Orally active insulin mimics: where do we stand now?

No abstract is available for this paper.

• Publication year

  2001

• Venue

  Journal of Biosciences

• Publication date

  2001-09-01

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1007/BF02703748PMID 11568484
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• Crystallographic and Solution Studies of an Activation Loop Mutant of the Insulin Receptor Tyrosine Kinase

  2001cited by this paper
• Time-action profile of the long-acting insulin analog insulin glargine (HOE901) in comparison with those of NPH insulin and placebo.

  2000cited by this paper
• Chemistry and insulin-like properties of vanadium(IV) and vanadium(V) compounds.

  2000cited by this paper
• The Molecular Mechanism of the Insulin-mimetic/sensitizing Activity of the Antidiabetic Sulfonylurea Drug Amaryl

  2000cited by this paper
• Structure-based Design of a Low Molecular Weight, Nonphosphorus, Nonpeptide, and Highly Selective Inhibitor of Protein-tyrosine Phosphatase 1B*

  2000cited by this paper
• An orally active antidiabetic vanadyl complex, bis(1-oxy-2-pyridinethiolato)oxovanadium(IV), with VO(S2O2) coordination mode; in vitro and in vivo evaluations in rats.

  2000cited by this paper
• Molecular basis for the dephosphorylation of the activation segment of the insulin receptor by protein tyrosine phosphatase 1B.

  2000cited by this paper
• Oral hypoglycaemic activity of Ipomoea aquatica.

  2000cited by this paper
• Peroxovanadate induces tyrosine phosphorylation of phosphoinositide-dependent protein kinase-1 potential involvement of src kinase.

  2000cited by this paper
• Oral peptide drug delivery: polymer-inhibitor conjugates protecting insulin from enzymatic degradation in vitro.

  2000cited by this paper
• Design and In Vivo Evaluation of An Oral Delivery System for Insulin

  2000cited by this paper
• Discovery of a potent, highly selective, and orally efficacious small-molecule activator of the insulin receptor.

  2000cited by this paper
• Mechanisms of vanadium action: insulin-mimetic or insulin-enhancing agent?

  2000cited by this paper
• Activation of Insulin Signal Transduction Pathway and Anti-diabetic Activity of Small Molecule Insulin Receptor Activators*

  2000cited by this paper
• 2-(Oxalylamino)-Benzoic Acid Is a General, Competitive Inhibitor of Protein-tyrosine Phosphatases*

  2000cited by this paper
• New azolidinediones as inhibitors of protein tyrosine phosphatase 1B with antihyperglycemic properties.

  2000cited by this paper
• Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene.

  1999cited by this paper
• Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle.

  1999cited by this paper
• A phosphotyrosyl mimetic peptide reverses impairment of insulin-stimulated translocation of GLUT4 caused by overexpression of PTP1B in rat adipose cells.

  1999cited by this paper
• Characterization of selective resistance to insulin signaling in the vasculature of obese Zucker (fa/fa) rats.

  1999cited by this paper
• Oral insulin delivery.

  1999cited by this paper
• Discovery of a small molecule insulin mimetic with antidiabetic activity in mice.

  1999influential reference
• Quaternary structure of the insulin-insulin receptor complex.

  1999cited by this paper
• Vanadyl-biguanide complexes as potential synergistic insulin mimics.

  1999cited by this paper
• Membrane-targeted Phosphatidylinositol 3-Kinase Mimics Insulin Actions and Induces a State of Cellular Insulin Resistance*

  1999cited by this paper
• Transdermally delivered peroxovanadium can lower blood glucose levels in diabetic rats.

  1999cited by this paper
• The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action.

  1998cited by this paper
• Regulation of PTP-1 and Insulin Receptor Kinase by Fractions from Cinnamon: Implications for Cinnamon Regulation of Insulin Signalling

  1998cited by this paper
• Insulin-mimetic signalling of synthetic phosphoinositolglycans in isolated rat adipocytes.

  1998cited by this paper
• Intracellular Localization of Phosphatidylinositide 3-kinase and Insulin Receptor Substrate-1 in Adipocytes: Potential Involvement of a Membrane Skeleton

  1998cited by this paper
• The IRS-signaling system: a network of docking proteins that mediate insulin and cytokine action.

  1998cited by this paper
• Insulin-Stimulated Akt Kinase Activity Is Reduced in Skeletal Muscle From NIDDM Subjects

  1998cited by this paper
• Insulin-releasing and insulin-like activity of Agaricus campestris (mushroom).

  1998cited by this paper
• Signalling pathways of an insulin-mimetic phosphoinositolglycan-peptide in muscle and adipose tissue.

  1998cited by this paper
• The IRS-signalling system: A network of docking proteins that mediate insulin action

  1998cited by this paper
• Membrane-permeant Esters of Phosphatidylinositol 3,4,5-Trisphosphate*

  1998cited by this paper
• Mechanism of activation and function of protein kinase B.

  1998cited by this paper
• Protein-tyrosine Phosphatases PTP1B and Syp Are Modulators of Insulin-stimulated Translocation of GLUT4 in Transfected Rat Adipose Cells*

  1997cited by this paper
• Early signaling events triggered by peroxovanadium [bpV(phen)] are insulin receptor kinase (IRK)-dependent: specificity of inhibition of IRK-associated protein tyrosine phosphatase(s) by bpV(phen).

  1997cited by this paper
• Crystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analog

  1997cited by this paper
• Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse.

  1997cited by this paper
• Early neonatal death in mice homozygous for a null allele of the insulin receptor gene

  1996cited by this paper
• Visualization of intermediate and transition-state structures in protein-tyrosine phosphatase catalysis.

  1996cited by this paper
• Insulin action impaired by deficiency of the G-protein subunit G ialpha2.

  1996cited by this paper
• Targeted disruption of the insulin receptor gene in the mouse results in neonatal lethality.

  1996cited by this paper
• Expression of a Constitutively Active Akt Ser/Thr Kinase in 3T3-L1 Adipocytes Stimulates Glucose Uptake and Glucose Transporter 4 Translocation*

  1996cited by this paper
• Insulin action impaired by deficiency of the G-protein subunit Giα2

  1996cited by this paper
• Extrapancreatic effects of sulfonylureas--a comparison between glimepiride and conventional sulfonylureas.

  1995cited by this paper
• The inability of phosphatidylinositol 3-kinase activation to stimulate GLUT4 translocation indicates additional signaling pathways are required for insulin-stimulated glucose uptake.

  1995cited by this paper
• Peroxovanadium compounds: Biolgoical actions and mechanism of insulin-mimesis

  1995cited by this paper
• Roles of 1-phosphatidylinositol 3-kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cells

  1995cited by this paper
• Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects.

  1995cited by this paper
• Oral vanadyl sulfate improves hepatic and peripheral insulin sensitivity in patients with non-insulin-dependent diabetes mellitus.

  1995cited by this paper
• Growth factor-induced stimulation of hexose transport in 3T3-L1 adipocytes: evidence that insulin-induced translocation of GLUT4 is independent of activation of MAP kinase.

  1994cited by this paper
• Peroxovanadium compounds. A new class of potent phosphotyrosine phosphatase inhibitors which are insulin mimetics.

  1994cited by this paper
• Crystal structure of the tyrosine kinase domain of the human insulin receptor

  1994cited by this paper
• Oral vanadate decreases muscle insulin resistance in obese fa/fa rats

  1992cited by this paper
• Lilly Lecture: Syndromes of Insulin Resistance: From Patient to Gene and Back Again

  1992cited by this paper
• Lilly Lecture: Molecular Mechanisms of Insulin Resistance: Lessons From Patients With Mutations in the Insulin-Receptor Gene

  1992cited by this paper
• [Syndromes of insulin resistance].

  1991cited by this paper
• Insulin-sensitive tyrosine kinase: relationship with in vivo insulin action in humans.

  1990cited by this paper
• Traditional Plant Medicines as Treatments for Diabetes

  1989cited by this paper
• A membrane-anchored cytoplasmic domain of the human insulin receptor mediates a constitutively elevated insulin-independent uptake of 2-deoxyglucose.

  1987cited by this paper
• Oral administration of vanadate normalizes blood glucose levels in streptozotocin-treated rats. Characterization and mode of action.

  1987cited by this paper
• Decreased kinase activity of insulin receptors from adipocytes of non-insulin-dependent diabetic subjects.

  1987cited by this paper
• Insulin receptor kinase in human skeletal muscle from obese subjects with and without noninsulin dependent diabetes.

  1987cited by this paper
• Insulin receptor kinase defects as a possible cause of cellular insulin resistance.

  1987cited by this paper
• Studies on the mechanism of insulin resistance in the liver from humans with noninsulin-dependent diabetes. Insulin action and binding in isolated hepatocytes, insulin receptor structure, and kinase activity.

  1986cited by this paper
• Tyrosine phosphorylation of the insulin receptor beta subunit activates the receptor-associated tyrosine kinase activity.

  1984cited by this paper
• Phosphorylation activates the insulin receptor tyrosine protein kinase.

  1983cited by this paper
• Insulin stimulates the phosphorylation of the 95,000-dalton subunit of its own receptor.

  1982cited by this paper
• Decreased insulin binding to adipocytes and circulating monocytes from obese subjects.

  1976cited by this paper

• PTP1b Inhibition, A Promising Approach for the Treatment of Diabetes Type II.

  2019cites this paper
• Manufacture, Characterization, and Release Profiles of Insulin-Loaded Mesoporous PLGA Microspheres

  2016cites this paper
• Low molecular weight regulators of the intracellular insulin signal transduction as a correction method of the insulin resistance in the treatment of type 2 diabetes

  2016cites this paper
• [Low molecular weight regulators of the intracellular insulin signal transduction as a correction method of the insulin resistance in the treatment of type 2 diabetes].

  2016cites this paper
• Low molecular weight regulators of the intracellular insulin signal transduction as the method of correction of insulin resistance in the treatment of type 2 diabetes mellitus

  2015cites this paper
• Detection and molecular characterization of rabies virus in Mongolia during 2008-2010

  2015cites this paper
• Genes involved in pancreatic islet cell rejuvenation

  2013cites this paper
• Protein Tyrosine Phosphatase 1B Inhibitors: A Molecular Level Legitimate Approach for the Management of Diabetes Mellitus

  2012cites this paper
• Chemical Information Review Document for Oral Exposure to Tetravalent and Pentavalent Vanadium Compounds

  2008cites this paper
• A Nonspecific Phosphotyrosine Phosphatase Inhibitor, Bis(maltolato)oxovanadium(IV), Improves Glucose Tolerance and Prevents Diabetes in Zucker Diabetic Fatty Rats

  2005cites this paper
• The effects of peroxovanadate and peroxovanadyl on glucose metabolism in vivo and identification of signal transduction proteins involved in the mechanism of action in isolated soleus muscle

  2005cites this paper
• Structure-based de novo design of ligands using a three-dimensional model of the insulin receptor.

  2004cites this paper
• Long-Term Beneficial Effects of Vanadate, Tungstate, and Molybdate on Insulin Secretion and Function of Cultured Beta Cells

  2004cites this paper