1991cites this paper
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  1991cites this paper
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  1991cites this paper
• Insulin receptors in the central nervous system: localization, signalling mechanisms and functional aspects.

  1991cites this paper
• Insulin receptor binding and glucose metabolism in normal human pregnancy and gestational diabetes mellitus. A review.

  1990cites this paper
• Effect of Streptozocin-Induced Diabetes on Insulin-Receptor Tyrosine Kinase Activity in Obese Zucker Rats

  1990cites this paper
• The Insulin Receptor Tyrosine Kinase

  1990cites this paper
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  1989cites this paper
• Alterations in the hepatic insulin receptor kinase in genetic and acquired obesity in rats.

  1989cites this paper
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  1989cites this paper