Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse.

No abstract is available for this paper.

• Publication year

  1997

• Venue

  Journal of Clinical Investigation

• Publication date

  1997-12-15

• Fields of study

  Biology, Medicine

• Identifiers
  DOI 10.1172/JCI119872PMID 9399964PMCID PMC508530
• External record

  Open on Semantic Scholar

• Source metadata

  Semantic Scholar, PubMed

• No claims are published for this paper.

• No concepts are published for this paper.

• p85alpha gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-Kinase), p50alpha, p55alpha, and p85alpha, with different PI 3-kinase activity elevating responses to insulin.

  1997cited by this paper
• p85α Gene Generates Three Isoforms of Regulatory Subunit for Phosphatidylinositol 3-Kinase (PI 3-Kinase), p50α, p55α, and p85α, with Different PI 3-Kinase Activity Elevating Responses to Insulin*

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  1997influential reference
• The 60 kDa insulin receptor substrate functions like an IRS protein (pp60IRS3) in adipose cells.

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• A Novel 160-kDa Phosphotyrosine Protein in Insulin-treated Embryonic Kidney Cells Is a New Member of the Insulin Receptor Substrate Family*

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• Phenotypes of Mouse diabetes and Rat fatty Due to Mutations in the OB (Leptin) Receptor

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• A Grb2-associated docking protein in EGF- and insulin-receptor signalling

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• Structural Organization and Alternative Splicing of the Murine Phosphoinositide 3-Kinase p85α Gene

  1996cited by this paper
• A Novel 55-kDa Regulatory Subunit for Phosphatidylinositol 3-Kinase Structurally Similar to p55PIK Is Generated by Alternative Splicing of the p85 Gene (*)

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• Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene.

  1996cited by this paper
• Insulin receptor substrate 1 binds two novel splice variants of the regulatory subunit of phosphatidylinositol 3-kinase in muscle and brain

  1996influential reference
• Phosphatidylinositol 3-Kinase Inhibitors Block Differentiation of Skeletal Muscle Cells*

  1996cited by this paper
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• Wortmannin, a specific phosphatidylinositol 3-kinase inhibitor, inhibits adipocytic differentiation of 3T3-L1 cells.

  1995cited by this paper
• Identification of a 190-kDa Protein as a Novel Substrate for the Insulin Receptor Kinase Functionally Similar to Insulin Receptor Substrate-1 (*)

  1995cited by this paper
• Insulin action and the insulin signaling network.

  1995cited by this paper
• The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase

  1995cited by this paper
• 4PS/Insulin Receptor Substrate (IRS)-2 Is the Alternative Substrate of the Insulin Receptor in IRS-1-deficient Mice (*)

  1995cited by this paper
• New frontiers in insulin receptor substrate signaling.

  1995cited by this paper
• Role of IRS-2 in insulin and cytokine signalling

  1995cited by this paper
• The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity.

  1994cited by this paper
• Phosphatidylinositol 3‐kinase

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• Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

  1994cited by this paper
• Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

  1994cited by this paper
• Regulation of human insulin receptor RNA splicing in vivo.

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• Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation

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• Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1

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• Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1

  1993cited by this paper
• Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus.

  1993influential reference
• The insulin-elicited 60-kDa phosphotyrosine protein in rat adipocytes is associated with phosphatidylinositol 3-kinase.

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• Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats.

  1993influential reference
• Altered pattern of insulin receptor isotypes in skeletal muscle membranes of Type 2 (non-insulin-dependent) diabetic subjects

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• IRS-1 is a common element in insulin and insulin-like growth factor-I signaling to the phosphatidylinositol 3'-kinase.

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• Phosphatidylinositol 3-kinase: structure and expression of the 110 kd catalytic subunit.

  1992cited by this paper
• Insulin and insulinomimetic agents induce activation of phosphatidylinositol 3'-kinase upon its association with pp185 (IRS-1) in intact rat livers.

  1992cited by this paper
• Insulin resistance in obese Zucker rat (fa/fa) skeletal muscle is associated with a failure of glucose transporter translocation.

  1992cited by this paper
• Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance.

  1992influential reference
• Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew.

  1992cited by this paper
• Phosphatidylinositol 3′‐kinase is activated by association with IRS‐1 during insulin stimulation.

  1992cited by this paper
• Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases.

  1991cited by this paper
• Characterization of two 85 kd proteins that associate with receptor tyrosine kinases, middle-T/pp60c-src complexes, and PI3-kinase.

  1991cited by this paper
• Structure of the insulin receptor substrate IRS-1 defines a unique signal transduction protein

  1991cited by this paper
• Altered expression of insulin receptor types A and B in the skeletal muscle of non-insulin-dependent diabetes mellitus patients.

  1991cited by this paper
• cDNA cloning of a novel 85 kd protein that has SH2 domains and regulates binding of PI3-kinase to the PDGF beta-receptor.

  1991cited by this paper
• Phosphatidylinositol kinase or an associated protein is a substrate for the insulin receptor tyrosine kinase.

  1990cited by this paper
• Insulin receptor deficiency in genetic and acquired obesity.

  1975influential reference
• Insulin-receptor interaction in the obese-hyperglycemic mouse. A model of insulin resistance.

  1973influential reference

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